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First appraisal of brain pathology owing to A30P mutant alpha-synuclein.
Seidel K, Schöls L, Nuber S, Petrasch-Parwez E, Gierga K, Wszolek Z, Dickson D, Gai WP, Bornemann A, Riess O, Rami A, Den Dunnen WF, Deller T, Rüb U, Krüger R. Seidel K, et al. Among authors: gai wp. Ann Neurol. 2010 May;67(5):684-9. doi: 10.1002/ana.21966. Ann Neurol. 2010. PMID: 20437567
Alpha-synuclein aggregates activate calcium pump SERCA leading to calcium dysregulation.
Betzer C, Lassen LB, Olsen A, Kofoed RH, Reimer L, Gregersen E, Zheng J, Calì T, Gai WP, Chen T, Moeller A, Brini M, Fu Y, Halliday G, Brudek T, Aznar S, Pakkenberg B, Andersen JP, Jensen PH. Betzer C, et al. Among authors: gai wp. EMBO Rep. 2018 May;19(5):e44617. doi: 10.15252/embr.201744617. Epub 2018 Mar 29. EMBO Rep. 2018. PMID: 29599149 Free PMC article.
Axonal dystrophy in the brain of mice with Sanfilippo syndrome.
Beard H, Hassiotis S, Gai WP, Parkinson-Lawrence E, Hopwood JJ, Hemsley KM. Beard H, et al. Among authors: gai wp. Exp Neurol. 2017 Sep;295:243-255. doi: 10.1016/j.expneurol.2017.06.010. Epub 2017 Jun 8. Exp Neurol. 2017. PMID: 28601604
Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein α-synuclein.
Wang W, Nguyen LT, Burlak C, Chegini F, Guo F, Chataway T, Ju S, Fisher OS, Miller DW, Datta D, Wu F, Wu CX, Landeru A, Wells JA, Cookson MR, Boxer MB, Thomas CJ, Gai WP, Ringe D, Petsko GA, Hoang QQ. Wang W, et al. Among authors: gai wp. Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9587-92. doi: 10.1073/pnas.1610099113. Epub 2016 Aug 1. Proc Natl Acad Sci U S A. 2016. PMID: 27482083 Free PMC article.
Quantitative protein profiling of hippocampus during human aging.
Xu B, Gao Y, Zhan S, Xiong F, Qiu W, Qian X, Wang T, Wang N, Zhang D, Yang Q, Wang R, Bao X, Dou W, Tian R, Meng S, Gai WP, Huang Y, Yan XX, Ge W, Ma C. Xu B, et al. Among authors: gai wp. Neurobiol Aging. 2016 Mar;39:46-56. doi: 10.1016/j.neurobiolaging.2015.11.029. Epub 2015 Dec 8. Neurobiol Aging. 2016. PMID: 26923401
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