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Page 1
Exome sequencing and analysis of 454,787 UK Biobank participants.
Backman JD, Li AH, Marcketta A, Sun D, Mbatchou J, Kessler MD, Benner C, Liu D, Locke AE, Balasubramanian S, Yadav A, Banerjee N, Gillies CE, Damask A, Liu S, Bai X, Hawes A, Maxwell E, Gurski L, Watanabe K, Kosmicki JA, Rajagopal V, Mighty J; Regeneron Genetics Center; DiscovEHR; Jones M, Mitnaul L, Stahl E, Coppola G, Jorgenson E, Habegger L, Salerno WJ, Shuldiner AR, Lotta LA, Overton JD, Cantor MN, Reid JG, Yancopoulos G, Kang HM, Marchini J, Baras A, Abecasis GR, Ferreira MAR. Backman JD, et al. Nature. 2021 Nov;599(7886):628-634. doi: 10.1038/s41586-021-04103-z. Epub 2021 Oct 18. Nature. 2021. PMID: 34662886 Free PMC article.
We discovered several risk-increasing associations with traits related to liver disease, eye disease and cancer, among others, as well as risk-lowering associations for hypertension (SLC9A3R2), diabetes (MAP3K15, FAM234A) and asthma (SLC27A3). Six genes were associated wit …
We discovered several risk-increasing associations with traits related to liver disease, eye disease and cancer, among others, as wel …
WTAP/IGF2BP3-mediated GBE1 expression accelerates the proliferation and enhances stemness in pancreatic cancer cells via upregulating c-Myc.
Jin W, Yao Y, Fu Y, Lei X, Fu W, Lu Q, Tong X, Xu Q, Su W, Hu X. Jin W, et al. Cell Mol Biol Lett. 2024 Jul 3;29(1):97. doi: 10.1186/s11658-024-00611-8. Cell Mol Biol Lett. 2024. PMID: 38961325 Free PMC article.
BACKGROUND: Pancreatic cancer (PC) is one of the most malignant cancers with highly aggressiveness and poor prognosis. ...CONCLUSIONS: Our study uncovered the oncogenic role of GBE1/c-Myc axis in PC progression and revealed WTAP/IGF2BP3-mediated m6A modificat …
BACKGROUND: Pancreatic cancer (PC) is one of the most malignant cancers with highly aggressiveness and poor prognosis. ...CONC …
GBE1 Promotes Glioma Progression by Enhancing Aerobic Glycolysis through Inhibition of FBP1.
Chen Z, Bao H, Long J, Zhao P, Hu X, Wang H, Zhang Y, Yang J, Zhuge Q, Xia L. Chen Z, et al. Cancers (Basel). 2023 Mar 3;15(5):1594. doi: 10.3390/cancers15051594. Cancers (Basel). 2023. PMID: 36900384 Free PMC article.
Recent studies have found that glycogen branching enzyme 1 (GBE1) is involved in cancer progression. However, the study of GBE1 in gliomas is limited. ...These results suggest that GBE1 can be a novel target for glioma in metabolic therapy....
Recent studies have found that glycogen branching enzyme 1 (GBE1) is involved in cancer progression. However, the study of …
Lung adenocarcinoma-intrinsic GBE1 signaling inhibits anti-tumor immunity.
Li L, Yang L, Cheng S, Fan Z, Shen Z, Xue W, Zheng Y, Li F, Wang D, Zhang K, Lian J, Wang D, Zhu Z, Zhao J, Zhang Y. Li L, et al. Mol Cancer. 2019 Jun 20;18(1):108. doi: 10.1186/s12943-019-1027-x. Mol Cancer. 2019. PMID: 31221150 Free PMC article.
BACKGROUND: Changes in glycogen metabolism is an essential feature among the various metabolic adaptations used by cancer cells to adjust to the conditions imposed by the tumor microenvironment. Our previous study showed that glycogen branching enzyme (GBE1) is down …
BACKGROUND: Changes in glycogen metabolism is an essential feature among the various metabolic adaptations used by cancer cells to ad …
GBE1 Is an Independent Prognostic Marker and Associated With CD163(+) Tumor-Associated Macrophage Infiltration in Lung Adenocarcinoma.
Liang Y, Lei Y, Liang M, Du M, Liu Z, Li X, Meng X, Zhou B, Gao Y. Liang Y, et al. Front Oncol. 2022 Jan 27;11:781344. doi: 10.3389/fonc.2021.781344. eCollection 2021. Front Oncol. 2022. PMID: 35155189 Free PMC article.
Herein, we firstly analyzed the expression level of GBE1 in LUAD tissues and adjacent lung tissues via The Cancer Genome Atlas (TCGA) database. ...We found the expression level of GBE1 was significantly higher in LUAD tissues. High expression of GBE1 w …
Herein, we firstly analyzed the expression level of GBE1 in LUAD tissues and adjacent lung tissues via The Cancer Genome Atlas …
PX-478 induces apoptosis in acute myeloid leukemia under hypoxia by inhibiting the PI3K/AKT/mTOR pathway through downregulation of GBE1.
Liu W, Dou C, Zhang C, Chen P, Zhang S, Wang R, Han Q, Zhao H, Li D. Liu W, et al. Biochem Pharmacol. 2024 Dec;230(Pt 3):116620. doi: 10.1016/j.bcp.2024.116620. Epub 2024 Nov 9. Biochem Pharmacol. 2024. PMID: 39528073 Free article.
In experiments using AML cells with reduced GBE1 expression (shGBE1), PX-478 treatment did not further downregulate the pathway or enhance apoptosis. Re-expression of GBE1 in shGBE1 cells alleviated apoptosis and reduced PX-478- induced apoptosis and pathway downreg …
In experiments using AML cells with reduced GBE1 expression (shGBE1), PX-478 treatment did not further downregulate the pathway or en …
Hypoxia-induced GBE1 expression promotes tumor progression through metabolic reprogramming in lung adenocarcinoma.
Li L, Yang L, Fan Z, Xue W, Shen Z, Yuan Y, Sun X, Wang D, Lian J, Wang L, Zhao J, Zhang Y. Li L, et al. Signal Transduct Target Ther. 2020 May 22;5(1):54. doi: 10.1038/s41392-020-0152-8. Signal Transduct Target Ther. 2020. PMID: 32439898 Free PMC article.
Herein, the effect of GBE1 on tumor progression via changes in metabolic signaling under hypoxia in vitro and in vivo was evaluated, and GBE1-related genes from human specimens and data sets were analyzed. Hypoxia induced GBE1 upregulation in LUAD cells. G …
Herein, the effect of GBE1 on tumor progression via changes in metabolic signaling under hypoxia in vitro and in vivo was evaluated, …
A family study implicates GBE1 in the etiology of autism spectrum disorder.
Fanjul-Fernández M, Brown NJ, Hickey P, Diakumis P, Rafehi H, Bozaoglu K, Green CC, Rattray A, Young S, Alhuzaimi D, Mountford HS, Gillies G, Lukic V, Vick T, Finlay K, Coe BP, Eichler EE, Delatycki MB, Wilson SJ, Bahlo M, Scheffer IE, Lockhart PJ. Fanjul-Fernández M, et al. Hum Mutat. 2022 Jan;43(1):16-29. doi: 10.1002/humu.24289. Epub 2021 Oct 21. Hum Mutat. 2022. PMID: 34633740 Free PMC article.
We identified a rare heterozygous variant in the gene encoding 1,4--glucan branching enzyme 1 (GBE1) that was present in seven of seven individuals with ASD, nine of ten individuals with the BAP, and none of four tested unaffected individuals. ...The variant was not enrich …
We identified a rare heterozygous variant in the gene encoding 1,4--glucan branching enzyme 1 (GBE1) that was present in seven of sev …
Target of obstructive sleep apnea syndrome merge lung cancer: based on big data platform.
Li L, Lu J, Xue W, Wang L, Zhai Y, Fan Z, Wu G, Fan F, Li J, Zhang C, Zhang Y, Zhao J. Li L, et al. Oncotarget. 2017 Mar 28;8(13):21567-21578. doi: 10.18632/oncotarget.15372. Oncotarget. 2017. PMID: 28423489 Free PMC article.
In the gene expression and network-level information, we revealed significant alterations of molecules related to HIF1 and metabolic pathways in the hypoxic-conditioned lung cancer cells. We also observed that GBE1 and HK2 are downstream of HIF1 pathway important in …
In the gene expression and network-level information, we revealed significant alterations of molecules related to HIF1 and metabolic pathway …
Unveiling GBE1 as a hypoxia-related prognostic gene with significant impact on immune cell infiltration in HER2-enriched breast cancer.
Hasannejad F, Darzi M, Yasaei M. Hasannejad F, et al. Discov Oncol. 2025 Jun 1;16(1):975. doi: 10.1007/s12672-025-02826-3. Discov Oncol. 2025. PMID: 40450610 Free PMC article.
Hypoxia, a condition characterized by low oxygen availability, plays a significant role in cancer biology and tumor behavior. The interplay between hypoxia-related prognostic genes and immune cell infiltration is pivotal in shaping the clinical outcomes of HER2-enriched br …
Hypoxia, a condition characterized by low oxygen availability, plays a significant role in cancer biology and tumor behavior. The int …
26 results