Characterization of Pyrrolidinyl-hexahydro-pyranopiperazines as a Novel Kappa Opioid Receptor Agonist Scaffold.
Reed B, Miller M, Michino M, Butelman ER, Ben-Ezra A, Pikus P, Morochnik M, Kim Y, Ripka A, Vacca J, Kreek MJ.
Reed B, et al. Among authors: ripka a.
ACS Chem Neurosci. 2022 Jul 6;13(13):1849-1856. doi: 10.1021/acschemneuro.2c00258. Epub 2022 Jun 23.
ACS Chem Neurosci. 2022.
PMID: 35738565
Free PMC article.
The modulation of kappa receptor potency/G-protein activation and arrestin recruitment with respect to changes of the piperazine R group in A was demonstrated. ...These studies demonstrate a novel kappa receptor agonist scaffold with potential for G-protein signalin …
The modulation of kappa receptor potency/G-protein activation and arrestin recruitment with respect to changes of the piperazine R gr …