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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1977 1
1979 1
1980 3
1981 3
1982 2
1983 2
1984 3
1985 2
1986 2
1987 4
1988 2
1989 2
1990 3
1991 3
1992 7
1993 3
1994 2
1995 6
1996 5
1997 2
1999 5
2000 2
2001 2
2002 1
2003 2
2004 1
2005 2
2006 4
2007 5
2008 3
2009 3
2010 1
2011 3
2012 4
2013 1
2014 5
2015 7
2016 5
2017 2
2018 1
2019 5
2020 11
2021 5
2022 3
2023 12
2024 3

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146 results

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Page 1
The potential of GHK as an anti-aging peptide.
Dou Y, Lee A, Zhu L, Morton J, Ladiges W. Dou Y, et al. Aging Pathobiol Ther. 2020 Mar 27;2(1):58-61. doi: 10.31491/apt.2020.03.014. Aging Pathobiol Ther. 2020. PMID: 35083444 Free PMC article.
The molecule has a very high affinity for copper and forms the chelate GHK-Cu. The peptide as well as its Cu (II) chelate have anti-inflammatory and tissue remodeling properties. GHK-Cu has been shown to promote skin remodeling, wound healing and regen …
The molecule has a very high affinity for copper and forms the chelate GHK-Cu. The peptide as well as its Cu (II) chelate have …
Liposomes as Carriers of GHK-Cu Tripeptide for Cosmetic Application.
Dymek M, Olechowska K, Hąc-Wydro K, Sikora E. Dymek M, et al. Pharmaceutics. 2023 Oct 18;15(10):2485. doi: 10.3390/pharmaceutics15102485. Pharmaceutics. 2023. PMID: 37896245 Free PMC article.
The influence of total lipid content, lipid composition and GHK-Cu concentration on the physicochemical properties of liposomes was studied. ...As the best carriers, 25 mg/cm(3) CL and AL hydrated with 0.5 mg/cm(3) GHK-Cu were selected with EE of 31.7 …
The influence of total lipid content, lipid composition and GHK-Cu concentration on the physicochemical properties of liposome …
Glycyl-l-histidyl-l-lysine-Cu2+ rescues cigarette smoking-induced skeletal muscle dysfunction via a sirtuin 1-dependent pathway.
Deng M, Zhang Q, Yan L, Bian Y, Li R, Gao J, Wang Y, Miao J, Li J, Zhou X, Hou G. Deng M, et al. J Cachexia Sarcopenia Muscle. 2023 Jun;14(3):1365-1380. doi: 10.1002/jcsm.13213. Epub 2023 Mar 10. J Cachexia Sarcopenia Muscle. 2023. PMID: 36905132 Free PMC article.
Mechanistically, GHK-Cu directly binds and activates SIRT1(the binding energy was -6.1 kcal/mol). ...Finally, GHK-Cu could protect mice against CS-induced skeletal muscle dysfunction via SIRT1. ...
Mechanistically, GHK-Cu directly binds and activates SIRT1(the binding energy was -6.1 kcal/mol). ...Finally, GHK-Cu …
GHK-Cu-liposomes accelerate scald wound healing in mice by promoting cell proliferation and angiogenesis.
Wang X, Liu B, Xu Q, Sun H, Shi M, Wang D, Guo M, Yu J, Zhao C, Feng B. Wang X, et al. Wound Repair Regen. 2017 Apr;25(2):270-278. doi: 10.1111/wrr.12520. Epub 2017 Apr 27. Wound Repair Regen. 2017. PMID: 28370978
The nanoscaled GHK-Cu-liposomes promoted HUVECs proliferation, with a 33.1% increased rate. ...In a mice scald model, angiogenesis in burned skin treated with GHK-Cu-liposomes was better compared with free GHK-Cu, and immunofluorescence a …
The nanoscaled GHK-Cu-liposomes promoted HUVECs proliferation, with a 33.1% increased rate. ...In a mice scald model, angiogen …
Synergy of GHK-Cu and hyaluronic acid on collagen IV upregulation via fibroblast and ex-vivo skin tests.
Jiang F, Wu Y, Liu Z, Hong M, Huang Y. Jiang F, et al. J Cosmet Dermatol. 2023 Sep;22(9):2598-2604. doi: 10.1111/jocd.15763. Epub 2023 Apr 16. J Cosmet Dermatol. 2023. PMID: 37062921
INTRODUCTION: GHK-Cu and HA are two commonly used skin care ingredients, both of which were reported to enhance collagen synthesis. ...CONCLUSION: The co-effect of GHK-Cu and HA was revealed. Their synergy brings an insight to anti-aging technology: ch …
INTRODUCTION: GHK-Cu and HA are two commonly used skin care ingredients, both of which were reported to enhance collagen synth …
Protective effects of GHK-Cu in bleomycin-induced pulmonary fibrosis via anti-oxidative stress and anti-inflammation pathways.
Ma WH, Li M, Ma HF, Li W, Liu L, Yin Y, Zhou XM, Hou G. Ma WH, et al. Life Sci. 2020 Jan 15;241:117139. doi: 10.1016/j.lfs.2019.117139. Epub 2019 Dec 4. Life Sci. 2020. PMID: 31809714
Glycyl-L-histidyl-l-lysine (GHK) is a tripeptide participating into wound healing and regeneration. GHK-Cu complexes improve GHK bioavailability. Thus, the current study aimed to explore the therapeutic role of GHK-Cu on bleomycin (BLM)-induced pulmona …
Glycyl-L-histidyl-l-lysine (GHK) is a tripeptide participating into wound healing and regeneration. GHK-Cu complexes improve G …
The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health.
Pickart L, Vasquez-Soltero JM, Margolina A. Pickart L, et al. Oxid Med Cell Longev. 2012;2012:324832. doi: 10.1155/2012/324832. Epub 2012 May 10. Oxid Med Cell Longev. 2012. PMID: 22666519 Free PMC article. Review.
It has high affinity for copper ions and easily forms a copper complex or GHK-Cu. In addition, GHK possesses a plethora of other regenerative and protective actions including antioxidant, anti-inflammatory, and wound healing properties. ...
It has high affinity for copper ions and easily forms a copper complex or GHK-Cu. In addition, GHK possesses a plethora of oth …
The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice.
Park JR, Lee H, Kim SI, Yang SR. Park JR, et al. Oncotarget. 2016 Sep 6;7(36):58405-58417. doi: 10.18632/oncotarget.11168. Oncotarget. 2016. PMID: 27517151 Free PMC article.
The tripeptide-copper complex glycyl-l-histidyl-l-lysine-Cu (II) (GHK-Cu) is involved in wound healing and tissue remodeling. Although GHK-Cu exhibits anti-aging and tissue renewing properties, its roles in acute lung injury (ALI)/acute respiratory dis …
The tripeptide-copper complex glycyl-l-histidyl-l-lysine-Cu (II) (GHK-Cu) is involved in wound healing and tissue remodeling. …
146 results