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Sofosbuvir as treatment against dengue?
Gan CS, Lim SK, Chee CF, Yusof R, Heh CH. Gan CS, et al. Chem Biol Drug Des. 2018 Feb;91(2):448-455. doi: 10.1111/cbdd.13091. Epub 2017 Sep 13. Chem Biol Drug Des. 2018. PMID: 28834304
Alternatively, we have used a marketed anti-HCV prodrug sofosbuvir to study its in silico and in vitro effects against dengue. As a result, the active metabolite of sofosbuvir (GS-461203) was predicted to bind to the catalytic motif (Gly-Asp-Asp) of dengue viral pol …
Alternatively, we have used a marketed anti-HCV prodrug sofosbuvir to study its in silico and in vitro effects against dengue. As a result, …
Clinical Pharmacokinetics and Pharmacodynamics of Ledipasvir/Sofosbuvir, a Fixed-Dose Combination Tablet for the Treatment of Hepatitis C.
German P, Mathias A, Brainard D, Kearney BP. German P, et al. Clin Pharmacokinet. 2016 Nov;55(11):1337-1351. doi: 10.1007/s40262-016-0397-0. Clin Pharmacokinet. 2016. PMID: 27193156 Review.
Sofosbuvir undergoes intracellular activation to an active triphosphate GS-461203 (not detected in plasma) and ultimately to GS-331007, a predominant circulating metabolite, which is the primary analyte of interest in clinical pharmacology studies. ...
Sofosbuvir undergoes intracellular activation to an active triphosphate GS-461203 (not detected in plasma) and ultimately to G …
Pharmacokinetic, Pharmacodynamic, and Drug-Interaction Profile of the Hepatitis C Virus NS5B Polymerase Inhibitor Sofosbuvir.
Kirby BJ, Symonds WT, Kearney BP, Mathias AA. Kirby BJ, et al. Clin Pharmacokinet. 2015 Jul;54(7):677-90. doi: 10.1007/s40262-015-0261-7. Clin Pharmacokinet. 2015. PMID: 25822283 Review.
Sofosbuvir (SOVALDI()), a potent, once-daily, orally administered nucleotide analog prodrug inhibitor of the hepatitis C virus (HCV) NS5B polymerase is approved in the USA, EU, Canada, and other regions for the treatment of HCV infection as a component of an antiviral treatment r …
Sofosbuvir (SOVALDI()), a potent, once-daily, orally administered nucleotide analog prodrug inhibitor of the hepatitis C virus (HCV) NS5B po …
Acute interstitial nephritis following treatment with direct-acting antiviral agents in hepatitis C virus-infected patients: A case series.
Duque JC, Dejman A, Venkat V, Hernandez M, Roth D, Ladino MA. Duque JC, et al. Clin Nephrol. 2021 Jan;95(1):22-27. doi: 10.5414/CN110276. Clin Nephrol. 2021. PMID: 32909545
Sofosbuvir is a DAA prodrug that is phosphorylated into the active metabolite GS-461203, with subsequent dephosphorylation into the inactive metabolite GS-331007. ...
Sofosbuvir is a DAA prodrug that is phosphorylated into the active metabolite GS-461203, with subsequent dephosphorylation int …
Cell-line dependent antiviral activity of sofosbuvir against Zika virus.
Mumtaz N, Jimmerson LC, Bushman LR, Kiser JJ, Aron G, Reusken CBEM, Koopmans MPG, van Kampen JJA. Mumtaz N, et al. Antiviral Res. 2017 Oct;146:161-163. doi: 10.1016/j.antiviral.2017.09.004. Epub 2017 Sep 11. Antiviral Res. 2017. PMID: 28912011 Free article.
This correlated with differences in intracellular concentration of the active triphosphate metabolite of sofosbuvir, GS-461203 or 007-TP, which was 11-342 times higher in Huh7 cells compared to Vero and A549 cells. ...
This correlated with differences in intracellular concentration of the active triphosphate metabolite of sofosbuvir, GS-461203 …