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Page 1
Glutathione peroxidases.
Brigelius-Flohé R, Maiorino M. Brigelius-Flohé R, et al. Biochim Biophys Acta. 2013 May;1830(5):3289-303. doi: 10.1016/j.bbagen.2012.11.020. Epub 2012 Nov 29. Biochim Biophys Acta. 2013. PMID: 23201771 Review.
MAJOR CONCLUSIONS: GPxs are involved in balancing the H2O2 homeostasis in signalling cascades, e.g. in the insulin signalling pathway by GPx1; GPx2 plays a dual role in carcinogenesis depending on the mode of initiation and cancer stage; GPx3 is membrane associated possibl …
MAJOR CONCLUSIONS: GPxs are involved in balancing the H2O2 homeostasis in signalling cascades, e.g. in the insulin signalling pathway by GPx …
Potential relationship between the selenoproteome and cancer.
Jia Y, Dai J, Zeng Z. Jia Y, et al. Mol Clin Oncol. 2020 Dec;13(6):83. doi: 10.3892/mco.2020.2153. Epub 2020 Oct 11. Mol Clin Oncol. 2020. PMID: 33133596 Free PMC article.
The role of the selenoproteome, which is the collection of all proteins containing selenium in an organism, in cancer development, growth and progression requires further investigation, due to the importance of selenium in both cancer and immune system function. ... …
The role of the selenoproteome, which is the collection of all proteins containing selenium in an organism, in cancer development, gr …
Bioinformatics analysis on the expression of GPX family in gastric cancer and its correlation with the prognosis of gastric cancer.
Ye S, Lin R, Guo X, Xing J, Liu K, Yang W, Guo N. Ye S, et al. Heliyon. 2022 Dec 9;8(12):e12214. doi: 10.1016/j.heliyon.2022.e12214. eCollection 2022 Dec. Heliyon. 2022. PMID: 36636221 Free PMC article.
BACKGROUND: Gastric cancer (GC) is one of the most common cancers of the digestive tract, with the fifth-highest incidence and third highest mortality rate in the world. ...RESULTS: The results showed that with the increase of GPX1 and GPX2 mRNA low expression level …
BACKGROUND: Gastric cancer (GC) is one of the most common cancers of the digestive tract, with the fifth-highest incidence and …
Knockout of glutathione peroxidase 5 down-regulates the piRNAs in the caput epididymidis of aged mice.
Chu C, Yu L, Henry-Berger J, Ru YF, Kocer A, Champroux A, Li ZT, He M, Xie SS, Ma WB, Ni MJ, Ni ZM, Guo YL, Fei ZL, Gou LT, Liu Q, Sharma S, Zhou Y, Liu MF, Chen CD, Eamens AL, Nixon B, Zhou YC, Drevet JR, Zhang YL. Chu C, et al. Asian J Androl. 2020 Nov-Dec;22(6):590-601. doi: 10.4103/aja.aja_3_20. Asian J Androl. 2020. PMID: 32270769 Free PMC article.
In mice, the risk of oxidative damage to spermatozoa is mitigated through the expression and secretion of glutathione peroxidase 5 (GPX5) as a major luminal scavenger in the proximal caput epididymidal segment. Accordingly, the loss of GPX5-mediated protection leads …
In mice, the risk of oxidative damage to spermatozoa is mitigated through the expression and secretion of glutathione peroxidase 5 (GPX5 …
The Male Reproductive Toxicity Caused by 2-Naphthylamine Was Related to Testicular Immunity Disorders.
Dai P, Ding M, Yu J, Gao Y, Wang M, Ling J, Dong S, Zhang X, Zeng X, Sun X. Dai P, et al. Toxics. 2024 May 7;12(5):342. doi: 10.3390/toxics12050342. Toxics. 2024. PMID: 38787121 Free PMC article.
2-naphthylamine (NAP) was classified as a group I carcinogen associated with bladder cancer. The daily exposure is mostly from cigarette and E-cigarette smoke. NAP can lead to testicular atrophy and interstitial tissue hyperplasia; however, the outcomes of NAP treatment on …
2-naphthylamine (NAP) was classified as a group I carcinogen associated with bladder cancer. The daily exposure is mostly from cigare …
Glutathione Peroxidase gpx1 to gpx8 Genes Expression in Experimental Brain Tumors Reveals Gender-Dependent Patterns.
Cueto-Ureña C, Ramírez-Expósito MJ, Mayas MD, Carrera-González MP, Godoy-Hurtado A, Martínez-Martos JM. Cueto-Ureña C, et al. Genes (Basel). 2023 Aug 24;14(9):1674. doi: 10.3390/genes14091674. Genes (Basel). 2023. PMID: 37761814 Free PMC article.
Employing the delta-delta Ct method for RT-PCR, we observed minimal expression levels of gpx2, gpx5, gpx6, and gpx7 in the brain tissue from the healthy control animals, while gpx3 and gpx8 exhibited moderate expression levels. ...Conversely, the tumor tissue exhibited ele …
Employing the delta-delta Ct method for RT-PCR, we observed minimal expression levels of gpx2, gpx5, gpx6, and gpx7 in the brain tiss …
The prognostic and antitumor roles of key genes of ferroptosis in liver hepatocellular cancer and stomach adenocarcinoma.
Pei W, Jiang M, Liu H, Song J, Hu J. Pei W, et al. Cancer Biomark. 2024;39(4):335-347. doi: 10.3233/CBM-230114. Cancer Biomark. 2024. PMID: 38393890 Free PMC article.
BACKGROUND: Liver hepatocellular cancer (LIHC) and stomach adenocarcinoma (STAD) are common malignancies with high lethal ratios worldwide. ...The relationship of PTGS2 and ACSL4 to immune cell infiltration was analysed using the TIMER website. The viability and GPX5 …
BACKGROUND: Liver hepatocellular cancer (LIHC) and stomach adenocarcinoma (STAD) are common malignancies with high lethal ratios worl …
Distinct prognostic values of mRNA expression of glutathione peroxidases in non-small cell lung cancer.
Liu K, Jin M, Xiao L, Liu H, Wei S. Liu K, et al. Cancer Manag Res. 2018 Aug 28;10:2997-3005. doi: 10.2147/CMAR.S163432. eCollection 2018. Cancer Manag Res. 2018. PMID: 30214294 Free PMC article.
However, the prognostic value of individual GPx in non-small cell lung cancer (NSCLC) remains elusive. MATERIALS AND METHODS: In the current study, we investigated the prognostic value of GPxs in NSCLC patients through the "Kaplan-Meier plotter" database, wherein updated g …
However, the prognostic value of individual GPx in non-small cell lung cancer (NSCLC) remains elusive. MATERIALS AND METHODS: In the …
Genetic variations in multiple drug action pathways and survival in advanced stage non-small cell lung cancer treated with chemotherapy.
Li Y, Sun Z, Cunningham JM, Aubry MC, Wampfler JA, Croghan GA, Johnson C, Wu D, Aakre JA, Molina J, Wang L, Pankratz VS, Yang P. Li Y, et al. Clin Cancer Res. 2011 Jun 1;17(11):3830-40. doi: 10.1158/1078-0432.CCR-10-2877. Clin Cancer Res. 2011. PMID: 21636554 Free PMC article.
PURPOSE: Variations in genes related to biological activity of anticancer drugs could influence treatment responses and lung cancer prognosis. Genetic variants in four biological pathways, that is, glutathione metabolism, DNA repair, cell cycle, and epidermal growth factor …
PURPOSE: Variations in genes related to biological activity of anticancer drugs could influence treatment responses and lung cancer p …
Clinical relevance of thyroid cell models in redox research.
Cammarota F, Fiscardi F, Esposito T, de Vita G, Salvatore M, Laukkanen MO. Cammarota F, et al. Cancer Cell Int. 2015 Dec 9;15:113. doi: 10.1186/s12935-015-0264-3. eCollection 2015. Cancer Cell Int. 2015. PMID: 26664298 Free PMC article.
BACKGROUND: Thyroid-derived cell models are commonly used to investigate the characteristics of thyroid cancers. It is noteworthy that each in vitro single cell model system imitates only a few characteristics of thyroid cancer depending on e.g. source of cells or o …
BACKGROUND: Thyroid-derived cell models are commonly used to investigate the characteristics of thyroid cancers. It is noteworthy tha …
15 results