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Page 1
Genetic Risk Factors for Epilepsy: From Familial Studies to Gene Discoveries and Polygenic Risk Scores, Strides Toward Unlocking an Age-Old Question in Epilepsy.
Yano ST, Phitsanuwong C. Yano ST, et al. Epilepsy Curr. 2026 Feb 19:15357597251410840. doi: 10.1177/15357597251410840. Online ahead of print. Epilepsy Curr. 2026. PMID: 41726570 Free PMC article. Review.
Other genes with de novo mutations in this cohort include CACNA1A, CHD2, FLNA, GABRA1, GRIN1, GRIN2B, HNRNPU, IQSEC2, MTOR, and NEDD4L. Finally, we show that the de novo mutations observed are enriched in specific gene sets including genes regulated by the fragile X protei …
Other genes with de novo mutations in this cohort include CACNA1A, CHD2, FLNA, GABRA1, GRIN1, GRIN2B, HNRNPU, IQSEC2, MTOR, and NEDD4 …
Neurodevelopmental disorder-causing GRIN1 Y647S variant alters red blood cell physiology in mice.
Okafor SC, Horsfall W, Finnie PSB, Holicka C, Wen T, Khatir B, Loriamini M, Salahpour A, Golovin K, Branch DR, Scott GR, Edgar LJ, Kalev-Zylinska ML, Ramsey AJ. Okafor SC, et al. Physiol Rep. 2026 Feb;14(4):e70759. doi: 10.14814/phy2.70759. Physiol Rep. 2026. PMID: 41714299 Free PMC article.
Here we have used well-established in vivo and ex vivo methods to investigate hematological (primarily RBC-linked) phenotypes in transgenic mice carrying heterozygous Grin1 Y647S (Grin1(Y647S/+)) variant. We found that Grin1(Y647S/+) mice had slightly increas …
Here we have used well-established in vivo and ex vivo methods to investigate hematological (primarily RBC-linked) phenotypes in transgenic …
Antidepressant Mechanisms of L-Theanine in Tea Based on Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulations.
Shi Y, Yang Y, Cheng X, Huang C, Huang Y, Lu L, Wang S, Zheng Y, Wang F, Zhang B, Zheng S. Shi Y, et al. Foods. 2026 Feb 4;15(3):555. doi: 10.3390/foods15030555. Foods. 2026. PMID: 41683141 Free PMC article.
Protein-protein interaction (PPI) network analysis subsequently pinpointed five hub targets: PRKACA, GRIA2, GRIN1, GRIA1, and HTR1A. Functional enrichment analyses (KEGG and GO) indicated that these targets are primarily implicated in critical pathological processes of dep …
Protein-protein interaction (PPI) network analysis subsequently pinpointed five hub targets: PRKACA, GRIA2, GRIN1, GRIA1, and HTR1A. …
Mechanistic signatures of comorbid PTSD with cognitive impairment implicate cortisol-induced neural toxicity.
Kuang Z, Chesebro AG, Strey SG, Clouston SAP, Luft BJ, Mujica-Parodi LR. Kuang Z, et al. Neuropsychopharmacology. 2026 Feb 12. doi: 10.1038/s41386-026-02358-6. Online ahead of print. Neuropsychopharmacology. 2026. PMID: 41680478 Free article.
Consistent significant correlations were found between PTSD + CI signatures and ZNF48, TOMM40, and GRIN1 expression distributions. The cortisol-induced neurotoxicity pathway was consistently found with the PTSD + CI signature, while the p53 signaling pathway was observed a …
Consistent significant correlations were found between PTSD + CI signatures and ZNF48, TOMM40, and GRIN1 expression distributions. Th …
A HISTORY OF ADOLESCENT OXYCODONE SELF-ADMINISTRATION: NEURAL MECHANISMS UNDERLYING NEUROCOGNITIVE IMPAIRMENTS.
McLaurin KA, Elder TR, Li H, Veenstra BJ, Nelson KJ, Mactutus CF, Turner JR, Booze RM. McLaurin KA, et al. bioRxiv [Preprint]. 2026 Jan 22:2026.01.19.700403. doi: 10.64898/2026.01.19.700403. bioRxiv. 2026. PMID: 41648547 Free PMC article. Preprint.
In male rodents, a dose-dependent decrease in mRNA expression of GRIN1, a N-methyl-D-aspartate receptor, was observed in animals with a history of adolescent OXY self-administration relative to controls. ...
In male rodents, a dose-dependent decrease in mRNA expression of GRIN1, a N-methyl-D-aspartate receptor, was observed in animals with …
Drospirenone inhibits neurobehavioral activity in zebrafish larvae by modulating NMDA receptors.
Chen M, Yu T, Wang X, Wu W, Wan Q, Liu J, Li K, Yue J, Xi J, Yang Z. Chen M, et al. J Hazard Mater. 2026 Feb 15;504:141269. doi: 10.1016/j.jhazmat.2026.141269. Epub 2026 Jan 26. J Hazard Mater. 2026. PMID: 41621298
Molecular docking, DARTS assays, and downstream marker measurements indicated target engagement between DRS and the Grin1 and Grin2 subunits of NMDAR, suggesting that DRS may alter receptor conformation and function. ...
Molecular docking, DARTS assays, and downstream marker measurements indicated target engagement between DRS and the Grin1 and Grin2 s …
Discovery of new MicroRNAs and their mRNA targets in patients with acute ischemic stroke.
Eyileten C, Wicik Z, Gasecka A, Ahmadova S, Di Martino MT, Mucha J, Mirowska-Guzel D, De Rosa S, Kurkowska-Jastrzebska I, Czlonkowska A, Postula M. Eyileten C, et al. BMC Med Genomics. 2026 Jan 24;19(1):37. doi: 10.1186/s12920-025-02302-5. BMC Med Genomics. 2026. PMID: 41580787 Free PMC article.
Top non-coding regulators of ischemia (miR-18a-5p, miR-4467, miR-199a-5p and miR-3135b) and their predicted target genes (ANKRD12, HIF1A, GNAI2, GRIN1) were detected via qRT-PCR. RESULTS: 146 upregulated and 258 downregulated differentially expressed RNAs were detected by …
Top non-coding regulators of ischemia (miR-18a-5p, miR-4467, miR-199a-5p and miR-3135b) and their predicted target genes (ANKRD12, HIF1A, GN …
Integrative Transcriptomic and Perturbagen Analyses Reveal Sex-Specific Molecular Signatures Across Glioma Subtypes.
Rami Reddy MVSR, Wood JF, Norris J, Becker K, Murphy SC, Doddi S, Imami A, Ryan V WG, Nguyen J, Schroeder J, Eisenmann K, McCullumsmith RE. Rami Reddy MVSR, et al. Cancers (Basel). 2025 Dec 24;18(1):52. doi: 10.3390/cancers18010052. Cancers (Basel). 2025. PMID: 41514565 Free PMC article.
In both sexes, LGG-HGG and LGG-GBM grade comparisons converged on neuronal and synaptic programs, with enrichment of glutamatergic receptor genes and postsynaptic modules, including GRIN2B, GRIN2A, GRIN2C, GRIN1, and CHRNA7. In contrast, collateral pathways diverged by sex …
In both sexes, LGG-HGG and LGG-GBM grade comparisons converged on neuronal and synaptic programs, with enrichment of glutamatergic receptor …
Unveiling Dragon's Blood Radiation Mitigation Mechanism: Identifying Key Targets and Bioactive Compounds with Multiomics Using Integrated AI-Driven Models.
Li B, Han C, Zhang H, Li B. Li B, et al. ACS Omega. 2025 Nov 25;10(48):59926-59946. doi: 10.1021/acsomega.5c10620. eCollection 2025 Dec 9. ACS Omega. 2025. PMID: 41502721 Free PMC article.
Ensemble analysis integrating proteomics, WGCNA, machine learning, and PPI pinpointed 24 DB radiation mitigation-related proteins. Among these, eight targets (Grin1, Gabra4, Grm2, Grm3, Grm7, Prkcb, Shank3, and Pak7) functioning via ligand-target interactions were dysregul …
Ensemble analysis integrating proteomics, WGCNA, machine learning, and PPI pinpointed 24 DB radiation mitigation-related proteins. Among the …
Synaptic Dysfunction and Compensation After NMDA Receptor Ablation in the Mouse Medial Prefrontal Cortex.
Dick RM, Cunitz LB, Perez AT, Ahmed H, Adke AP, Rivera Quiles C, Mitchell JS, Marron Fernandez de Velasco E, Grissom NM, Rothwell PE. Dick RM, et al. bioRxiv [Preprint]. 2025 Dec 23:2025.08.14.669968. doi: 10.1101/2025.08.14.669968. bioRxiv. 2025. PMID: 41497613 Free PMC article. Preprint.
In this study, we used in vivo genome editing to ablate expression of the Grin1 gene, which encodes the obligate GluN1 subunit of NMDARs, in medial PFC neurons of female and male adolescent mice. ...
In this study, we used in vivo genome editing to ablate expression of the Grin1 gene, which encodes the obligate GluN1 subunit of NMD …
Memantine treatment in individuals with GRIN gain-of-function variants is associated with improvements in behavior, development, and seizure frequency.
Karnstedt M, Perszyk RE, Myers SJ, McDaniels E, Somorai M, Borggraefe I, Veenma DCM, Schoonjans AS, Striano P, Fantaneanu TA, Syrbe S, Park K, Chen W, Yuan H, Traynelis SF, Benke TA, Lemke JR, Krey I. Karnstedt M, et al. Epilepsia. 2026 Jan 5. doi: 10.1002/epi.70090. Online ahead of print. Epilepsia. 2026. PMID: 41489401
OBJECTIVE: GRIN-related disorders due to pathogenic variants in GRIN1, GRIN2A, GRIN2B, or GRIN2D genes are associated with altered N-methyl-D-aspartate receptor (NMDAR) function. ...
OBJECTIVE: GRIN-related disorders due to pathogenic variants in GRIN1, GRIN2A, GRIN2B, or GRIN2D genes are associated with altered N- …
Prenatal Exposure to Bonito Broth Attenuates the Induction of Drd1 and Grin1 upon Corn Oil Ingestion in Offspring.
Fushimi S, Ozawa T, Matsui S, Tsuzuki S, Hikida T, Sasaki T. Fushimi S, et al. J Nutr Sci Vitaminol (Tokyo). 2025;71(6):552-563. doi: 10.3177/jnsv.71.552. J Nutr Sci Vitaminol (Tokyo). 2025. PMID: 41485971 Free article.
In control offspring, the mRNA expression of genes related to dopamine (Drd1), opioid (Oprm1, Oprk1), glutamate (Grin1), and GABA (Gabra1) signaling was upregulated in the NAc after exposure to corn oil, and the response was significantly attenuated in the gestation group. …
In control offspring, the mRNA expression of genes related to dopamine (Drd1), opioid (Oprm1, Oprk1), glutamate (Grin1), and GABA (Ga …
Cellular reprogramming of H3K27M pediatric high-grade glioma to neuron-like state.
Uthamacumaran A, Horth C, Bareke E, Gravel M, Majewski J. Uthamacumaran A, et al. Acta Neuropathol Commun. 2025 Dec 30;14(1):30. doi: 10.1186/s40478-025-02185-8. Acta Neuropathol Commun. 2025. PMID: 41469740 Free PMC article.
Differentially expressed genes such as GRIK1, GRIN1, NRXN3, NRXN1, CALB2, SCGN, SLC32A1, SLC1A2, KCNC3, and neurodevelopmental regulators including WNT7A, DLX6, ERBB4, ARX, BCL11B, SEMA3C, and FGFBP3 were identified as key markers regulating the neuron-like lineage transit …
Differentially expressed genes such as GRIK1, GRIN1, NRXN3, NRXN1, CALB2, SCGN, SLC32A1, SLC1A2, KCNC3, and neurodevelopmental regula …
Decoding the pituitary response to photoperiod in geese: Central role in regulating reproduction.
Chen X, Mei H, Liu J, Feng Y, Dai Z, Guo B, Zhu H, He B. Chen X, et al. Theriogenology. 2026 Mar 1;252:117787. doi: 10.1016/j.theriogenology.2025.117787. Epub 2025 Dec 17. Theriogenology. 2026. PMID: 41420901
Within this pathway, we identified key receptor genes, including neurotransmitter receptors (e.g., Gamma-Aminobutyric Acid Type A Receptor Subunit Gamma1 (GABRG1), Gamma-Aminobutyric Acid Type B Receptor Subunit 2 (GABBR2), Glutamate Ionotropic Receptor NMDA Type Subunit 1 (GR …
Within this pathway, we identified key receptor genes, including neurotransmitter receptors (e.g., Gamma-Aminobutyric Acid Type A Receptor S …
Multilayered genetic dissection of autism: insights from whole-exome sequencing, molecular karyotyping, and cytogenetic analyses in a small Turkish cohort.
Eser M, Hekimoglu G, Kutlubay B. Eser M, et al. Neurogenetics. 2025 Dec 20;27(1):2. doi: 10.1007/s10048-025-00873-0. Neurogenetics. 2025. PMID: 41420732
The frequencies of these VUS in total cases were as follows: DLG3-1.6%, MECP2-1.6%, SETD5-1.6%, GRIN1-1.6%, ASXL3-3%, KMT2D - 5%, AP1G1-3%, SPTBN1-3%, TRIP12-1.6%, HCN1-3%, ZNF292-1.6%, and ACSL4-1.6%. ...
The frequencies of these VUS in total cases were as follows: DLG3-1.6%, MECP2-1.6%, SETD5-1.6%, GRIN1-1.6%, ASXL3-3%, KMT2D - 5%, AP1 …
Enriched and deficient omega-3 PUFA exposure from gestation to adulthood modulates anxiety-related behavior and stress- and neuroplasticity-related brain gene expression in mice.
Bianconi S, Cantarelli VI, Robledo Almonacid JE, Zingerling E, Weigandt DM, Baez MDC, Ponzio MF, Williams MJ, Schiöth HB, Santillán ME, Stutz G, Carlini VP. Bianconi S, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2026 Jan 2;144:111581. doi: 10.1016/j.pnpbp.2025.111581. Epub 2025 Dec 9. Prog Neuropsychopharmacol Biol Psychiatry. 2026. PMID: 41380933 Free article.
At the molecular level, the Deficient diet downregulated Grin1, while the Enriched diet upregulated Creb1 in the hippocampus, providing insight into how omega-3 PUFAs influence cognitive processes. ...
At the molecular level, the Deficient diet downregulated Grin1, while the Enriched diet upregulated Creb1 in the hippocampus, providi …
Corticosterone-Induced Depression in Rats: Region-Specific and Time-Dependent Dysregulation of Glutamatergic Signaling, Synaptic Markers, and MMP-2 Expression.
Gusmão CTP, Fonseca KM, Santos Júnior MA, Gomes NS, Bezerra DL, Silva MFS, Lucena DF, Macêdo DS. Gusmão CTP, et al. Mol Neurobiol. 2025 Nov 22;63(1):143. doi: 10.1007/s12035-025-05286-6. Mol Neurobiol. 2025. PMID: 41273623
Molecular analyses targeted the hippocampus and hypothalamus by RT-qPCR for Nr3c1 (GR), Nr3c2 (MR), Grin1 (NR1), and Dlg4 (PSD-95), and by immunofluorescence for NR2B, PSD-95, and MMP-2. CORT caused sustained weight loss, adrenal atrophy, and increased immobility in the FS …
Molecular analyses targeted the hippocampus and hypothalamus by RT-qPCR for Nr3c1 (GR), Nr3c2 (MR), Grin1 (NR1), and Dlg4 (PSD-95), a …
Ionotropic Glutamate Receptor Function in Interpeduncular Nucleus Is Modulated by Nicotine Exposure.
Yan Y, Tucker BR, Tapp AE, Thomas LN, Drenan DR, Drenan RM. Yan Y, et al. eNeuro. 2025 Dec 1;12(12):ENEURO.0052-25.2025. doi: 10.1523/ENEURO.0052-25.2025. Print 2025 Dec. eNeuro. 2025. PMID: 41253496 Free PMC article.
After confirming mRNA expression of Gria1 and Grin1 iGluR subunits in IPR, we employed glutamate uncaging coupled with two-photon imaging and patch-clamp electrophysiology. ...
After confirming mRNA expression of Gria1 and Grin1 iGluR subunits in IPR, we employed glutamate uncaging coupled with two-photon ima …
Mechanism of Herbal Pairs Modulating Endogenous Melatonin to Ameliorate Sleep Disorders: Data Mining, Network Pharmacology and Meta-Analysis.
Zhai Z, Dai J, Kong F, Zhu Z, Cai J, Xie D, Huang S, Jiang T, Xu Y, Sun T. Zhai Z, et al. Comb Chem High Throughput Screen. 2025 Oct 20. doi: 10.2174/0113862073393993250930120235. Online ahead of print. Comb Chem High Throughput Screen. 2025. PMID: 41121516
CONCLUSION: Meta-analysis and network pharmacology suggest that the PA-BR pair might offer superior efficacy by modulating membrane potential and nicotine addiction pathways, targeting GRIN2A, GRIN1, GRIN3A, and GRIN2B to regulate melatonin levels....
CONCLUSION: Meta-analysis and network pharmacology suggest that the PA-BR pair might offer superior efficacy by modulating membrane potentia …
The effect of sertraline and voluntary exercise during pregnancy on litter characteristics and postpartum affective behaviour in rat dams.
Jarbou NS, Mairinger O, Kulen E, Mushahwar L, Walpole S, Matthews J, Maksour S, Weston-Green K, Dottori M, Newell KA. Jarbou NS, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2025 Oct 2;142:111520. doi: 10.1016/j.pnpbp.2025.111520. Epub 2025 Oct 8. Prog Neuropsychopharmacol Biol Psychiatry. 2025. PMID: 41072714 Free article.
Gene expression of DNA methylation markers (Dnmt1, Dnmt3a) and glutamate receptors (Grin1, Grin2a, Grin2b) were measured in the prefrontal cortex (PFC), using RT-qPCR. RESULT: The WKY-Sertraline group gained 39 % less weight in their first pregnancy week compared to all ot …
Gene expression of DNA methylation markers (Dnmt1, Dnmt3a) and glutamate receptors (Grin1, Grin2a, Grin2b) were measured in the prefr …
MINING THE CELLMINER DATABASE TO IDENTIFY SHARED BIOMARKERS OF 5-FU AND OXALIPLATIN RESPONSE.
Abdullah M. Abdullah M. Georgian Med News. 2025 Jul-Aug;(364-365):327-341. Georgian Med News. 2025. PMID: 41072534
CONCLUSION: This integrative analysis identify potential biomarkers associated with 5-FU and Oxaliplatin response, nominating ALDH9A1, FERMT3, NT5E, HIF1A, and specific microRNAs as resistance biomarkers, while GRIN1, MTHFD2, and miR-7 emerge as sensitizers. Importantly, r …
CONCLUSION: This integrative analysis identify potential biomarkers associated with 5-FU and Oxaliplatin response, nominating ALDH9A1, FERMT …
An Integrative Approach to Identifying Neuroprotective Natural Compounds for Neurodevelopmental Disorders.
Souza JADCR, Xavier RM, Souza T, Farias D. Souza JADCR, et al. Int J Mol Sci. 2025 Sep 12;26(18):8873. doi: 10.3390/ijms26188873. Int J Mol Sci. 2025. PMID: 41009441 Free PMC article.
Three key targets emerged as hubs: CSNK2B, GRIN1, and MAPK1. Molecular docking demonstrated high-affinity binding of caryophyllene oxide, linoleic acid, and tangeretin, supported by stable interactions with catalytic residues. ...
Three key targets emerged as hubs: CSNK2B, GRIN1, and MAPK1. Molecular docking demonstrated high-affinity binding of caryophyllene ox …
Tonic GABA and Glycine Inhibition Control Pain Hypersensitivity via Limiting α2δ-1- and mGluR5-Dependent NMDA Receptor Activity at Primary Afferent→Excitatory Neuron Synapses.
Huang 黄玉莹 Y, Chen 陈红 H, Chen 陈少瑞 SR, Pan 潘惠麟 HL. Huang 黄玉莹 Y, et al. J Neurosci. 2025 Oct 29;45(44):e1469252025. doi: 10.1523/JNEUROSCI.1469-25.2025. J Neurosci. 2025. PMID: 41006062
These effects were abolished by silencing neuronal activity with tetrodotoxin or in Cacna2d1 knock-out (KO) mice. In mice with conditional Grin1 KO in primary sensory neurons (Grin1-cKO), gabazine and strychnine did not affect mEPSC frequency but still enhanced puff …
These effects were abolished by silencing neuronal activity with tetrodotoxin or in Cacna2d1 knock-out (KO) mice. In mice with conditional …
Inhibition of GluN2B-containing N-methyl-D-aspartate receptors by radiprodil.
Banke TG, Regan MC, Perszyk RE, Zhang L, Xing H, Chen J, Won S, Simorowski N, Diaz ES, Kim S, Song R, Rong J, Zhou X, Chaudhary AF, Zhang J, Traynelis JF, McDaniels ED, Nitsche K, Roache S, Raymond CS, Low CM, Myers SJ, Roche KW, Liang SH, Traynelis SF, Furukawa H, Yuan H. Banke TG, et al. Brain. 2026 Mar 5;149(3):976-992. doi: 10.1093/brain/awaf355. Brain. 2026. PMID: 40994429 Free PMC article.
Most NMDA receptors are tetrameric assemblies of two GluN1 and two GluN2 subunits encoded by five genes (GRIN1 and GRIN2A-GRIN2D), which produce GluN1 and GluN2A-GluN2D subunits. NMDA receptors that contain the GluN2B subunit have unique pharmacological properties, being i …
Most NMDA receptors are tetrameric assemblies of two GluN1 and two GluN2 subunits encoded by five genes (GRIN1 and GRIN2A-GRIN2D), wh …
Involvement of the Endothelial N-Methyl-d-Aspartate Receptor on Vessel-Associated Positioning and Differentiation of Cortical Oligodendrocytes and on Motor Activity.
Beranger A, Lafenêtre M, Lacomme S, Lebon A, Genty D, Brosolo M, Janin F, Leroy A, Guérout N, Vivien D, Galas L, Marret S, Marguet F, Gontier E, Gonzalez BJ, Lecointre M. Beranger A, et al. J Neurosci. 2025 Oct 22;45(43):e0199252025. doi: 10.1523/JNEUROSCI.0199-25.2025. J Neurosci. 2025. PMID: 40957680
This raises the hypothesis that eNMDAR might influence the fate of vessel-associated OPC. In this study, a Grin1(lox/lox)/VeCad(Cre) mouse model was used to investigate in females and males the effects of endothelial GluN1 invalidation (eNMDAR(-/-)) on (1) positioning and …
This raises the hypothesis that eNMDAR might influence the fate of vessel-associated OPC. In this study, a Grin1(lox/lox)/VeCad(Cre) …
Kisspeptin-13 induces hyperalgesia and modulates the expression of opioid and glutamate receptors in mice.
Bodnár É, Ibos KE, Filkor K, Csabafi K. Bodnár É, et al. Pharmacol Biochem Behav. 2025 Nov;256:174098. doi: 10.1016/j.pbb.2025.174098. Epub 2025 Sep 10. Pharmacol Biochem Behav. 2025. PMID: 40939812 Free article.
In another group of animals, after KP-13 treatment, qPCR was used to determine the relative gene expression of Oprd1, Oprk1, Oprm1, Grin1, Grin2b, Grin2d, and Grm5 in samples of the dorsal root ganglion (DRG), amygdala, hypothalamus, and anterior cingulate cortex (ACC). .. …
In another group of animals, after KP-13 treatment, qPCR was used to determine the relative gene expression of Oprd1, Oprk1, Oprm1, Grin1 …
Neonatal Freeze Lesion-Induced Cortical Malformation Alters Hippocampal Gene Expression and Leads to Persistent Cognitive and Emotional Deficits in Adult Male Wistar Rats.
Zubareva OE, Kovalenko AA, Sinyak DS, Postnikova TY, Subkhankulov MR, Sabirova ER, Zaitsev AV. Zubareva OE, et al. J Neurosci Res. 2025 Sep;103(9):e70077. doi: 10.1002/jnr.70077. J Neurosci Res. 2025. PMID: 40874645
Unilateral cortical lesions were induced at postnatal day 0 (P0), and molecular changes in hippocampal gene expression (glutamatergic signaling: Grin1, Grin2a, Grin2b, Gria1, Gria2; neuroinflammation: Nlrp3, Il1b, Il1rn; glial markers: Gfap, Aif1; neurotrophic factors: Bdn …
Unilateral cortical lesions were induced at postnatal day 0 (P0), and molecular changes in hippocampal gene expression (glutamatergic signal …
Antidepressant ketamine via oral gavage impairs fear memory, suppresses 22 kHz ultrasonic vocalizations, lowers GluN2A/B expression, and reduces medial habenula activity in rats.
Asrar B, Metin S, Sen Z, Unal G. Asrar B, et al. Neuropharmacology. 2025 Nov 15;279:110650. doi: 10.1016/j.neuropharm.2025.110650. Epub 2025 Aug 21. Neuropharmacology. 2025. PMID: 40849088
ELISA was used to measure expression levels of the NMDAR subunit GRIN1 (GluN1), while immunohistochemistry was used for the GluN2A and GluN2B subunits as well as c-Fos. 45 mg/kg ketamine reduced immobility in the FST, transiently impaired fear memory retrieval and reduced …
ELISA was used to measure expression levels of the NMDAR subunit GRIN1 (GluN1), while immunohistochemistry was used for the GluN2A an …
Adolescent isolation disrupts medial amygdala and ventral tegmental area maturation and sex-specifically dysregulates transcriptional responses to cocaine and stress.
Andrus MD, Vu T, Juarez B, Walker DM. Andrus MD, et al. Neuropharmacology. 2025 Nov 15;279:110629. doi: 10.1016/j.neuropharm.2025.110629. Epub 2025 Aug 12. Neuropharmacology. 2025. PMID: 40812510
In the VTA, isolation increases expression of NMDA receptor subunits Grin1 and Grin2b in females, while reducing Grin1 and increasing dopamine receptor Drd2 expression in males. ...
In the VTA, isolation increases expression of NMDA receptor subunits Grin1 and Grin2b in females, while reducing Grin1 and inc …
Molecular targets of neuroplasticity in ischemic stroke: insights from GEO database, single-cell analysis and immune infiltration analysis.
Yang H, Li Z, Zhang L, Zhang H, Liu Y, Chen W, Zhang F. Yang H, et al. Front Aging Neurosci. 2025 Jul 25;17:1561282. doi: 10.3389/fnagi.2025.1561282. eCollection 2025. Front Aging Neurosci. 2025. PMID: 40787669 Free PMC article.
Our study screened five significant neuroplasticity-related hub genes (CCR5, CXCR4, TIMP1, GRIN1, and GRM1). Moreover, single-cell analysis revealed that the CCR5 was specifically expressed in microglia and macrophages, while the CXCR4 was specifically expressed in T cells …
Our study screened five significant neuroplasticity-related hub genes (CCR5, CXCR4, TIMP1, GRIN1, and GRM1). Moreover, single-cell an …
Identification and validation of integrated stress-response-related genes as biomarkers for age-related macular degeneration.
Niu J, Jin L, Hu Y, Wang Y, Hao X, Geng W, Ma R. Niu J, et al. Front Mol Biosci. 2025 Jul 16;12:1583237. doi: 10.3389/fmolb.2025.1583237. eCollection 2025. Front Mol Biosci. 2025. PMID: 40740189 Free PMC article.
SLFN11 and GRIN1 were mainly enriched in pathways such as proteasome, lysosome, and neuroactive ligand receptor interaction. ...CONCLUSION: SLFN11 and GRIN1 were identified as AMD biomarkers, exhibiting robust diagnostic performance and providing new insights into t …
SLFN11 and GRIN1 were mainly enriched in pathways such as proteasome, lysosome, and neuroactive ligand receptor interaction. ...CONCL …
Increased Neuroplasticity in Frontal Cortex to Reduce Compulsive Behavior: A Preclinical tDCS Study in Male Rats.
Olmedo-Córdoba M, Prados-Pardo A, Martín-González E, Moreno-Montoya M. Olmedo-Córdoba M, et al. Mol Neurobiol. 2025 Dec;62(12):15701-15714. doi: 10.1007/s12035-025-05218-4. Epub 2025 Jul 23. Mol Neurobiol. 2025. PMID: 40702287 Free PMC article.
However, RT-qPCR analyses revealed that tDCS led to a significant increase in different neuroplasticity markers, such as Htr2a, Grin1, Bdnf, Ngf, and Scn2a in the FC of compulsive rats compared to sham treatment. In contrast, tDCS treatment did not induce any change in the …
However, RT-qPCR analyses revealed that tDCS led to a significant increase in different neuroplasticity markers, such as Htr2a, Grin1 …
Network pharmacology and molecular docking reveal that honeysuckle blood components mitigate smoke inhalation-induced lung injury via NF-κB pathway.
Zou H, Chang X, Wu Y, Mou X, Fan H, Lv Q. Zou H, et al. Allergol Immunopathol (Madr). 2025 Jul 1;53(4):39-50. doi: 10.15586/aei.v53i4.1342. eCollection 2025. Allergol Immunopathol (Madr). 2025. PMID: 40682227
Fifteen common targets of the blood components of honeysuckle were identified: CTSD, KLF5, TTR, HIF1A, CAPN1, GRIN1, ADAM10, ERAP1, NFE2L2, LGALS3, TLR4, GRB2, NF-kappaB1, RPS6KA1, and PTPN11. Network PPI analysis indicated that NF-kappaB1 was among the core targets. ...
Fifteen common targets of the blood components of honeysuckle were identified: CTSD, KLF5, TTR, HIF1A, CAPN1, GRIN1, ADAM10, ERAP1, N …
Effective Analysis of Alzheimer's Disease and Mechanisms of Methyl-4- Hydroxybenzoate using Network Toxicology, Molecular Docking, and Machine Learning Strategies.
Wen J, Hu J, Yang X, Luo F, Zou G. Wen J, et al. Curr Alzheimer Res. 2025;22(6):456-475. doi: 10.2174/0115672050399031250623062112. Curr Alzheimer Res. 2025. PMID: 40671224
Molecular docking analysis showed a good binding ability between MEP and CREBBP, BCL6, CXCR4, GRIN1, GOT2 and ITGA5. In addition, changes in the immune microenvironment revealed a significant impact of immune status on AD. ...CONCLUSION: Overall, CREBBP, BCL6, CXCR4, GR …
Molecular docking analysis showed a good binding ability between MEP and CREBBP, BCL6, CXCR4, GRIN1, GOT2 and ITGA5. In addition, cha …
Proinflammatory transcriptomic and kinomic alterations in astrocytes derived from patients with familial Alzheimer's disease.
Siciliano B, Henkel ND, Ryan V WG, Imami AS, Vergis JM, Xu C, Arvay TO, Sahay S, Pulvender P, Hamoud AR, Hales C, McCullumsmith RE, Wen Z. Siciliano B, et al. Brain Behav Immun Health. 2025 Jun 21;47:101044. doi: 10.1016/j.bbih.2025.101044. eCollection 2025 Aug. Brain Behav Immun Health. 2025. PMID: 40656638 Free PMC article.
Our transcriptomic analysis identified 1249 significantly differentially expressed genes, highlighting a pronounced upregulation of inflammatory genes (SERPINA3, IL6R, IL1RAP, TNFRSF11A) and a concomitant downregulation of genes essential for synaptic support and ion channel func …
Our transcriptomic analysis identified 1249 significantly differentially expressed genes, highlighting a pronounced upregulation of inflamma …
Mechanistic investigation of methadone, tolfenamic acid, and cilnidipine in traumatic brain injury: a novel multi-target perspective outcome of network pharmacology.
Kumar M, Chaudhary J, Kamboj S, Jain A. Kumar M, et al. Inflammopharmacology. 2025 Jul;33(7):3969-3982. doi: 10.1007/s10787-025-01845-4. Epub 2025 Jul 7. Inflammopharmacology. 2025. PMID: 40622465
MTD inhibits the NOS1, NOS2, NOS3, and MPO, CXCR4 activated gene pathways and stimulates the DRD2, SLC6A3, SLC6A4, SLC18A2, HTR1A, and AKT1 deactivated gene pathways. TA inhibits the GRIN1, MAPK1, and COX-II activated gene pathways. CLD inhibits the MAP2K1, CACNA1C, CACNA1 …
MTD inhibits the NOS1, NOS2, NOS3, and MPO, CXCR4 activated gene pathways and stimulates the DRD2, SLC6A3, SLC6A4, SLC18A2, HTR1A, and AKT1 …
The effect of chloroquine on cervical cancer via the PI3K/AKT/MDM2 pathway.
Xu D, Hou C, Chang J, Yang S, Yang Z, Yuan Z, Li J, Liu S, Liu Y, Su Y, Gao P, Liu X. Xu D, et al. Discov Oncol. 2025 Jun 23;16(1):1179. doi: 10.1007/s12672-025-02939-9. Discov Oncol. 2025. PMID: 40549065 Free PMC article.
Through PPI network analysis of 100 common targets, eight core targets were identified: TNF, MDM2, SLC6A4, GRIN1, CHRM1, EZH2, ACHE, and ADRB2. KEGG enrichment analysis revealed the PI3K/AKT signaling pathway as a central pathway of interest. ...
Through PPI network analysis of 100 common targets, eight core targets were identified: TNF, MDM2, SLC6A4, GRIN1, CHRM1, EZH2, ACHE, …
Influence of Glutamate Neurotransmission Genes on the Outcomes of Antipsychotic Treatments.
Cendrós M, Catalán R, Torra M, Penadés R, González-Rodríguez A, Brunet M, Perez-Blanco J, Cullell N, Serra-Llovich A, Hernandez MH, Arranz MJ. Cendrós M, et al. Pharmacopsychiatry. 2025 Sep;58(5):205-215. doi: 10.1055/a-2603-0871. Epub 2025 Jun 17. Pharmacopsychiatry. 2025. PMID: 40527340 Free PMC article.
The aim of the study was to explore whether the variation in glutamate receptors, transporters and metabolism can influence the outcome of drug treatments.A total of 45 polymorphisms in the genes GRIN1, GRIN2A, GRIN2B, GRIN3A, GRIA1, GRIK2, GRM2, GRM3, GRM5, GRM8, SLC1A1, …
The aim of the study was to explore whether the variation in glutamate receptors, transporters and metabolism can influence the outcome of d …
Integrating network pharmacology and experimental validation to reveal the anti-growth mechanism of panaxadiol against glioblastoma via calcium signaling.
Qiu G, Wu Z, Yang D, Zhou L. Qiu G, et al. Front Mol Biosci. 2025 May 16;12:1598413. doi: 10.3389/fmolb.2025.1598413. eCollection 2025. Front Mol Biosci. 2025. PMID: 40452916 Free PMC article.
Further, In our study, we employed the MOCDE and CytoHubba plugins within the Cytoscape framework to identify seven hub genes, including GRIA2, GRIN1, GRIN2B, GRM1, GRM5, HTR1A, and HTR2A, and validated their binding capabilities with Panaxadiol through molecular docking. …
Further, In our study, we employed the MOCDE and CytoHubba plugins within the Cytoscape framework to identify seven hub genes, including GRI …
APOE-mediated associations of promoter variants of GRIN1 and GRIN2B with behavioral symptoms and age at onset of Alzheimer's disease dementia.
de Oliveira FF, de Almeida TE, Cardoso AF, Faria TC, Souza GS, de Almeida SS, Mazzotti DR, Chen ES, Smith MC, Ferreira Bertolucci PH. de Oliveira FF, et al. Neurol Res. 2025 Oct;47(10):1013-1022. doi: 10.1080/01616412.2025.2511095. Epub 2025 May 29. Neurol Res. 2025. PMID: 40441773
OBJECTIVE: To determine associations of alleles of rs11146020 (GRIN1) and rs3764028 (GRIN2B), encoding subunits of the N-methyl-D-aspartate (NMDA) receptor, with the age at Alzheimer's disease dementia onset and with behavioral symptoms in each dementia stage, mediated by …
OBJECTIVE: To determine associations of alleles of rs11146020 (GRIN1) and rs3764028 (GRIN2B), encoding subunits of the N-methyl-D-asp …
Genetic aetiologies in relation to response to the ketogenic diet in 226 children with epilepsy.
Dahlin M, Stödberg T, Ekman E, Töhönen V, Wedell A. Dahlin M, et al. Brain Commun. 2025 Apr 5;7(2):fcaf134. doi: 10.1093/braincomms/fcaf134. eCollection 2025. Brain Commun. 2025. PMID: 40290421 Free PMC article.
To our knowledge not described previously, we report a good ketogenic diet response related to causative variants in CSNK2A1, FARS2, GABRB3, GRIN1, KCNA2, KCTD3, STX1B and SLC16A2 but a lack of response for causative variants in CLN5, GLI3, MACF1, MAGEL2, NANS, NEMO/IKBKG, …
To our knowledge not described previously, we report a good ketogenic diet response related to causative variants in CSNK2A1, FARS2, GABRB3, …
Gene signatures and immune correlations in Parkinson's disease Braak stages.
Sun RX, Guo Y. Sun RX, et al. Eur J Med Res. 2025 Apr 15;30(1):278. doi: 10.1186/s40001-025-02554-y. Eur J Med Res. 2025. PMID: 40229859 Free PMC article.
Furthermore, eights Braak stages-related hub genes were identified, including CAMK2B, CPLX2, GAPDH, GRIN1, KCNA1, MAPK3, MAPT, and STXBP1 through the cytoHubba plugin and LASSO analysis. ...
Furthermore, eights Braak stages-related hub genes were identified, including CAMK2B, CPLX2, GAPDH, GRIN1, KCNA1, MAPK3, MAPT, and ST …
Dysregulated ac4C modification of mRNA in a mouse model of early-stage Alzheimer's disease.
Ji HN, Zhou HQ, Qie JB, Lu WM, Gao HT, Wu DH. Ji HN, et al. Cell Biosci. 2025 Apr 13;15(1):45. doi: 10.1186/s13578-025-01389-8. Cell Biosci. 2025. PMID: 40223095 Free PMC article.
Genes that are essential for synaptic function and cognition, including GRIN1, MAP2, and DNAJC6, exhibited reduced ac4C and protein levels in 3-months-old 5 FAD mice, without any corresponding changes in the mRNA levels, compared with WT littermates. ...
Genes that are essential for synaptic function and cognition, including GRIN1, MAP2, and DNAJC6, exhibited reduced ac4C and protein l …
Targeted NMDA receptor knockdown in recall-activated neuronal ensembles impairs remote fear extinction.
Sung Y, Han DH, Kim J, Park P, Kaang BK. Sung Y, et al. Mol Brain. 2025 Apr 5;18(1):30. doi: 10.1186/s13041-025-01203-z. Mol Brain. 2025. PMID: 40188029 Free PMC article.
Here, we investigated the role of N-Methyl-D-Aspartate receptors (NMDARs) in remote memory recall-activated neurons within the basolateral amygdala and the medial prefrontal cortex during extinction training in mice. We found that Grin1 knockdown in these specific ensemble …
Here, we investigated the role of N-Methyl-D-Aspartate receptors (NMDARs) in remote memory recall-activated neurons within the basolateral a …
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