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2000 3
2001 6
2002 4
2003 10
2004 13
2005 14
2006 8
2007 5
2008 6
2009 5
2010 8
2011 8
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Page 1
Characterization of VldE (Spr1875), a Pneumococcal Two-State l,d-Endopeptidase with a Four-Zinc Cluster in the Active Site.
Miguel-Ruano V, Acebrón I, Lee M, Martín-Galiano AJ, Freton C, de José UP, Ramachandran B, Gago F, Kjos M, Hesek D, Grangeasse C, Håvarstein LS, Straume D, Mobashery S, Hermoso JA. Miguel-Ruano V, et al. Among authors: gago f. ACS Catal. 2024 Dec 11;14(24):18786-18798. doi: 10.1021/acscatal.4c05090. eCollection 2024 Dec 20. ACS Catal. 2024. PMID: 39722888 Free PMC article.
Modulation of taxane binding to tubulin curved and straight conformations by systematic 3'N modification provides for improved microtubule binding, persistent cytotoxicity and in vivo potency.
Ma Y, Josa-Prado F, Essif JN, Liu S, Li S, Lucena-Agell D, Chan PY, Goossens K, Hortigüela R, Matesanz R, Wang Y, Gago F, Wang H, Risinger A, Diaz JF, Fang WS. Ma Y, et al. Among authors: gago f. Eur J Med Chem. 2023 Nov 5;259:115668. doi: 10.1016/j.ejmech.2023.115668. Epub 2023 Jul 19. Eur J Med Chem. 2023. PMID: 37490800
Molecular basis of the final step of cell division in Streptococcus pneumoniae.
Martínez-Caballero S, Freton C, Molina R, Bartual SG, Gueguen-Chaignon V, Mercy C, Gago F, Mahasenan KV, Muñoz IG, Lee M, Hesek D, Mobashery S, Hermoso JA, Grangeasse C. Martínez-Caballero S, et al. Among authors: gago f. Cell Rep. 2023 Jul 25;42(7):112756. doi: 10.1016/j.celrep.2023.112756. Epub 2023 Jul 6. Cell Rep. 2023. PMID: 37418323 Free PMC article.
Structural insight into the stabilization of microtubules by taxanes.
Prota AE, Lucena-Agell D, Ma Y, Estevez-Gallego J, Li S, Bargsten K, Josa-Prado F, Altmann KH, Gaillard N, Kamimura S, Mühlethaler T, Gago F, Oliva MA, Steinmetz MO, Fang WS, Díaz JF. Prota AE, et al. Among authors: gago f. Elife. 2023 Mar 6;12:e84791. doi: 10.7554/eLife.84791. Elife. 2023. PMID: 36876916 Free PMC article.
Chemical modulation of microtubule structure through the laulimalide/peloruside site.
Estévez-Gallego J, Álvarez-Bernad B, Pera B, Wullschleger C, Raes O, Menche D, Martínez JC, Lucena-Agell D, Prota AE, Bonato F, Bargsten K, Cornelus J, Giménez-Abián JF, Northcote P, Steinmetz MO, Kamimura S, Altmann KH, Paterson I, Gago F, Van der Eycken J, Díaz JF, Oliva MÁ. Estévez-Gallego J, et al. Among authors: gago f. Structure. 2023 Jan 5;31(1):88-99.e5. doi: 10.1016/j.str.2022.11.006. Epub 2022 Dec 2. Structure. 2023. PMID: 36462501 Free article.
Identification of 1,2,3-triazolium salt-based inhibitors of Leishmania infantum trypanothione disulfide reductase with enhanced antileishmanial potency in cellulo and increased selectivity.
de Lucio H, Revuelto A, Carriles AA, de Castro S, García-González S, García-Soriano JC, Alcón-Calderón M, Sánchez-Murcia PA, Hermoso JA, Gago F, Camarasa MJ, Jiménez-Ruiz A, Velázquez S. de Lucio H, et al. Among authors: gago f. Eur J Med Chem. 2022 Dec 15;244:114878. doi: 10.1016/j.ejmech.2022.114878. Epub 2022 Oct 29. Eur J Med Chem. 2022. PMID: 36332553 Free article.
Identification of L. infantum trypanothione synthetase inhibitors with leishmanicidal activity from a (non-biased) in-house chemical library.
Alcón-Calderón M, de Lucio H, García-Soriano JC, Revuelto A, de Castro S, López-Gutiérrez C, San-Félix A, Quesada E, Gago F, Camarasa MJ, Jiménez-Ruiz A, Velázquez S. Alcón-Calderón M, et al. Among authors: gago f. Eur J Med Chem. 2022 Dec 5;243:114675. doi: 10.1016/j.ejmech.2022.114675. Epub 2022 Aug 18. Eur J Med Chem. 2022. PMID: 36075146 Free article.
A Versatile Class of 1,4,4-Trisubstituted Piperidines Block Coronavirus Replication In Vitro.
De Castro S, Stevaert A, Maldonado M, Delpal A, Vandeput J, Van Loy B, Eydoux C, Guillemot JC, Decroly E, Gago F, Canard B, Camarasa MJ, Velázquez S, Naesens L. De Castro S, et al. Among authors: gago f. Pharmaceuticals (Basel). 2022 Aug 18;15(8):1021. doi: 10.3390/ph15081021. Pharmaceuticals (Basel). 2022. PMID: 36015168 Free PMC article.
Organotropic dendrons with high potency as HIV-1, HIV-2 and EV-A71 cell entry inhibitors.
Martí-Marí O, Martínez-Gualda B, Fernández-Barahona I, Mills A, Abdelnabi R, Noppen S, Neyts J, Schols D, Camarasa MJ, Herranz F, Gago F, San-Félix A. Martí-Marí O, et al. Among authors: gago f. Eur J Med Chem. 2022 Jul 5;237:114414. doi: 10.1016/j.ejmech.2022.114414. Epub 2022 Apr 27. Eur J Med Chem. 2022. PMID: 35512567 Free article.
Double Arylation of the Indole Side Chain of Tri- and Tetrapodal Tryptophan Derivatives Renders Highly Potent HIV-1 and EV-A71 Entry Inhibitors†.
Martí-Marí O, Martínez-Gualda B, de la Puente-Secades S, Mills A, Quesada E, Abdelnabi R, Sun L, Boonen A, Noppen S, Neyts J, Schols D, Camarasa MJ, Gago F, San-Félix A. Martí-Marí O, et al. Among authors: gago f. J Med Chem. 2021 Jul 22;64(14):10027-10046. doi: 10.1021/acs.jmedchem.1c00315. Epub 2021 Jul 7. J Med Chem. 2021. PMID: 34229438 Free PMC article.
Multivalent Tryptophan- and Tyrosine-Containing [60]Fullerene Hexa-Adducts as Dual HIV and Enterovirus A71 Entry Inhibitors.
Ruiz-Santaquiteria M, Illescas BM, Abdelnabi R, Boonen A, Mills A, Martí-Marí O, Noppen S, Neyts J, Schols D, Gago F, San-Félix A, Camarasa MJ, Martín N. Ruiz-Santaquiteria M, et al. Among authors: gago f. Chemistry. 2021 Jul 21;27(41):10700-10710. doi: 10.1002/chem.202101098. Epub 2021 Jun 1. Chemistry. 2021. PMID: 33851758 Free PMC article.
Structural Cues for Understanding eEF1A2 Moonlighting.
Carriles AA, Mills A, Muñoz-Alonso MJ, Gutiérrez D, Domínguez JM, Hermoso JA, Gago F. Carriles AA, et al. Among authors: gago f. Chembiochem. 2021 Jan 15;22(2):374-391. doi: 10.1002/cbic.202000516. Epub 2020 Oct 20. Chembiochem. 2021. PMID: 32875694
Peptides Mimicking the β7/β8 Loop of HIV-1 Reverse Transcriptase p51 as "Hotspot-Targeted" Dimerization Inhibitors.
Sánchez-Murcia PA, de Castro S, García-Aparicio C, Jiménez MA, Corona A, Tramontano E, Sluis-Cremer N, Menéndez-Arias L, Velázquez S, Gago F, Camarasa MJ. Sánchez-Murcia PA, et al. Among authors: gago f. ACS Med Chem Lett. 2020 Jan 24;11(5):811-817. doi: 10.1021/acsmedchemlett.9b00623. eCollection 2020 May 14. ACS Med Chem Lett. 2020. PMID: 32435389 Free PMC article.
N-benzyl 4,4-disubstituted piperidines as a potent class of influenza H1N1 virus inhibitors showing a novel mechanism of hemagglutinin fusion peptide interaction.
de Castro S, Ginex T, Vanderlinden E, Laporte M, Stevaert A, Cumella J, Gago F, Camarasa MJ, Luque FJ, Naesens L, Velazquez S. de Castro S, et al. Among authors: gago f. Eur J Med Chem. 2020 May 15;194:112223. doi: 10.1016/j.ejmech.2020.112223. Epub 2020 Mar 13. Eur J Med Chem. 2020. PMID: 32220685
Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties.
Herrera-Arozamena C, Estrada-Valencia M, Pérez C, Lagartera L, Morales-García JA, Pérez-Castillo A, Franco-Gonzalez JF, Michalska P, Duarte P, León R, López MG, Mills A, Gago F, García-Yagüe ÁJ, Fernández-Ginés R, Cuadrado A, Rodríguez-Franco MI. Herrera-Arozamena C, et al. Among authors: gago f. Eur J Med Chem. 2020 Mar 15;190:112090. doi: 10.1016/j.ejmech.2020.112090. Epub 2020 Jan 25. Eur J Med Chem. 2020. PMID: 32018096 Free article.
Recognition and Activation of the Plant AKT1 Potassium Channel by the Kinase CIPK23.
Sánchez-Barrena MJ, Chaves-Sanjuan A, Raddatz N, Mendoza I, Cortés Á, Gago F, González-Rubio JM, Benavente JL, Quintero FJ, Pardo JM, Albert A. Sánchez-Barrena MJ, et al. Among authors: gago f. Plant Physiol. 2020 Apr;182(4):2143-2153. doi: 10.1104/pp.19.01084. Epub 2020 Feb 3. Plant Physiol. 2020. PMID: 32015077 Free PMC article.
Scaffold Simplification Strategy Leads to a Novel Generation of Dual Human Immunodeficiency Virus and Enterovirus-A71 Entry Inhibitors.
Martínez-Gualda B, Sun L, Martí-Marí O, Noppen S, Abdelnabi R, Bator CM, Quesada E, Delang L, Mirabelli C, Lee H, Schols D, Neyts J, Hafenstein S, Camarasa MJ, Gago F, San-Félix A. Martínez-Gualda B, et al. Among authors: gago f. J Med Chem. 2020 Jan 9;63(1):349-368. doi: 10.1021/acs.jmedchem.9b01737. Epub 2019 Dec 20. J Med Chem. 2020. PMID: 31809045
Differential phenotypic expression of a novel PDHA1 mutation in a female monozygotic twin pair.
Horga A, Woodward CE, Mills A, Pareés I, Hargreaves IP, Brown RM, Bugiardini E, Brooks T, Manole A, Remzova E, Rahman S, Reilly MM, Houlden H, Sweeney MG, Brown GK, Polke JM, Gago F, Parton MJ, Pitceathly RDS, Hanna MG. Horga A, et al. Among authors: gago f. Hum Genet. 2019 Dec;138(11-12):1313-1322. doi: 10.1007/s00439-019-02075-9. Epub 2019 Oct 31. Hum Genet. 2019. PMID: 31673819 Free PMC article.
Viral engagement with host receptors blocked by a novel class of tryptophan dendrimers that targets the 5-fold-axis of the enterovirus-A71 capsid.
Sun L, Lee H, Thibaut HJ, Lanko K, Rivero-Buceta E, Bator C, Martinez-Gualda B, Dallmeier K, Delang L, Leyssen P, Gago F, San-Félix A, Hafenstein S, Mirabelli C, Neyts J. Sun L, et al. Among authors: gago f. PLoS Pathog. 2019 May 9;15(5):e1007760. doi: 10.1371/journal.ppat.1007760. eCollection 2019 May. PLoS Pathog. 2019. PMID: 31071193 Free PMC article.
Pyrrolopyrimidine vs Imidazole-Phenyl-Thiazole Scaffolds in Nonpeptidic Dimerization Inhibitors of Leishmania infantum Trypanothione Reductase.
Revuelto A, Ruiz-Santaquiteria M, de Lucio H, Gamo A, Carriles AA, Gutiérrez KJ, Sánchez-Murcia PA, Hermoso JA, Gago F, Camarasa MJ, Jiménez-Ruiz A, Velázquez S. Revuelto A, et al. Among authors: gago f. ACS Infect Dis. 2019 Jun 14;5(6):873-891. doi: 10.1021/acsinfecdis.8b00355. Epub 2019 Apr 23. ACS Infect Dis. 2019. PMID: 30983322
Identification of NEK3 and MOK as novel targets for lithium.
Bravo A, de Lucio H, Sánchez-Murcia PA, Jiménez-Ruiz A, Petrone PM, Gago F, Cortés Cabrera A. Bravo A, et al. Among authors: gago f. Chem Biol Drug Des. 2019 May;93(5):965-969. doi: 10.1111/cbdd.13487. Epub 2019 Feb 12. Chem Biol Drug Des. 2019. PMID: 30667602
Trypanothione reductase inhibition and anti-leishmanial activity of all-hydrocarbon stapled α-helical peptides with improved proteolytic stability.
Ruiz-Santaquiteria M, de Castro S, Toro MA, de Lucio H, Gutiérrez KJ, Sánchez-Murcia PA, Jiménez MÁ, Gago F, Jiménez-Ruiz A, Camarasa MJ, Velázquez S. Ruiz-Santaquiteria M, et al. Among authors: gago f. Eur J Med Chem. 2018 Apr 10;149:238-247. doi: 10.1016/j.ejmech.2018.02.071. Epub 2018 Feb 24. Eur J Med Chem. 2018. PMID: 29501944 Free article.
Engineering Erg10 Thiolase from Saccharomyces cerevisiae as a Synthetic Toolkit for the Production of Branched-Chain Alcohols.
Torres-Salas P, Bernal V, López-Gallego F, Martínez-Crespo J, Sánchez-Murcia PA, Barrera V, Morales-Jiménez R, García-Sánchez A, Mañas-Fernández A, Seoane JM, Sagrera Polo M, Miranda JD, Calvo J, Huertas S, Torres JL, Alcalde-Bascones A, González-Barrera S, Gago F, Morreale A, González-Barroso MDM. Torres-Salas P, et al. Among authors: gago f. Biochemistry. 2018 Feb 27;57(8):1338-1348. doi: 10.1021/acs.biochem.7b01186. Epub 2018 Feb 6. Biochemistry. 2018. PMID: 29360348
Improved proteolytic stability and potent activity against Leishmania infantum trypanothione reductase of α/β-peptide foldamers conjugated to cell-penetrating peptides.
de Lucio H, Gamo AM, Ruiz-Santaquiteria M, de Castro S, Sánchez-Murcia PA, Toro MA, Gutiérrez KJ, Gago F, Jiménez-Ruiz A, Camarasa MJ, Velázquez S. de Lucio H, et al. Among authors: gago f. Eur J Med Chem. 2017 Nov 10;140:615-623. doi: 10.1016/j.ejmech.2017.09.032. Epub 2017 Sep 21. Eur J Med Chem. 2017. PMID: 29017116 Free article.
First example of peptides targeting the dimer interface of Leishmania infantum trypanothione reductase with potent in vitro antileishmanial activity.
Ruiz-Santaquiteria M, Sánchez-Murcia PA, Toro MA, de Lucio H, Gutiérrez KJ, de Castro S, Carneiro FAC, Gago F, Jiménez-Ruiz A, Camarasa MJ, Velázquez S. Ruiz-Santaquiteria M, et al. Among authors: gago f. Eur J Med Chem. 2017 Jul 28;135:49-59. doi: 10.1016/j.ejmech.2017.04.020. Epub 2017 Apr 13. Eur J Med Chem. 2017. PMID: 28431354 Free article.
Structural Determinants of the Dictyostatin Chemotype for Tubulin Binding Affinity and Antitumor Activity Against Taxane- and Epothilone-Resistant Cancer Cells.
Trigili C, Barasoain I, Sánchez-Murcia PA, Bargsten K, Redondo-Horcajo M, Nogales A, Gardner NM, Meyer A, Naylor GJ, Gómez-Rubio E, Gago F, Steinmetz MO, Paterson I, Prota AE, Díaz JF. Trigili C, et al. Among authors: gago f. ACS Omega. 2016 Dec 31;1(6):1192-1204. doi: 10.1021/acsomega.6b00317. Epub 2016 Dec 13. ACS Omega. 2016. PMID: 30023505 Free PMC article.
Modular Architecture and Unique Teichoic Acid Recognition Features of Choline-Binding Protein L (CbpL) Contributing to Pneumococcal Pathogenesis.
Gutiérrez-Fernández J, Saleh M, Alcorlo M, Gómez-Mejía A, Pantoja-Uceda D, Treviño MA, Voß F, Abdullah MR, Galán-Bartual S, Seinen J, Sánchez-Murcia PA, Gago F, Bruix M, Hammerschmidt S, Hermoso JA. Gutiérrez-Fernández J, et al. Among authors: gago f. Sci Rep. 2016 Dec 5;6:38094. doi: 10.1038/srep38094. Sci Rep. 2016. PMID: 27917891 Free PMC article.
A functional BH3 domain in an aquaporin from Leishmania infantum.
Genes CM, de Lucio H, González VM, Sánchez-Murcia PA, Rico E, Gago F, Fasel N, Jiménez-Ruiz A. Genes CM, et al. Among authors: gago f. Cell Death Discov. 2016 Jul 4;2:16043. doi: 10.1038/cddiscovery.2016.43. eCollection 2016. Cell Death Discov. 2016. PMID: 27551533 Free PMC article.
Enantioselective oxidation of galactitol 1-phosphate by galactitol-1-phosphate 5-dehydrogenase from Escherichia coli.
Benavente R, Esteban-Torres M, Kohring GW, Cortés-Cabrera Á, Sánchez-Murcia PA, Gago F, Acebrón I, de las Rivas B, Muñoz R, Mancheño JM. Benavente R, et al. Among authors: gago f. Acta Crystallogr D Biol Crystallogr. 2015 Jul;71(Pt 7):1540-54. doi: 10.1107/S1399004715009281. Epub 2015 Jun 30. Acta Crystallogr D Biol Crystallogr. 2015. PMID: 26143925
One-pot synthesis of vinca alkaloids-phomopsin hybrids.
Gherbovet O, Coderch C, García Alvarez MC, Bignon J, Thoret S, Guéritte F, Gago F, Roussi F. Gherbovet O, et al. Among authors: gago f. J Med Chem. 2014 Jun 26;57(12):5470-6. doi: 10.1021/jm500530v. Epub 2014 Jun 10. J Med Chem. 2014. PMID: 24871162
Leishmania infantum EndoG is an endo/exo-nuclease essential for parasite survival.
Rico E, Oliva C, Gutierrez KJ, Alzate JF, Genes CM, Moreno D, Casanova E, Gigante A, Pérez-Pérez MJ, Camarasa MJ, Clos J, Gago F, Jiménez-Ruiz A. Rico E, et al. Among authors: gago f. PLoS One. 2014 Feb 26;9(2):e89526. doi: 10.1371/journal.pone.0089526. eCollection 2014. PLoS One. 2014. PMID: 24651293 Free PMC article.
Molecular recognition of epothilones by microtubules and tubulin dimers revealed by biochemical and NMR approaches.
Canales A, Nieto L, Rodríguez-Salarichs J, Sánchez-Murcia PA, Coderch C, Cortés-Cabrera A, Paterson I, Carlomagno T, Gago F, Andreu JM, Altmann KH, Jiménez-Barbero J, Díaz JF. Canales A, et al. Among authors: gago f. ACS Chem Biol. 2014 Apr 18;9(4):1033-43. doi: 10.1021/cb400673h. Epub 2014 Feb 25. ACS Chem Biol. 2014. PMID: 24524625 Free article.
ALFA: automatic ligand flexibility assignment.
Klett J, Cortés-Cabrera Á, Gil-Redondo R, Gago F, Morreale A. Klett J, et al. Among authors: gago f. J Chem Inf Model. 2014 Jan 27;54(1):314-23. doi: 10.1021/ci400453n. Epub 2014 Jan 15. J Chem Inf Model. 2014. PMID: 24392957
A structure-based design of new C2- and C13-substituted taxanes: tubulin binding affinities and extended quantitative structure-activity relationships using comparative binding energy (COMBINE) analysis.
Coderch C, Tang Y, Klett J, Zhang SE, Ma YT, Shaorong W, Matesanz R, Pera B, Canales A, Jiménez-Barbero J, Morreale A, Díaz JF, Fang WS, Gago F. Coderch C, et al. Among authors: gago f. Org Biomol Chem. 2013 May 14;11(18):3046-56. doi: 10.1039/c3ob40407b. Org Biomol Chem. 2013. PMID: 23532250 Free article.
MM-ISMSA: An Ultrafast and Accurate Scoring Function for Protein-Protein Docking.
Klett J, Núñez-Salgado A, Dos Santos HG, Cortés-Cabrera Á, Perona A, Gil-Redondo R, Abia D, Gago F, Morreale A. Klett J, et al. Among authors: gago f. J Chem Theory Comput. 2012 Sep 11;8(9):3395-408. doi: 10.1021/ct300497z. Epub 2012 Aug 14. J Chem Theory Comput. 2012. PMID: 26605745
AtlasCBS: a web server to map and explore chemico-biological space.
Cortés-Cabrera A, Morreale A, Gago F, Abad-Zapatero C. Cortés-Cabrera A, et al. Among authors: gago f. J Comput Aided Mol Des. 2012 Sep;26(9):995-1003. doi: 10.1007/s10822-012-9587-5. Epub 2012 Jul 14. J Comput Aided Mol Des. 2012. PMID: 22798082
CRDOCK: an ultrafast multipurpose protein-ligand docking tool.
Cortés Cabrera Á, Klett J, Dos Santos HG, Perona A, Gil-Redondo R, Francis SM, Priego EM, Gago F, Morreale A. Cortés Cabrera Á, et al. Among authors: gago f. J Chem Inf Model. 2012 Aug 27;52(8):2300-9. doi: 10.1021/ci300194a. Epub 2012 Jul 19. J Chem Inf Model. 2012. PMID: 22764680
Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway.
Balzarini J, Gago F, Kulik W, van Kuilenburg AB, Karlsson A, Peterson MA, Robins MJ. Balzarini J, et al. Among authors: gago f. J Biol Chem. 2012 Aug 31;287(36):30444-54. doi: 10.1074/jbc.M112.378091. Epub 2012 Jun 24. J Biol Chem. 2012. PMID: 22730407 Free PMC article.
Rationale for the opposite stereochemistry of the major monoadducts and interstrand crosslinks formed by mitomycin C and its decarbamoylated analogue at CpG steps in DNA and the effect of cytosine modification on reactivity.
Bueren-Calabuig JA, Negri A, Morreale A, Gago F. Bueren-Calabuig JA, et al. Among authors: gago f. Org Biomol Chem. 2012 Feb 28;10(8):1543-52. doi: 10.1039/c1ob06675g. Epub 2012 Jan 5. Org Biomol Chem. 2012. PMID: 22222915 Free article.
Reflections on the past 25 years.
Gago F. Gago F. J Comput Aided Mol Des. 2012 Jan;26(1):45. doi: 10.1007/s10822-011-9510-5. Epub 2011 Dec 21. J Comput Aided Mol Des. 2012. PMID: 22187138 No abstract available.
PM01183, a new DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity.
Leal JF, Martínez-Díez M, García-Hernández V, Moneo V, Domingo A, Bueren-Calabuig JA, Negri A, Gago F, Guillén-Navarro MJ, Avilés P, Cuevas C, García-Fernández LF, Galmarini CM. Leal JF, et al. Among authors: gago f. Br J Pharmacol. 2010 Nov;161(5):1099-110. doi: 10.1111/j.1476-5381.2010.00945.x. Br J Pharmacol. 2010. PMID: 20977459 Free PMC article.
In memoriam. Angel Ramírez Ortiz (1966-2008).
Abia D, Bastolla U, Chacón P, Fábrega C, Gago F, Morreale A, Tramontano A. Abia D, et al. Among authors: gago f. Proteins. 2010 Jan;78(1):iii-viii. doi: 10.1002/prot.22660. Proteins. 2010. PMID: 19937956 No abstract available.
Molecular pharmacology and antitumor activity of Zalypsis in several human cancer cell lines.
Leal JF, García-Hernández V, Moneo V, Domingo A, Bueren-Calabuig JA, Negri A, Gago F, Guillén-Navarro MJ, Avilés P, Cuevas C, García-Fernández LF, Galmarini CM. Leal JF, et al. Among authors: gago f. Biochem Pharmacol. 2009 Jul 15;78(2):162-70. doi: 10.1016/j.bcp.2009.04.003. Epub 2009 Apr 11. Biochem Pharmacol. 2009. PMID: 19427997
Identification of aspartic acid-203 in human thymidine phosphorylase as an important residue for both catalysis and non-competitive inhibition by the small molecule "crystallization chaperone" 5'-O-tritylinosine (KIN59).
Bronckaers A, Aguado L, Negri A, Camarasa MJ, Balzarini J, Pérez-Pérez MJ, Gago F, Liekens S. Bronckaers A, et al. Among authors: gago f. Biochem Pharmacol. 2009 Aug 1;78(3):231-40. doi: 10.1016/j.bcp.2009.04.011. Epub 2009 Apr 21. Biochem Pharmacol. 2009. PMID: 19389384 Free article.
Antitumor activity, X-ray crystal structure, and DNA binding properties of thiocoraline A, a natural bisintercalating thiodepsipeptide.
Negri A, Marco E, García-Hernández V, Domingo A, Llamas-Saiz AL, Porto-Sandá S, Riguera R, Laine W, David-Cordonnier MH, Bailly C, García-Fernández LF, Vaquero JJ, Gago F. Negri A, et al. Among authors: gago f. J Med Chem. 2007 Jul 12;50(14):3322-33. doi: 10.1021/jm070381s. Epub 2007 Jun 16. J Med Chem. 2007. PMID: 17571868
Involvement of novel human immunodeficiency virus type 1 reverse transcriptase mutations in the regulation of resistance to nucleoside inhibitors.
Svicher V, Sing T, Santoro MM, Forbici F, Rodríguez-Barrios F, Bertoli A, Beerenwinkel N, Bellocchi MC, Gago F, d'Arminio Monforte A, Antinori A, Lengauer T, Ceccherini-Silberstein F, Perno CF. Svicher V, et al. Among authors: gago f. J Virol. 2006 Jul;80(14):7186-98. doi: 10.1128/JVI.02084-05. J Virol. 2006. PMID: 16809324 Free PMC article.
Discovery of TSAO derivatives with an unusual HIV-1 activity/resistance profile.
de Castro S, García-Aparicio C, Van Laethem K, Gago F, Lobatón E, De Clercq E, Balzarini J, Camarasa MJ, Velázquez S. de Castro S, et al. Among authors: gago f. Antiviral Res. 2006 Aug;71(1):15-23. doi: 10.1016/j.antiviral.2006.02.009. Epub 2006 Mar 29. Antiviral Res. 2006. PMID: 16616962
Mitochondrial thymidine kinase inhibitors.
Pérez-Pérez MJ, Hernández AI, Priego EM, Rodríguez-Barrios F, Gago F, Camarasa MJ, Balzarini J. Pérez-Pérez MJ, et al. Among authors: gago f. Curr Top Med Chem. 2005;5(13):1205-19. doi: 10.2174/156802605774463097. Curr Top Med Chem. 2005. PMID: 16305527 Review.
High sequence conservation of human immunodeficiency virus type 1 reverse transcriptase under drug pressure despite the continuous appearance of mutations.
Ceccherini-Silberstein F, Gago F, Santoro M, Gori C, Svicher V, Rodríguez-Barrios F, d'Arrigo R, Ciccozzi M, Bertoli A, d'Arminio Monforte A, Balzarini J, Antinori A, Perno CF. Ceccherini-Silberstein F, et al. Among authors: gago f. J Virol. 2005 Aug;79(16):10718-29. doi: 10.1128/JVI.79.16.10718-10729.2005. J Virol. 2005. PMID: 16051864 Free PMC article.
The N137 and P140 amino acids in the p51 and the P95 amino acid in the p66 subunit of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase are instrumental to maintain catalytic activity and to design new classes of anti-HIV-1 drugs.
Auwerx J, Van Nieuwenhove J, Rodríguez-Barrios F, de Castro S, Velázquez S, Ceccherini-Silberstein F, De Clercq E, Camarasa MJ, Perno CF, Gago F, Balzarini J. Auwerx J, et al. Among authors: gago f. FEBS Lett. 2005 Apr 25;579(11):2294-300. doi: 10.1016/j.febslet.2005.02.077. FEBS Lett. 2005. PMID: 15848161 Free article.
The amino acid Asn136 in HIV-1 reverse transcriptase (RT) maintains efficient association of both RT subunits and enables the rational design of novel RT inhibitors.
Balzarini J, Auwerx J, Rodríguez-Barrios F, Chedad A, Farkas V, Ceccherini-Silberstein F, García-Aparicio C, Velázquez S, De Clercq E, Perno CF, Camarasa MJ, Gago F. Balzarini J, et al. Among authors: gago f. Mol Pharmacol. 2005 Jul;68(1):49-60. doi: 10.1124/mol.105.012435. Epub 2005 Apr 15. Mol Pharmacol. 2005. PMID: 15833734
Development of a new family of conformationally restricted peptides as potent nucleators of beta-turns. Design, synthesis, structure, and biological evaluation of a beta-lactam peptide analogue of melanostatin.
Palomo C, Aizpurua JM, Benito A, Miranda JI, Fratila RM, Matute C, Domercq M, Gago F, Martin-Santamaria S, Linden A. Palomo C, et al. Among authors: gago f. J Am Chem Soc. 2003 Dec 31;125(52):16243-60. doi: 10.1021/ja038180a. J Am Chem Soc. 2003. PMID: 14692766
Improving the selectivity of acyclic nucleoside analogues as inhibitors of human mitochondrial thymidine kinase: replacement of a triphenylmethoxy moiety with substituted amines and carboxamides.
Hernández AI, Balzarini J, Rodríguez-Barrios F, San-Félix A, Karlsson A, Gago F, Camarasa MJ, Pérez-Pérez MJ. Hernández AI, et al. Among authors: gago f. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3027-30. doi: 10.1016/s0960-894x(03)00639-5. Bioorg Med Chem Lett. 2003. PMID: 12941326
Identification of a putative binding site for [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine (TSAO) derivatives at the p51-p66 interface of HIV-1 reverse transcriptase.
Rodríguez-Barrios F, Pérez C, Lobatón E, Velázquez S, Chamorro C, San-Félix A, Pérez-Pérez MJ, Camarasa MJ, Pelemans H, Balzarini J, Gago F. Rodríguez-Barrios F, et al. Among authors: gago f. J Med Chem. 2001 Jun 7;44(12):1853-65. doi: 10.1021/jm001095i. J Med Chem. 2001. PMID: 11384232
Regulation of cyclooxygenase activity by metamizol.
Campos C, de Gregorio R, García-Nieto R, Gago F, Ortiz P, Alemany S. Campos C, et al. Among authors: gago f. Eur J Pharmacol. 1999 Aug 13;378(3):339-47. doi: 10.1016/s0014-2999(99)00477-x. Eur J Pharmacol. 1999. PMID: 10493111 Free article.
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