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GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease.
Cruchaga C, Kauwe JS, Harari O, Jin SC, Cai Y, Karch CM, Benitez BA, Jeng AT, Skorupa T, Carrell D, Bertelsen S, Bailey M, McKean D, Shulman JM, De Jager PL, Chibnik L, Bennett DA, Arnold SE, Harold D, Sims R, Gerrish A, Williams J, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Peskind ER, Galasko D, Fagan AM, Holtzman DM, Morris JC; GERAD Consortium; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Alzheimer Disease Genetic Consortium (ADGC), Goate AM. Cruchaga C, et al. Neuron. 2013 Apr 24;78(2):256-68. doi: 10.1016/j.neuron.2013.02.026. Epub 2013 Apr 4. Neuron. 2013. PMID: 23562540 Free PMC article.
Cerebrospinal fluid (CSF) tau, tau phosphorylated at threonine 181 (ptau), and Abeta42 are established biomarkers for Alzheimer's disease (AD) and have been used as quantitative traits for genetic analyses. We performed the largest
Cerebrospinal fluid (CSF) tau, tau phosphorylated at threonine 181 (ptau), and Abeta42 are established biomarker
Genome-wide association study for variants that modulate relationships between cerebrospinal fluid amyloid-beta 42, tau, and p-tau levels.
Maxwell TJ, Corcoran C, Del-Aguila JL, Budde JP, Deming Y, Cruchaga C, Goate AM, Kauwe JSK; Alzheimer’s Disease Neuroimaging Initiative. Maxwell TJ, et al. Alzheimers Res Ther. 2018 Aug 28;10(1):86. doi: 10.1186/s13195-018-0410-y. Alzheimers Res Ther. 2018. PMID: 30153862 Free PMC article.
On follow-up, rs1036819 and rs74025622 were associated with Alzheimer's disease (AD) case/control status; rs15205 and rs79099429 were associated with rate of decline. ...It resides in the ZFAT gene, which is related to autoimmune thyroid disease. For …
On follow-up, rs1036819 and rs74025622 were associated with Alzheimer's disease (AD) case/control status; rs15205 and r …
SNPs associated with cerebrospinal fluid phospho-tau levels influence rate of decline in Alzheimer's disease.
Cruchaga C, Kauwe JS, Mayo K, Spiegel N, Bertelsen S, Nowotny P, Shah AR, Abraham R, Hollingworth P, Harold D, Owen MM, Williams J, Lovestone S, Peskind ER, Li G, Leverenz JB, Galasko D; Alzheimer's Disease Neuroimaging Initiative, Morris JC, Fagan AM, Holtzman DM, Goate AM. Cruchaga C, et al. PLoS Genet. 2010 Sep 16;6(9):e1001101. doi: 10.1371/journal.pgen.1001101. PLoS Genet. 2010. PMID: 20862329 Free PMC article.
Alzheimer's Disease (AD) is a complex and multifactorial disease. While large genome-wide association studies have had some success in identifying novel genetic risk factors for AD, case-control studies are less likel
Alzheimer's Disease (AD) is a complex and multifactorial disease. While large genome-wide assoc
Genome-Wide Association Studies for Cerebrospinal Fluid Soluble TREM2 in Alzheimer's Disease.
Liu C, Yu J. Liu C, et al. Front Aging Neurosci. 2019 Oct 25;11:297. doi: 10.3389/fnagi.2019.00297. eCollection 2019. Front Aging Neurosci. 2019. PMID: 31708768 Free PMC article.
Alzheimer's disease (AD) is the most common form of dementia. Rare variants in triggering receptor expressed on myeloid cells 2 (TREM2) have been identified as risk factors for AD. ...To explore the roles of CSF sTREM2 on the pathogenesis
Alzheimer's disease (AD) is the most common form of dementia. Rare variants in triggering receptor expressed on
Functional genomic analyses uncover APOE-mediated regulation of brain and cerebrospinal fluid beta-amyloid levels in Parkinson disease.
Ibanez L, Bahena JA, Yang C, Dube U, Farias FHG, Budde JP, Bergmann K, Brenner-Webster C, Morris JC, Perrin RJ, Cairns NJ, O'Donnell J, Álvarez I, Diez-Fairen M, Aguilar M, Miller R, Davis AA, Pastor P, Kotzbauer P, Campbell MC, Perlmutter JS, Rhinn H, Harari O, Cruchaga C, Benitez BA. Ibanez L, et al. Acta Neuropathol Commun. 2020 Nov 19;8(1):196. doi: 10.1186/s40478-020-01072-8. Acta Neuropathol Commun. 2020. PMID: 33213513 Free PMC article.
Here, genome-wide association studies of CSF biomarker levels in a cohort of individuals with Parkinson's disease and controls (N = 1960) were performed. ...No genome-wide loci associated with CSF alpha-synuclein, total t
Here, genome-wide association studies of CSF biomarker levels in a cohort of individuals with Parkinson's
Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status.
Piccio L, Deming Y, Del-Águila JL, Ghezzi L, Holtzman DM, Fagan AM, Fenoglio C, Galimberti D, Borroni B, Cruchaga C. Piccio L, et al. Acta Neuropathol. 2016 Jun;131(6):925-33. doi: 10.1007/s00401-016-1533-5. Epub 2016 Jan 11. Acta Neuropathol. 2016. PMID: 26754641 Free PMC article.
Low frequency coding variants in TREM2 are associated with increased Alzheimer disease (AD) risk, while loss of functions mutations in the gene lead to an autosomal recessive early-onset dementia, named Nasu-Hakola disease (NHD). ...We also perf …
Low frequency coding variants in TREM2 are associated with increased Alzheimer disease (AD) risk, while loss of …
Genome-wide association study of Alzheimer's disease CSF biomarkers in the EMIF-AD Multimodal Biomarker Discovery dataset.
Hong S, Prokopenko D, Dobricic V, Kilpert F, Bos I, Vos SJB, Tijms BM, Andreasson U, Blennow K, Vandenberghe R, Cleynen I, Gabel S, Schaeverbeke J, Scheltens P, Teunissen CE, Niemantsverdriet E, Engelborghs S, Frisoni G, Blin O, Richardson JC, Bordet R, Molinuevo JL, Rami L; Alzheimer’s Disease Neuroimaging Initiative (ADNI), Kettunen P, Wallin A, Lleó A, Sala I, Popp J, Peyratout G, Martinez-Lage P, Tainta M, Dobson RJB, Legido-Quigley C, Sleegers K, Van Broeckhoven C, Ten Kate M, Barkhof F, Zetterberg H, Lovestone S, Streffer J, Wittig M, Franke A, Tanzi RE, Visser PJ, Bertram L. Hong S, et al. Transl Psychiatry. 2020 Nov 22;10(1):403. doi: 10.1038/s41398-020-01074-z. Transl Psychiatry. 2020. PMID: 33223526 Free PMC article.
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder and the most common form of dementia in the elderly. ...Specifically, we performed genome-wide association study (GWAS) analyses on 16 traits, includi
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder and the most common form of dementia in the e
Common Variants in PLXNA4 and Correlation to CSF-related Phenotypes in Alzheimer's Disease.
Han Q, Sun YA, Zong Y, Chen C, Wang HF, Tan L; Alzheimer's Disease Neuroimaging Initiative. Han Q, et al. Front Neurosci. 2018 Dec 18;12:946. doi: 10.3389/fnins.2018.00946. eCollection 2018. Front Neurosci. 2018. PMID: 30618575 Free PMC article.
The Plexin-A 4 (PLXNA4) gene, has recently been identified in genome wide association studies (GWAS), as a novel genetic player associated with Alzheimer's disease (AD). ...Multiple linear regression models were used to expl …
The Plexin-A 4 (PLXNA4) gene, has recently been identified in genome wide association studies (GWAS), as …
Alterations in cholesterol metabolism-related genes in sporadic Alzheimer's disease.
Picard C, Julien C, Frappier J, Miron J, Théroux L, Dea D; United Kingdom Brain Expression Consortium and for the Alzheimer's Disease Neuroimaging Initiative, Breitner JCS, Poirier J. Picard C, et al. Neurobiol Aging. 2018 Jun;66:180.e1-180.e9. doi: 10.1016/j.neurobiolaging.2018.01.018. Epub 2018 Feb 9. Neurobiol Aging. 2018. PMID: 29503034
Genome-wide association studies have identified several cholesterol metabolism-related genes as top risk factors for late-onset Alzheimer's disease (LOAD). ...Targeted association studies were conducted with available
Genome-wide association studies have identified several cholesterol metabolism-related genes as top risk
CSF protein changes associated with hippocampal sclerosis risk gene variants highlight impact of GRN/PGRN.
Fardo DW, Katsumata Y, Kauwe JSK, Deming Y, Harari O, Cruchaga C; Alzheimer's Disease Neuroimaging Initiative, Nelson PT. Fardo DW, et al. Exp Gerontol. 2017 Apr;90:83-89. doi: 10.1016/j.exger.2017.01.025. Epub 2017 Feb 9. Exp Gerontol. 2017. PMID: 28189700 Free PMC article.
OBJECTIVE: Hippocampal sclerosis of aging (HS-Aging) is a common cause of dementia in older adults. We tested the variability in cerebrospinal fluid (CSF) proteins associated with previously identified HS-Aging risk single nucleotide polymorphisms (SNP …
OBJECTIVE: Hippocampal sclerosis of aging (HS-Aging) is a common cause of dementia in older adults. We tested the variability in cerebros
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