G0901606/MRC_/Medical Research Council/United Kingdom[Grant Number] - Search Results

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Year	Number of Results
2009	1
2010	1
2011	1
2012	1
2013	3
2022	0

Page 1

Generation of assays and antibodies to facilitate the study of human 5'-tyrosyl DNA phosphodiesterase.

Thomson G, Watson A, Caldecott K, Denneny O, Depledge P, Hamilton N, Hopkins G, Jordan A, Morrow C, Raoof A, Waddell I, Ogilvie D. Thomson G, et al. Anal Biochem. 2013 May 15;436(2):145-50. doi: 10.1016/j.ab.2013.02.001. Epub 2013 Feb 12. Anal Biochem. 2013. PMID: 23416181

Toxoflavins and deazaflavins as the first reported selective small molecule inhibitors of tyrosyl-DNA phosphodiesterase II.

Raoof A, Depledge P, Hamilton NM, Hamilton NS, Hitchin JR, Hopkins GV, Jordan AM, Maguire LA, McGonagle AE, Mould DP, Rushbrooke M, Small HF, Smith KM, Thomson GJ, Turlais F, Waddell ID, Waszkowycz B, Watson AJ, Ogilvie DJ. Raoof A, et al. J Med Chem. 2013 Aug 22;56(16):6352-70. doi: 10.1021/jm400568p. Epub 2013 Jul 31. J Med Chem. 2013. PMID: 23859074

A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage.

Cortes Ledesma F, El Khamisy SF, Zuma MC, Osborn K, Caldecott KW. Cortes Ledesma F, et al. Nature. 2009 Oct 1;461(7264):674-8. doi: 10.1038/nature08444. Nature. 2009. PMID: 19794497

Tyrosyl DNA phosphodiesterase 2, an enzyme fit for purpose.

Caldecott KW. Caldecott KW. Nat Struct Mol Biol. 2012 Dec;19(12):1212-3. doi: 10.1038/nsmb.2455. Nat Struct Mol Biol. 2012. PMID: 23211766 No abstract available.

TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo.

Gómez-Herreros F, Romero-Granados R, Zeng Z, Alvarez-Quilón A, Quintero C, Ju L, Umans L, Vermeire L, Huylebroeck D, Caldecott KW, Cortés-Ledesma F. Gómez-Herreros F, et al. PLoS Genet. 2013;9(3):e1003226. doi: 10.1371/journal.pgen.1003226. Epub 2013 Mar 7. PLoS Genet. 2013. PMID: 23505375 Free PMC article.

TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage.

Zeng Z, Cortés-Ledesma F, El Khamisy SF, Caldecott KW. Zeng Z, et al. J Biol Chem. 2011 Jan 7;286(1):403-9. doi: 10.1074/jbc.M110.181016. Epub 2010 Oct 28. J Biol Chem. 2011. PMID: 21030584 Free PMC article.

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