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Year Number of Results
2007 4
2009 1
2010 4
2020 0
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Page 1
Beyond directed evolution--semi-rational protein engineering and design.
Lutz S. Lutz S. Curr Opin Biotechnol. 2010 Dec;21(6):734-43. doi: 10.1016/j.copbio.2010.08.011. Epub 2010 Sep 24. Curr Opin Biotechnol. 2010. PMID: 20869867 Free PMC article. Review.
Biochemistry. Reengineering enzymes.
Lutz S. Lutz S. Science. 2010 Jul 16;329(5989):285-7. doi: 10.1126/science.1192224. Science. 2010. PMID: 20647454 Free PMC article. No abstract available.
Computational design of orthogonal nucleoside kinases.
Liu L, Murphy P, Baker D, Lutz S. Liu L, et al. Chem Commun (Camb). 2010 Dec 14;46(46):8803-5. doi: 10.1039/c0cc02961k. Epub 2010 Oct 19. Chem Commun (Camb). 2010. PMID: 20959903 Free PMC article.
Directed evolution of an orthogonal nucleoside analog kinase via fluorescence-activated cell sorting.
Liu L, Li Y, Liotta D, Lutz S. Liu L, et al. Nucleic Acids Res. 2009 Jul;37(13):4472-81. doi: 10.1093/nar/gkp400. Epub 2009 May 27. Nucleic Acids Res. 2009. PMID: 19474348 Free PMC article.
Exploiting temperature-dependent substrate promiscuity for nucleoside analogue activation by thymidine kinase from Thermotoga maritima.
Lutz S, Lichter J, Liu L. Lutz S, et al. J Am Chem Soc. 2007 Jul 18;129(28):8714-5. doi: 10.1021/ja0734391. Epub 2007 Jun 26. J Am Chem Soc. 2007. PMID: 17592850 Free PMC article.
Quaternary structure change as a mechanism for the regulation of thymidine kinase 1-like enzymes.
Segura-Peña D, Lichter J, Trani M, Konrad M, Lavie A, Lutz S. Segura-Peña D, et al. Structure. 2007 Dec;15(12):1555-66. doi: 10.1016/j.str.2007.09.025. Structure. 2007. PMID: 18073106 Free PMC article.
Non-homologous recombination of deoxyribonucleoside kinases from human and Drosophila melanogaster yields human-like enzymes with novel activities.
Gerth ML, Lutz S. Gerth ML, et al. J Mol Biol. 2007 Jul 20;370(4):742-51. doi: 10.1016/j.jmb.2007.05.021. Epub 2007 May 22. J Mol Biol. 2007. PMID: 17543337 Free PMC article.
Synthesis of fluorescent nucleoside analogs as probes for 2'-deoxyribonucleoside kinases.
Li Y, Soni PB, Liu L, Zhang X, Liotta DC, Lutz S. Li Y, et al. Bioorg Med Chem Lett. 2010 Feb 1;20(3):841-3. doi: 10.1016/j.bmcl.2009.12.097. Epub 2010 Jan 4. Bioorg Med Chem Lett. 2010. PMID: 20060716 Free PMC article.
Mutagenesis of non-conserved active site residues improves the activity and narrows the specificity of human thymidine kinase 2.
Gerth ML, Lutz S. Gerth ML, et al. Biochem Biophys Res Commun. 2007 Mar 16;354(3):802-7. doi: 10.1016/j.bbrc.2007.01.070. Epub 2007 Jan 23. Biochem Biophys Res Commun. 2007. PMID: 17266931 Free PMC article.