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Galectin-1 as a potential therapeutic target in autoimmune disorders and cancer.
Salatino M, Croci DO, Bianco GA, Ilarregui JM, Toscano MA, Rabinovich GA. Salatino M, et al. Expert Opin Biol Ther. 2008 Jan;8(1):45-57. doi: 10.1517/14712598.8.1.45. Expert Opin Biol Ther. 2008. PMID: 18081536 Review.
This endogenous lectin widely expressed at sites of inflammation and tumour growth, has been postulated as an attractive immunosuppressive agent to restore immune cell tolerance and homeostasis in autoimmune and inflammatory settings. On the other hand, galectin- …
This endogenous lectin widely expressed at sites of inflammation and tumour growth, has been postulated as an attractive immunosuppressive a …
Galectin-1: A Jack-of-All-Trades in the Resolution of Acute and Chronic Inflammation.
Sundblad V, Morosi LG, Geffner JR, Rabinovich GA. Sundblad V, et al. J Immunol. 2017 Dec 1;199(11):3721-3730. doi: 10.4049/jimmunol.1701172. J Immunol. 2017. PMID: 29158348 Review.
Regulatory signals provide negative input to immunological networks promoting resolution of acute and chronic inflammation. Galectin-1 (Gal-1), a member of a family of evolutionarily conserved glycan-binding proteins, displays broad anti-inflammatory and proresolvin …
Regulatory signals provide negative input to immunological networks promoting resolution of acute and chronic inflammation. Galectin- …
The sweet and the bitter sides of galectin-1 in immunity: its role in immune cell functions, apoptosis, and immunotherapies for cancer with a focus on T cells.
Novák J, Takács T, Tilajka Á, László L, Oravecz O, Farkas E, Than NG, Buday L, Balogh A, Vas V. Novák J, et al. Semin Immunopathol. 2025 Apr 3;47(1):24. doi: 10.1007/s00281-025-01047-8. Semin Immunopathol. 2025. PMID: 40178639 Free PMC article. Review.
These processes are key in resolving inflammation and preventing autoimmune diseases. On the other hand, Gal-1 has significant implications in cancer, where tumor cells and the tumor microenvironment (TME) (e.g., tumor-associated fibroblasts, myeloid-derived …
These processes are key in resolving inflammation and preventing autoimmune diseases. On the other hand, Gal-1 has significant …
Generation and characterization of a monoclonal antibody that binds to Galectin-1.
Pfeffer K, Ho TH, Grill FJ, Ruiz Y, Lake DF. Pfeffer K, et al. Protein Expr Purif. 2023 Oct;210:106308. doi: 10.1016/j.pep.2023.106308. Epub 2023 May 18. Protein Expr Purif. 2023. PMID: 37209931 Free PMC article.
Galectin-1 is a beta-galactoside-binding lectin that has been implicated as a suppressive molecule in cancer and autoimmune diseases. Gal-1 has known immunomodulatory activity and was found to be expressed on regulatory T cells, leading to the p …
Galectin-1 is a beta-galactoside-binding lectin that has been implicated as a suppressive molecule in cancer and aut …