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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 2
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1999 30
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927 results

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Page 1
Insulin resistance: Review of the underlying molecular mechanisms.
Yaribeygi H, Farrokhi FR, Butler AE, Sahebkar A. Yaribeygi H, et al. J Cell Physiol. 2019 Jun;234(6):8152-8161. doi: 10.1002/jcp.27603. Epub 2018 Oct 14. J Cell Physiol. 2019. PMID: 30317615 Review.
Most human cells utilize glucose as the primary substrate, cellular uptake requiring insulin. Insulin signaling is therefore critical for these tissues. However, decrease in insulin sensitivity due to the disruption of various molecular pathways causes ins …
Most human cells utilize glucose as the primary substrate, cellular uptake requiring insulin. Insulin signaling is therefore c …
Metformin and Insulin Resistance: A Review of the Underlying Mechanisms behind Changes in GLUT4-Mediated Glucose Transport.
Herman R, Kravos NA, Jensterle M, Janež A, Dolžan V. Herman R, et al. Int J Mol Sci. 2022 Jan 23;23(3):1264. doi: 10.3390/ijms23031264. Int J Mol Sci. 2022. PMID: 35163187 Free PMC article. Review.
Metformin is the most commonly used treatment to increase insulin sensitivity in insulin-resistant (IR) conditions such as diabetes, prediabetes, polycystic ovary syndrome, and obesity. ...Our aim is to provide a comprehensive review of the studies in this field in …
Metformin is the most commonly used treatment to increase insulin sensitivity in insulin-resistant (IR) conditions such as dia …
Berberine in the Treatment of Diabetes Mellitus: A Review.
Baska A, Leis K, Gałązka P. Baska A, et al. Endocr Metab Immune Disord Drug Targets. 2021;21(8):1379-1386. doi: 10.2174/1568026620666201022144405. Endocr Metab Immune Disord Drug Targets. 2021. PMID: 33092516 Review.
The compound also protects pancreatic beta-cells and increases sensitivity to insulin in peripheral tissues via the induction of GLUT-1, GLUT-4 and insulin type 1 (Ins-1) receptors activity. It also stimulates glycolysis and leads to a decrease in i …
The compound also protects pancreatic beta-cells and increases sensitivity to insulin in peripheral tissues via the induction of GLUT …
From insulin receptor signalling to Glut 4 translocation abnormalities in obesity and insulin resistance.
Le Marchand-Brustel Y, Tanti JF, Cormont M, Ricort JM, Grémeaux T, Grillo S. Le Marchand-Brustel Y, et al. J Recept Signal Transduct Res. 1999 Jan-Jul;19(1-4):217-28. doi: 10.3109/10799899909036647. J Recept Signal Transduct Res. 1999. PMID: 10071760 Review.
Insulin resistance is commonly associated with obesity in rodents. Using mice made obese with goldthioglucose (GTG-obese mice), we have shown that insulin resistance results from defects at the level of the receptor and from intracellular alterations i …
Insulin resistance is commonly associated with obesity in rodents. Using mice made obese with goldthioglucose (GTG-obese mice) …
Adipocyte Insulin Resistance in PCOS: Relationship With GLUT-4 Expression and Whole-Body Glucose Disposal and beta-Cell Function.
Ezeh U, Chen IY, Chen YH, Azziz R. Ezeh U, et al. J Clin Endocrinol Metab. 2020 Jul 1;105(7):e2408-20. doi: 10.1210/clinem/dgaa235. J Clin Endocrinol Metab. 2020. PMID: 32382742 Free PMC article.
OBJECTIVES: To test the hypothesis that insulin resistance (IR) in AT is associated with whole-body insulin sensitivity and beta-cell function in PCOS. ...METHODS: Eighteen participants with PCOS and 18-matched control participants underwent a modified freque …
OBJECTIVES: To test the hypothesis that insulin resistance (IR) in AT is associated with whole-body insulin sensitivity …
GLUT-4, tumor necrosis factor, essential fatty acids and daf-genes and their role in insulin resistance and non-insulin dependent diabetes mellitus.
Das UN. Das UN. Prostaglandins Leukot Essent Fatty Acids. 1999 Jan;60(1):13-20. doi: 10.1054/plef.1998.0003. Prostaglandins Leukot Essent Fatty Acids. 1999. PMID: 10319913 Review.
EFAs and their metabolites can alter the cell membrane fluidity and enhance the expression of GLUT-4 and insulin receptors. EFAs can suppress TNF-alpha production and secretion, a mechanism that may have relevance to the role of these fatty acids in the patho …
EFAs and their metabolites can alter the cell membrane fluidity and enhance the expression of GLUT-4 and insulin recept …
PTEN, Insulin Resistance and Cancer.
Li A, Qiu M, Zhou H, Wang T, Guo W. Li A, et al. Curr Pharm Des. 2017;23(25):3667-3676. doi: 10.2174/1381612823666170704124611. Curr Pharm Des. 2017. PMID: 28677502 Review.
Insulin resistance is a common metabolic feature and established risk factor of many diseases. ...RESULTS: Suppressing PTEN expression plays a role in pro- or anti-inflammatory state during insulin resistance associated with obesity. Selective disrupti …
Insulin resistance is a common metabolic feature and established risk factor of many diseases. ...RESULTS: Suppressing PTEN ex …
Insulin resistance and impaired adipogenesis.
Gustafson B, Hedjazifar S, Gogg S, Hammarstedt A, Smith U. Gustafson B, et al. Trends Endocrinol Metab. 2015 Apr;26(4):193-200. doi: 10.1016/j.tem.2015.01.006. Epub 2015 Feb 18. Trends Endocrinol Metab. 2015. PMID: 25703677 Review.
The adipose tissue is crucial in regulating insulin sensitivity and risk for diabetes through its lipid storage capacity and thermogenic and endocrine functions. ...We review the regulation of adipogenesis, its relation to SAT expandability and the risks of ectopic fat acc …
The adipose tissue is crucial in regulating insulin sensitivity and risk for diabetes through its lipid storage capacity and thermoge …
Etiology of insulin resistance.
Petersen KF, Shulman GI. Petersen KF, et al. Am J Med. 2006 May;119(5 Suppl 1):S10-6. doi: 10.1016/j.amjmed.2006.01.009. Am J Med. 2006. PMID: 16563942 Free PMC article. Review.
Novel investigational techniques based on magnetic resonance spectroscopy (MRS) have allowed real-time insight into the molecular defects in patients with type 2 diabetes, revealing that insulin resistance is a product of decreased insulin-stimulated skeletal …
Novel investigational techniques based on magnetic resonance spectroscopy (MRS) have allowed real-time insight into the molecular defects in …
927 results