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Year Number of Results
1969 2
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1977 24
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1979 22
1980 51
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1982 83
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1984 141
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1987 334
1988 436
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1990 749
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2008 3017
2009 2970
2010 3070
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2014 3545
2015 3298
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86,634 results

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Page 1
Metabolic enzyme LDHA activates Rac1 GTPase as a noncanonical mechanism to promote cancer.
Liu J, Zhang C, Zhang T, Chang CY, Wang J, Bazile L, Zhang L, Haffty BG, Hu W, Feng Z. Liu J, et al. Nat Metab. 2022 Dec;4(12):1830-1846. doi: 10.1038/s42255-022-00708-4. Epub 2022 Dec 19. Nat Metab. 2022. PMID: 36536137 Free PMC article.
The oncogenic effect of LDHA has been attributed to its glycolytic enzyme activity. Here we report an unexpected noncanonical oncogenic mechanism of LDHA; LDHA activates small GTPase Rac1 to promote cancer independently of its glycolytic enzyme activity …
The oncogenic effect of LDHA has been attributed to its glycolytic enzyme activity. Here we report an unexpected noncanonical oncogen …
OsATG1 and OsATG8 exhibit autophagy-independent functions to oppositely regulate ROP GTPase-mediated plant immunity in rice.
He F, Tao H, Wang R, Liu J, Hao Z, Wang D, Shi X, Zhang F, Long J, Zhang H, Yang X, Qin M, Peng S, Zhang C, You X, Guo H, Li F, Gao C, Liu Y, Wang GL, Ning Y. He F, et al. Mol Plant. 2025 Sep 1;18(9):1472-1489. doi: 10.1016/j.molp.2025.07.006. Epub 2025 Jul 23. Mol Plant. 2025. PMID: 40708194
ROP GTPases regulate various cellular processes, including plant immunity. While ROP GTPase activation has been reported during plant immune responses, the mechanisms underlying the dynamic deactivation of ROP GTPases remain unclear. In this study, we …
ROP GTPases regulate various cellular processes, including plant immunity. While ROP GTPase activation has been reporte …
GAPs for rho-related GTPases.
Lamarche N, Hall A. Lamarche N, et al. Trends Genet. 1994 Dec;10(12):436-40. doi: 10.1016/0168-9525(94)90114-7. Trends Genet. 1994. PMID: 7871593 Review.
Ras-related GTP-binding proteins (GTPases) of the rho subfamily play important roles in regulating the organization of the actin cytoskeleton. A large number of multifunctional proteins that can stimulate their intrinsic GTPase activity have been ident …
Ras-related GTP-binding proteins (GTPases) of the rho subfamily play important roles in regulating the organization of the act …
GTP-specific fab fragment-based GTPase activity assay.
Kopra K, Rozwandowicz-Jansen A, Syrjänpää M, Blaževitš O, Ligabue A, Veltel S, Lamminmäki U, Abankwa D, Härmä H. Kopra K, et al. Anal Chem. 2015 Mar 17;87(6):3527-34. doi: 10.1021/acs.analchem.5b00117. Epub 2015 Mar 3. Anal Chem. 2015. PMID: 25707436
GTPases are central cellular signaling proteins, which cycle between a GDP-bound inactive and a GTP-bound active conformation in a controlled manner. ...The method allows studying the GEF dependent H-Ras activation (GTP binding) and GAP-catalyze …
GTPases are central cellular signaling proteins, which cycle between a GDP-bound inactive and a GTP-bound active confor …
RGS10 is a selective activator of G alpha i GTPase activity.
Hunt TW, Fields TA, Casey PJ, Peralta EG. Hunt TW, et al. Nature. 1996 Sep 12;383(6596):175-7. doi: 10.1038/383175a0. Nature. 1996. PMID: 8774883
In vitro assays with purified proteins indicate that RGS10 increases potently and selectively the GTP hydrolytic activity of several members of the G alphai family, including G alphai3, G alphaz, and G alpha0. These results demonstrate that RGS proteins can attenuat …
In vitro assays with purified proteins indicate that RGS10 increases potently and selectively the GTP hydrolytic activity of s …
Skeletal muscle Rac1 mediates exercise training adaptations towards muscle glycogen resynthesis and protein synthesis.
Raun SH, Henriquez-Olguín C, Frank E, Schlabs F, Hahn NJ, Knudsen JR, Ali MS, Andersen NR, Møller LLV, Davey J, Qian H, Coelho A, Carl CS, Voldstedlund CT, Kiens B, Holmdahl R, Gregorevic P, Jensen TE, Deshmukh AS, Richter EA, Sylow L. Raun SH, et al. Redox Biol. 2025 Oct;86:103844. doi: 10.1016/j.redox.2025.103844. Epub 2025 Aug 28. Redox Biol. 2025. PMID: 40886619 Free PMC article.
Rho GTPases are among the most regulated groups of proteins after exercise in human skeletal muscle, yet, unexplored candidates for mediating the effects of exercise training. We found that the Rho GTPase Rac1 was activated acutely after multipl …
Rho GTPases are among the most regulated groups of proteins after exercise in human skeletal muscle, yet, unexplored candidate …
3D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights Into MFN-2-Mediated Changes.
Scudese E, Marshall AG, Vue Z, Exil V, Rodriguez BI, Demirci M, Vang L, López EG, Neikirk K, Shao B, Le H, Stephens D, Hall DD, Rostami R, Rodman T, Kabugi K, Shao JQ, Mungai M, AshShareef ST, Hicsasmaz I, Manus S, Wanjalla CN, Whiteside A, Dasari R, Williams CR, Damo SM, Gaddy JA, Glancy B, Dantas EHM, Kinder A, Kadam A, Tomar D, Scartoni F, Baffi M, McReynolds MR, Phillips MA, Cooper A, Murray SA, Quintana AM, Wandira N, Ochayi OM, Ameka M, Kirabo A, Masenga SK, Harris C, Oliver A, Martin P, Gaye A, Korolkova O, Sharma V, Mobley BC, Katti P, Hinton A. Scudese E, et al. Aging Cell. 2025 Jul;24(7):e70054. doi: 10.1111/acel.70054. Epub 2025 Apr 25. Aging Cell. 2025. PMID: 40285369 Free PMC article.
Additionally, aged samples showed a larger volume phenotype in both female and male humans, indicating potential mitochondrial swelling. Concomitantly, muscle area, exercise capacity, and mitochondrial dynamic proteins showed age-related losses. Exercise stimulation …
Additionally, aged samples showed a larger volume phenotype in both female and male humans, indicating potential mitochondrial swelling. Con …
Spatiotemporal Regulation of RhoA during Cytokinesis.
Basant A, Glotzer M. Basant A, et al. Curr Biol. 2018 May 7;28(9):R570-R580. doi: 10.1016/j.cub.2018.03.045. Curr Biol. 2018. PMID: 29738735 Free PMC article. Review.
The active form of the small GTPase RhoA is necessary and sufficient for formation of a cytokinetic furrow in animal cells. ...Here, we discuss our current knowledge of the mechanisms underlying spatiotemporal regulation of RhoA during cytokinesis by upstream act …
The active form of the small GTPase RhoA is necessary and sufficient for formation of a cytokinetic furrow in animal cells. .. …
Intrinsic GTPase Activity of K-RAS Monitored by Native Mass Spectrometry.
Moghadamchargari Z, Huddleston J, Shirzadeh M, Zheng X, Clemmer DE, M Raushel F, Russell DH, Laganowsky A. Moghadamchargari Z, et al. Biochemistry. 2019 Aug 6;58(31):3396-3405. doi: 10.1021/acs.biochem.9b00532. Epub 2019 Jul 22. Biochemistry. 2019. PMID: 31306575 Free PMC article.
Mutations in RAS are associated with many different cancers and have been a therapeutic target for more than three decades. RAS cycles from an active to inactive state by both intrinsic and GTPase-activating protein (GAP)-stimulated hydrolysis. ...Our results …
Mutations in RAS are associated with many different cancers and have been a therapeutic target for more than three decades. RAS cycles from …
Ras-Specific GTPase-Activating Proteins-Structures, Mechanisms, and Interactions.
Scheffzek K, Shivalingaiah G. Scheffzek K, et al. Cold Spring Harb Perspect Med. 2019 Mar 1;9(3):a031500. doi: 10.1101/cshperspect.a031500. Cold Spring Harb Perspect Med. 2019. PMID: 30104198 Free PMC article. Review.
Ras-specific GTPase-activating proteins (RasGAPs) down-regulate the biological activity of Ras proteins by accelerating their intrinsic rate of GTP hydrolysis, basically by a transition state stabilizing mechanism. Oncogenic Ras is commonly not sensiti …
Ras-specific GTPase-activating proteins (RasGAPs) down-regulate the biological activity of Ras proteins by accelerating …
86,634 results
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