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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1994 1
1995 1
1996 2
1997 3
1998 2
1999 7
2000 2
2001 8
2002 11
2003 6
2004 12
2005 8
2006 11
2007 20
2008 13
2009 23
2010 24
2011 26
2012 32
2013 35
2014 21
2015 28
2016 25
2017 16
2018 23
2019 20
2020 17
2021 17
2022 14
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379 results
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Page 1
Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair.
Xin M, Olson EN, Bassel-Duby R. Xin M, et al. Nat Rev Mol Cell Biol. 2013 Aug;14(8):529-41. doi: 10.1038/nrm3619. Epub 2013 Jul 10. Nat Rev Mol Cell Biol. 2013. PMID: 23839576 Free PMC article. Review.
As the adult mammalian heart has limited potential for regeneration and repair, the loss of cardiomyocytes during injury and disease can result in heart failure and death. The cellular processes and regulatory mechanisms involved in heart growth and de …
As the adult mammalian heart has limited potential for regeneration and repair, the loss of cardiomyocytes during injury and d …
Genetic Origins of Tetralogy of Fallot.
Morgenthau A, Frishman WH. Morgenthau A, et al. Cardiol Rev. 2018 Mar/Apr;26(2):86-92. doi: 10.1097/CRD.0000000000000170. Cardiol Rev. 2018. PMID: 29045289 Review.
Due to improved survival and clinical outcomes, congenital heart disease (CHD) is an area of growing importance within the medical community. ...Tetralogy of Fallot (TOF) is one of the oldest documented CHDs, with a growing prevalence of adult patients, and thus ser …
Due to improved survival and clinical outcomes, congenital heart disease (CHD) is an area of growing importance within the medical co …
Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes.
Kikuchi K, Holdway JE, Werdich AA, Anderson RM, Fang Y, Egnaczyk GF, Evans T, Macrae CA, Stainier DY, Poss KD. Kikuchi K, et al. Nature. 2010 Mar 25;464(7288):601-5. doi: 10.1038/nature08804. Nature. 2010. PMID: 20336144 Free PMC article.
By contrast, zebrafish efficiently regenerate lost cardiac muscle, providing a model for understanding how natural heart regeneration may be blocked or enhanced. In the absence of lineage-tracing technology applicable to adult zebrafish, the cellular origins of newl …
By contrast, zebrafish efficiently regenerate lost cardiac muscle, providing a model for understanding how natural heart regeneration …
Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.
Nielsen JB, Thorolfsdottir RB, Fritsche LG, Zhou W, Skov MW, Graham SE, Herron TJ, McCarthy S, Schmidt EM, Sveinbjornsson G, Surakka I, Mathis MR, Yamazaki M, Crawford RD, Gabrielsen ME, Skogholt AH, Holmen OL, Lin M, Wolford BN, Dey R, Dalen H, Sulem P, Chung JH, Backman JD, Arnar DO, Thorsteinsdottir U, Baras A, O'Dushlaine C, Holst AG, Wen X, Hornsby W, Dewey FE, Boehnke M, Kheterpal S, Mukherjee B, Lee S, Kang HM, Holm H, Kitzman J, Shavit JA, Jalife J, Brummett CM, Teslovich TM, Carey DJ, Gudbjartsson DF, Stefansson K, Abecasis GR, Hveem K, Willer CJ. Nielsen JB, et al. Nat Genet. 2018 Sep;50(9):1234-1239. doi: 10.1038/s41588-018-0171-3. Epub 2018 Jul 30. Nat Genet. 2018. PMID: 30061737 Free PMC article.
Many of the identified risk variants fall near genes where more deleterious mutations have been reported to cause serious heart defects in humans (GATA4, MYH6, NKX2-5, PITX2, TBX5)(1), or near genes important for striated muscle function and integrity (for example, …
Many of the identified risk variants fall near genes where more deleterious mutations have been reported to cause serious heart defec …
Heart repair by reprogramming non-myocytes with cardiac transcription factors.
Song K, Nam YJ, Luo X, Qi X, Tan W, Huang GN, Acharya A, Smith CL, Tallquist MD, Neilson EG, Hill JA, Bassel-Duby R, Olson EN. Song K, et al. Nature. 2012 May 13;485(7400):599-604. doi: 10.1038/nature11139. Nature. 2012. PMID: 22660318 Free PMC article.
The adult mammalian heart possesses little regenerative potential following injury. ...Here we show that four transcription factors, GATA4, HAND2, MEF2C and TBX5, can cooperatively reprogram adult mouse tail-tip and cardiac fibroblasts into beating car …
The adult mammalian heart possesses little regenerative potential following injury. ...Here we show that four transcription fa …
Novel cell lines derived from adult human ventricular cardiomyocytes.
Davidson MM, Nesti C, Palenzuela L, Walker WF, Hernandez E, Protas L, Hirano M, Isaac ND. Davidson MM, et al. J Mol Cell Cardiol. 2005 Jul;39(1):133-47. doi: 10.1016/j.yjmcc.2005.03.003. J Mol Cell Cardiol. 2005. PMID: 15913645
. - We have established proliferating human cardiomyocyte cell lines derived from non-proliferating primary cultures of adult ventricular heart tissue, using a novel method that may be applicable to many post-mitotic primary cultures. ...Clones were homogeneous morp …
. - We have established proliferating human cardiomyocyte cell lines derived from non-proliferating primary cultures of adult ventric …
The histone reader PHF7 cooperates with the SWI/SNF complex at cardiac super enhancers to promote direct reprogramming.
Garry GA, Bezprozvannaya S, Chen K, Zhou H, Hashimoto H, Morales MG, Liu N, Bassel-Duby R, Olson EN. Garry GA, et al. Nat Cell Biol. 2021 May;23(5):467-475. doi: 10.1038/s41556-021-00668-z. Epub 2021 May 3. Nat Cell Biol. 2021. PMID: 33941892 Free PMC article.
Cardiac reprogramming was initially achieved through overexpression of the transcription factors Gata4, Mef2c and Tbx5; later, Hand2 and Akt1 were found to further enhance this process(1-5). Yet, staunch epigenetic barriers severely limit the ability of these cocktails to …
Cardiac reprogramming was initially achieved through overexpression of the transcription factors Gata4, Mef2c and Tbx5; later, Hand2 …
Association of NFKB1, NKX2-5, GATA4 and RANKL Gene Polymorphisms with Sporadic Congenital Heart Disease in Greek Patients.
Aidinidou L, Chatzikyriakidou A, Giannopoulos A, Karpa V, Tzimou I, Aidinidou E, Fidani L. Aidinidou L, et al. Balkan J Med Genet. 2021 Jul 27;24(1):15-20. doi: 10.2478/bjmg-2021-0014. eCollection 2021 Jun. Balkan J Med Genet. 2021. PMID: 34447654 Free PMC article.
Congenital heart disease (CHD) is a group of structural defects of the heart and the great vessels, and one of the leading causes of death among infants and young adults. ...A total of 43 CHD patients and 100 healthy adults were included in the study. …
Congenital heart disease (CHD) is a group of structural defects of the heart and the great vessels, and one of the leading cau …
A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart.
Iyer LM, Nagarajan S, Woelfer M, Schoger E, Khadjeh S, Zafiriou MP, Kari V, Herting J, Pang ST, Weber T, Rathjens FS, Fischer TH, Toischer K, Hasenfuss G, Noack C, Johnsen SA, Zelarayán LC. Iyer LM, et al. Nucleic Acids Res. 2018 Apr 6;46(6):2850-2867. doi: 10.1093/nar/gky049. Nucleic Acids Res. 2018. PMID: 29394407 Free PMC article.
Chromatin remodelling precedes transcriptional and structural changes in heart failure. A body of work suggests roles for the developmental Wnt signalling pathway in cardiac remodelling. ...Mechanistically, TCF7L2 co-occupies distal genomic regions with cardiac transcripti …
Chromatin remodelling precedes transcriptional and structural changes in heart failure. A body of work suggests roles for the develop …
In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes.
Qian L, Huang Y, Spencer CI, Foley A, Vedantham V, Liu L, Conway SJ, Fu JD, Srivastava D. Qian L, et al. Nature. 2012 May 31;485(7400):593-8. doi: 10.1038/nature11044. Nature. 2012. PMID: 22522929 Free PMC article.
The reprogramming of adult cells into pluripotent cells or directly into alternative adult cell types holds great promise for regenerative medicine. We reported previously that cardiac fibroblasts,which represent 50%of the cells in the mammalian heart, can be …
The reprogramming of adult cells into pluripotent cells or directly into alternative adult cell types holds great promise for …
379 results