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Page 1
The complex genetic architecture of Alzheimer's disease: novel insights and future directions.
Andrews SJ, Renton AE, Fulton-Howard B, Podlesny-Drabiniok A, Marcora E, Goate AM. Andrews SJ, et al. EBioMedicine. 2023 Apr;90:104511. doi: 10.1016/j.ebiom.2023.104511. Epub 2023 Mar 10. EBioMedicine. 2023. PMID: 36907103 Free PMC article. Review.
BACKGROUND: Alzheimer's disease (AD) is a complex multifactorial neurodegenerative disorder and the most common form of dementia. ...Second, sample sizes of non-European ancestry populations in AD GWAS remain small. Third, GWAS of AD neuroimagin …
BACKGROUND: Alzheimer's disease (AD) is a complex multifactorial neurodegenerative disorder and the most common form of …
GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease.
Cruchaga C, Kauwe JS, Harari O, Jin SC, Cai Y, Karch CM, Benitez BA, Jeng AT, Skorupa T, Carrell D, Bertelsen S, Bailey M, McKean D, Shulman JM, De Jager PL, Chibnik L, Bennett DA, Arnold SE, Harold D, Sims R, Gerrish A, Williams J, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Peskind ER, Galasko D, Fagan AM, Holtzman DM, Morris JC; GERAD Consortium; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Alzheimer Disease Genetic Consortium (ADGC); Goate AM. Cruchaga C, et al. Neuron. 2013 Apr 24;78(2):256-68. doi: 10.1016/j.neuron.2013.02.026. Epub 2013 Apr 4. Neuron. 2013. PMID: 23562540 Free PMC article.
Cerebrospinal fluid (CSF) tau, tau phosphorylated at threonine 181 (ptau), and Abeta42 are established biomarkers for Alzheimer's disease (AD) and have been used as quantitative traits for genetic analyses. We performed the largest
Cerebrospinal fluid (CSF) tau, tau phosphorylated at threonine 181 (ptau), and Abeta42 are established biomarker
Genome-Wide Meta-Analysis of Cerebrospinal Fluid Biomarkers in Alzheimer's Disease and Parkinson's Disease Cohorts.
Ta M, Blauwendraat C, Antar T, Leonard HL, Singleton AB, Nalls MA, Iwaki H; Alzheimer's Disease Neuroimaging Initiative (ADNI); and the Fox Investigation for New Discovery of Biomarkers. Ta M, et al. Mov Disord. 2023 Sep;38(9):1697-1705. doi: 10.1002/mds.29511. Epub 2023 Aug 4. Mov Disord. 2023. PMID: 37539664
BACKGROUND: Amyloid-beta, phosphorylated tau (p-tau), and total tau (t-tau) in cerebrospinal fluid are established biomarkers for Alzheimer's disease (AD). ...METHODS: We conducted genome-wide associa
BACKGROUND: Amyloid-beta, phosphorylated tau (p-tau), and total tau (t-tau) in cerebrospinal fluid
Genetic architecture of plasma Alzheimer disease biomarkers.
Bradley J, Gorijala P, Schindler SE, Sung YJ, Ances B; Alzheimer’s Disease Neuroimaging Initiative, the Human Connectome Project; Fernandez MV, Cruchaga C. Bradley J, et al. Hum Mol Genet. 2023 Jul 20;32(15):2532-2543. doi: 10.1093/hmg/ddad087. Hum Mol Genet. 2023. PMID: 37208024
Genome-wide association studies (GWAS) of cerebrospinal fluid (CSF) Alzheimer's Disease (AD) biomarker levels have identified novel genes implicated in disease risk, onset and progression.
Genome-wide association studies (GWAS) of cerebrospinal fluid (CSF) Alzheimer's D
Genome-wide meta-analysis of CSF biomarkers in Alzheimer's disease and Parkinson's disease cohorts.
Ta M, Blauwendraat C, Antar T, Leonard HL, Singleton AB, Nalls MA, Iwaki H; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Fox Investigation for New Discovery of Biomarkers. Ta M, et al. medRxiv [Preprint]. 2023 Jun 19:2023.06.13.23291354. doi: 10.1101/2023.06.13.23291354. medRxiv. 2023. PMID: 37398091 Free PMC article. Updated. Preprint.
BACKGROUND: Amyloid beta (Abeta), phosphorylated tau (p-tau), and total tau (t-tau) in cerebrospinal fluid are established biomarkers for Alzheimer's disease (AD). ...CONCLUSIONS: Our study identified a …
BACKGROUND: Amyloid beta (Abeta), phosphorylated tau (p-tau), and total tau (t-tau) in cerebrospinal f
Genome-Wide Association Studies for Cerebrospinal Fluid Soluble TREM2 in Alzheimer's Disease.
Liu C, Yu J. Liu C, et al. Front Aging Neurosci. 2019 Oct 25;11:297. doi: 10.3389/fnagi.2019.00297. eCollection 2019. Front Aging Neurosci. 2019. PMID: 31708768 Free PMC article.
Alzheimer's disease (AD) is the most common form of dementia. Rare variants in triggering receptor expressed on myeloid cells 2 (TREM2) have been identified as risk factors for AD. ...To explore the roles of CSF sTREM2 on the pathogenesis
Alzheimer's disease (AD) is the most common form of dementia. Rare variants in triggering receptor expressed on
SNPs associated with cerebrospinal fluid phospho-tau levels influence rate of decline in Alzheimer's disease.
Cruchaga C, Kauwe JS, Mayo K, Spiegel N, Bertelsen S, Nowotny P, Shah AR, Abraham R, Hollingworth P, Harold D, Owen MM, Williams J, Lovestone S, Peskind ER, Li G, Leverenz JB, Galasko D; Alzheimer's Disease Neuroimaging Initiative; Morris JC, Fagan AM, Holtzman DM, Goate AM. Cruchaga C, et al. PLoS Genet. 2010 Sep 16;6(9):e1001101. doi: 10.1371/journal.pgen.1001101. PLoS Genet. 2010. PMID: 20862329 Free PMC article.
Alzheimer's Disease (AD) is a complex and multifactorial disease. While large genome-wide association studies have had some success in identifying novel genetic risk factors for AD, case-control studies are less likel
Alzheimer's Disease (AD) is a complex and multifactorial disease. While large genome-wide assoc
Genome-wide association study for variants that modulate relationships between cerebrospinal fluid amyloid-beta 42, tau, and p-tau levels.
Maxwell TJ, Corcoran C, Del-Aguila JL, Budde JP, Deming Y, Cruchaga C, Goate AM, Kauwe JSK; Alzheimer’s Disease Neuroimaging Initiative. Maxwell TJ, et al. Alzheimers Res Ther. 2018 Aug 28;10(1):86. doi: 10.1186/s13195-018-0410-y. Alzheimers Res Ther. 2018. PMID: 30153862 Free PMC article.
On follow-up, rs1036819 and rs74025622 were associated with Alzheimer's disease (AD) case/control status; rs15205 and rs79099429 were associated with rate of decline. ...It resides in the ZFAT gene, which is related to autoimmune thyroid disease. For …
On follow-up, rs1036819 and rs74025622 were associated with Alzheimer's disease (AD) case/control status; rs15205 and r …
Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status.
Piccio L, Deming Y, Del-Águila JL, Ghezzi L, Holtzman DM, Fagan AM, Fenoglio C, Galimberti D, Borroni B, Cruchaga C. Piccio L, et al. Acta Neuropathol. 2016 Jun;131(6):925-33. doi: 10.1007/s00401-016-1533-5. Epub 2016 Jan 11. Acta Neuropathol. 2016. PMID: 26754641 Free PMC article.
Low frequency coding variants in TREM2 are associated with increased Alzheimer disease (AD) risk, while loss of functions mutations in the gene lead to an autosomal recessive early-onset dementia, named Nasu-Hakola disease (NHD). TREM2 can be de …
Low frequency coding variants in TREM2 are associated with increased Alzheimer disease (AD) risk, while loss of …
Functional genomic analyses uncover APOE-mediated regulation of brain and cerebrospinal fluid beta-amyloid levels in Parkinson disease.
Ibanez L, Bahena JA, Yang C, Dube U, Farias FHG, Budde JP, Bergmann K, Brenner-Webster C, Morris JC, Perrin RJ, Cairns NJ, O'Donnell J, Álvarez I, Diez-Fairen M, Aguilar M, Miller R, Davis AA, Pastor P, Kotzbauer P, Campbell MC, Perlmutter JS, Rhinn H, Harari O, Cruchaga C, Benitez BA. Ibanez L, et al. Acta Neuropathol Commun. 2020 Nov 19;8(1):196. doi: 10.1186/s40478-020-01072-8. Acta Neuropathol Commun. 2020. PMID: 33213513 Free PMC article.
The use of CSF levels of amyloid beta(1-42), total tau, and phosphorylated tau(181) as quantitative traits in genetic studies have provided novel insights into Alzheimer's disease pathophysiology. ...No genome-wide loci asso …
The use of CSF levels of amyloid beta(1-42), total tau, and phosphorylated tau(181) as quantitative traits in genetic s …
16 results