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Dynein, Lis1 and CLIP-170 counteract Eg5-dependent centrosome separation during bipolar spindle assembly.
Tanenbaum ME, Macůrek L, Galjart N, Medema RH. Tanenbaum ME, et al. Among authors: galjart n. EMBO J. 2008 Dec 17;27(24):3235-45. doi: 10.1038/emboj.2008.242. Epub 2008 Nov 20. EMBO J. 2008. PMID: 19020519 Free PMC article.
A mutation in a mild form of galactosialidosis impairs dimerization of the protective protein and renders it unstable.
Zhou XY, Galjart NJ, Willemsen R, Gillemans N, Galjaard H, d'Azzo A. Zhou XY, et al. Among authors: galjart nj. EMBO J. 1991 Dec;10(13):4041-8. EMBO J. 1991. PMID: 1756715 Free PMC article.
CLIP-115, a novel brain-specific cytoplasmic linker protein, mediates the localization of dendritic lamellar bodies.
De Zeeuw CI, Hoogenraad CC, Goedknegt E, Hertzberg E, Neubauer A, Grosveld F, Galjart N. De Zeeuw CI, et al. Among authors: galjart n. Neuron. 1997 Dec;19(6):1187-99. doi: 10.1016/s0896-6273(00)80411-0. Neuron. 1997. PMID: 9427243
This protein contains two N-terminal microtubule-binding domains and a long coiled-coil region; it binds to microtubules and is homologous to CLIP-170, a protein mediating the binding of endosomes to microtubules. ...
This protein contains two N-terminal microtubule-binding domains and a long coiled-coil region; it binds to microtubules and is homol …
Functional analysis of CLIP-115 and its binding to microtubules.
Hoogenraad CC, Akhmanova A, Grosveld F, De Zeeuw CI, Galjart N. Hoogenraad CC, et al. Among authors: galjart n. J Cell Sci. 2000 Jun;113 ( Pt 12):2285-97. J Cell Sci. 2000. PMID: 10825300
Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts.
Akhmanova A, Hoogenraad CC, Drabek K, Stepanova T, Dortland B, Verkerk T, Vermeulen W, Burgering BM, De Zeeuw CI, Grosveld F, Galjart N. Akhmanova A, et al. Among authors: galjart n. Cell. 2001 Mar 23;104(6):923-35. doi: 10.1016/s0092-8674(01)00288-4. Cell. 2001. PMID: 11290329
Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes.
Hoogenraad CC, Akhmanova A, Howell SA, Dortland BR, De Zeeuw CI, Willemsen R, Visser P, Grosveld F, Galjart N. Hoogenraad CC, et al. Among authors: galjart n. EMBO J. 2001 Aug 1;20(15):4041-54. doi: 10.1093/emboj/20.15.4041. EMBO J. 2001. PMID: 11483508 Free PMC article.
Overexpression of the N-terminal domain of BICD2 disrupts minus-end-directed organelle distribution and this portion of BICD2 co-precipitates with cytoplasmic dynein. ...
Overexpression of the N-terminal domain of BICD2 disrupts minus-end-directed organelle distribution and this portion of BICD2 co-prec …
LIS1, CLIP-170's key to the dynein/dynactin pathway.
Coquelle FM, Caspi M, Cordelières FP, Dompierre JP, Dujardin DL, Koifman C, Martin P, Hoogenraad CC, Akhmanova A, Galjart N, De Mey JR, Reiner O. Coquelle FM, et al. Among authors: galjart n. Mol Cell Biol. 2002 May;22(9):3089-102. doi: 10.1128/mcb.22.9.3089-3102.2002. Mol Cell Biol. 2002. PMID: 11940666 Free PMC article.
Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice.
Hoogenraad CC, Koekkoek B, Akhmanova A, Krugers H, Dortland B, Miedema M, van Alphen A, Kistler WM, Jaegle M, Koutsourakis M, Van Camp N, Verhoye M, van der Linden A, Kaverina I, Grosveld F, De Zeeuw CI, Galjart N. Hoogenraad CC, et al. Among authors: galjart n. Nat Genet. 2002 Sep;32(1):116-27. doi: 10.1038/ng954. Epub 2002 Aug 26. Nat Genet. 2002. PMID: 12195424
Visualization of microtubule growth in cultured neurons via the use of EB3-GFP (end-binding protein 3-green fluorescent protein).
Stepanova T, Slemmer J, Hoogenraad CC, Lansbergen G, Dortland B, De Zeeuw CI, Grosveld F, van Cappellen G, Akhmanova A, Galjart N. Stepanova T, et al. Among authors: galjart n. J Neurosci. 2003 Apr 1;23(7):2655-64. doi: 10.1523/JNEUROSCI.23-07-02655.2003. J Neurosci. 2003. PMID: 12684451 Free PMC article.
Bicaudal D induces selective dynein-mediated microtubule minus end-directed transport.
Hoogenraad CC, Wulf P, Schiefermeier N, Stepanova T, Galjart N, Small JV, Grosveld F, de Zeeuw CI, Akhmanova A. Hoogenraad CC, et al. Among authors: galjart n. EMBO J. 2003 Nov 17;22(22):6004-15. doi: 10.1093/emboj/cdg592. EMBO J. 2003. PMID: 14609947 Free PMC article.
Here we report that the N-terminal portion of human Bicaudal D2 (BICD2) is capable of inducing microtubule minus end-directed movement independently of the molecular context. ...Here, we use the BICD2 N-terminal domain as a chimera with mitochondria and peroxisome-a …
Here we report that the N-terminal portion of human Bicaudal D2 (BICD2) is capable of inducing microtubule minus end-directed movemen …
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