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192 results

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GRIK2 is a target for bladder cancer stem-like cell-targeting immunotherapy.
Miyata H, Hirohashi Y, Yamada S, Yanagawa J, Murai A, Hashimoto S, Tokita S, Hori K, Abe T, Kubo T, Tsukahara T, Kanaseki T, Shinohara N, Torigoe T. Miyata H, et al. Cancer Immunol Immunother. 2022 Apr;71(4):795-806. doi: 10.1007/s00262-021-03025-z. Epub 2021 Aug 18. Cancer Immunol Immunother. 2022. PMID: 34405274 Free PMC article.
HLA ligandome analysis and cap analysis of gene expression using ALDH(high) clone cells revealed a distinctive antigenic peptide repertoire in bladder CSCs/CICs, and we found that a glutamate receptor, ionotropic, kainite 2 (GRIK2)-derived antigenic peptide (LMYDAVHVV) was …
HLA ligandome analysis and cap analysis of gene expression using ALDH(high) clone cells revealed a distinctive antigenic peptide repertoire …
A novel AAV9-dual microRNA-vector targeting GRIK2 in the hippocampus as a treatment for mesial temporal lobe epilepsy.
Baudouin SJ, Giles AR, Pearson N, Deforges S, He C, Boileau C, Partouche N, Borta A, Gautron J, Wartel M, Bočkaj I, Scavarda D, Bartolomei F, Penchet G, Aupy J, Sims J, Smith J, Mercer A, Danos O, Mulle C, Crépel V, Porter R. Baudouin SJ, et al. Mol Ther Methods Clin Dev. 2024 Sep 16;32(4):101342. doi: 10.1016/j.omtm.2024.101342. eCollection 2024 Dec 12. Mol Ther Methods Clin Dev. 2024. PMID: 39429724 Free PMC article.
Here, we engineered an adeno-associated virus serotype 9 vector expressing a cluster of two synthetic microRNAs (miRNAs), expressed from the human synapsin promoter, that target GRIK2 mRNA. Intra-hippocampal delivery of this vector in a mouse model of mTLE significantly re …
Here, we engineered an adeno-associated virus serotype 9 vector expressing a cluster of two synthetic microRNAs (miRNAs), expressed from the …
Alternative Promoters of GRIK2 (GluR6) Gene in Human Carcinoma Cell Lines Are Regulated by Differential Methylation of CpG Dinucleotides.
Zhawar VK, Kandpal RP, Athwal RS. Zhawar VK, et al. Genes (Basel). 2022 Mar 10;13(3):490. doi: 10.3390/genes13030490. Genes (Basel). 2022. PMID: 35328043 Free PMC article.
The ionotropic glutamate receptor 6 (GluR6 or GRIK2) gene is transcribed by two cell-type-specific promoters in neuronal and non-neuronal cells, which results in five different transcript variants. ...
The ionotropic glutamate receptor 6 (GluR6 or GRIK2) gene is transcribed by two cell-type-specific promoters in neuronal and non-neur …
Correlation between GRIK2 rs6922753, rs2227283 polymorphism and aggressive behaviors with Bipolar Mania in the Chinese Han population.
Ma H, Xun G, Zhang R, Yang X, Cao Y. Ma H, et al. Brain Behav. 2019 Nov;9(11):e01449. doi: 10.1002/brb3.1449. Epub 2019 Oct 20. Brain Behav. 2019. PMID: 31631587 Free PMC article.
OBJECTIVES: Animal studies have shown that glutamate receptor ionotropic kainate 2 (GRIK2) gene knockout mice are more impulsive and aggressive. This study aims to verify whether the rs6922753 and rs2227283 polymorphisms of the GRIK2 gene are associated with both ag …
OBJECTIVES: Animal studies have shown that glutamate receptor ionotropic kainate 2 (GRIK2) gene knockout mice are more impulsive and …
Interaction among GRIK2 gene on epilepsy susceptibility in Chinese children.
Xiong S, Wang Y, Li H, Zhang X. Xiong S, et al. Acta Neurol Scand. 2019 Jun;139(6):540-545. doi: 10.1111/ane.13089. Epub 2019 Apr 9. Acta Neurol Scand. 2019. PMID: 30908586
AIMS: The association of single nucleotide polymorphisms (SNPs) of glutamate receptor 2 (GRIK2) gene, as well as gene-gene interaction with the risk of early-onset epilepsy susceptibility, was studied in Chinese children. ...Participants with rs4840200-CT/TT and rs9390754- …
AIMS: The association of single nucleotide polymorphisms (SNPs) of glutamate receptor 2 (GRIK2) gene, as well as gene-gene interactio …
Epigenetic signature discriminates lymphatic metastasis in BRAF wild-type thyroid carcinoma: methylation role of GRIK2.
Peng J, Zhang Q, Lin F, Ke C, Deng W, Yang A, Su X. Peng J, et al. Epigenomics. 2023 Nov;15(21):1101-1119. doi: 10.2217/epi-2023-0334. Epub 2023 Nov 22. Epigenomics. 2023. PMID: 37990886
Results: The model showed high accuracy (AUC: 0.924 training set; 0.812 and 0.773 external cohorts). TAGLN, MRPL4, CLDN10 and GRIK2 emerged as diagnostic markers. GRIK2, downregulated due to promoter hypermethylation, acted as a TC suppressor. Conclusion: Our 5-CpG …
Results: The model showed high accuracy (AUC: 0.924 training set; 0.812 and 0.773 external cohorts). TAGLN, MRPL4, CLDN10 and GRIK2 e …
GRIK2 has a role in the maintenance of urothelial carcinoma stem-like cells, and its expression is associated with poorer prognosis.
Inoue R, Hirohashi Y, Kitamura H, Nishida S, Murai A, Takaya A, Yamamoto E, Matsuki M, Tanaka T, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Sato N, Masumori N, Torigoe T. Inoue R, et al. Oncotarget. 2017 Apr 25;8(17):28826-28839. doi: 10.18632/oncotarget.16259. Oncotarget. 2017. PMID: 28418868 Free PMC article.
GRIK2 gene knockdown by siRNAs decreased the sphere-forming ability and invasion ability, whereas GRIK2 overexpression increased the sphere-forming ability, invasion ability and tumorigenicity, indicating that GRIK2 has a role in the maintenance of CSCs/CICs. …
GRIK2 gene knockdown by siRNAs decreased the sphere-forming ability and invasion ability, whereas GRIK2 overexpression increas …
Clustered mutations in the GRIK2 kainate receptor subunit gene underlie diverse neurodevelopmental disorders.
Stolz JR, Foote KM, Veenstra-Knol HE, Pfundt R, Ten Broeke SW, de Leeuw N, Roht L, Pajusalu S, Part R, Rebane I, Õunap K, Stark Z, Kirk EP, Lawson JA, Lunke S, Christodoulou J, Louie RJ, Rogers RC, Davis JM, Innes AM, Wei XC, Keren B, Mignot C, Lebel RR, Sperber SM, Sakonju A, Dosa N, Barge-Schaapveld DQCM, Peeters-Scholte CMPCD, Ruivenkamp CAL, van Bon BW, Kennedy J, Low KJ, Ellard S, Pang L, Junewick JJ, Mark PR, Carvill GL, Swanson GT. Stolz JR, et al. Am J Hum Genet. 2021 Sep 2;108(9):1692-1709. doi: 10.1016/j.ajhg.2021.07.007. Epub 2021 Aug 9. Am J Hum Genet. 2021. PMID: 34375587 Free PMC article.
The extent to which mono-allelic variants in GRIK2 also underlie NDDs is less understood because only a single individual has been reported previously. Here, we describe an additional eleven individuals with heterozygous de novo variants in GRIK2 causative for neuro …
The extent to which mono-allelic variants in GRIK2 also underlie NDDs is less understood because only a single individual has been re …
Senescence of Normal Human Fibroblasts Relates to the Expression of Ionotropic Glutamate Receptor GluR6/Grik2.
Zhawar VK, Kandpal RP, Athwal RS. Zhawar VK, et al. Cancer Genomics Proteomics. 2020 Nov-Dec;17(6):707-714. doi: 10.21873/cgp.20225. Cancer Genomics Proteomics. 2020. PMID: 33099472 Free PMC article.
MATERIALS AND METHODS: We introduced expression constructs of all five isoforms (A-E) of GRIK2 in normal human fibroblasts and investigated the cells for the presence and localization of GRIK2, as well as for cell proliferation and senescence over a period of 24 day …
MATERIALS AND METHODS: We introduced expression constructs of all five isoforms (A-E) of GRIK2 in normal human fibroblasts and invest …
Isoforms of Ionotropic Glutamate Receptor GRIK2 Induce Senescence of Carcinoma Cells.
Zhawar VK, Kandpal RP, Athwal RS. Zhawar VK, et al. Cancer Genomics Proteomics. 2019 Jan-Feb;16(1):59-64. doi: 10.21873/cgp.20111. Cancer Genomics Proteomics. 2019. PMID: 30587499 Free PMC article.
MATERIALS AND METHODS: By using gene transfer technique, SKOV3 ovarian carcinoma cells were transduced with an expression construct of glutamate receptor 6 (glutamate ionotropic receptor kainate type subunit 2, GRIK2) in retroviral vector PQCXIP. The senescence of transduc …
MATERIALS AND METHODS: By using gene transfer technique, SKOV3 ovarian carcinoma cells were transduced with an expression construct of gluta …
192 results