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The need to regulate replication fork speed.
Gómez-González B, Aguilera A. Gómez-González B, et al. Science. 2017 Nov 10;358(6364):722-723. doi: 10.1126/science.aaq0678. Science. 2017. PMID: 29123052 No abstract available.
Genome instability: a mechanistic view of its causes and consequences.
Aguilera A, Gómez-González B. Aguilera A, et al. Nat Rev Genet. 2008 Mar;9(3):204-17. doi: 10.1038/nrg2268. Nat Rev Genet. 2008. PMID: 18227811 Review.
The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability.
González-Aguilera C, Tous C, Gómez-González B, Huertas P, Luna R, Aguilera A. González-Aguilera C, et al. Mol Biol Cell. 2008 Oct;19(10):4310-8. doi: 10.1091/mbc.e08-04-0355. Epub 2008 Jul 30. Mol Biol Cell. 2008. PMID: 18667528 Free PMC article.
The S-phase checkpoint is required to respond to R-loops accumulated in THO mutants.
Gómez-González B, Felipe-Abrio I, Aguilera A. Gómez-González B, et al. Mol Cell Biol. 2009 Oct;29(19):5203-13. doi: 10.1128/MCB.00402-09. Epub 2009 Aug 3. Mol Cell Biol. 2009. PMID: 19651896 Free PMC article.
AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants.
Ruiz JF, Gómez-González B, Aguilera A. Ruiz JF, et al. PLoS Genet. 2011 Feb;7(2):e1002009. doi: 10.1371/journal.pgen.1002009. Epub 2011 Feb 24. PLoS Genet. 2011. PMID: 21383964 Free PMC article.
Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles.
Gómez-González B, García-Rubio M, Bermejo R, Gaillard H, Shirahige K, Marín A, Foiani M, Aguilera A. Gómez-González B, et al. EMBO J. 2011 Jun 24;30(15):3106-19. doi: 10.1038/emboj.2011.206. EMBO J. 2011. PMID: 21701562 Free PMC article.
Genome instability and transcription elongation impairment in human cells depleted of THO/TREX.
Domínguez-Sánchez MS, Barroso S, Gómez-González B, Luna R, Aguilera A. Domínguez-Sánchez MS, et al. PLoS Genet. 2011 Dec;7(12):e1002386. doi: 10.1371/journal.pgen.1002386. Epub 2011 Dec 1. PLoS Genet. 2011. PMID: 22144908 Free PMC article.
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