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Loss of ARHGAP15 affects the directional control of migrating interneurons in the embryonic cortex and increases susceptibility to epilepsy.
Liaci C, Camera M, Zamboni V, Sarò G, Ammoni A, Parmigiani E, Ponzoni L, Hidisoglu E, Chiantia G, Marcantoni A, Giustetto M, Tomagra G, Carabelli V, Torelli F, Sala M, Yanagawa Y, Obata K, Hirsch E, Merlo GR. Liaci C, et al. Among authors: saro g. Front Cell Dev Biol. 2022 Dec 8;10:875468. doi: 10.3389/fcell.2022.875468. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 36568982 Free PMC article.
Disruption of ArhGAP15 results in hyperactive Rac1, affects the architecture and function of hippocampal inhibitory neurons and causes cognitive deficits.
Zamboni V, Armentano M, Sarò G, Ciraolo E, Ghigo A, Germena G, Umbach A, Valnegri P, Passafaro M, Carabelli V, Gavello D, Bianchi V, D'Adamo P, de Curtis I, El-Assawi N, Mauro A, Priano L, Ferri N, Hirsch E, Merlo GR. Zamboni V, et al. Among authors: saro g. Sci Rep. 2016 Oct 7;6:34877. doi: 10.1038/srep34877. Sci Rep. 2016. PMID: 27713499 Free PMC article.