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Galectin-1 as a potential therapeutic target in autoimmune disorders and cancer.
Salatino M, Croci DO, Bianco GA, Ilarregui JM, Toscano MA, Rabinovich GA. Salatino M, et al. Expert Opin Biol Ther. 2008 Jan;8(1):45-57. doi: 10.1517/14712598.8.1.45. Expert Opin Biol Ther. 2008. PMID: 18081536 Review.
This endogenous lectin widely expressed at sites of inflammation and tumour growth, has been postulated as an attractive immunosuppressive agent to restore immune cell tolerance and homeostasis in autoimmune and inflammatory settings. On the other hand, galectin- …
This endogenous lectin widely expressed at sites of inflammation and tumour growth, has been postulated as an attractive immunosuppressive a …
Galectin-1: A Jack-of-All-Trades in the Resolution of Acute and Chronic Inflammation.
Sundblad V, Morosi LG, Geffner JR, Rabinovich GA. Sundblad V, et al. J Immunol. 2017 Dec 1;199(11):3721-3730. doi: 10.4049/jimmunol.1701172. J Immunol. 2017. PMID: 29158348 Review.
Regulatory signals provide negative input to immunological networks promoting resolution of acute and chronic inflammation. Galectin-1 (Gal-1), a member of a family of evolutionarily conserved glycan-binding proteins, displays broad anti-inflammatory and pror …
Regulatory signals provide negative input to immunological networks promoting resolution of acute and chronic inflammation. Galectin- …
Generation and characterization of a monoclonal antibody that binds to Galectin-1.
Pfeffer K, Ho TH, Grill FJ, Ruiz Y, Lake DF. Pfeffer K, et al. Protein Expr Purif. 2023 May 18;210:106308. doi: 10.1016/j.pep.2023.106308. Online ahead of print. Protein Expr Purif. 2023. PMID: 37209931
Galectin-1 is a beta-galactoside-binding lectin that has been implicated as a suppressive molecule in cancer and autoimmune diseases. Gal-1 has known immunomodulatory activity and was found to be expressed on regulatory T cells, leading t …
Galectin-1 is a beta-galactoside-binding lectin that has been implicated as a suppressive molecule in cancer and aut …