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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1994 1
1995 1
1996 2
1997 3
1998 2
1999 7
2000 2
2001 8
2002 11
2003 6
2004 12
2005 8
2006 11
2007 20
2008 13
2009 23
2010 24
2011 26
2012 32
2013 35
2014 21
2015 28
2016 25
2017 16
2018 23
2019 20
2020 17
2021 17
2022 17
2023 4
2024 3

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388 results

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Page 1
Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair.
Xin M, Olson EN, Bassel-Duby R. Xin M, et al. Nat Rev Mol Cell Biol. 2013 Aug;14(8):529-41. doi: 10.1038/nrm3619. Epub 2013 Jul 10. Nat Rev Mol Cell Biol. 2013. PMID: 23839576 Free PMC article. Review.
As the adult mammalian heart has limited potential for regeneration and repair, the loss of cardiomyocytes during injury and disease can result in heart failure and death. The cellular processes and regulatory mechanisms involved in heart growth and de …
As the adult mammalian heart has limited potential for regeneration and repair, the loss of cardiomyocytes during injury and d …
Genetic Origins of Tetralogy of Fallot.
Morgenthau A, Frishman WH. Morgenthau A, et al. Cardiol Rev. 2018 Mar/Apr;26(2):86-92. doi: 10.1097/CRD.0000000000000170. Cardiol Rev. 2018. PMID: 29045289 Review.
Due to improved survival and clinical outcomes, congenital heart disease (CHD) is an area of growing importance within the medical community. ...Tetralogy of Fallot (TOF) is one of the oldest documented CHDs, with a growing prevalence of adult patients, and thus ser …
Due to improved survival and clinical outcomes, congenital heart disease (CHD) is an area of growing importance within the medical co …
Direct Reprogramming Improves Cardiac Function and Reverses Fibrosis in Chronic Myocardial Infarction.
Tani H, Sadahiro T, Yamada Y, Isomi M, Yamakawa H, Fujita R, Abe Y, Akiyama T, Nakano K, Kuze Y, Seki M, Suzuki Y, Fujisawa M, Sakata-Yanagimoto M, Chiba S, Fukuda K, Ieda M. Tani H, et al. Circulation. 2023 Jan 17;147(3):223-238. doi: 10.1161/CIRCULATIONAHA.121.058655. Epub 2022 Dec 12. Circulation. 2023. PMID: 36503256
BACKGROUND: Because adult cardiomyocytes have little regenerative capacity, resident cardiac fibroblasts (CFs) synthesize extracellular matrix after myocardial infarction (MI) to form fibrosis, leading to cardiac dysfunction and heart failure. ...These findings pres …
BACKGROUND: Because adult cardiomyocytes have little regenerative capacity, resident cardiac fibroblasts (CFs) synthesize extracellul …
Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.
Nielsen JB, Thorolfsdottir RB, Fritsche LG, Zhou W, Skov MW, Graham SE, Herron TJ, McCarthy S, Schmidt EM, Sveinbjornsson G, Surakka I, Mathis MR, Yamazaki M, Crawford RD, Gabrielsen ME, Skogholt AH, Holmen OL, Lin M, Wolford BN, Dey R, Dalen H, Sulem P, Chung JH, Backman JD, Arnar DO, Thorsteinsdottir U, Baras A, O'Dushlaine C, Holst AG, Wen X, Hornsby W, Dewey FE, Boehnke M, Kheterpal S, Mukherjee B, Lee S, Kang HM, Holm H, Kitzman J, Shavit JA, Jalife J, Brummett CM, Teslovich TM, Carey DJ, Gudbjartsson DF, Stefansson K, Abecasis GR, Hveem K, Willer CJ. Nielsen JB, et al. Nat Genet. 2018 Sep;50(9):1234-1239. doi: 10.1038/s41588-018-0171-3. Epub 2018 Jul 30. Nat Genet. 2018. PMID: 30061737 Free PMC article.
Many of the identified risk variants fall near genes where more deleterious mutations have been reported to cause serious heart defects in humans (GATA4, MYH6, NKX2-5, PITX2, TBX5)(1), or near genes important for striated muscle function and integrity (for example, …
Many of the identified risk variants fall near genes where more deleterious mutations have been reported to cause serious heart defec …
TBX20 Improves Contractility and Mitochondrial Function During Direct Human Cardiac Reprogramming.
Tang Y, Aryal S, Geng X, Zhou X, Fast VG, Zhang J, Lu R, Zhou Y. Tang Y, et al. Circulation. 2022 Nov 15;146(20):1518-1536. doi: 10.1161/CIRCULATIONAHA.122.059713. Epub 2022 Sep 14. Circulation. 2022. PMID: 36102189 Free PMC article.
RESULTS: We identified TBX20 (T-box transcription factor 20) as the top cardiac gene that is unable to be activated by the MGT133 reprogramming cocktail (MEF2C, GATA4, TBX5, and miR-133). TBX20 is required for normal heart development and cardiac function in adul
RESULTS: We identified TBX20 (T-box transcription factor 20) as the top cardiac gene that is unable to be activated by the MGT133 reprogramm …
In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes.
Qian L, Huang Y, Spencer CI, Foley A, Vedantham V, Liu L, Conway SJ, Fu JD, Srivastava D. Qian L, et al. Nature. 2012 May 31;485(7400):593-8. doi: 10.1038/nature11044. Nature. 2012. PMID: 22522929 Free PMC article.
The reprogramming of adult cells into pluripotent cells or directly into alternative adult cell types holds great promise for regenerative medicine. We reported previously that cardiac fibroblasts,which represent 50%of the cells in the mammalian heart, can be …
The reprogramming of adult cells into pluripotent cells or directly into alternative adult cell types holds great promise for …
Novel cell lines derived from adult human ventricular cardiomyocytes.
Davidson MM, Nesti C, Palenzuela L, Walker WF, Hernandez E, Protas L, Hirano M, Isaac ND. Davidson MM, et al. J Mol Cell Cardiol. 2005 Jul;39(1):133-47. doi: 10.1016/j.yjmcc.2005.03.003. J Mol Cell Cardiol. 2005. PMID: 15913645
. - We have established proliferating human cardiomyocyte cell lines derived from non-proliferating primary cultures of adult ventricular heart tissue, using a novel method that may be applicable to many post-mitotic primary cultures. ...Clones were homogeneous morp …
. - We have established proliferating human cardiomyocyte cell lines derived from non-proliferating primary cultures of adult ventric …
A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network.
Broman MT, Nadadur RD, Perez-Cervantes C, Burnicka-Turek O, Lazarevic S, Gams A, Laforest B, Steimle JD, Iddir S, Wang Z, Smith L, Mazurek SR, Olivey HE, Zhou P, Gadek M, Shen KM, Khan Z, Theisen JWM, Yang XH, Ikegami K, Efimov IR, Pu WT, Weber CR, McNally EM, Svensson EC, Moskowitz IP. Broman MT, et al. Circulation. 2024 Apr 9;149(15):1205-1230. doi: 10.1161/CIRCULATIONAHA.123.066804. Epub 2024 Jan 8. Circulation. 2024. PMID: 38189150
BACKGROUND: The relationship between heart failure (HF) and atrial fibrillation (AF) is clear, with up to half of patients with HF progressing to AF. ...METHODS: FOG2 expression was assessed in human atria. The effect of adult-specific FOG2 overexpression in the mou …
BACKGROUND: The relationship between heart failure (HF) and atrial fibrillation (AF) is clear, with up to half of patients with HF pr …
GATA transcription factors in the developing and adult heart.
Pikkarainen S, Tokola H, Kerkelä R, Ruskoaho H. Pikkarainen S, et al. Cardiovasc Res. 2004 Aug 1;63(2):196-207. doi: 10.1016/j.cardiores.2004.03.025. Cardiovasc Res. 2004. PMID: 15249177 Review.
During the past decade, emerging evidence has accumulated of different nuclear transcription factors in regulation of cardiac development and growth as well as in cardiac hypertrophy and heart failure. GATA-4, -5 and -6 are zinc finger transcription factors that are expres …
During the past decade, emerging evidence has accumulated of different nuclear transcription factors in regulation of cardiac development an …
Isolation, Characterization, and Differentiation of Cardiac Stem Cells from the Adult Mouse Heart.
Yadav SK, Mishra PK. Yadav SK, et al. J Vis Exp. 2019 Jan 7;(143):10.3791/58448. doi: 10.3791/58448. J Vis Exp. 2019. PMID: 30663680 Free PMC article.
Although several strategies have been used to regenerate myocardium, stem cell therapy remains a major approach to replenish the dead myocardium of an MI heart. Accumulating evidence suggests the presence of resident cardiac stem cells (CSCs) in the adult heart
Although several strategies have been used to regenerate myocardium, stem cell therapy remains a major approach to replenish the dead myocar …
388 results