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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 1
1972 1
1973 3
1974 2
1975 9
1976 5
1977 1
1978 3
1979 2
1980 6
1981 5
1982 7
1983 5
1984 10
1985 14
1986 17
1987 12
1988 21
1989 19
1990 31
1991 16
1992 46
1993 42
1994 60
1995 78
1996 89
1997 116
1998 120
1999 147
2000 156
2001 164
2002 177
2003 220
2004 231
2005 230
2006 267
2007 275
2008 297
2009 298
2010 314
2011 316
2012 376
2013 605
2014 450
2015 435
2016 414
2017 367
2018 380
2019 427
2020 481
2021 521
2022 501
2023 474
2024 452
2025 532
2026 449
2027 1

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9,668 results

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Page 1
GAPDH: a common enzyme with uncommon functions.
Nicholls C, Li H, Liu JP. Nicholls C, et al. Clin Exp Pharmacol Physiol. 2012 Aug;39(8):674-9. doi: 10.1111/j.1440-1681.2011.05599.x. Clin Exp Pharmacol Physiol. 2012. PMID: 21895736 Review.
Recent studies have shown that GAPDH has multiple functions independent of its role in energy metabolism. Although increased GAPDH gene expression and enzymatic function is associated with cell proliferation and tumourigenesis, conditions such as oxidative stress im …
Recent studies have shown that GAPDH has multiple functions independent of its role in energy metabolism. Although increased GAPDH …
Tobacco Smoking Rewires Cell Metabolism by Inducing GAPDH Succinylation to Promote Lung Cancer Progression.
Wang K, Li J, Zhang H, Ma H, Cui HY, Ju HQ, Zhang J, Ma QZ, Zhao M, Zeng QM, Zou J, Sun XX, Nan G, Qian M, Jing L, Li Y, Xiong CF, Yang QZ, Wang H, Jiang JL, Chen ZN, Chen L, Huang W. Wang K, et al. Cancer Res. 2025 Aug 1;85(15):2838-2857. doi: 10.1158/0008-5472.CAN-24-3525. Cancer Res. 2025. PMID: 40366632 Free PMC article.
Proteomic analyses identified elevated K251 succinylation (K251-Su) of GAPDH, a key enzyme in glycolysis, in NSCLC samples, and GAPDH K251-Su was significantly higher in patients who smoke compared with nonsmokers. ...K251-Su increased GAPDH stability by supp …
Proteomic analyses identified elevated K251 succinylation (K251-Su) of GAPDH, a key enzyme in glycolysis, in NSCLC samples, and GA …
GAPDH in neuroblastoma: Functions in metabolism and survival.
Cornett K, Puderbaugh A, Back O, Craven R. Cornett K, et al. Front Oncol. 2022 Oct 4;12:979683. doi: 10.3389/fonc.2022.979683. eCollection 2022. Front Oncol. 2022. PMID: 36267982 Free PMC article. Review.
This mini-review will focus on glyceraldehyde 3-phosphate dehydrogenase (GAPDH), one of the central enzymes in glycolysis. GAPDH has a key role in metabolism, catalyzing the sixth step in glycolysis and generating NADH. ...One membrane-associated function of GAPD …
This mini-review will focus on glyceraldehyde 3-phosphate dehydrogenase (GAPDH), one of the central enzymes in glycolysis. GAPDH …
GAPDH as a housekeeping gene: analysis of GAPDH mRNA expression in a panel of 72 human tissues.
Barber RD, Harmer DW, Coleman RA, Clark BJ. Barber RD, et al. Physiol Genomics. 2005 May 11;21(3):389-95. doi: 10.1152/physiolgenomics.00025.2005. Epub 2005 Mar 15. Physiol Genomics. 2005. PMID: 15769908
To investigate the value of GAPDH as a housekeeping gene in human tissues, the expression of GAPDH mRNA was measured in a panel of 72 different pathologically normal human tissue types. ...No specific effect of either age or gender was observed on GAPDH mRNA …
To investigate the value of GAPDH as a housekeeping gene in human tissues, the expression of GAPDH mRNA was measured in a pane …
GAPDH as a model non-canonical AU-rich RNA binding protein.
Garcin ED. Garcin ED. Semin Cell Dev Biol. 2019 Feb;86:162-173. doi: 10.1016/j.semcdb.2018.03.013. Epub 2018 Mar 24. Semin Cell Dev Biol. 2019. PMID: 29574117 Review.
Despite the clear involvement of GAPDH in gene expression regulation, how and where GAPDH binds to its RNA targets is still unknown. In addition, the mechanism by which GAPDH switches among its various cellular functions is also unknown. This review will summ …
Despite the clear involvement of GAPDH in gene expression regulation, how and where GAPDH binds to its RNA targets is still un …
Compartmentation of GAPDH.
Seidler NW. Seidler NW. Adv Exp Med Biol. 2013;985:61-101. doi: 10.1007/978-94-007-4716-6_3. Adv Exp Med Biol. 2013. PMID: 22851447 Review.
The concept of the cytosol as a space that contains discrete zones of metabolites is discussed relative to the contribution of GAPDH. GAPDH is directed to very specific cell compartments. This chapter describes the utilization of GAPDH's enzymatic function fo …
The concept of the cytosol as a space that contains discrete zones of metabolites is discussed relative to the contribution of GAPDH. …
GAPDH as a sensor of NO stress.
Hara MR, Cascio MB, Sawa A. Hara MR, et al. Biochim Biophys Acta. 2006 May;1762(5):502-9. doi: 10.1016/j.bbadis.2006.01.012. Epub 2006 Mar 9. Biochim Biophys Acta. 2006. PMID: 16574384 Free article. Review.
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a classic glycolytic enzyme, and accumulating evidence has suggested that GAPDH is a multi-functional protein. ...The NO/GAPDH/Siah1 death cascade will contribute to the molecular understanding of a role of …
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a classic glycolytic enzyme, and accumulating evidence has suggested that GAPD …
GAPDH is involved in the heme-maturation of myoglobin and hemoglobin.
Tupta B, Stuehr E, Sumi MP, Sweeny EA, Smith B, Stuehr DJ, Ghosh A. Tupta B, et al. FASEB J. 2022 Feb;36(2):e22099. doi: 10.1096/fj.202101237RR. FASEB J. 2022. PMID: 34972240 Free PMC article.
Utilizing cell culture systems, we found that overexpression of wild-type GAPDH increased, whereas GAPDH mutants H53A and K227A decreased, the heme content of Mb and Hbalpha and Hbbeta. Overexpression of wild-type GAPDH fully recovered the heme-maturation inh …
Utilizing cell culture systems, we found that overexpression of wild-type GAPDH increased, whereas GAPDH mutants H53A and K227 …
Multifunctional glyceraldehyde-3-phosphate dehydrogenase (GAPDH) of parasites.
Mishra P, Joshi P. Mishra P, et al. Mol Biochem Parasitol. 2026 Jun;266:111732. doi: 10.1016/j.molbiopara.2026.111732. Epub 2026 Jan 23. Mol Biochem Parasitol. 2026. PMID: 41581767 Review.
Trichomonas vaginalis GAPDH interacts with many extracellular matrix proteins that may support initial adhesion of the organism to the host tissues. Surface associated GAPDH of Plasmodium berghei interacts with CD68 of Kupffer cells; a prerequisite for hepatocyte in …
Trichomonas vaginalis GAPDH interacts with many extracellular matrix proteins that may support initial adhesion of the organism to th …
GAPDH citrullination as a molecular signature of neurodegeneration, assessed in prion diseases.
Jang B, Kim MJ, Choi H, Ishigami A, Kim YS, Choi EK. Jang B, et al. J Alzheimers Dis. 2025 Dec;108(4):1520-1536. doi: 10.1177/13872877251389157. Epub 2025 Oct 24. J Alzheimers Dis. 2025. PMID: 41134984
Citrullinated GAPDH existed as both monomers and reversible oligomers, and citrullination did not alter its enzymatic activity. Immunoprecipitation demonstrated that GAPDH containing citrullinated forms interacts with prion protein. Tandem mass spectrometry analysis …
Citrullinated GAPDH existed as both monomers and reversible oligomers, and citrullination did not alter its enzymatic activity. Immun …
9,668 results