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GRIN2D-Related Developmental and Epileptic Encephalopathy Associated With Polymorphic Seizures Including Epileptic Spasms.
Obregón Gómez LR, Juanes M, Touzon MS, Romero A, Maenza L, Borgani K, Alonso C, Reyes G, Caraballo R. Obregón Gómez LR, et al. Int J Dev Neurosci. 2026 Feb;86(1):e70108. doi: 10.1002/jdn.70108. Int J Dev Neurosci. 2026. PMID: 41673952
Whole-exome sequencing identified a de novo likely pathogenic variant in the GRIN2D gene, affecting one of the transmembrane domains (M3), which is essential for normal NMDAR function and harbours most of the pathogenic variants reported to date. Our case represents the 14 …
Whole-exome sequencing identified a de novo likely pathogenic variant in the GRIN2D gene, affecting one of the transmembrane domains …
Promotion of lung cancer growth via glutamate ionotropic receptor N-methyl-D-aspartate-type subunit 2D (GRIN2D).
Lv Y, Bu X, Du Z, Zhang Y, Si Y, Shi H, Han L, Bao H. Lv Y, et al. J Thorac Dis. 2026 Jan 31;18(1):36. doi: 10.21037/jtd-2025-1-2538. Epub 2026 Jan 27. J Thorac Dis. 2026. PMID: 41660435 Free PMC article.
Meanwhile, glutamate ionotropic receptor N-methyl-D-aspartate-type subunit 2D (GRIN2D), which encodes NMDAR subunit 2D, may play a role in colorectal cancer. The study examined whether GRIN2D is involved in lung cancer. ...Esketamine, a GRIN2D inhibitor, and …
Meanwhile, glutamate ionotropic receptor N-methyl-D-aspartate-type subunit 2D (GRIN2D), which encodes NMDAR subunit 2D, may play a ro …
Glutamate enhances the production of inflammatory cytokines IL-6 and IL-11, as well as chemokines CXCL2, CXCL3, and CXCL8 in keloid fibroblasts.
Chen Y, Xu Y, Zhang J, Feng C, Chen J, Song Y, Pan J, Zhu J, Cheng H. Chen Y, et al. Front Mol Biosci. 2026 Jan 5;12:1720876. doi: 10.3389/fmolb.2025.1720876. eCollection 2025. Front Mol Biosci. 2026. PMID: 41562114 Free PMC article.
RESULTS: Transcriptomic analysis revealed significant enrichment of the neuroactive ligand-receptor interaction pathway in keloid tissue, with marked upregulation of the glutamate receptor subunit GRIN2D. Single-cell and histological analyses demonstrated that GRIN2D …
RESULTS: Transcriptomic analysis revealed significant enrichment of the neuroactive ligand-receptor interaction pathway in keloid tissue, wi …
Integrated bioinformatics and experimental validation identify FOXQ1, GRIN2D, and SCNN1B as novel biomarkers for distinguishing high-risk sessile serrated lesions from hyperplastic polyps.
Fatemi N, Piryaei Z, Abkenar ED, Zonoobi E, Badr N, Aghaei A, Mirbahari SN, Mirzaei E, Parvizi M, Niasar MS, Moghadam PK, Sadeghi A, Kuppen PJK, Nazemalhosseini-Mojarad E. Fatemi N, et al. J Mol Histol. 2026 Jan 17;57(1):53. doi: 10.1007/s10735-025-10680-4. J Mol Histol. 2026. PMID: 41546794 No abstract available.
Rutin alleviates pirarubicin-induced cardiotoxicity and enhances chemosensitivity in breast cancer.
Li Q, Qin M, Liu P, Liu M. Li Q, et al. Phytomedicine. 2026 Feb;151:157818. doi: 10.1016/j.phymed.2026.157818. Epub 2026 Jan 10. Phytomedicine. 2026. PMID: 41539100
PURPOSE: We investigated the contribution of the miR-129-1-3p/GRIN2D axis in mediating the cardioprotective and chemosensitizing effects of rutin in breast cancer. ...CONCLUSION: Rutin mitigates THP-induced cardiotoxicity and enhances chemotherapeutic efficacy via the nove …
PURPOSE: We investigated the contribution of the miR-129-1-3p/GRIN2D axis in mediating the cardioprotective and chemosensitizing effe …
Transcriptional and epigenetic changes associated with lead exposure in spermatozoa.
Zhang X, Shen XR, Wu B, Wang XM, Shi HJ, Zhang TC. Zhang X, et al. Asian J Androl. 2026 Jan 13. doi: 10.4103/aja202563. Online ahead of print. Asian J Androl. 2026. PMID: 41527937 Free article.
We revealed differences in promoter activity between methylated and unmethylated promoter regions of seven cloned genes, namely calcium voltage-gated channel subunit alpha1 H (CACNA1H), calcium voltage-gated channel subunit alpha1 G (CACNA1G), calcium voltage-gated channel subuni …
We revealed differences in promoter activity between methylated and unmethylated promoter regions of seven cloned genes, namely calcium volt …
Memantine treatment in individuals with GRIN gain-of-function variants is associated with improvements in behavior, development, and seizure frequency.
Karnstedt M, Perszyk RE, Myers SJ, McDaniels E, Somorai M, Borggraefe I, Veenma DCM, Schoonjans AS, Striano P, Fantaneanu TA, Syrbe S, Park K, Chen W, Yuan H, Traynelis SF, Benke TA, Lemke JR, Krey I. Karnstedt M, et al. Epilepsia. 2026 Jan 5. doi: 10.1002/epi.70090. Online ahead of print. Epilepsia. 2026. PMID: 41489401
OBJECTIVE: GRIN-related disorders due to pathogenic variants in GRIN1, GRIN2A, GRIN2B, or GRIN2D genes are associated with altered N-methyl-D-aspartate receptor (NMDAR) function. ...
OBJECTIVE: GRIN-related disorders due to pathogenic variants in GRIN1, GRIN2A, GRIN2B, or GRIN2D genes are associated with altered N- …
Production and Optimization of Anti-Aging Peptides from Pleurotus eryngii Mushroom Feet: Mechanistic Insights via Integrated Transcriptomics and Metabolomics.
Wang S, Li H, Zhao F, Gao J, Huang S, Liu X, Ma B. Wang S, et al. Foods. 2025 Nov 20;14(22):3977. doi: 10.3390/foods14223977. Foods. 2025. PMID: 41300134 Free PMC article.
This included modulating key pathways related to oxidative stress, synaptic function, and energy metabolism (e.g., glutamatergic synapse, pentose phosphate pathway, and TCA cycle), and reversing the aberrant expression of aging-associated genes (e.g., Arap3, Grin2d and Npy …
This included modulating key pathways related to oxidative stress, synaptic function, and energy metabolism (e.g., glutamatergic synapse, pe …
The NMDA receptor subunit GluN2D is a potential target for rapid antidepressant action.
Vestring S, Veleanu M, Perez MC, Schuberth LE, Bronnec M, Li A, Würz LM, Erdogdu F, Stocker J, Moos J, Weigel D, Theiß A, Wendler E, Borger LM, Voita S, Heynicke F, Brandl J, Hummel F, Vivet C, Jocher D, Loewe P, Barmann S, Smoltczyk L, Zimmermann S, Prabhakaran P, Lokaj G, Sarrazin DH, Suarez G, Bernhardt J, du Vinage C, Grießbach E, Lais J, Gensch N, Wojtas M, Knafo S, Wendel J, Warneke J, Grohe JP, Günther S, Moumbock AFA, Domschke K, Serchov T, Bischofberger J, Normann C. Vestring S, et al. Nat Commun. 2025 Nov 26;16(1):10613. doi: 10.1038/s41467-025-66774-w. Nat Commun. 2025. PMID: 41298447 Free PMC article.
We use ketamine, the selective GluN2C/D inhibitor NAB-14, Grin2d-siRNA and chemogenetic approaches in hippocampal slices and in vivo mice. We find that GluN2D antagonism inhibits NMDAR currents in interneurons but not pyramidal cells, and that GluN2D-mediated recruitment o …
We use ketamine, the selective GluN2C/D inhibitor NAB-14, Grin2d-siRNA and chemogenetic approaches in hippocampal slices and in vivo …
Expression and localization of NMDA receptor GluN2 subunits in dorsal horn pain circuits across sex, species, and late postnatal development.
Armstrong J, Griffiths K, Martin N, Oneil E, Temi S, Dedek A, Parnell J, Rudyk C, Bursey J, Krajewski JL, McDermott JS, Levine AJ, Li B, Tsai EC, Hildebrand ME. Armstrong J, et al. bioRxiv [Preprint]. 2025 Oct 22:2025.10.22.683915. doi: 10.1101/2025.10.22.683915. bioRxiv. 2025. PMID: 41280119 Free PMC article. Preprint.
Analysis of single-cell/nuclei sequencing datasets revealed that the GluN2A (GRIN2A) and GluN2B (GRIN2B) subunits are robustly expressed in dorsal horn neurons of both mice and humans, with moderate expression of GluN2D (GRIN2D) and minimal expression of GluN2C (GRIN2C). I …
Analysis of single-cell/nuclei sequencing datasets revealed that the GluN2A (GRIN2A) and GluN2B (GRIN2B) subunits are robustly expressed in …
Adolescent White Matter Maturation Mediates Epigenetic Associations With Cognitive Development.
Jensen D, Chen J, Turner JA, Stephen JM, Wang YP, Wilson TW, Calhoun VD, Liu J. Jensen D, et al. Dev Neurobiol. 2026 Jan;86(1):e70000. doi: 10.1002/dneu.70000. Dev Neurobiol. 2026. PMID: 41273056 Free PMC article.
Continuing that work, we investigate the relationships between the changes in DNAm of these genes (GRIN2D, GABRB3, KCNC1, SLC12A9, CHD5, STXBP5, and NFASC), four networks of FA change, and scores from seven cognitive tests. ...
Continuing that work, we investigate the relationships between the changes in DNAm of these genes (GRIN2D, GABRB3, KCNC1, SLC12A9, CH …
Gastric Signet Ring Cell Carcinoma: Tumor Microenvironment Reprogramming and Novel Therapeutic Targets With Emphasis on GRIN2D.
Raju D, Prabhu S, Maria A, Shirodkar SNS, Damerla RR, Chakrabarty S, Shetty PS, Rao M, Kumar NAN. Raju D, et al. Clin Transl Sci. 2025 Nov;18(11):e70424. doi: 10.1111/cts.70424. Clin Transl Sci. 2025. PMID: 41250973 Free PMC article. Review.
Recent research has highlighted the significance of key biomarkers, including MSMB, AGR2, CLDN18.2, and notably GRIN2D, which play roles in tumor angiogenesis, immune evasion, and metabolic reprogramming. ...Innovative strategies that integrate stromal-targeting agents, co …
Recent research has highlighted the significance of key biomarkers, including MSMB, AGR2, CLDN18.2, and notably GRIN2D, which play ro …
Sensory neurons drive pancreatic cancer progression through glutamatergic neuron-cancer pseudo-synapses.
Ren L, Liu C, Çifcibaşı K, Ballmann M, Rammes G, Mota Reyes C, Tokalov S, Klingl A, Grünert J, Goyal K, Neckel PH, Mattheus U, Schoeps B, Yıldızhan SE, Sezerman OU, Cevik NC, Sever EA, Karakas D, Safak O, Steiger K, Muckenhuber A, Görgülü K, Chen Z, Zhang J, Ye L, Maula Ali MI, Tiwari VK, Romanyuk N, Giesert F, Saur D, Rad R, Schmid RM, Algül H, Krüger A, Friess H, Ceyhan GO, Istvanffy R, Demir IE. Ren L, et al. Cancer Cell. 2025 Dec 8;43(12):2241-2258.e8. doi: 10.1016/j.ccell.2025.09.003. Epub 2025 Sep 25. Cancer Cell. 2025. PMID: 41005304 Free article.
These synaptic sites exhibit a selective enrichment of the glutamatergic N-methyl-D-aspartate receptor (NMDA) receptor subunit NMDAR2D (GRIN2D) on the cancer cells, which turns PDAC cells responsive to neuron-derived glutamate and promotes tumor growth and spread. ...Moreo …
These synaptic sites exhibit a selective enrichment of the glutamatergic N-methyl-D-aspartate receptor (NMDA) receptor subunit NMDAR2D (G …
Inhibition of GluN2B-containing N-methyl-D-aspartate receptors by radiprodil.
Banke TG, Regan MC, Perszyk RE, Zhang L, Xing H, Chen J, Won S, Simorowski N, Diaz ES, Kim S, Song R, Rong J, Zhou X, Chaudhary AF, Zhang J, Traynelis JF, McDaniels ED, Nitsche K, Roache S, Raymond CS, Low CM, Myers SJ, Roche KW, Liang SH, Traynelis SF, Furukawa H, Yuan H. Banke TG, et al. Brain. 2026 Mar 5;149(3):976-992. doi: 10.1093/brain/awaf355. Brain. 2026. PMID: 40994429 Free PMC article.
Most NMDA receptors are tetrameric assemblies of two GluN1 and two GluN2 subunits encoded by five genes (GRIN1 and GRIN2A-GRIN2D), which produce GluN1 and GluN2A-GluN2D subunits. NMDA receptors that contain the GluN2B subunit have unique pharmacological properties, being i …
Most NMDA receptors are tetrameric assemblies of two GluN1 and two GluN2 subunits encoded by five genes (GRIN1 and GRIN2A-GRIN2D), wh …
Kisspeptin-13 induces hyperalgesia and modulates the expression of opioid and glutamate receptors in mice.
Bodnár É, Ibos KE, Filkor K, Csabafi K. Bodnár É, et al. Pharmacol Biochem Behav. 2025 Nov;256:174098. doi: 10.1016/j.pbb.2025.174098. Epub 2025 Sep 10. Pharmacol Biochem Behav. 2025. PMID: 40939812 Free article.
In another group of animals, after KP-13 treatment, qPCR was used to determine the relative gene expression of Oprd1, Oprk1, Oprm1, Grin1, Grin2b, Grin2d, and Grm5 in samples of the dorsal root ganglion (DRG), amygdala, hypothalamus, and anterior cingulate cortex (ACC). .. …
In another group of animals, after KP-13 treatment, qPCR was used to determine the relative gene expression of Oprd1, Oprk1, Oprm1, Grin1, G …
Effect of ketamine and esketamine on RNA expression and its relevance for depression: A systematic review.
Pisanu C, Carvalho Silva R, Meattini M, Gennarelli M, Baune BT, Squassina A, Minelli A. Pisanu C, et al. Pharmacol Res. 2025 Sep;219:107894. doi: 10.1016/j.phrs.2025.107894. Epub 2025 Jul 31. Pharmacol Res. 2025. PMID: 40752781 Free article.
Transcriptome and candidate gene expression studies revealed modulation of genes and pathways related to glutamatergic signaling (GRM2, GRIN2D), immune regulation (STAT3, CCL22, IL6), and neuroplasticity (IGF2). No consistent peripheral biomarkers emerged, but transcriptio …
Transcriptome and candidate gene expression studies revealed modulation of genes and pathways related to glutamatergic signaling (GRM2, G …
The consumption of monosodium glutamate during the periconceptional period can impair preimplantation embryo development.
Šefčíková Z, Špirková A, Kovaříková V, Rušinová L, Baran V, Pisko J, Babeľová J, Fabian D, Čikoš Š. Šefčíková Z, et al. Reprod Toxicol. 2025 Oct;137:109014. doi: 10.1016/j.reprotox.2025.109014. Epub 2025 Jul 25. Reprod Toxicol. 2025. PMID: 40716463 Free article.
In silico analysis of RNA-seq datasets containing data from human preimplantation embryos performed in this study revealed that NMDA receptors (formed from the GRIN2D or GRIN2B and GRIN3B subunits) and the GRM4 and GRM8 metabotropic receptors are expressed in human blastoc …
In silico analysis of RNA-seq datasets containing data from human preimplantation embryos performed in this study revealed that NMDA recepto …
Differential Effects of Prenatal Poly I:C Exposure and Antipsychotics on NMDA/GABA Receptors and GSK3β-Mediated Signaling in the Dorsal Raphe Nucleus of Female Rats.
Chen S, Lian J, Su Y, Deng C. Chen S, et al. Fundam Clin Pharmacol. 2025 Aug;39(4):e70033. doi: 10.1111/fcp.70033. Fundam Clin Pharmacol. 2025. PMID: 40562368 Free PMC article.
Antipsychotics significantly increased the mRNA expression of PKA, CREB1, beta-catenin, GSK3beta, and Grin2d subunits in the DRN of Poly I:C rats. Prenatal Poly I:C exposure led to decreased expression of GAD2, which was partially reversed antipsychotics. ...
Antipsychotics significantly increased the mRNA expression of PKA, CREB1, beta-catenin, GSK3beta, and Grin2d subunits in the DRN of P …
Genetic polymorphisms as predictors of the response of hepatocellular carcinoma patients to doxorubicin chemotherapy: a genome-wide association study.
Shilbayeh SAR, Khedr NF, Alshabeeb MA, Alsaleh AA, Alanizi AH, Abd El-Baset OA, Werida RH. Shilbayeh SAR, et al. Front Pharmacol. 2025 Jun 4;16:1604473. doi: 10.3389/fphar.2025.1604473. eCollection 2025. Front Pharmacol. 2025. PMID: 40535770 Free PMC article.
RESULTS: Six hits in five genes [AK3 (rs378117), TRPM3 (rs1329774 and rs4745058), CDH4 (rs2427043), LINC00504 (rs76228864), and GRIN2D (rs76754767)] were associated with a risk of tumour progression, whereas variants in HPGD (rs45593131) and RC3H2 (rs2792999) were suggeste …
RESULTS: Six hits in five genes [AK3 (rs378117), TRPM3 (rs1329774 and rs4745058), CDH4 (rs2427043), LINC00504 (rs76228864), and GRIN2D …
A mouse model of GRIN2D developmental and epileptic encephalopathy recapitulates the human disease.
Yam M, Nassir J, Galber D, Quinn S, Gal R, Ovadia M, Bordeynik-Cohen M, Peled E, Makinson CD, Hausman-Kedem M, Fattal-Valevski A, Frankel WN, Avraham KB, Rubinstein M. Yam M, et al. Brain. 2026 Jan 8;149(1):90-104. doi: 10.1093/brain/awaf149. Brain. 2026. PMID: 40277233 Free PMC article.
Pathogenic variants in GRIN2D, encoding one of the subunits of the N-methyl-D-aspartate receptor (NMDAR), are associated with developmental and epileptic encephalopathies (DEEs). ...Conversely, memantine (10 mg/kg) and phenytoin (30 mg/kg) demonstrated a small corrective e …
Pathogenic variants in GRIN2D, encoding one of the subunits of the N-methyl-D-aspartate receptor (NMDAR), are associated with develop …
ADAMTSL2 is an independent predictor for the prognosis of gastric cancer.
Zhu X, Cui Z, Li S, She Y, Wu Z. Zhu X, et al. Discov Oncol. 2025 Apr 19;16(1):570. doi: 10.1007/s12672-025-02259-y. Discov Oncol. 2025. PMID: 40252157 Free PMC article.
Among these genes, ADAMTSL2, DSCC1, COL5A3, F2RL2, GRIN2D, IGSF6, IER5L, PLA2G7, PODNL1, RCN3 and RTN4RL2 were significantly associated with the overall survival, first progression and post progression survival of GC patients. Moreover, protein levels of ADAMTSL2, COL5A3, …
Among these genes, ADAMTSL2, DSCC1, COL5A3, F2RL2, GRIN2D, IGSF6, IER5L, PLA2G7, PODNL1, RCN3 and RTN4RL2 were significantly associat …
Synaptic dysregulation in a mouse model of GRIN2D developmental and epileptic encephalopathy.
Teoh J, Simko J, Camp CR, Liu CJ, Wang W, Williams DJ, Ma L, Soundararajan D, Martin C, Taylor NK, François E, Petri S, Kanber A, Ravichandra A, Pero ME, Bartolini F, Swayne TC, Lutz CM, Zuberi A, Rubinstein M, Hausman-Kedem M, Yuan H, Gelinas JN, Sands TT, Harper SQ, Traynelis SF, Makinson CD, Frankel WN. Teoh J, et al. Brain. 2025 Nov 4;148(11):3973-3988. doi: 10.1093/brain/awaf125. Brain. 2025. PMID: 40200555
Gain-of-function (GoF) variants in the GRIN2D gene, encoding the GluN2D subunit of the N-methyl-D-aspartate receptor (NMDAR), cause a severe developmental and epileptic encephalopathy (DEE) characterized by intractable seizures, hypotonia and neurodevelopmental delay. We g …
Gain-of-function (GoF) variants in the GRIN2D gene, encoding the GluN2D subunit of the N-methyl-D-aspartate receptor (NMDAR), cause a …
Downregulation of miR-27a-3p induces endothelial injury and senescence and its significance in the development of coronary heart disease.
Song CY, Huang HZ, Yan TT, Cui CX, Wu HY, Chen J, Peng JH, Chen NY, Tang J, Pan SL. Song CY, et al. Cell Signal. 2025 Jul;131:111759. doi: 10.1016/j.cellsig.2025.111759. Epub 2025 Mar 25. Cell Signal. 2025. PMID: 40147550 Free article.
RNA sequencing and bioinformatics revealed glutamate ionotropic receptor NMDA type subunit 2D (GRIN2D) as a target gene of miR-27a-3p, and dual luciferase assays confirmed the direct binding of miR-27a-3p to the 3'UTR of GRIN2D. ...In conclusion, miR-27a-3p played a …
RNA sequencing and bioinformatics revealed glutamate ionotropic receptor NMDA type subunit 2D (GRIN2D) as a target gene of miR-27a-3p …
An antidepressant mechanism underlying the allosteric inhibition of GluN2D-incorporated NMDA receptors at GABAergic interneurons.
Zhang J, Duan J, Li W, Wang X, Ren S, Ye L, Liu F, Tian X, Xie Y, Huang Y, Sun Y, Song N, Li T, Cai X, Liu Z, Zhou H, Huang C, Li Y, Zhu S, Guo F. Zhang J, et al. Sci Adv. 2025 Mar 7;11(10):eadq0444. doi: 10.1126/sciadv.adq0444. Epub 2025 Mar 5. Sci Adv. 2025. PMID: 40043126 Free PMC article.
Behavioral assays demonstrate YY-23's rapid antidepressant effects in both stress-naive and stress-exposed models, which are lost in mice with global or selective knockout of the grin2d gene in parvalbumin-positive interneurons. These findings highlight GluN2D-containing N …
Behavioral assays demonstrate YY-23's rapid antidepressant effects in both stress-naive and stress-exposed models, which are lost in mice wi …
Multi-ancestry genome-wide association study reveals novel genetic signals for lung function decline.
Patchen BK, Zhang J, Gaddis N, Bartz TM, Chen J, Debban C, Leonard H, Nguyen NQ, Seo J, Tern C, Allen R, DeMeo DL, Fornage M, Melbourne C, Minto M, Moll M, O'Connor G, Pottinger T, Psaty BM, Rich SS, Rotter JI, Silverman EK, Stratford J, Graham Barr R, Cho MH, Gharib SA, Manichaikul A, North K, Oelsner EC, Simonsick EM, Tobin MD, Yu B, Choi SH, Dupuis J, Cassano PA, Hancock DB. Patchen BK, et al. medRxiv [Preprint]. 2024 Nov 27:2024.11.25.24317794. doi: 10.1101/2024.11.25.24317794. medRxiv. 2024. Update in: Respir Res. 2026 Feb 28;27(1):110. doi: 10.1186/s12931-026-03565-x. PMID: 39649580 Free PMC article. Updated. Preprint.
Using the GWAS results, gene-level analysis implicated 38 genes, including eight (XIRP2, GRIN2D, SATB1, MARCHF4, SIPA1L2, ANO5, H2BC10, and FAF2) with consistent associations across ancestries or decline phenotypes. ...
Using the GWAS results, gene-level analysis implicated 38 genes, including eight (XIRP2, GRIN2D, SATB1, MARCHF4, SIPA1L2, ANO5, H2BC1 …
BHLHE40-mediated transcriptional activation of GRIN2D in gastric cancer is involved in metabolic reprogramming.
Liu B, Sun Y, Wang W, Ren J, Wang D. Liu B, et al. Funct Integr Genomics. 2024 Nov 15;24(6):214. doi: 10.1007/s10142-024-01495-9. Funct Integr Genomics. 2024. PMID: 39546079
The effect of GRIN2D knockdown on the malignant behavior and glycolysis of GC cells was explored. GRIN2D expression was upregulated in GC cells and promoted the malignant behavior of GC cells by activating glycolysis. Class E basic helix-loop-helix protein 40 (BHLHE …
The effect of GRIN2D knockdown on the malignant behavior and glycolysis of GC cells was explored. GRIN2D expression was upregu …
Ligand distances as key predictors of pathogenicity and function in NMDA receptors.
Montanucci L, Brünger T, Bhattarai N, Boßelmann CM, Kim S, Allen JP, Zhang J, Klöckner C, Krey I, Fariselli P, May P, Lemke JR, Myers SJ, Yuan H, Traynelis SF, Lal D. Montanucci L, et al. Hum Mol Genet. 2025 Jan 29;34(2):128-139. doi: 10.1093/hmg/ddae156. Hum Mol Genet. 2025. PMID: 39535073 Free PMC article.
Genetic variants in the genes GRIN1, GRIN2A, GRIN2B, and GRIN2D, which encode subunits of the N-methyl-D-aspartate receptor (NMDAR), have been associated with severe and heterogeneous neurologic and neurodevelopmental disorders, including early onset epilepsy, developmenta …
Genetic variants in the genes GRIN1, GRIN2A, GRIN2B, and GRIN2D, which encode subunits of the N-methyl-D-aspartate receptor (NMDAR), …
Neural mechanisms of mutualistic fish cleaning behaviour: a study in the wild.
Romeo D, Ramirez-Calero S, Ravasi T, Rodolfo-Metalpa R, Schunter C. Romeo D, et al. Biol Lett. 2024 Oct;20(10):20240339. doi: 10.1098/rsbl.2024.0339. Epub 2024 Oct 16. Biol Lett. 2024. PMID: 39406338 Free PMC article.
The brain transcriptomes revealed 233 differentially expressed genes in cleaners that were interacting with a client. Among these genes, grin2d, npy, slc6a3 and immediate early genes (IEGs; fosb and fosl1) were related to learning and memory, glutamate and dopamine pathway …
The brain transcriptomes revealed 233 differentially expressed genes in cleaners that were interacting with a client. Among these genes, …
Adenylate cyclase 1 knockdown attenuates pirarubicin-induced cardiotoxicity.
Zhang W, Shu Z, Huang P, Cheng H, Ji J, Wei D, Ren L. Zhang W, et al. Clin Exp Pharmacol Physiol. 2024 Oct;51(10):e13920. doi: 10.1111/1440-1681.13920. Clin Exp Pharmacol Physiol. 2024. PMID: 39227014
Western blotting showed that ADCY1, phospho-protein kinase A and GRIN2D expression were also significantly elevated. Knockdown of ADCY1 attenuated THP-induced cardiotoxicity, possibly by regulating the ADCY1/PKA/GRIN2D pathway....
Western blotting showed that ADCY1, phospho-protein kinase A and GRIN2D expression were also significantly elevated. Knockdown of ADC …
BNST GluN2D-containing NMDARs contribute to ethanol intake but not negative affective behaviors in female mice.
Doyle MA, Salimando GJ, Altemus ME, Badt JK, Bedenbaugh MN, Vardy AS, Adank DN, Park AS, Winder DG. Doyle MA, et al. Alcohol Clin Exp Res (Hoboken). 2024 Oct;48(10):1876-1891. doi: 10.1111/acer.15432. Epub 2024 Aug 23. Alcohol Clin Exp Res (Hoboken). 2024. PMID: 39179522 Free PMC article.
While BNST Grin2b expression was significantly increased in protracted abstinence following CDFA, no differences in Grin2d expression were observed in the dBNST or dBNST Crh+ neurons. Finally, we find that deletion of GluN2D fails to alter negative affect in ethanol-naive …
While BNST Grin2b expression was significantly increased in protracted abstinence following CDFA, no differences in Grin2d expression …
m6A-YTHDF1 Mediated Regulation of GRIN2D in Bladder Cancer Progression and Aerobic Glycolysis.
Le M, Qing M, Zeng X, Cheng S. Le M, et al. Biochem Genet. 2025 Aug;63(4):3220-3239. doi: 10.1007/s10528-024-10875-6. Epub 2024 Jun 29. Biochem Genet. 2025. PMID: 38951355
Our analysis identified a significant upregulation of m6A modification in bladder cancer tissues. YTHDF1 was found to regulate GRIN2D expression positively. Functionally, GRIN2D was implicated in promoting bladder cancer cell proliferation and enhancing aerobic glyc …
Our analysis identified a significant upregulation of m6A modification in bladder cancer tissues. YTHDF1 was found to regulate GRIN2D …
Sevoflurane acts as an antidepressant by suppression of GluN2D-containing NMDA receptors on interneurons.
Guo F, Zhang B, Shen F, Li Q, Song Y, Li T, Zhang Y, Du W, Li Y, Liu W, Cao H, Zhou X, Zheng Y, Zhu S, Li Y, Liu Z. Guo F, et al. Br J Pharmacol. 2024 Sep;181(18):3483-3502. doi: 10.1111/bph.16420. Epub 2024 May 23. Br J Pharmacol. 2024. PMID: 38779864 Free article.
Multiple-channel electrophysiology in freely moving mice was performed to evaluate sevoflurane's effects on neuronal activity, and GluN2D knockout (grin2d(-/-)) mice were used to confirm the requirement of GluN2D for the antidepressant effects. ...In contrast, sevoflurane …
Multiple-channel electrophysiology in freely moving mice was performed to evaluate sevoflurane's effects on neuronal activity, and GluN2D kn …
Distances from ligands as main predictive features for pathogenicity and functional effect of variants in NMDA receptors.
Montanucci L, Brünger T, Bhattarai N, Boßelmann CM, Kim S, Allen JP, Zhang J, Klöckner C, Fariselli P, May P, Lemke JR, Myers SJ, Yuan H, Traynelis SF, Lal D. Montanucci L, et al. medRxiv [Preprint]. 2024 May 7:2024.05.06.24306939. doi: 10.1101/2024.05.06.24306939. medRxiv. 2024. PMID: 38766179 Free PMC article. Preprint.
Genetic variants in genes GRIN1 , GRIN2A , GRIN2B , and GRIN2D , which encode subunits of the N-methyl-D-aspartate receptor (NMDAR), have been associated with severe and heterogeneous neurologic diseases. ...
Genetic variants in genes GRIN1 , GRIN2A , GRIN2B , and GRIN2D , which encode subunits of the N-methyl-D-aspartate receptor (NMDAR), …
Identifying candidate genes associated with hippocampal dysfunction in a hemiparkinsonian rat model by transcriptomic profiling.
Kim B, Hong S, Lee J, Kang S, Kim JS, Jung C, Shin T, Youn B, Moon C. Kim B, et al. Anim Cells Syst (Seoul). 2024 Apr 30;28(1):198-215. doi: 10.1080/19768354.2024.2348671. eCollection 2024. Anim Cells Syst (Seoul). 2024. PMID: 38693920 Free PMC article.
STRING analysis confirmed a notable upregulation of eight hub genes (Notch3, Gng4, Itga3, Grin2d, Hgf, Fgf11, Htr3a, and Col6a2), along with a significant downregulation of two hub genes (Itga11 and Plp1), as validated by reverse transcription-quantitative polymerase chain …
STRING analysis confirmed a notable upregulation of eight hub genes (Notch3, Gng4, Itga3, Grin2d, Hgf, Fgf11, Htr3a, and Col6a2), alo …
BNST GluN2D-containing NMDARs contribute to ethanol intake but not negative affective behaviors in female mice.
Doyle MA, Salimando GJ, Altemus ME, Badt JK, Bedenbaugh MN, Vardy AS, Adank DN, Park AS, Winder DG. Doyle MA, et al. bioRxiv [Preprint]. 2024 Apr 21:2024.04.19.590258. doi: 10.1101/2024.04.19.590258. bioRxiv. 2024. Update in: Alcohol Clin Exp Res (Hoboken). 2024 Oct;48(10):1876-1891. doi: 10.1111/acer.15432. PMID: 38659775 Free PMC article. Updated. Preprint.
While BNST Grin2b expression was significantly increased in protracted abstinence following CDFA, no differences in Grin2d expression were observed in dBNST or specifically in dBNST Crh + neurons. Finally, to determine the impact of GluN2D expression on negative affective …
While BNST Grin2b expression was significantly increased in protracted abstinence following CDFA, no differences in Grin2d expression …
CircBIRC6 facilitates the malignant progression via miR-488/GRIN2D-mediated CAV1-autophagy signal axis in gastric cancer.
Tang Z, Li J, Lu B, Zhang X, Yang L, Qi Y, Jiang S, Wu Q, Wang Y, Cheng T, Xu M, Sun P, Wang X, Miao K, Wu H, Huang J. Tang Z, et al. Pharmacol Res. 2024 Apr;202:107127. doi: 10.1016/j.phrs.2024.107127. Epub 2024 Mar 2. Pharmacol Res. 2024. PMID: 38438090 Free article.
Functionally, it acts as a molecular sponge for miR-488, consequently upregulating GRIN2D expression and promoting GC proliferation, migration, and invasion. Moreover, overexpression of circBIRC6 leads to increased GRIN2D expression, which in turn enhances caveolin- …
Functionally, it acts as a molecular sponge for miR-488, consequently upregulating GRIN2D expression and promoting GC proliferation, …
Genetic variants identified in novel candidate genes for anorexia nervosa and analysis of molecular pathways for diagnostic applications.
Donato K, Medori MC, Macchia A, Cecchin S, Ceccarini MR, Beccari T, Gatta V, Stuppia L, Benfatti V, Dalla Ragione L, Micheletti PCC, Dhuli K, Madeo G, Bonetti G, Marceddu G, Bertelli M. Donato K, et al. Eur Rev Med Pharmacol Sci. 2023 Dec;27(6 Suppl):77-88. doi: 10.26355/eurrev_202312_34692. Eur Rev Med Pharmacol Sci. 2023. PMID: 38112957 Free article.
Variants were also found in known AN-related genes (CD36, DRD4, GCKR, GHRL, GRIN3B, GPR55, LEPR) and in other 16 candidate genes (A2M, AEBP1, ABHD4, ACBD7, CNTNAP, GFRAL, GRIN2D, LIPE, LMNA, NMU, PDE3B, POMC, RYR1, TNXB, TYK2, VPS13B), highlighting the complexity of AN's g …
Variants were also found in known AN-related genes (CD36, DRD4, GCKR, GHRL, GRIN3B, GPR55, LEPR) and in other 16 candidate genes (A2M, AEBP1 …
The promoting effects of Grin2d expression in tumorigenesis and the aggressiveness of esophageal cancer.
Wang LL, Li J, Xue H, Zhang L, Yu DY, Yang N, Yun WJ, Zhao MZ, Zheng HC. Wang LL, et al. Histol Histopathol. 2024 May;39(5):659-670. doi: 10.14670/HH-18-674. Epub 2023 Nov 9. Histol Histopathol. 2024. PMID: 37982578
Grin2d is an ionotropic NMDA receptor, a subunit of glutamate-dependent, and a facilitator of cellular calcium influx in neuronal tissue. ...Grin2d knockout caused the opposite effects. These findings indicated that upregulated Grin2d expression played an imp …
Grin2d is an ionotropic NMDA receptor, a subunit of glutamate-dependent, and a facilitator of cellular calcium influx in neuronal tis …
Multivariate GWAS of Alzheimer's disease CSF biomarker profiles implies GRIN2D in synaptic functioning.
Neumann A, Ohlei O, Küçükali F, Bos IJ, Timsina J, Vos S, Prokopenko D, Tijms BM, Andreasson U, Blennow K, Vandenberghe R, Scheltens P, Teunissen CE, Engelborghs S, Frisoni GB, Blin O, Richardson JC, Bordet R, Lleó A, Alcolea D, Popp J, Marsh TW, Gorijala P, Clark C, Peyratout G, Martinez-Lage P, Tainta M, Dobson RJB, Legido-Quigley C, Van Broeckhoven C, Tanzi RE, Ten Kate M, Lill CM, Barkhof F, Cruchaga C, Lovestone S, Streffer J, Zetterberg H, Visser PJ, Sleegers K, Bertram L; EMIF-AD & ADNI study group. Neumann A, et al. Genome Med. 2023 Oct 4;15(1):79. doi: 10.1186/s13073-023-01233-z. Genome Med. 2023. PMID: 37794492 Free PMC article.
RESULTS: Five loci showed genome-wide significant association with CSF profiles, two were novel (rs145791381 [inflammation] and GRIN2D [synaptic functioning]) and three were previously described (APOE, TMEM106B, and CHI3L1). Follow-up analyses of the two novel signals in i …
RESULTS: Five loci showed genome-wide significant association with CSF profiles, two were novel (rs145791381 [inflammation] and GRIN2D …
Loss of Grin2a causes a transient delay in the electrophysiological maturation of hippocampal parvalbumin interneurons.
Camp CR, Vlachos A, Klöckner C, Krey I, Banke TG, Shariatzadeh N, Ruggiero SM, Galer P, Park KL, Caccavano A, Kimmel S, Yuan X, Yuan H, Helbig I, Benke TA, Lemke JR, Pelkey KA, McBain CJ, Traynelis SF. Camp CR, et al. Commun Biol. 2023 Sep 19;6(1):952. doi: 10.1038/s42003-023-05298-9. Commun Biol. 2023. PMID: 37723282 Free PMC article.
NMDARs are heterotetrameric assemblies of two obligate GluN1 subunits (GRIN1) and two GluN2 subunits (GRIN2A-GRIN2D). Sequencing data shows that 43% (297/679) of all currently known NMDAR disease-associated genetic variants are within the GRIN2A gene, which encodes the Glu …
NMDARs are heterotetrameric assemblies of two obligate GluN1 subunits (GRIN1) and two GluN2 subunits (GRIN2A-GRIN2D). Sequencing data …
Impact of Amplified Oncogenes on Salivary Gland Carcinomas.
Papanikolaou V, Chrysovergis A, Asimakopoulos AD, Spyropoulou D, Ragos V, Papanastasiou G, Papouliakos S, Mastronikoli S, Roukas D, Tsiambas E, Pantos P, Peschos D, Mastronikolis N, Manaios L, Fotiades P, Vylliotis A, Kyrodimos E. Papanikolaou V, et al. Cancer Diagn Progn. 2023 Sep 3;3(5):528-532. doi: 10.21873/cdp.10250. eCollection 2023 Sep-Oct. Cancer Diagn Progn. 2023. PMID: 37671310 Free PMC article. Review.
In particular, amplifications in specific genes [human epidermal growth factor receptor 2 (HER2), human epidermal growth factor receptor 4 (HER4), epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), Mouse double minute 2 homolog (MDM2), androgen receptor (A …
In particular, amplifications in specific genes [human epidermal growth factor receptor 2 (HER2), human epidermal growth factor receptor 4 ( …
Bioinformatic Analysis on the Prognostic Value of Neurotransmitter Receptor-Related Genes in Kidney Renal Clear Cell Carcinoma.
Zhang H, Wang N, Yu T, Li Q, Yang L, Su Y, Wang P, Liu J, Yang L, Zhang J. Zhang H, et al. Altern Ther Health Med. 2023 Nov;29(8):356-365. Altern Ther Health Med. 2023. PMID: 37632962 Free article.
Subsequently, the research team found eight prognostic biomarkers-histamine receptor H2 (HRH2), gamma-aminobutyric acid (GABA) receptor subunit epsilon (GABRE), cholinergic receptor nicotinic delta subunit (CHRND), glutamate receptor ionotropic subunit 2D (GRIN2D), glutama …
Subsequently, the research team found eight prognostic biomarkers-histamine receptor H2 (HRH2), gamma-aminobutyric acid (GABA) receptor subu …
Identification of GRIN2D as a novel therapeutic target in pancreatic ductal adenocarcinoma.
Wang J, Wong CH, Zhu Y, Yao X, Ng KKC, Zhou C, To KF, Chen Y. Wang J, et al. Biomark Res. 2023 Aug 8;11(1):74. doi: 10.1186/s40364-023-00514-4. Biomark Res. 2023. PMID: 37553583 Free PMC article.
Western blot, immunohistochemistry, and analysis on Gene Expression Omnibus were used for detecting the expression of GRIN2D in PDAC. Cellular experiments were conducted for exploring the functions of GRIN2D in vitro while subcutaneous and orthotopic injections were …
Western blot, immunohistochemistry, and analysis on Gene Expression Omnibus were used for detecting the expression of GRIN2D in PDAC. …
Epigenetic associations with adolescent grey matter maturation and cognitive development.
Jensen D, Chen J, Turner JA, Stephen JM, Wang YP, Wilson TW, Calhoun VD, Liu J. Jensen D, et al. Front Genet. 2023 Jul 17;14:1222619. doi: 10.3389/fgene.2023.1222619. eCollection 2023. Front Genet. 2023. PMID: 37529779 Free PMC article.
This data, from three time points roughly 1 year apart, was used to explore the relationships between seven cytosine-phosphate-guanine (CpG) sites in genes highly expressed in brain tissues (GRIN2D, GABRB3, KCNC1, SLC12A9, CHD5, STXBP5, and NFASC), seven networks of grey m …
This data, from three time points roughly 1 year apart, was used to explore the relationships between seven cytosine-phosphate-guanine (CpG) …
Behavioral and Transcriptome Profiling of Heterozygous Rab10 Knock-Out Mice.
Bunner W, Wang J, Cohen S, Bashtovyy D, Perry R, Shookster D, Landry T, Harris EM, Stackman R, Tran TD, Yasuda R, Szatmari EM. Bunner W, et al. eNeuro. 2023 May 22;10(5):ENEURO.0459-22.2023. doi: 10.1523/ENEURO.0459-22.2023. Print 2023 May. eNeuro. 2023. PMID: 37156612 Free PMC article.
We identified and validated several differentially expressed genes (DEGs), including Stx2, Stx1b, Vegfa, and Lrrc25 (downregulated) and Prkaa2, Syt4, and Grin2d (upregulated). Behavioral testing showed that Rab10(+/-) mice perform better in a hippocampal-dependent spatial …
We identified and validated several differentially expressed genes (DEGs), including Stx2, Stx1b, Vegfa, and Lrrc25 (downregulated) and Prka …
Whole-Genome Sequencing Among Kazakhstani Children with Early-Onset Epilepsy Revealed New Gene Variants and Phenotypic Variability.
Bayanova M, Bolatov AK, Bazenova A, Nazarova L, Nauryzbayeva A, Tanko NM, Rakhimova S, Satvaldina N, Samatkyzy D, Kozhamkulov U, Kairov U, Akilzhanova A, Sarbassov D. Bayanova M, et al. Mol Neurobiol. 2023 Aug;60(8):4324-4335. doi: 10.1007/s12035-023-03346-3. Epub 2023 Apr 24. Mol Neurobiol. 2023. PMID: 37095367 Free PMC article.
We identified pathogenic and likely pathogenic variants in 14 (70%) cases, among them, 6 novel disease gene variants (KCNQ2, CASK, WWOX, MT-CO3, GRIN2D, and SLC12A5). Other genes associated with the disease were SCN1A (x2), SLC2A1, ARX, CACNA1B, PCDH19, KCNT1, and CHRNA2. …
We identified pathogenic and likely pathogenic variants in 14 (70%) cases, among them, 6 novel disease gene variants (KCNQ2, CASK, WWOX, MT- …
GRIN2D knockdown suppresses the progression of lung adenocarcinoma by regulating the E2F signalling pathway.
Chen Z, Song Y, Li P, Gao W. Chen Z, et al. Cell Signal. 2023 Jul;107:110685. doi: 10.1016/j.cellsig.2023.110685. Epub 2023 Apr 19. Cell Signal. 2023. PMID: 37084840
METHODS: We determined the role of GRIN2D in LUAD. In addition, we investigated the potential mechanism of GRIN2D in LUAD using bioinformatics analysis and confirmed this mechanism using biological approaches. RESULTS: GRIN2D was found to be upregulated in LU …
METHODS: We determined the role of GRIN2D in LUAD. In addition, we investigated the potential mechanism of GRIN2D in LUAD usin …
134 results