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A yeast-based assay identifies drugs active against human mitochondrial disorders.
Couplan E, Aiyar RS, Kucharczyk R, Kabala A, Ezkurdia N, Gagneur J, St Onge RP, Salin B, Soubigou F, Le Cann M, Steinmetz LM, di Rago JP, Blondel M. Couplan E, et al. Among authors: gagneur j. Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11989-94. doi: 10.1073/pnas.1101478108. Epub 2011 Jun 29. Proc Natl Acad Sci U S A. 2011. PMID: 21715656 Free PMC article.
Mitochondrial protein sorting as a therapeutic target for ATP synthase disorders.
Aiyar RS, Bohnert M, Duvezin-Caubet S, Voisset C, Gagneur J, Fritsch ES, Couplan E, von der Malsburg K, Funaya C, Soubigou F, Courtin F, Suresh S, Kucharczyk R, Evrard J, Antony C, St Onge RP, Blondel M, di Rago JP, van der Laan M, Steinmetz LM. Aiyar RS, et al. Among authors: gagneur j. Nat Commun. 2014 Dec 18;5:5585. doi: 10.1038/ncomms6585. Nat Commun. 2014. PMID: 25519239 Free PMC article.
Experimental relocation of the mitochondrial ATP9 gene to the nucleus reveals forces underlying mitochondrial genome evolution.
Bietenhader M, Martos A, Tetaud E, Aiyar RS, Sellem CH, Kucharczyk R, Clauder-Münster S, Giraud MF, Godard F, Salin B, Sagot I, Gagneur J, Déquard-Chablat M, Contamine V, Hermann-Le Denmat S, Sainsard-Chanet A, Steinmetz LM, di Rago JP. Bietenhader M, et al. Among authors: gagneur j. PLoS Genet. 2012;8(8):e1002876. doi: 10.1371/journal.pgen.1002876. Epub 2012 Aug 16. PLoS Genet. 2012. PMID: 22916027 Free PMC article.
An evaluation of high-throughput approaches to QTL mapping in Saccharomyces cerevisiae.
Wilkening S, Lin G, Fritsch ES, Tekkedil MM, Anders S, Kuehn R, Nguyen M, Aiyar RS, Proctor M, Sakhanenko NA, Galas DJ, Gagneur J, Deutschbauer A, Steinmetz LM. Wilkening S, et al. Among authors: gagneur j. Genetics. 2014 Mar;196(3):853-65. doi: 10.1534/genetics.113.160291. Epub 2013 Dec 27. Genetics. 2014. PMID: 24374355 Free PMC article.
Negative feedback buffers effects of regulatory variants.
Bader DM, Wilkening S, Lin G, Tekkedil MM, Dietrich K, Steinmetz LM, Gagneur J. Bader DM, et al. Among authors: gagneur j. Mol Syst Biol. 2015 Jan 29;11(1):785. doi: 10.15252/msb.20145844. Mol Syst Biol. 2015. PMID: 25634765 Free PMC article.
87 results