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407 results

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Page 1
Direct Reprogramming Improves Cardiac Function and Reverses Fibrosis in Chronic Myocardial Infarction.
Tani H, Sadahiro T, Yamada Y, Isomi M, Yamakawa H, Fujita R, Abe Y, Akiyama T, Nakano K, Kuze Y, Seki M, Suzuki Y, Fujisawa M, Sakata-Yanagimoto M, Chiba S, Fukuda K, Ieda M. Tani H, et al. Circulation. 2023 Jan 17;147(3):223-238. doi: 10.1161/CIRCULATIONAHA.121.058655. Epub 2022 Dec 12. Circulation. 2023. PMID: 36503256
BACKGROUND: Because adult cardiomyocytes have little regenerative capacity, resident cardiac fibroblasts (CFs) synthesize extracellular matrix after myocardial infarction (MI) to form fibrosis, leading to cardiac dysfunction and heart failure. ...These findings pres …
BACKGROUND: Because adult cardiomyocytes have little regenerative capacity, resident cardiac fibroblasts (CFs) synthesize extracellul …
Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.
Nielsen JB, Thorolfsdottir RB, Fritsche LG, Zhou W, Skov MW, Graham SE, Herron TJ, McCarthy S, Schmidt EM, Sveinbjornsson G, Surakka I, Mathis MR, Yamazaki M, Crawford RD, Gabrielsen ME, Skogholt AH, Holmen OL, Lin M, Wolford BN, Dey R, Dalen H, Sulem P, Chung JH, Backman JD, Arnar DO, Thorsteinsdottir U, Baras A, O'Dushlaine C, Holst AG, Wen X, Hornsby W, Dewey FE, Boehnke M, Kheterpal S, Mukherjee B, Lee S, Kang HM, Holm H, Kitzman J, Shavit JA, Jalife J, Brummett CM, Teslovich TM, Carey DJ, Gudbjartsson DF, Stefansson K, Abecasis GR, Hveem K, Willer CJ. Nielsen JB, et al. Nat Genet. 2018 Sep;50(9):1234-1239. doi: 10.1038/s41588-018-0171-3. Epub 2018 Jul 30. Nat Genet. 2018. PMID: 30061737 Free PMC article.
Many of the identified risk variants fall near genes where more deleterious mutations have been reported to cause serious heart defects in humans (GATA4, MYH6, NKX2-5, PITX2, TBX5)(1), or near genes important for striated muscle function and integrity (for example, …
Many of the identified risk variants fall near genes where more deleterious mutations have been reported to cause serious heart defec …
Cardiomyocyte SORBS2 expression increases in heart failure and regulates integrin interactions and extracellular matrix composition.
Timmer LT, den Hertog E, Versteeg D, Post H, Verdonschot JAJ, Monshouwer-Kloots J, Kyriakopoulou E, Perini I, Koopmans T, van der Kraak P, Zentilin L, Heymans SRB, Vink A, Giacca M, Heck AJR, van Rooij E. Timmer LT, et al. Cardiovasc Res. 2025 May 6;121(4):585-600. doi: 10.1093/cvr/cvaf021. Cardiovasc Res. 2025. PMID: 39957251 Free PMC article.
Using mouse models and cardiac tissue from human heart failure patients, we demonstrated that SORBS2 expression is consistently increased during pathological remodelling, correlates to disease severity, and is regulated by GATA4. ...CONCLUSION: Sorbs2 is a cardiomyo …
Using mouse models and cardiac tissue from human heart failure patients, we demonstrated that SORBS2 expression is consistently incre …
Novel cell lines derived from adult human ventricular cardiomyocytes.
Davidson MM, Nesti C, Palenzuela L, Walker WF, Hernandez E, Protas L, Hirano M, Isaac ND. Davidson MM, et al. J Mol Cell Cardiol. 2005 Jul;39(1):133-47. doi: 10.1016/j.yjmcc.2005.03.003. J Mol Cell Cardiol. 2005. PMID: 15913645
. - We have established proliferating human cardiomyocyte cell lines derived from non-proliferating primary cultures of adult ventricular heart tissue, using a novel method that may be applicable to many post-mitotic primary cultures. ...Clones were homogeneous morp …
. - We have established proliferating human cardiomyocyte cell lines derived from non-proliferating primary cultures of adult ventric …
GATA transcription factors in the developing and adult heart.
Pikkarainen S, Tokola H, Kerkelä R, Ruskoaho H. Pikkarainen S, et al. Cardiovasc Res. 2004 Aug 1;63(2):196-207. doi: 10.1016/j.cardiores.2004.03.025. Cardiovasc Res. 2004. PMID: 15249177 Review.
During the past decade, emerging evidence has accumulated of different nuclear transcription factors in regulation of cardiac development and growth as well as in cardiac hypertrophy and heart failure. GATA-4, -5 and -6 are zinc finger transcription factors that are expres …
During the past decade, emerging evidence has accumulated of different nuclear transcription factors in regulation of cardiac development an …
Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair.
Xin M, Olson EN, Bassel-Duby R. Xin M, et al. Nat Rev Mol Cell Biol. 2013 Aug;14(8):529-41. doi: 10.1038/nrm3619. Epub 2013 Jul 10. Nat Rev Mol Cell Biol. 2013. PMID: 23839576 Free PMC article. Review.
As the adult mammalian heart has limited potential for regeneration and repair, the loss of cardiomyocytes during injury and disease can result in heart failure and death. The cellular processes and regulatory mechanisms involved in heart growth and de …
As the adult mammalian heart has limited potential for regeneration and repair, the loss of cardiomyocytes during injury and d …
Isolation, Characterization, and Differentiation of Cardiac Stem Cells from the Adult Mouse Heart.
Yadav SK, Mishra PK. Yadav SK, et al. J Vis Exp. 2019 Jan 7;(143):10.3791/58448. doi: 10.3791/58448. J Vis Exp. 2019. PMID: 30663680 Free PMC article.
Although several strategies have been used to regenerate myocardium, stem cell therapy remains a major approach to replenish the dead myocardium of an MI heart. Accumulating evidence suggests the presence of resident cardiac stem cells (CSCs) in the adult heart …
Although several strategies have been used to regenerate myocardium, stem cell therapy remains a major approach to replenish the dead myocar …
Dynamic GATA4 enhancers shape the chromatin landscape central to heart development and disease.
He A, Gu F, Hu Y, Ma Q, Ye LY, Akiyama JA, Visel A, Pennacchio LA, Pu WT. He A, et al. Nat Commun. 2014 Sep 24;5:4907. doi: 10.1038/ncomms5907. Nat Commun. 2014. PMID: 25249388 Free PMC article.
GATA4 chromatin occupancy changes markedly between fetal and adult heart, with a limited binding sites overlap. Cardiac stress restored GATA4 occupancy to a subset of fetal sites, but many stress-associated GATA4 binding sites localized to loci …
GATA4 chromatin occupancy changes markedly between fetal and adult heart, with a limited binding sites overlap. Cardiac …
A context-specific cardiac beta-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart.
Iyer LM, Nagarajan S, Woelfer M, Schoger E, Khadjeh S, Zafiriou MP, Kari V, Herting J, Pang ST, Weber T, Rathjens FS, Fischer TH, Toischer K, Hasenfuss G, Noack C, Johnsen SA, Zelarayán LC. Iyer LM, et al. Nucleic Acids Res. 2018 Apr 6;46(6):2850-2867. doi: 10.1093/nar/gky049. Nucleic Acids Res. 2018. PMID: 29394407 Free PMC article.
Chromatin remodelling precedes transcriptional and structural changes in heart failure. A body of work suggests roles for the developmental Wnt signalling pathway in cardiac remodelling. ...Mechanistically, TCF7L2 co-occupies distal genomic regions with cardiac transcripti …
Chromatin remodelling precedes transcriptional and structural changes in heart failure. A body of work suggests roles for the develop …
The histone reader PHF7 cooperates with the SWI/SNF complex at cardiac super enhancers to promote direct reprogramming.
Garry GA, Bezprozvannaya S, Chen K, Zhou H, Hashimoto H, Morales MG, Liu N, Bassel-Duby R, Olson EN. Garry GA, et al. Nat Cell Biol. 2021 May;23(5):467-475. doi: 10.1038/s41556-021-00668-z. Epub 2021 May 3. Nat Cell Biol. 2021. PMID: 33941892 Free PMC article.
Cardiac reprogramming was initially achieved through overexpression of the transcription factors Gata4, Mef2c and Tbx5; later, Hand2 and Akt1 were found to further enhance this process(1-5). Yet, staunch epigenetic barriers severely limit the ability of these cocktails to …
Cardiac reprogramming was initially achieved through overexpression of the transcription factors Gata4, Mef2c and Tbx5; later, Hand2 …
407 results