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Year Number of Results
1967 1
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1970 2
1971 1
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1973 2
1974 3
1975 15
1976 15
1977 13
1978 11
1979 7
1980 15
1981 20
1982 26
1983 41
1984 44
1985 62
1986 71
1987 86
1988 110
1989 163
1990 234
1991 332
1992 411
1993 474
1994 540
1995 603
1996 613
1997 659
1998 784
1999 793
2000 861
2001 1002
2002 1016
2003 1068
2004 1178
2005 1216
2006 1351
2007 1335
2008 1401
2009 1355
2010 1459
2011 1589
2012 1749
2013 1874
2014 1832
2015 1840
2016 1784
2017 1914
2018 1882
2019 1896
2020 2014
2021 2147
2022 1851
2023 1935
2024 2689
2025 2725
2026 2

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44,603 results

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Page 1
The Arf-GAP and protein scaffold Cat1/Git1 as a multifaceted regulator of cancer progression.
Yoo SM, Cerione RA, Antonyak MA. Yoo SM, et al. Small GTPases. 2020 Mar;11(2):77-85. doi: 10.1080/21541248.2017.1362496. Epub 2017 Dec 31. Small GTPases. 2020. PMID: 28981399 Free PMC article. Review.
Cool-associated tyrosine phosphorylated protein 1 (Cat1), also referred to as GPCR-kinase interacting protein 1 (Git1), is a ubiquitously expressed, multi-domain protein that is best known for regulating cell shape and migration. Cat1/Git1 functions as a G …
Cool-associated tyrosine phosphorylated protein 1 (Cat1), also referred to as GPCR-kinase interacting protein 1 (Git1), is a u …
Ras-GTPase activating protein (GAP): a putative effector for Ras.
Tocque B, Delumeau I, Parker F, Maurier F, Multon MC, Schweighoffer F. Tocque B, et al. Cell Signal. 1997 Feb;9(2):153-8. doi: 10.1016/s0898-6568(96)00135-0. Cell Signal. 1997. PMID: 9113414 Review.
One attractive candidate for a Ras effector protein, other than the Raf kinases, is Ras-GAP. Indeed, recent literature suggests that besides the Raf/MAP kinase cascade, additional pathways must be stimulated to elicit a full biological response to Ras. ...The newly …
One attractive candidate for a Ras effector protein, other than the Raf kinases, is Ras-GAP. Indeed, recent literature suggest …
Dysfunction of Ras-GAP protein AfgapA contributes to hypoxia fitness in Aspergillus fumigatus.
Bian C, Kusuya Y, Hagiwara D, Ban S, Lu Y, Nagayama M, Takahashi H. Bian C, et al. Curr Genet. 2022 Dec;68(5-6):593-603. doi: 10.1007/s00294-022-01249-9. Epub 2022 Aug 8. Curr Genet. 2022. PMID: 35941233
To gain further insights into hypoxic adaptation, we generated a laboratory-evolved strain (Afs35-G20) harboring hypoxia fitness, and identified a nonsense mutation in AfgapA encoding a Ras-GAP protein, which could result in the deletion of 22 amino acids at the C-t …
To gain further insights into hypoxic adaptation, we generated a laboratory-evolved strain (Afs35-G20) harboring hypoxia fitness, and identi …
SynGAP regulates synaptic plasticity and cognition independently of its catalytic activity.
Araki Y, Rajkovich KE, Gerber EE, Gamache TR, Johnson RC, Tran THN, Liu B, Zhu Q, Hong I, Kirkwood A, Huganir R. Araki Y, et al. Science. 2024 Mar;383(6686):eadk1291. doi: 10.1126/science.adk1291. Epub 2024 Mar 1. Science. 2024. PMID: 38422154 Free PMC article.
SynGAP is an abundant synaptic GTPase-activating protein (GAP) critical for synaptic plasticity, learning, memory, and cognition. ...It is unclear whether SynGAP imparts structural properties at synapses independently of its GAP activity. Here, …
SynGAP is an abundant synaptic GTPase-activating protein (GAP) critical for synaptic plasticity, learning, memor …
GEFs and GAPs: critical elements in the control of small G proteins.
Bos JL, Rehmann H, Wittinghofer A. Bos JL, et al. Cell. 2007 Jun 1;129(5):865-77. doi: 10.1016/j.cell.2007.05.018. Cell. 2007. PMID: 17540168 Free article. Review.
Guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs) regulate the activity of small guanine nucleotide-binding (G) proteins to control cellular functions. ...Recent evidence suggests that these proteins may be potenti …
Guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs) regulate the activity of small guanine …
Cryo-EM structure of the SEA complex.
Tafur L, Hinterndorfer K, Gabus C, Lamanna C, Bergmann A, Sadian Y, Hamdi F, Kyrilis FL, Kastritis PL, Loewith R. Tafur L, et al. Nature. 2022 Nov;611(7935):399-404. doi: 10.1038/s41586-022-05370-0. Epub 2022 Oct 26. Nature. 2022. PMID: 36289347 Free PMC article.
The SEA complex (SEAC) is a growth regulator that acts as a GTPase-activating protein (GAP) towards Gtr1, a Rag GTPase that relays nutrient status to the Target of Rapamycin Complex 1 (TORC1) in yeast(1). ...The wings are tethered to the core via Sea3, …
The SEA complex (SEAC) is a growth regulator that acts as a GTPase-activating protein (GAP) towards Gtr1, a Rag …
Allosteric regulation of GAP activity by phospholipids in regulators of G-protein signaling.
Tu Y, Wilkie TM. Tu Y, et al. Methods Enzymol. 2004;389:89-105. doi: 10.1016/S0076-6879(04)89006-2. Methods Enzymol. 2004. PMID: 15313561 Review.
Regulators of G-protein signaling (RGS) proteins are GTPase-activating proteins (GAPs) for alpha subunits of the Gi and/or Gq class of heterotrimeric G proteins. ...Ca2+/calmodulin does not directly affect GAP activity of RGS4 but …
Regulators of G-protein signaling (RGS) proteins are GTPase-activating proteins (GAPs) for alpha subunits …
FilGAP, a GAP protein for Rac, regulates front-rear polarity and tumor cell migration through the ECM.
Saito K, Mori M, Kambara N, Ohta Y. Saito K, et al. FASEB J. 2021 Apr;35(4):e21508. doi: 10.1096/fj.202002155R. FASEB J. 2021. PMID: 33710706
Regulation of Rac activity by its regulators should be required for effective motility. Here, we show that FilGAP, a GTPase-activating protein (GAP) for Rac, controls front-rear polarity and contributes to maintain effective tumor cell migration throug …
Regulation of Rac activity by its regulators should be required for effective motility. Here, we show that FilGAP, a GTPase-activa …
Endosomal Localization of RacGAP Protein ARHGAP22 Regulates its GAP Activity in Human Melanoma Cells.
Mori M, Saito K, Sekine A, Hasebe R, Ohta Y. Mori M, et al. Anticancer Res. 2022 Dec;42(12):5763-5771. doi: 10.21873/anticanres.16083. Anticancer Res. 2022. PMID: 36456117
BACKGROUND/AIM: Rho small GTPases regulate cancer cell adhesion, migration and invasion through reorganization of the actin cytoskeleton. Rho GTPase Activating Protein 22 (ARHGAP22) is a Rac-specific GAP and suppresses Rac-dependent lamella formation a …
BACKGROUND/AIM: Rho small GTPases regulate cancer cell adhesion, migration and invasion through reorganization of the actin cytoskeleton. Rh …
GRAF1-dependent endocytosis.
Doherty GJ, Lundmark R. Doherty GJ, et al. Biochem Soc Trans. 2009 Oct;37(Pt 5):1061-5. doi: 10.1042/BST0371061. Biochem Soc Trans. 2009. PMID: 19754452 Review.
It was recently shown that the BAR (Bin/amphiphysin/Rvs) and Rho GAP (GTPase-activating protein) domain-containing protein GRAF1 (GTPase regulator associated with focal adhesion kinase-1) is found on prevalent, pleiomorphic endocytic membranes, …
It was recently shown that the BAR (Bin/amphiphysin/Rvs) and Rho GAP (GTPase-activating protein) domain-containi …
44,603 results
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