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Page 1
Islet Autoantibodies.
Lampasona V, Liberati D. Lampasona V, et al. Curr Diab Rep. 2016 Jun;16(6):53. doi: 10.1007/s11892-016-0738-2. Curr Diab Rep. 2016. PMID: 27112957 Review.
Islet autoantibodies are the main markers of pancreatic autoimmunity in type 1 diabetes (T1D). Islet autoantibodies recognize insulin (IAA), glutamic acid decarboxylase (GADA), protein phosphatase-like IA-2 (IA-2A), and ZnT8 (ZnT8A …
Islet autoantibodies are the main markers of pancreatic autoimmunity in type 1 diabetes (T1D). Islet autoantibodies rec …
Autoantibodies to the IA-2 Extracellular Domain Refine the Definition of "A+" Subtypes of Ketosis-Prone Diabetes.
Mulukutla SN, Acevedo-Calado M, Hampe CS, Pietropaolo M, Balasubramanyam A. Mulukutla SN, et al. Diabetes Care. 2018 Dec;41(12):2637-2640. doi: 10.2337/dc18-0613. Epub 2018 Oct 16. Diabetes Care. 2018. PMID: 30327357 Free PMC article.
OBJECTIVE: Autoantibodies directed against tyrosine phosphatase IA-2 antibody (IA-2 Ab) are diagnostic for autoimmune type 1 diabetes. Conventional assays target the intracellular domain of IA-2. Among patients with ketosis- …
OBJECTIVE: Autoantibodies directed against tyrosine phosphatase IA-2 antibody (IA-2 Ab) are diagnostic fo …
Diagnostic Tests for Diabetes Mellitus.
Nelson M, Dungan KM. Nelson M, et al. 2025 Feb 7. In: Feingold KR, Adler RA, Ahmed SF, Anawalt B, Blackman MR, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Dungan K, Hamilton E, Hofland J, Jan de Beur S, Kalra S, Kaltsas G, Kapoor N, Kim M, Koch C, Kopp P, Korbonits M, Kovacs CS, Kuohung W, Laferrère B, Levy M, McGee EA, McLachlan R, Muzumdar R, Purnell J, Rey R, Sahay R, Shah AS, Sperling MA, Stratakis CA, Trence DL, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000–. 2025 Feb 7. In: Feingold KR, Adler RA, Ahmed SF, Anawalt B, Blackman MR, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Dungan K, Hamilton E, Hofland J, Jan de Beur S, Kalra S, Kaltsas G, Kapoor N, Kim M, Koch C, Kopp P, Korbonits M, Kovacs CS, Kuohung W, Laferrère B, Levy M, McGee EA, McLachlan R, Muzumdar R, Purnell J, Rey R, Sahay R, Shah AS, Sperling MA, Stratakis CA, Trence DL, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000–. PMID: 25905219 Free Books & Documents. Review.
Elevated measurements of pancreatic islet autoantibodies (e.g., to the 65-KDa isoform of glutamic acid decarboxylase (GAD65), tyrosine phosphatase related islet antigen 2 (IA-2), insulin (IAA), and zinc transporter (ZnT8)) suggest autoimm …
Elevated measurements of pancreatic islet autoantibodies (e.g., to the 65-KDa isoform of glutamic acid decarboxylase (GAD65), …
3 Screen islet cell autoantibody ELISA: A sensitive and specific ELISA for the combined measurement of autoantibodies to GAD(65), to IA-2 and to ZnT8.
Amoroso M, Achenbach P, Powell M, Coles R, Chlebowska M, Carr L, Furmaniak J, Scholz M, Bonifacio E, Ziegler AG, Rees Smith B. Amoroso M, et al. Clin Chim Acta. 2016 Nov 1;462:60-64. doi: 10.1016/j.cca.2016.08.013. Epub 2016 Aug 26. Clin Chim Acta. 2016. PMID: 27570064
3 Screen, a new ELISA for the combined measurement of autoantibodies to GAD(65), to IA-2 and to ZnT8, has been developed and evaluated. In the assay serum samples were incubated (overnight; 2-8 C) in ELISA plate wells coated with GAD(65), IA- …
3 Screen, a new ELISA for the combined measurement of autoantibodies to GAD(65), to IA-2 and to ZnT8, has been d …
Biomarkers in pancreas transplant.
Burke GW 3rd, Chen LJ, Ciancio G, Pugliese A. Burke GW 3rd, et al. Curr Opin Organ Transplant. 2016 Aug;21(4):412-8. doi: 10.1097/MOT.0000000000000333. Curr Opin Organ Transplant. 2016. PMID: 27348473 Free PMC article. Review.
Our center has focused on markers of autoimmunity, including assessment of autoantibodies and autoreactive T cells. We have found that conversion of autoantibodies (including GAD65, IA-2, and ZnT8), or the development of a new positive …
Our center has focused on markers of autoimmunity, including assessment of autoantibodies and autoreactive T cells. We have found tha …
Looking back at the TEDDY study: lessons and future directions.
Lernmark Å, Agardh D, Akolkar B, Gesualdo P, Hagopian WA, Haller MJ, Hyöty H, Johnson SB, Elding Larsson H, Liu E, Lynch KF, McKinney EF, McIndoe R, Melin J, Norris JM, Rewers M, Rich SS, Toppari J, Triplett E, Vehik K, Virtanen SM, Ziegler AG, Schatz DA, Krischer J. Lernmark Å, et al. Nat Rev Endocrinol. 2025 Mar;21(3):154-165. doi: 10.1038/s41574-024-01045-0. Epub 2024 Nov 4. Nat Rev Endocrinol. 2025. PMID: 39496810 Free PMC article. Review.
The goal of the TEDDY (The Environmental Determinants of Diabetes in the Young) study is to elucidate factors leading to the initiation of islet autoimmunity (first primary outcome) and those related to progression to type 1 diabetes mellitus (T1DM; second pr …
The goal of the TEDDY (The Environmental Determinants of Diabetes in the Young) study is to elucidate factors leading to the initiati …
GAD65 autoantibodies detected by electrochemiluminescence assay identify high risk for type 1 diabetes.
Miao D, Guyer KM, Dong F, Jiang L, Steck AK, Rewers M, Eisenbarth GS, Yu L. Miao D, et al. Diabetes. 2013 Dec;62(12):4174-8. doi: 10.2337/db13-0534. Epub 2013 Aug 23. Diabetes. 2013. PMID: 23974918 Free PMC article.
The identification of diabetes-relevant islet autoantibodies is essential for predicting and preventing type 1 diabetes (T1D). ...The assay was validated with serum samples from 227 newly diagnosed diabetic children; 68 prediabetic children who were pr …
The identification of diabetes-relevant islet autoantibodies is essential for predicting and preventing type 1 diabetes …
Novel diabetes autoantibodies and prediction of type 1 diabetes.
Wenzlau JM, Hutton JC. Wenzlau JM, et al. Curr Diab Rep. 2013 Oct;13(5):608-15. doi: 10.1007/s11892-013-0405-9. Curr Diab Rep. 2013. PMID: 23900975 Free PMC article. Review.
Autoantibodies are currently the most robust biomarkers of type 1 diabetes and are frequently used to establish entry criteria for the participation of genetically at-risk individuals in secondary prevention/intervention clinical trials. ...Currently, four major mol …
Autoantibodies are currently the most robust biomarkers of type 1 diabetes and are frequently used to establish entry criteria …
The broad clinical phenotype of Type 1 diabetes at presentation.
Merger SR, Leslie RD, Boehm BO. Merger SR, et al. Diabet Med. 2013 Feb;30(2):170-8. doi: 10.1111/dme.12048. Diabet Med. 2013. PMID: 23075321 Review.
Immune-mediated (auto-immune) Type 1 diabetes mellitus is not a homogenous entity, but nonetheless has distinctive characteristics. ...The therapeutic response can be predicted by measuring the levels of autoantibodies to various islet cell autoantigens, such …
Immune-mediated (auto-immune) Type 1 diabetes mellitus is not a homogenous entity, but nonetheless has distinctive characteris …
Neuropeptide Y autoantibodies in patients with long-term type 1 and type 2 diabetes and neuropathy.
Skärstrand H, Dahlin LB, Lernmark A, Vaziri-Sani F. Skärstrand H, et al. J Diabetes Complications. 2013 Nov-Dec;27(6):609-17. doi: 10.1016/j.jdiacomp.2013.06.007. Epub 2013 Jul 30. J Diabetes Complications. 2013. PMID: 23910631
We aimed to develop a radiobinding assay for NPY-L (Leucine) and NPY-P (Proline) autoantibodies (A) to study the levels and the association with other islet autoantibodies and neuropathy. METHODS: Autoantibodies against NPY-L, NPY-P, ZnT8, GAD65 …
We aimed to develop a radiobinding assay for NPY-L (Leucine) and NPY-P (Proline) autoantibodies (A) to study the levels and the assoc …
60 results