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Assessment of ELISA as endpoint in neuronal cell-based assay for BoNT detection using hiPSC derived neurons.
Pellett S, Tepp WH, Johnson EA, Sesardic D. Pellett S, et al. J Pharmacol Toxicol Methods. 2017 Nov;88(Pt 1):1-6. doi: 10.1016/j.vascn.2017.04.013. Epub 2017 Apr 29. J Pharmacol Toxicol Methods. 2017. PMID: 28465161 Free PMC article.
For decades, the only approved method for potency determination of pharmaceutical BoNTs was the mouse bioassay (MBA), but in recent years improvements in cell-assay technologies have enabled MBA replacement by cell-based assays for specific product evaluations. This projec …
For decades, the only approved method for potency determination of pharmaceutical BoNTs was the mouse bioassay (MBA), but in recent years im …
Development of human-like scFv-Fc antibodies neutralizing Botulinum toxin serotype B.
Rasetti-Escargueil C, Avril A, Chahboun S, Tierney R, Bak N, Miethe S, Mazuet C, Popoff MR, Thullier P, Hust M, Pelat T, Sesardic D. Rasetti-Escargueil C, et al. MAbs. 2015;7(6):1161-77. doi: 10.1080/19420862.2015.1082016. Epub 2015 Sep 18. MAbs. 2015. PMID: 26381852 Free PMC article.
Botulinum neurotoxins (BoNTs) are responsible for human botulism, a life-threatening disease characterized by flaccid muscle paralysis that occurs naturally by food poisoning or colonization of the gastrointestinal tract by BoNT-producing clostridia. BoNTs have been classified as …
Botulinum neurotoxins (BoNTs) are responsible for human botulism, a life-threatening disease characterized by flaccid muscle paralysis that …
Development of Human-Like scFv-Fc Neutralizing Botulinum Neurotoxin E.
Miethe S, Rasetti-Escargueil C, Avril A, Liu Y, Chahboun S, Korkeala H, Mazuet C, Popoff MR, Pelat T, Thullier P, Sesardic D, Hust M. Miethe S, et al. PLoS One. 2015 Oct 6;10(10):e0139905. doi: 10.1371/journal.pone.0139905. eCollection 2015. PLoS One. 2015. PMID: 26440796 Free PMC article.
BACKGROUND: Botulinum neurotoxins (BoNTs) are considered to be the most toxic substances known on earth and are responsible for human botulism, a life-threatening disease characterized by flaccid muscle paralysis that occurs naturally by food-poisoning or colonization of the gast …
BACKGROUND: Botulinum neurotoxins (BoNTs) are considered to be the most toxic substances known on earth and are responsible for human botuli …
Isolation of nanomolar scFvs of non-human primate origin, cross-neutralizing botulinum neurotoxins A1 and A2 by targeting their heavy chain.
Avril A, Miethe S, Popoff MR, Mazuet C, Chahboun S, Rasetti-Escargueil C, Sesardic D, Thullier P, Hust M, Pelat T. Avril A, et al. BMC Biotechnol. 2015 Sep 17;15:86. doi: 10.1186/s12896-015-0206-0. BMC Biotechnol. 2015. PMID: 26382731 Free PMC article.
They are classified among the six major biological warfare agents by the Centers for Disease Control. BoNTs act on the cholinergic motoneurons, where they cleave proteins implicated in acetylcholine vesicle exocytosis. ...
They are classified among the six major biological warfare agents by the Centers for Disease Control. BoNTs act on the cholinergic mo …