Setanaxib mitigates oxidative damage following retinal ischemia-reperfusion via NOX1 and NOX4 inhibition in retinal ganglion cells.
Liao J, Lai Z, Huang G, Lin J, Huang W, Qin Y, Chen Q, Hu Y, Cheng Q, Jiang L, Cui L, Zhong H, Li M, Wei Y, Xu F.
Liao J, et al.
Biomed Pharmacother. 2024 Jan;170:116042. doi: 10.1016/j.biopha.2023.116042. Epub 2023 Dec 20.
Biomed Pharmacother. 2024.
PMID: 38118351
Free article.
This study investigated the efficacy of setanaxib in ameliorating retinal ischemia-reperfusion (I/R) injury and elucidated its underlying mechanisms. ...Furthermore, setanaxib significantly suppressed ROS production, Hif-1alpha and FOXO1 upregulation, and NRF2 downr …
This study investigated the efficacy of setanaxib in ameliorating retinal ischemia-reperfusion (I/R) injury and elucidated its underl …