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The early local and systemic Type I interferon responses to ultraviolet B light exposure are cGAS dependent.
Skopelja-Gardner S, An J, Tai J, Tanaka L, Sun X, Hermanson P, Baum R, Kawasumi M, Green R, Gale M Jr, Kalus A, Werth VP, Elkon KB. Skopelja-Gardner S, et al. Among authors: Gale M. Sci Rep. 2020 May 13;10(1):7908. doi: 10.1038/s41598-020-64865-w. Sci Rep. 2020. PMID: 32404939 Free PMC article.
Innate Immunity in Hepatitis C Virus Infection.
Schwerk J, Negash A, Savan R, Gale M Jr. Schwerk J, et al. Among authors: Gale M. Cold Spring Harb Perspect Med. 2020 Apr 27:a036988. doi: 10.1101/cshperspect.a036988. Online ahead of print. Cold Spring Harb Perspect Med. 2020. PMID: 32341066
Flavivirus Nonstructural Protein NS5 Dysregulates HSP90 to Broadly Inhibit JAK/STAT Signaling.
Roby JA, Esser-Nobis K, Dewey-Verstelle EC, Fairgrieve MR, Schwerk J, Lu AY, Soveg FW, Hemann EA, Hatfield LD, Keller BC, Shapiro A, Forero A, Stencel-Baerenwald JE, Savan R, Gale M Jr. Roby JA, et al. Among authors: Gale M. Cells. 2020 Apr 7;9(4):899. doi: 10.3390/cells9040899. Cells. 2020. PMID: 32272626 Free PMC article.
Engagement of monocytes, NK cells, and CD4+ Th1 cells by ALVAC-SIV vaccination results in a decreased risk of SIVmac251 vaginal acquisition.
Gorini G, Fourati S, Vaccari M, Rahman MA, Gordon SN, Brown DR, Law L, Chang J, Green R, Barrenäs F, Liyanage NPM, Doster MN, Schifanella L, Bissa M, Silva de Castro I, Washington-Parks R, Galli V, Fuller DH, Santra S, Agy M, Pal R, Palermo RE, Tomaras GD, Shen X, LaBranche CC, Montefiori DC, Venzon DJ, Trinh HV, Rao M, Gale M Jr, Sekaly RP, Franchini G. Gorini G, et al. Among authors: Gale M. PLoS Pathog. 2020 Mar 12;16(3):e1008377. doi: 10.1371/journal.ppat.1008377. eCollection 2020 Mar. PLoS Pathog. 2020. PMID: 32163525 Free PMC article.
African green monkeys avoid SIV disease progression by preventing intestinal dysfunction and maintaining mucosal barrier integrity.
Raehtz KD, Barrenäs F, Xu C, Busman-Sahay K, Valentine A, Law L, Ma D, Policicchio BB, Wijewardana V, Brocca-Cofano E, Trichel A, Gale M Jr, Keele BF, Estes JD, Apetrei C, Pandrea I. Raehtz KD, et al. Among authors: Gale M. PLoS Pathog. 2020 Mar 2;16(3):e1008333. doi: 10.1371/journal.ppat.1008333. eCollection 2020 Mar. PLoS Pathog. 2020. PMID: 32119719 Free PMC article.
Human DNA-PK activates a STING-independent DNA sensing pathway.
Burleigh K, Maltbaek JH, Cambier S, Green R, Gale M Jr, James RC, Stetson DB. Burleigh K, et al. Among authors: Gale M. Sci Immunol. 2020 Jan 24;5(43):eaba4219. doi: 10.1126/sciimmunol.aba4219. Sci Immunol. 2020. PMID: 31980485
Author Correction: Macrophage-associated wound healing contributes to African green monkey SIV pathogenesis control.
Barrenas F, Raehtz K, Xu C, Law L, Green RR, Silvestri G, Bosinger SE, Nishida A, Li Q, Lu W, Zhang J, Thomas MJ, Chang J, Smith E, Weiss JM, Dawoud RA, Richter GH, Trichel A, Ma D, Peng X, Komorowski J, Apetrei C, Pandrea I, Gale M Jr. Barrenas F, et al. Among authors: Gale M. Nat Commun. 2019 Dec 13;10(1):5768. doi: 10.1038/s41467-019-13816-9. Nat Commun. 2019. PMID: 31836755 Free PMC article.
Strong TH1-biased CD4 T cell responses are associated with diminished SIV vaccine efficacy.
Chamcha V, Reddy PBJ, Kannanganat S, Wilkins C, Gangadhara S, Velu V, Green R, Law GL, Chang J, Bowen JR, Kozlowski PA, Lifton M, Santra S, Legere T, Chea LS, Chennareddi L, Yu T, Suthar MS, Silvestri G, Derdeyn CA, Gale M Jr, Villinger F, Hunter E, Amara RR. Chamcha V, et al. Among authors: Gale M. Sci Transl Med. 2019 Nov 20;11(519):eaav1800. doi: 10.1126/scitranslmed.aav1800. Sci Transl Med. 2019. PMID: 31748228
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