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2012 192
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3,230 results

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From synapse to system: mechanistic pathways of neural signaling dysfunction in psychiatric disorders.
Gupta R, Jha NK, Kumar N, Nagraik R, Ravi K. Gupta R, et al. Front Cell Dev Biol. 2026 Feb 20;14:1762930. doi: 10.3389/fcell.2026.1762930. eCollection 2026. Front Cell Dev Biol. 2026. PMID: 41799440 Free PMC article. Review.
Moreover, genetic and epigenetic variations in signaling genes, such as CACNA1C, GRIN2B, and DISC1, along with developmental and environmental factors, contribute to network vulnerability and clinical heterogeneity. ...
Moreover, genetic and epigenetic variations in signaling genes, such as CACNA1C, GRIN2B, and DISC1, along with developmental and envi …
In vivo mapping of protein-protein interactions of schizophrenia risk factors generates an interconnected disease network.
McClatchy DB, Lane J, Powell SB, Yates Iii JR. McClatchy DB, et al. Schizophrenia (Heidelb). 2026 Mar 7. doi: 10.1038/s41537-026-00734-1. Online ahead of print. Schizophrenia (Heidelb). 2026. PMID: 41794814 Free article.
In this study, we performed in vivo PPI analysis of several SCZ risk factors (i.e., Grin2b, Grm5, Gsk3b, Map2k1, Ppp1ca, Stx1a, Syngap1, and Syt1) in the rodent brain. Using endogenous antibody immunoprecipitations analyzed by liquid chromatography coupled to mass spectrom …
In this study, we performed in vivo PPI analysis of several SCZ risk factors (i.e., Grin2b, Grm5, Gsk3b, Map2k1, Ppp1ca, Stx1a, Synga …
Claudin 24-A novel enhancer of AMPA receptor fidelity.
Strasdeit T, Amin E, Obst S, Biermann B, Newton TP, Kösters SC, Schouwink M, Fedotov S, Shaukat J, Bhattacharya S, Aslam M, Anstötz M, Okka FN, Sevillano Quispe OG, Bouvain P, Vedyashkin J, Sobolevsky AI, Traynelis SF, von Engelhardt J, Erlenhardt N, Hollmann M, Klöcker N. Strasdeit T, et al. Sci Adv. 2026 Mar 6;12(10):eaeb0196. doi: 10.1126/sciadv.aeb0196. Epub 2026 Mar 6. Sci Adv. 2026. PMID: 41790882 Free PMC article.
Multisession epidural direct current stimulation of the auditory cortex mitigates age-related transcriptomic dysregulation in Wistar rats.
Fernández Del Campo IS, Cebrián-León A, Hernández-Del Caño C, Varela-Andrés N, Plaza I, Deogracias R, Merchán MA. Fernández Del Campo IS, et al. Hear Res. 2026 Feb 19;473:109580. doi: 10.1016/j.heares.2026.109580. Online ahead of print. Hear Res. 2026. PMID: 41747412 Free article.
The upregulated genes included Gabrb1, Grin2b, Rac3c, Tnr, and Ndst1, suggesting compensatory hyperactivity, excitatory/inhibitory imbalance, and stiffening of perineuronal nets (PNN) around parvalbumin (PV) interneurons. ...Also, many of the 121 common DEGs across compari …
The upregulated genes included Gabrb1, Grin2b, Rac3c, Tnr, and Ndst1, suggesting compensatory hyperactivity, excitatory/inhibitory im …
Genetic Risk Factors for Epilepsy: From Familial Studies to Gene Discoveries and Polygenic Risk Scores, Strides Toward Unlocking an Age-Old Question in Epilepsy.
Yano ST, Phitsanuwong C. Yano ST, et al. Epilepsy Curr. 2026 Feb 19:15357597251410840. doi: 10.1177/15357597251410840. Online ahead of print. Epilepsy Curr. 2026. PMID: 41726570 Free PMC article. Review.
Other genes with de novo mutations in this cohort include CACNA1A, CHD2, FLNA, GABRA1, GRIN1, GRIN2B, HNRNPU, IQSEC2, MTOR, and NEDD4L. Finally, we show that the de novo mutations observed are enriched in specific gene sets including genes regulated by the fragile X protei …
Other genes with de novo mutations in this cohort include CACNA1A, CHD2, FLNA, GABRA1, GRIN1, GRIN2B, HNRNPU, IQSEC2, MTOR, and NEDD4 …
Grin2b 3'UTR is necessary for synaptic plasticity and spatial learning.
Harvey AC, Bølcho U, Main BS, Nykjær A, Holm MM, Nissen P, Kjærgaard M, Poulsen H. Harvey AC, et al. Proc Natl Acad Sci U S A. 2026 Feb 24;123(8):e2518282123. doi: 10.1073/pnas.2518282123. Epub 2026 Feb 18. Proc Natl Acad Sci U S A. 2026. PMID: 41706899
To investigate its role, we generated a 3'UTR mouse line by deleting the Grin2b 3'UTR while preserving the coding sequence. Despite unchanged Grin2b mRNA levels in 3'UTR mice, GluN2B protein was reduced 50%. ...Together, these findings demonstrate that the 3'UTR i …
To investigate its role, we generated a 3'UTR mouse line by deleting the Grin2b 3'UTR while preserving the coding sequence. Despite …
Identification of Key Bioactive Compounds of Medicine-Food Homologous Substances and Their Multi-Target Intervention Effects in Osteosarcoma Treatment.
Ren J, Zhang X, Chen S, Liu R, Yi P, Liu S. Ren J, et al. Int J Mol Sci. 2026 Jan 29;27(3):1360. doi: 10.3390/ijms27031360. Int J Mol Sci. 2026. PMID: 41683786 Free PMC article.
Regulatory networks identified 5 key target genes (SOST, ACACB, TACR1, GRIN2B, MPO), 10 key compounds (e.g., ellagic acid dihydrate) and 8 MFHs (e.g., Daidaihua). ...
Regulatory networks identified 5 key target genes (SOST, ACACB, TACR1, GRIN2B, MPO), 10 key compounds (e.g., ellagic acid dihydrate) …
Aberrant mRNA splicing and impaired hippocampal neurogenesis in Grin2b mutant mice.
Farsi Z, Nicolella A, Simmons SK, Shin W, Kang M, Lee G, Kwon MJ, Brenner KS, Picard I, Shepard N, Misri D, Perzel Mandell KA, Levin JZ, Kim E, Sheng M. Farsi Z, et al. iScience. 2026 Jan 15;29(2):114700. doi: 10.1016/j.isci.2026.114700. eCollection 2026 Feb 20. iScience. 2026. PMID: 41675057 Free PMC article.
Here, we investigated heterozygous mouse mutants carrying the ASD-linked C456Y mutation of Grin2b, a high-confidence ASD risk gene encoding the GluN2B subunit of NMDA receptors. ...These findings underscore the distinct role of Grin2b in brain development and functi …
Here, we investigated heterozygous mouse mutants carrying the ASD-linked C456Y mutation of Grin2b, a high-confidence ASD risk gene en …
Treatment with perampanel alleviates depression-like behavior in mice via modulating GluN2B expression to improve excitatory synaptic transmission.
Liu JM, Zhang YL, Guo F, Li BW, Chen H, Mo Y, Kong J, Tan X, Wu W, Cao X. Liu JM, et al. Transl Psychiatry. 2026 Feb 11;16(1):90. doi: 10.1038/s41398-026-03874-1. Transl Psychiatry. 2026. PMID: 41672997 Free PMC article.
In mechanism, perampanel reduce the abnormal increase in the expression of the NMDA receptor subunit GluN2B (Grin2b) in the medial prefrontal cortex (mPFC), further increase the expression of the AMPA receptor subunit GluA1 (Gria1), and improve the functional impairment of …
In mechanism, perampanel reduce the abnormal increase in the expression of the NMDA receptor subunit GluN2B (Grin2b) in the medial pr …
Characterization of a novel female chronic social defeat stress (femCSDS) model utilizing persistently aggressive CD1 parous females.
Patel S, Kushwaha R, Anusha PV, Arvind A, Dhaygude SS, Pattnaik SR, Kumar A, Idris M, Chakravarty S. Patel S, et al. Neuropsychopharmacology. 2026 Feb 10. doi: 10.1038/s41386-026-02359-5. Online ahead of print. Neuropsychopharmacology. 2026. PMID: 41667637 Free article.
Biochemical analysis revealed elevated glutamate levels in Nucleus Accumbens (NAc) and caudate putamen (CPu). Alterations in EAAT1, GRIN2B, and Neurabin expression were observed in CPu, indicating excitotoxic stress and compromised synaptic integrity. ...
Biochemical analysis revealed elevated glutamate levels in Nucleus Accumbens (NAc) and caudate putamen (CPu). Alterations in EAAT1, GRIN2 …
Hypoxia-inducible factor signaling regulates embryonic interneuron development, GRIN2B expression and adult cortical function.
Lu IL, Song M, Rangel-Sandoval C, Palacios JM, Kim J, Huang EJ, Alvarez-Buylla A, Kriegstein A, Paredes MF, Rowitch DH. Lu IL, et al. Dev Cell. 2026 Feb 5:S1534-5807(26)00030-4. doi: 10.1016/j.devcel.2026.01.007. Online ahead of print. Dev Cell. 2026. PMID: 41650955
We also show that HIF1A directly activates glutamate ionotropic receptor NMDA type subunit 2B (GRIN2B), encoding glutamate ionotropic receptor N-methyl-D-aspartate (NMDA) subunit 2B. ...These findings identify non-canonical roles for HIF signaling that are essential for PV …
We also show that HIF1A directly activates glutamate ionotropic receptor NMDA type subunit 2B (GRIN2B), encoding glutamate ionotropic …
Mice carrying a GluN2B protein-truncating variant have altered NMDA receptor subunit composition and their behavior recapitulates patient phenotypes.
Fili K, Kuchtiak V, Tomovic E, Candelas Serra M, Kubik-Zahorodna A, Harant K, Bozikova P, Cerny J, Korinek M, Hrcka Krausova B, Abramova V, Dobrovolski M, Abdel Rahman FES, Prochazka J, Balik A, Smejkalova T, Vyklicky L. Fili K, et al. Cell Mol Life Sci. 2026 Jan 30;83(1):89. doi: 10.1007/s00018-025-06057-1. Cell Mol Life Sci. 2026. PMID: 41615455 Free PMC article.
Pathogenic variants in GRIN2B, encoding the NMDA receptor (NMDAR) GluN2B subunit, are linked to intellectual disability (ID) and related neurodevelopmental disorders. ...These results demonstrate that a monoallelic GluN2B PTV alters NMDAR subunit composition and function, …
Pathogenic variants in GRIN2B, encoding the NMDA receptor (NMDAR) GluN2B subunit, are linked to intellectual disability (ID) and rela …
Sex- and etiology-specific effects on predictive processing in the inferior colliculus of two rat models of autism.
Cacciato-Salcedo S, Lao-Rodríguez AB, Malmierca MS. Cacciato-Salcedo S, et al. Commun Biol. 2026 Jan 30;9(1):356. doi: 10.1038/s42003-026-09585-z. Commun Biol. 2026. PMID: 41611979 Free PMC article.
Here we examine predictive auditory processing at the single-neuron level in the inferior colliculus of two adult rat models of autism: a genetic model with a heterozygous Grin2b deletion (Grin2b + /-) and an environmental model based on prenatal valproic acid expos …
Here we examine predictive auditory processing at the single-neuron level in the inferior colliculus of two adult rat models of autism: a ge …
Computational Identification of Blood-Brain Barrier-Permeant Microbiome Metabolites with Binding Affinity to Neurotransmitter Receptors in Neurodevelopmental Disorders.
Buendia-Corona RE, Velasco Dey MF, Valencia Robles L, Hernández-Biviano HJ, Hermosillo-Abundis C, Castro-Pastrana LI. Buendia-Corona RE, et al. Molecules. 2026 Jan 20;31(2):366. doi: 10.3390/molecules31020366. Molecules. 2026. PMID: 41599414 Free PMC article.
Following 3D conformational optimization (from SMILES) and curation based on 32 rotatable bonds, molecular docking was performed against five neurotransmitter receptors representing ionotropic (GABRA2, GRIA2, GRIN2B) and metabotropic (DRD4, HTR1A) receptor classes. The to …
Following 3D conformational optimization (from SMILES) and curation based on 32 rotatable bonds, molecular docking was performed against fi …
Modulating splicing in 5' untranslated regions to treat rare haploinsufficient disease.
Beer Wells ES, De Conti L, Kim HC, Rohani N, Chundru K, Watts LM, Dawes R, Chen Y, Martin-Geary AC, Griffiths MJ, Scott S, Bamford RA, Mill J, Wright CF, Baralle M, Sanders SJ, Whiffin N. Beer Wells ES, et al. bioRxiv [Preprint]. 2025 Dec 9:2025.12.07.692584. doi: 10.64898/2025.12.07.692584. bioRxiv. 2025. PMID: 41573882 Free PMC article. Preprint.
We demonstrate that removing the target exon significantly increased protein translation (between 1.4-5.5 fold) in a luciferase reporter assay for four of six prioritised target 5'UTR exons in neurodevelopmental disorder genes ( CTCF , GRIN2B , KRIT1 , and TSC1 ). Overall, …
We demonstrate that removing the target exon significantly increased protein translation (between 1.4-5.5 fold) in a luciferase reporter ass …
Prior stress history shapes adolescent alcohol-induced transcriptional changes in striatal glutamatergic and endocannabinoid pathways.
Sanchez-Marin L, Canoluk B, Verheul-Campos J, Gavito A, Reviriego R, Pavon J, Serrano A, Rodríguez de Fonseca F. Sanchez-Marin L, et al. Adicciones. 2025 Dec 23;37(4):369-382. doi: 10.20882/adicciones.2483. Adicciones. 2025. PMID: 41557451 Free article. English, Spanish.
At adult age, striatal mRNA expression of dopaminergic (Drd1, Drd2, Th), glutamatergic (Gls, Gls2, Gria2, Grin2a, Grin2b), endocannabinoid (Cnr1, Cnr2, Napepld, Faah, Dagla, Daglb, Mgll), neurotrophic (Bdnf, Ntrk2), and glial (Gfap, Aif1) genes was quantified. ...
At adult age, striatal mRNA expression of dopaminergic (Drd1, Drd2, Th), glutamatergic (Gls, Gls2, Gria2, Grin2a, Grin2b), endocannab …
Placental Insulin-like Growth Factor 1 Deficiency Drives Autism-Relevant Behavioral Changes with Sex-Specific Vulnerabilities.
Carver AJ, Fairbairn FM, Taylor RJ Jr, Hing BWQ, Gajmer A, Fair RT, Stevens HE. Carver AJ, et al. bioRxiv [Preprint]. 2026 Jan 6:2026.01.06.697024. doi: 10.64898/2026.01.06.697024. bioRxiv. 2026. PMID: 41542650 Free PMC article. Preprint.
Altered genes in female forebrain were enriched for autism-risk genes including Grin2b and Dync1h1. Following these transcriptomic differences, postnatal neurobehavioral trajectories were sex specific. ...
Altered genes in female forebrain were enriched for autism-risk genes including Grin2b and Dync1h1. Following these transcriptomic di …
Assessing the Neuro- and Immunotoxicity of Dissolved Ru3+ from Proton Exchange Membrane Electrolyzers by Zebrafish Models.
Liu Z, Gao Y, Guo X, Li S. Liu Z, et al. ACS Appl Mater Interfaces. 2026 Jan 28;18(3):5229-5242. doi: 10.1021/acsami.5c20368. Epub 2026 Jan 15. ACS Appl Mater Interfaces. 2026. PMID: 41537674
Molecular docking identified key protein targets (CASP3, DLG4, GRIN2B, and GSTO1) underlying the toxicity. These findings establish a preemptive safety benchmark for Ru(3+) and underscore the necessity of incorporating ecotoxicological considerations into the sustainable d …
Molecular docking identified key protein targets (CASP3, DLG4, GRIN2B, and GSTO1) underlying the toxicity. These findings establish a …
Multi-biofluid metabolomics coupled with gene network reveals stage-specific alterations in mild cognitive impairment and Alzheimer's disease in an ethnically mixed cohort.
Cadaxo AS, Cotrin JC, Valente AP, Lopes FG, Veras RP, Torres DS, Molina da Costa RQ, Dos Santos Junior GC, Santos-Rebouças CB. Cadaxo AS, et al. Brain Res. 2026 Mar 1;1874:150167. doi: 10.1016/j.brainres.2026.150167. Epub 2026 Jan 12. Brain Res. 2026. PMID: 41534821
Integration of metabolite data with AD-associated genes from genome-wide association studies (GWAS) revealed six genes (CYCS, NFAT5, GRIN2B, SLC43A2, MAPT, and SLC38A1) common to all biofluids, reinforcing convergent systemic pathways. ...
Integration of metabolite data with AD-associated genes from genome-wide association studies (GWAS) revealed six genes (CYCS, NFAT5, GRIN …
Zipper-interacting Protein Kinase Modulates Gene Expression Linked to Synaptic and Neuronal Processes after Traumatic Brain Injury.
Mei Y, Zheng L, He M, Wang L, Zhou Y, Zhang T, Lee TH, Chen D. Mei Y, et al. Mol Neurobiol. 2026 Jan 13;63(1):358. doi: 10.1007/s12035-025-05657-z. Mol Neurobiol. 2026. PMID: 41526727
In addition, quantitative real-time PCR analysis validated changes in the expression of multiple genes related to synaptic function, including Drd1, Grin2a, Grin2b, Dlg4, Fn1, and Pecam1, which were identified by gene correlation analysis and protein-protein interaction an …
In addition, quantitative real-time PCR analysis validated changes in the expression of multiple genes related to synaptic function, includi …
Gingerol-Enriched Ginger Extract Effects on Anxiety-like Behavior in a Neuropathic Pain Model via Colonic Microbiome-Neuroimmune Modulation.
Mendóza R, Santos JM, Liu X, Elmassry MM, Ji G, Kiritoshi T, Neugebauer V, Shen CL. Mendóza R, et al. Molecules. 2026 Jan 1;31(1):166. doi: 10.3390/molecules31010166. Molecules. 2026. PMID: 41515464 Free PMC article.
GEG modulated neurotransmission via clearance of excessive glutamate release as suggested by increased gene expression of SLC1A3 (frontal cortex: both sides, hippocampus: right) and via augmenting mGluR5 signaling as shown by increased gene expression of GRM5 (hippocampus: both s …
GEG modulated neurotransmission via clearance of excessive glutamate release as suggested by increased gene expression of SLC1A3 (frontal co …
Integrative Transcriptomic and Perturbagen Analyses Reveal Sex-Specific Molecular Signatures Across Glioma Subtypes.
Rami Reddy MVSR, Wood JF, Norris J, Becker K, Murphy SC, Doddi S, Imami A, Ryan V WG, Nguyen J, Schroeder J, Eisenmann K, McCullumsmith RE. Rami Reddy MVSR, et al. Cancers (Basel). 2025 Dec 24;18(1):52. doi: 10.3390/cancers18010052. Cancers (Basel). 2025. PMID: 41514565 Free PMC article.
In both sexes, LGG-HGG and LGG-GBM grade comparisons converged on neuronal and synaptic programs, with enrichment of glutamatergic receptor genes and postsynaptic modules, including GRIN2B, GRIN2A, GRIN2C, GRIN1, and CHRNA7. In contrast, collateral pathways diverged by sex …
In both sexes, LGG-HGG and LGG-GBM grade comparisons converged on neuronal and synaptic programs, with enrichment of glutamatergic receptor …
Memantine treatment in individuals with GRIN gain-of-function variants is associated with improvements in behavior, development, and seizure frequency.
Karnstedt M, Perszyk RE, Myers SJ, McDaniels E, Somorai M, Borggraefe I, Veenma DCM, Schoonjans AS, Striano P, Fantaneanu TA, Syrbe S, Park K, Chen W, Yuan H, Traynelis SF, Benke TA, Lemke JR, Krey I. Karnstedt M, et al. Epilepsia. 2026 Jan 5. doi: 10.1002/epi.70090. Online ahead of print. Epilepsia. 2026. PMID: 41489401
OBJECTIVE: GRIN-related disorders due to pathogenic variants in GRIN1, GRIN2A, GRIN2B, or GRIN2D genes are associated with altered N-methyl-D-aspartate receptor (NMDAR) function. ...
OBJECTIVE: GRIN-related disorders due to pathogenic variants in GRIN1, GRIN2A, GRIN2B, or GRIN2D genes are associated with altered N- …
Discrete interneuron subsets participate in GluN1/GluN3A excitatory glycine receptor (eGlyR)-mediated regulation of hippocampal network activity throughout development and evolution.
Kim JH, Vlachos A, Mahadevan V, Caccavano AP, Banke T, Crawley OC, Navarro AI, Yuan X, Abebe D, Hunt S, Vargish GA, Chittajallu R, Eldridge MAG, Azadi R, Cummins AC, Tangen AC, Harmon P, Plotnikova A, Mohanty A, Furlanis E, Wang Y, Dai M, Garcia BL, Liu D, Zhu Z, Yuan H, Summer SL, Epplin MP, Liotta DC, Pickel J, Averbeck BB, Perez-Otaño I, Dimidschstein J, Fishell G, Traynelis SF, McBain CJ, Pelkey KA. Kim JH, et al. bioRxiv [Preprint]. 2025 Sep 25:2025.09.24.678342. doi: 10.1101/2025.09.24.678342. bioRxiv. 2025. PMID: 41473287 Free PMC article. Preprint.
Discrete interneuron subsets participate in GluN1/GluN3A excitatory glycine receptor (eGlyR)-mediated regulation of hippocampal network activity throughout development and evolution.
Kim JH, Vlachos A, Mahadevan V, Caccavano AP, Banke TG, Crawley OC, Navarro AI, Yuan X, Abebe D, Hunt S, Vargish GA, Chittajallu R, Eldridge MAG, Azadi R, Cummins AC, Tangen AC, Harmon P, Plotnikova A, Mohanty A, Furlanis E, Wang Y, Dai M, Garcia BL, Liu D, Zhu Z, Yuan H, Summer SL, Epplin MP, Liotta DC, Pickel J, Averbeck BB, Pérez-Otaño I, Dimidschstein J, Fishell G, Traynelis SF, McBain CJ, Pelkey KA. Kim JH, et al. Res Sq [Preprint]. 2025 Oct 15:rs.3.rs-7822078. doi: 10.21203/rs.3.rs-7822078/v1. Res Sq. 2025. PMID: 41472680 Free PMC article. Preprint.
Infantile Spasms (West Syndrome): Integrating Genetic, Neurotrophic, and Hormonal Mechanisms Toward Precision Therapy.
Abdygalyk B, Rabandiyarov M, Lepessova M, Koshkimbayeva G, Zharkinbekova N, Tekebayeva L, Zhailganov A, Issabekova A, Myrzaliyeva B, Tulendiyeva A, Kurmantay A, Turmanbetova A, Yerkenova S. Abdygalyk B, et al. Medicina (Kaunas). 2025 Dec 16;61(12):2223. doi: 10.3390/medicina61122223. Medicina (Kaunas). 2025. PMID: 41470225 Free PMC article. Review.
Growing use of genomic diagnostics has revealed that variants in STXBP1, KCNQ2, GRIN2A, GRIN2B, and TSC-related genes are more common than previously recognized and can be linked to partially actionable pathways. ...
Growing use of genomic diagnostics has revealed that variants in STXBP1, KCNQ2, GRIN2A, GRIN2B, and TSC-related genes are more common …
Epigenetic and Transcriptomic Alterations of Protein Aggregation-Linked Genes in Suicide: A Pilot Study.
Bedene T, Šmon J, Videtič Paska A, Zupanc T, Kouter K. Bedene T, et al. Genes (Basel). 2025 Dec 8;16(12):1467. doi: 10.3390/genes16121467. Genes (Basel). 2025. PMID: 41465140 Free PMC article.
Results: Reanalysis revealed hypomethylation in suicide cases within CRMP1, DISC1, MAPT, SOD1, PRKN, GABARAPL1, GRIN2A, and GRIN2B. In the hippocampus, suicides exhibited increased expression of CRMP1, SOD1, PRKN, GABARAPL1, and GRIN2A, and decreased MAPT expression. The G …
Results: Reanalysis revealed hypomethylation in suicide cases within CRMP1, DISC1, MAPT, SOD1, PRKN, GABARAPL1, GRIN2A, and GRIN2B. I …
Role of Genetic and Epigenetic Biomarkers in Treatment-Resistant Depression: A Literature Review.
Sulić P, Ražić Pavičić A, Đapić Ivančić B, Božina T, Božina N, Živković M. Sulić P, et al. Genes (Basel). 2025 Dec 2;16(12):1443. doi: 10.3390/genes16121443. Genes (Basel). 2025. PMID: 41465113 Free PMC article. Review.
Variants in glutamatergic receptor genes (GRIN2A, GRIN2B, GRIA2, GRIA3) were predicted to result in a rapid and sustained response to ketamine. ...
Variants in glutamatergic receptor genes (GRIN2A, GRIN2B, GRIA2, GRIA3) were predicted to result in a rapid and sustained response to …
Reduced expression of N-methyl-D-aspartate receptor and calcium signaling genes in gray matter is associated with cognitive function in patients with breast cancer.
Kesler SR, Franco-Rocha OY, Kogon M, Braun S, Tolby L, Nyagaka R, De La Torre Schutz A, Blayney DW, Palesh O. Kesler SR, et al. medRxiv [Preprint]. 2025 Dec 17:2025.12.15.25342306. doi: 10.64898/2025.12.15.25342306. medRxiv. 2025. PMID: 41445626 Free PMC article. Preprint.

Imaging transcriptomics was used to measure the expression of genes in the brain involved in N-methyl-D-aspartate (NMDA) and calcium-mediated neurotransmission. GRIN2A, GRIN2B, CACNA1C were significantly expressed in gray matter in both groups (R (2) > 0.094, p < 0.0

…
Imaging transcriptomics was used to measure the expression of genes in the brain involved in N-methyl-D-aspartate (NMDA) and calcium-mediate …
Assessing oligodendrocyte and myelin alterations following absence seizures in a rat model of GRIN2B neurodevelopmental disorder.
Francsics Z, Tsoukala E, Hristova K, Gonzalez-Sulser A, Zoupi L. Francsics Z, et al. Brain Neurosci Adv. 2025 Dec 21;9:23982128251405032. doi: 10.1177/23982128251405032. eCollection 2025 Jan-Dec. Brain Neurosci Adv. 2025. PMID: 41438242 Free PMC article.
Here we examined oligodendrocyte populations and myelin architecture in a rat model of GRIN2B neurodevelopmental disorder, a rare and severe condition that is frequently accompanied by absence seizures. ...
Here we examined oligodendrocyte populations and myelin architecture in a rat model of GRIN2B neurodevelopmental disorder, a rare and …
NMDA glutamate receptor polymorphisms modulate antipsychotic-induced hyperprolactinemia in schizophrenia.
Fedorenko OY, Poltavskaya EG, Kornetova EG, Freidin MB, Bocharova AV, Boiko AS, Stepanov VA, Bokhan NA, Ivanova SA, Strelnikov K. Fedorenko OY, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2025 Dec 20;143:111569. doi: 10.1016/j.pnpbp.2025.111569. Epub 2025 Dec 5. Prog Neuropsychopharmacol Biol Psychiatry. 2025. PMID: 41352652
We hypothesized that polymorphisms in GRIN2A and GRIN2B, encoding NMDA glutamate receptor subunits, modify the neuroendocrine consequences of dopamine receptor inhibition. ...In a cross-sectional analysis of 536 schizophrenia patients, we measured prolactin levels-a sensit …
We hypothesized that polymorphisms in GRIN2A and GRIN2B, encoding NMDA glutamate receptor subunits, modify the neuroendocrine consequ …
Housing environment bilaterally alters transcriptomic profile in the rat hippocampal CA1 region.
Kubota A, Kojima K, Koketsu S, Kannon T, Sato T, Hosomichi K, Shinohara Y, Tajima A. Kubota A, et al. PLoS One. 2025 Dec 4;20(12):e0338190. doi: 10.1371/journal.pone.0338190. eCollection 2025. PLoS One. 2025. PMID: 41343550 Free PMC article.
Immediate early genes formed consistent central hubs across both hemispheres, and a common Mecp2-Grin2b-Cdkl5-Tet3 protein interaction cluster was identified as a potential integrative regulatory module. ...
Immediate early genes formed consistent central hubs across both hemispheres, and a common Mecp2-Grin2b-Cdkl5-Tet3 protein interactio …
3,230 results