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2013 1
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Page 1
Kinome-Wide Synthetic Lethal Screen Identifies PANK4 as a Modulator of Temozolomide Resistance in Glioblastoma.
Vella V, Ditsiou A, Chalari A, Eravci M, Wooller SK, Gagliano T, Bani C, Kerschbamer E, Karakostas C, Xu B, Zhang Y, Pearl FMG, Lopez G, Peng L, Stebbing J, Klinakis A, Giamas G. Vella V, et al. Among authors: gagliano t. Adv Sci (Weinh). 2024 Apr;11(15):e2306027. doi: 10.1002/advs.202306027. Epub 2024 Feb 14. Adv Sci (Weinh). 2024. PMID: 38353396 Free PMC article.
Temozolomide (TMZ) represents the cornerstone of therapy for glioblastoma (GBM). However, acquisition of resistance limits its therapeutic potential. The human kinome is an undisputable source of druggable targets, still, current knowledge remains confined to a limited fra …
Temozolomide (TMZ) represents the cornerstone of therapy for glioblastoma (GBM). However, acquisition of resistance limits its therap …
Estrogen receptor status heterogeneity in breast cancer tumor: role in response to endocrine treatment.
Malavasi E, Giamas G, Gagliano T. Malavasi E, et al. Among authors: gagliano t. Cancer Gene Ther. 2023 Jul;30(7):932-935. doi: 10.1038/s41417-023-00618-x. Epub 2023 Apr 21. Cancer Gene Ther. 2023. PMID: 37085602
The aim of this study was to investigate breast tumor heterogeneity and its role in endocrine resistance onset. For this purpose, we used ER(+) (T47D, CAMA1) and triple-negative breast cancer cell lines (TNBC; MDA-MB-231, HCC70), co-cultures using 2D and 3D models. ...
The aim of this study was to investigate breast tumor heterogeneity and its role in endocrine resistance onset. For this purpose, we …
Androgen receptor signaling regulates the transcriptome of prostate cancer cells by modulating global alternative splicing.
Shah K, Gagliano T, Garland L, O'Hanlon T, Bortolotti D, Gentili V, Rizzo R, Giamas G, Dean M. Shah K, et al. Among authors: gagliano t. Oncogene. 2020 Sep;39(39):6172-6189. doi: 10.1038/s41388-020-01429-2. Epub 2020 Aug 20. Oncogene. 2020. PMID: 32820253 Free PMC article.
Hence, there is a need to understand the mechanisms underlying CRPC progression and eventual treatment resistance. Here, we have leveraged next-generation sequencing and newly developed analytical methodologies to evaluate the role of AR signaling in regulating the transcr …
Hence, there is a need to understand the mechanisms underlying CRPC progression and eventual treatment resistance. Here, we have leve …
LMTK3 confers chemo-resistance in breast cancer.
Stebbing J, Shah K, Lit LC, Gagliano T, Ditsiou A, Wang T, Wendler F, Simon T, Szabó KS, O'Hanlon T, Dean M, Roslani AC, Cheah SH, Lee SC, Giamas G. Stebbing J, et al. Among authors: gagliano t. Oncogene. 2018 Jun;37(23):3113-3130. doi: 10.1038/s41388-018-0197-0. Epub 2018 Mar 15. Oncogene. 2018. PMID: 29540829 Free PMC article.
Lemur tyrosine kinase 3 (LMTK3) is an oncogenic kinase that is involved in different types of cancer (breast, lung, gastric, colorectal) and biological processes including proliferation, invasion, migration, chromatin remodeling as well as innate and acquired endocrine resista …
Lemur tyrosine kinase 3 (LMTK3) is an oncogenic kinase that is involved in different types of cancer (breast, lung, gastric, colorectal) and …
Direct Effects of Anti-Angiogenic Therapies on Tumor Cells: VEGF Signaling.
Simon T, Gagliano T, Giamas G. Simon T, et al. Among authors: gagliano t. Trends Mol Med. 2017 Mar;23(3):282-292. doi: 10.1016/j.molmed.2017.01.002. Epub 2017 Feb 2. Trends Mol Med. 2017. PMID: 28162910 Review.
Over recent decades anti-angiogenic therapies (AATs) have produced promising results in the treatment of different malignancies. Unfortunately, resistance often develops and patients ultimately relapse. In an attempt to elucidate the causes of recurrence, most studies have …
Over recent decades anti-angiogenic therapies (AATs) have produced promising results in the treatment of different malignancies. Unfortunate …
Mitotane enhances doxorubicin cytotoxic activity by inhibiting P-gp in human adrenocortical carcinoma cells.
Gagliano T, Gentilin E, Benfini K, Di Pasquale C, Tassinari M, Falletta S, Feo C, Tagliati F, Uberti ED, Zatelli MC. Gagliano T, et al. Endocrine. 2014 Dec;47(3):943-51. doi: 10.1007/s12020-014-0374-z. Epub 2014 Aug 6. Endocrine. 2014. PMID: 25096913
It was previously demonstrated that mitotane potentiates chemotherapeutic drugs cytotoxicity in cancer cells displaying chemoresistance due to P-glycoprotein (P-gp), an efflux pump involved in cancer multidrug resistance. The majority of ACC expresses high levels of P-gp a …
It was previously demonstrated that mitotane potentiates chemotherapeutic drugs cytotoxicity in cancer cells displaying chemoresistance due …
N-carbamidoyl-4-((3-ethyl-2,4,4-trimethylcyclohexyl)methyl)benzamide enhances staurosporine cytotoxic effects likely inhibiting the protective action of Magmas toward cell apoptosis.
Zatelli MC, Gagliano T, Pelà M, Bianco S, Bertolasi V, Tagliati F, Guerrini R, degli Uberti E, Salvadori S, Trapella C. Zatelli MC, et al. Among authors: gagliano t. J Med Chem. 2014 Jun 12;57(11):4606-14. doi: 10.1021/jm5000535. Epub 2014 May 14. J Med Chem. 2014. PMID: 24761782
We recently demonstrated that Magmas overexpression protects GH-secreting rat pitutitary adenoma cell lines from apoptosis by inhibiting cytochrome c release from mitochondria after treatment with staurosporine, strongly suggesting a role of Magmas in preventing apoptosis. The ai …
We recently demonstrated that Magmas overexpression protects GH-secreting rat pitutitary adenoma cell lines from apoptosis by inhibiting cyt …
mTOR, p70S6K, AKT, and ERK1/2 levels predict sensitivity to mTOR and PI3K/mTOR inhibitors in human bronchial carcinoids.
Gagliano T, Bellio M, Gentilin E, Molè D, Tagliati F, Schiavon M, Cavallesco NG, Andriolo LG, Ambrosio MR, Rea F, Degli Uberti E, Zatelli MC. Gagliano T, et al. Endocr Relat Cancer. 2013 Jun 24;20(4):463-75. doi: 10.1530/ERC-13-0042. Print 2013 Aug. Endocr Relat Cancer. 2013. PMID: 23653462
Human BC primary cultures may display resistance to everolimus, an inhibitor of the mammalian target of rapamycin (mTOR), in terms of cell viability reduction. ...'Resistant' cells display lower levels of mTOR, p70S6K, AKT, and ERK1/2, indicating that these proteins may be …
Human BC primary cultures may display resistance to everolimus, an inhibitor of the mammalian target of rapamycin (mTOR), in terms of …