Gaffney P - Search Results

1

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

Balendran A, Casamayor A, Deak M, Paterson A, Gaffney P, Currie R, Downes CP, Alessi DR. Balendran A, et al. Among authors: gaffney p. Curr Biol. 1999 Apr 22;9(8):393-404. doi: 10.1016/s0960-9822(99)80186-9. Curr Biol. 1999. PMID: 10226025 Free article.

2

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase.

Alessi DR, Deak M, Casamayor A, Caudwell FB, Morrice N, Norman DG, Gaffney P, Reese CB, MacDougall CN, Harbison D, Ashworth A, Bownes M. Alessi DR, et al. Among authors: gaffney p. Curr Biol. 1997 Oct 1;7(10):776-89. doi: 10.1016/s0960-9822(06)00336-8. Curr Biol. 1997. PMID: 9368760 Free article.

3

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha.

Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB, Cohen P. Alessi DR, et al. Among authors: gaffney pr. Curr Biol. 1997 Apr 1;7(4):261-9. doi: 10.1016/s0960-9822(06)00122-9. Curr Biol. 1997. PMID: 9094314 Free article.

4

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B.

Stephens L, Anderson K, Stokoe D, Erdjument-Bromage H, Painter GF, Holmes AB, Gaffney PR, Reese CB, McCormick F, Tempst P, Coadwell J, Hawkins PT. Stephens L, et al. Among authors: gaffney pr. Science. 1998 Jan 30;279(5351):710-4. doi: 10.1126/science.279.5351.710. Science. 1998. PMID: 9445477

5

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B.

Stokoe D, Stephens LR, Copeland T, Gaffney PR, Reese CB, Painter GF, Holmes AB, McCormick F, Hawkins PT. Stokoe D, et al. Among authors: gaffney pr. Science. 1997 Jul 25;277(5325):567-70. doi: 10.1126/science.277.5325.567. Science. 1997. PMID: 9228007

6

Understanding the relative affinity and specificity of the pleckstrin homology domain of protein kinase B for inositol phosphates.

Rosen SA, Gaffney PR, Spiess B, Gould IR. Rosen SA, et al. Phys Chem Chem Phys. 2012 Jan 14;14(2):929-36. doi: 10.1039/c1cp22240f. Epub 2011 Nov 25. Phys Chem Chem Phys. 2012. PMID: 22121510

7

Structural and biochemical evaluation of the interaction of the phosphatidylinositol 3-kinase p85alpha Src homology 2 domains with phosphoinositides and inositol polyphosphates.

Surdo PL, Bottomley MJ, Arcaro A, Siegal G, Panayotou G, Sankar A, Gaffney PR, Riley AM, Potter BV, Waterfield MD, Driscoll PC. Surdo PL, et al. Among authors: gaffney pr. J Biol Chem. 1999 May 28;274(22):15678-85. doi: 10.1074/jbc.274.22.15678. J Biol Chem. 1999. PMID: 10336465 Free article.

8

PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40(phox).

Ellson CD, Gobert-Gosse S, Anderson KE, Davidson K, Erdjument-Bromage H, Tempst P, Thuring JW, Cooper MA, Lim ZY, Holmes AB, Gaffney PR, Coadwell J, Chilvers ER, Hawkins PT, Stephens LR. Ellson CD, et al. Among authors: gaffney pr. Nat Cell Biol. 2001 Jul;3(7):679-82. doi: 10.1038/35083076. Nat Cell Biol. 2001. PMID: 11433301

9

A theoretical investigation of inositol 1,3,4,5-tetrakisphosphate.

Rosen SA, Gaffney PR, Gould IR. Rosen SA, et al. Phys Chem Chem Phys. 2011 Jan 21;13(3):1070-81. doi: 10.1039/c0cp00956c. Epub 2010 Nov 12. Phys Chem Chem Phys. 2011. PMID: 21076747

10

Regioselective deprotection of orthobenzoates for the synthesis of inositol phosphates.

Swarbrick JM, Cooper S, Bultynck G, Gaffney PR. Swarbrick JM, et al. Org Biomol Chem. 2009 Apr 21;7(8):1709-15. doi: 10.1039/b901890e. Epub 2009 Mar 6. Org Biomol Chem. 2009. PMID: 19343261

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