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Page 1
GKT137831 and hydrogen peroxide increase the release of 6-nitrodopamine from the human umbilical artery, rat-isolated right atrium, and rat-isolated vas deferens.
Britto-Júnior J, Furlaneto R, Lima AT, de Oliveira MG, Severino B, Frecentese F, Fiorino F, Caliendo G, Muscará MN, De Nucci G. Britto-Júnior J, et al. Front Pharmacol. 2024 Apr 5;15:1348876. doi: 10.3389/fphar.2024.1348876. eCollection 2024. Front Pharmacol. 2024. PMID: 38645555 Free PMC article.
Results and Discussion: Pre-incubation (30 min) of the tissues with GKT137831 (1 muM) caused a significant increase in the basal release of 6-ND from all tissues. ...Pre-treatment of the HUA with L-NAME (100 muM) prevented the increase in the basal release of 6-ND induced …
Results and Discussion: Pre-incubation (30 min) of the tissues with GKT137831 (1 muM) caused a significant increase in the basal rele …
[Effects of M2-type macrophages and GKT137831 on oxidative stress in hepatic stellate cells].
Sun RG, Li J, Shen FJ. Sun RG, et al. Zhonghua Gan Zang Bing Za Zhi. 2024 Mar 20;32(3):201-207. doi: 10.3760/cma.j.cn501113-20231120-00206. Zhonghua Gan Zang Bing Za Zhi. 2024. PMID: 38584100 Chinese.
The optimal drug concentration was chosen and divided into an HSC co-culture group (the control group) and five experimental groups: the TGF-beta1 stimulation group, the TGF-beta1 +GKT137831 stimulation group, the M2-type macrophage + HSC co-culture group, the M2-type macr …
The optimal drug concentration was chosen and divided into an HSC co-culture group (the control group) and five experimental groups: the TGF …
Inhibition of both NOX and TNF-α exerts substantial renoprotective effects in renal ischemia reperfusion injury rat model.
Bayoumi AA, Ahmad EA, Ibrahim IAAE, Mahmoud MF, Elbatreek MH. Bayoumi AA, et al. Eur J Pharmacol. 2024 May 5;970:176507. doi: 10.1016/j.ejphar.2024.176507. Epub 2024 Mar 15. Eur J Pharmacol. 2024. PMID: 38492877
Rats were divided into five groups; sham, RIRI, and RIRI treated with setanaxib (NOX inhibitor, 10 mg/kg), etanercept (TNF-alpha inhibitor, 10 mg/kg), and setanaxib and etanercept (5 mg/kg each). ...RESULTS: Our in-silico analysis yielded a disease module with TNF r …
Rats were divided into five groups; sham, RIRI, and RIRI treated with setanaxib (NOX inhibitor, 10 mg/kg), etanercept (TNF-alpha inhi …
Reactive oxygen species augment contractile responses of saphenous artery in 10-15-day-old but not adult rats: Substantial role of NADPH oxidases.
Shvetsova AA, Khlystova MA, Makukha YA, Shateeva VS, Borzykh AA, Gaynullina DK, Tarasova OS. Shvetsova AA, et al. Free Radic Biol Med. 2024 Apr;216:24-32. doi: 10.1016/j.freeradbiomed.2024.03.005. Epub 2024 Mar 8. Free Radic Biol Med. 2024. PMID: 38460742
Finally, NOX2 inhibitor GSK2795039 (10 muM), but not NOX1/4 inhibitor GKT137831 (10 muM) weakened methoxamine-induced contractile responses of arteries from young rats. ...
Finally, NOX2 inhibitor GSK2795039 (10 muM), but not NOX1/4 inhibitor GKT137831 (10 muM) weakened methoxamine-induced contractile res …
Setanaxib mitigates oxidative damage following retinal ischemia-reperfusion via NOX1 and NOX4 inhibition in retinal ganglion cells.
Liao J, Lai Z, Huang G, Lin J, Huang W, Qin Y, Chen Q, Hu Y, Cheng Q, Jiang L, Cui L, Zhong H, Li M, Wei Y, Xu F. Liao J, et al. Biomed Pharmacother. 2024 Jan;170:116042. doi: 10.1016/j.biopha.2023.116042. Epub 2023 Dec 20. Biomed Pharmacother. 2024. PMID: 38118351 Free article.
This study investigated the efficacy of setanaxib in ameliorating retinal ischemia-reperfusion (I/R) injury and elucidated its underlying mechanisms. ...Furthermore, setanaxib significantly suppressed ROS production, Hif-1alpha and FOXO1 upregulation, and NRF2 downr …
This study investigated the efficacy of setanaxib in ameliorating retinal ischemia-reperfusion (I/R) injury and elucidated its underl …
Aspirin protects human trophoblast HTR-8/SVneo cells from H2O2-Induced oxidative stress via NADPH/ROS pathway.
Guo X, Dilidaxi D, Li L, Wang C, Ma X, Sang F, Pei G, Li W. Guo X, et al. Placenta. 2023 Dec;144:55-63. doi: 10.1016/j.placenta.2023.11.008. Epub 2023 Nov 18. Placenta. 2023. PMID: 37995441
METHODS: In vitro, extravillous trophoblast cell line (HTR-8/SVneo) were treated with hydrogen peroxide (H(2)O(2), 150 muM) after the presence of aspirin (90 and 120 muM) with or without GKT137831 (a Nox4 inhibitor, 20 muM). A series of experiments including CCK-8 assays, …
METHODS: In vitro, extravillous trophoblast cell line (HTR-8/SVneo) were treated with hydrogen peroxide (H(2)O(2), 150 muM) after the presen …
Advanced glycated end-products inhibit dilation through constitutive endothelial RAGE and Nox1/4 in rat isolated skeletal muscle arteries.
Naser N, Lonj CK, Rikard-Bell M, Sandow SL, Murphy TV. Naser N, et al. Microcirculation. 2024 Jan;31(1):e12837. doi: 10.1111/micc.12837. Epub 2023 Nov 20. Microcirculation. 2024. PMID: 37985248
Exogenous AGE (in vitro glycated bovine serum albumin) stimulated H2O2 accumulation in CMA, which was prevented by the RAGE antagonist FPS-ZM1, the NAD(P)H oxidase (Nox) inhibitor apocynin and inhibited by the Nox1/4 inhibitor setanaxib, but not the Nox2 inhibitor GSK27950 …
Exogenous AGE (in vitro glycated bovine serum albumin) stimulated H2O2 accumulation in CMA, which was prevented by the RAGE antagonist FPS-Z …
Cardiomyocyte NOX4 regulates resident macrophage-mediated inflammation and diastolic dysfunction in stress cardiomyopathy.
Vendrov AE, Xiao H, Lozhkin A, Hayami T, Hu G, Brody MJ, Sadoshima J, Zhang YY, Runge MS, Madamanchi NR. Vendrov AE, et al. Redox Biol. 2023 Nov;67:102937. doi: 10.1016/j.redox.2023.102937. Epub 2023 Oct 19. Redox Biol. 2023. PMID: 37871532 Free PMC article.
A significant increase in cardiac fibroblast activation and interstitial collagen deposition and a restrictive pattern of diastolic dysfunction with increased filling pressure was observed in wild-type hearts compared with Nox4(CM-/-) 7 days post-ISO. A selective NOX4 inhibitor, …
A significant increase in cardiac fibroblast activation and interstitial collagen deposition and a restrictive pattern of diastolic dysfunct …
NADPH oxidase 4 inhibition is a complementary therapeutic strategy for spinal muscular atrophy.
El Khoury M, Biondi O, Bruneteau G, Sapaly D, Bendris S, Bezier C, Clerc Z, Akar EA, Weill L, Eid AA, Charbonnier F. El Khoury M, et al. Front Cell Neurosci. 2023 Sep 14;17:1242828. doi: 10.3389/fncel.2023.1242828. eCollection 2023. Front Cell Neurosci. 2023. PMID: 37780204 Free PMC article.
Finally, we tested if GKT137831/Setanaxib could act synergistically with FDA-validated SMN-upregulating treatment (nusinersen). RESULTS: We show that NOX4 is overexpressed in SMA and its inhibition by GKT137831/Setanaxib protected spinal MN from SMA-in …
Finally, we tested if GKT137831/Setanaxib could act synergistically with FDA-validated SMN-upregulating treatment (nusinersen) …
GKT137831 in combination with adipose-derived stem cells alleviates high glucose-induced inflamm-aging and improves diabetic wound healing.
Dong Y, Zhang Y, Li F, Tang B, Lv D, Wang H, Luo S. Dong Y, et al. J Leukoc Biol. 2023 Sep 29:qiad116. doi: 10.1093/jleuko/qiad116. Online ahead of print. J Leukoc Biol. 2023. PMID: 37774495
However, reactive oxygen species (ROS) induced by high glucose (HG) lead to oxidative stress and aging in ADSCs, which limits the therapeutic effect of ADSCs. In this study, we investigated the role of GKT137831, a NOX1/4 inhibitor that can reduce ROS production, in protec …
However, reactive oxygen species (ROS) induced by high glucose (HG) lead to oxidative stress and aging in ADSCs, which limits the therapeuti …
144 results