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Page 1
Pyridine Derivatives as Insecticides. Part 3. Synthesis, Crystal Structure, and Toxicological Evaluation of Some New Partially Hydrogenated Isoquinolines against Aphis gossypii (Glover, 1887).
Bakhite EA, Marae IS, Gad MA, Mohamed SK, Mague JT, Abuelhassan S. Bakhite EA, et al. J Agric Food Chem. 2022 Aug 10;70(31):9637-9644. doi: 10.1021/acs.jafc.2c02776. Epub 2022 Jul 28. J Agric Food Chem. 2022. PMID: 35901495
Eleven new compounds 3a, 4a, 3b, 4b, 3c, 4c, 6a, 6b, 8, 9, and 10 were screneed for their toxicological activity against nymphs and adults of Aphis gossypii by using acetamprid, as a reference. After 24 h of treatment, the bioefficacy results indicate that all tested isoqu …
Eleven new compounds 3a, 4a, 3b, 4b, 3c, 4c, 6a, 6b, 8, 9, and 10 were screneed for their toxicological activity against nymphs and adults o …
Tumor-associated autoantibodies from mouse breast cancer models are found in serum of breast cancer patients.
Stanton SE, Gad E, Ramos E, Corulli L, Annis J, Childs J, Katayama H, Hanash S, Marks J, Disis ML. Stanton SE, et al. NPJ Breast Cancer. 2021 May 11;7(1):50. doi: 10.1038/s41523-021-00257-1. NPJ Breast Cancer. 2021. PMID: 33976232 Free PMC article.
Sixty-two candidate antigens were identified prior to palpable tumor development in TgMMTV-neu and C3(1)Tag transgenic mouse mammary tumor models. Five antigens (VPS35, ARPC2, SERBP1, KRT8, and PDIA6) were selected because their decreased expression decreased survival in h …
Sixty-two candidate antigens were identified prior to palpable tumor development in TgMMTV-neu and C3(1)Tag transgenic mouse mammary …
Immunization against HIF-1α Inhibits the Growth of Basal Mammary Tumors and Targets Mammary Stem Cells In Vivo.
Cecil DL, Slota M, O'Meara MM, Curtis BC, Gad E, Dang Y, Herendeen D, Rastetter L, Disis ML. Cecil DL, et al. Clin Cancer Res. 2017 Jul 1;23(13):3396-3404. doi: 10.1158/1078-0432.CCR-16-1678. Epub 2016 Dec 30. Clin Cancer Res. 2017. PMID: 28039264 Free PMC article.
Class II epitopes derived from the HIF-1alpha protein sequence were validated by ELISPOT. To assess therapeutic efficacy, we immunized Tg-MMTVneu and C3(1)Tag mice with HIF-1alpha Th1-inducing peptides. Stem cells were isolated via magnetic bead separation. ...After HIF-1a …
Class II epitopes derived from the HIF-1alpha protein sequence were validated by ELISPOT. To assess therapeutic efficacy, we immunized Tg-MM …
Natural history of tumor growth and immune modulation in common spontaneous murine mammary tumor models.
Gad E, Rastetter L, Slota M, Koehnlein M, Treuting PM, Dang Y, Stanton S, Disis ML. Gad E, et al. Breast Cancer Res Treat. 2014 Dec;148(3):501-10. doi: 10.1007/s10549-014-3199-9. Epub 2014 Nov 14. Breast Cancer Res Treat. 2014. PMID: 25395320 Free PMC article.
We aimed to evaluate the relationship between growth rates of tumors in common spontaneous mammary tumor models and immune biomarkers evaluated in the tumor and blood. TgMMTV-neu and C3(1)-Tag transgenic mice were followed longitudinally from birth, and MPA-DMBA-treated mi …
We aimed to evaluate the relationship between growth rates of tumors in common spontaneous mammary tumor models and immune biomarkers evalua …
The tumor antigen repertoire identified in tumor-bearing neu transgenic mice predicts human tumor antigens.
Lu H, Knutson KL, Gad E, Disis ML. Lu H, et al. Cancer Res. 2006 Oct 1;66(19):9754-61. doi: 10.1158/0008-5472.CAN-06-1083. Cancer Res. 2006. PMID: 17018635
After screening 3 x 10(6) clones from 3 different cDNA libraries, 15 tumor antigens were identified, including cytokeratin 2-8, glutamyl-prolyl-tRNA synthetase, complement C3, galectin 8, and serine/threonine-rich protein kinase 1. Multiple proteins involved in the Rho/Rho …
After screening 3 x 10(6) clones from 3 different cDNA libraries, 15 tumor antigens were identified, including cytokeratin 2-8, glutamyl-pro …
Vesicular glutamate transporter DNPI/VGLUT2 mRNA is present in C1 and several other groups of brainstem catecholaminergic neurons.
Stornetta RL, Sevigny CP, Guyenet PG. Stornetta RL, et al. J Comp Neurol. 2002 Mar 12;444(3):191-206. doi: 10.1002/cne.10141. J Comp Neurol. 2002. PMID: 11840474
DNPI/VGLUT2 mRNA was detected in most of the adrenergic neurons of the C1, C2, and C3 groups (75-80% of TH-ir neurons), in the A2 noradrenergic group (80%), and in vast numbers of area postrema cells. ...Within this region several catecholaminergic cell groups appear to be …
DNPI/VGLUT2 mRNA was detected in most of the adrenergic neurons of the C1, C2, and C3 groups (75-80% of TH-ir neurons), in the A2 nor …
Evidence for complement-dependent and -independent inhibition of insulin secretion from clonal beta-cells incubated in the presence of sera of newly diagnosed IDDM patients.
Conroy SJ, Abdel-Wahab YH, Caraher EM, Byrne PM, Murphy E, Nolan J, Flatt PR, Newsholme P. Conroy SJ, et al. J Endocrinol. 2000 Feb;164(2):139-47. doi: 10.1677/joe.0.1640139. J Endocrinol. 2000. PMID: 10657849
Indeed, the viability of the beta-cells was not significantly different between cells cultured in 10% (v/v) IDDM sera, normal human sera, or fetal calf serum after 24, 48 and 72 h. Alanine-stimulated insulin secretion from cells cultured for 24 h in (10% v/v) IDDM p …
Indeed, the viability of the beta-cells was not significantly different between cells cultured in 10% (v/v) IDDM sera, normal human sera, or …
Changes in central GABAergic function following acute and repeated stress.
Otero Losada ME. Otero Losada ME. Br J Pharmacol. 1988 Mar;93(3):483-90. doi: 10.1111/j.1476-5381.1988.tb10302.x. Br J Pharmacol. 1988. PMID: 3370385 Free PMC article.
In the corpus striatum the activity of the synthetic enzyme for GABA (glutamic acid decarboxylase, GAD) and the levels of GABA were reduced by acute immobilization stress (1 h). GABA turnover was reduced only by acute cold stress (3 h, 4 degrees C). 3. In the …
In the corpus striatum the activity of the synthetic enzyme for GABA (glutamic acid decarboxylase, GAD) and the levels of GABA were r …