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Proton pumping by complex I (NADH:ubiquinone oxidoreductase) from Yarrowia lipolytica reconstituted into proteoliposomes.
Dröse S, Galkin A, Brandt U. Dröse S, et al. Biochim Biophys Acta. 2005 Dec 20;1710(2-3):87-95. doi: 10.1016/j.bbabio.2005.10.001. Epub 2005 Oct 26. Biochim Biophys Acta. 2005. PMID: 16289468
A current controversy centers around the question whether electron transport of complex I is always linked to vectorial proton translocation or whether in some organisms the enzyme pumps sodium ions instead. ...
A current controversy centers around the question whether electron transport of complex I is always linked to vectorial proton transl
Differential susceptibility of mitochondrial complex II to inhibition by oxaloacetate in brain and heart.
Stepanova A, Shurubor Y, Valsecchi F, Manfredi G, Galkin A. Stepanova A, et al. Biochim Biophys Acta. 2016 Sep;1857(9):1561-1568. doi: 10.1016/j.bbabio.2016.06.002. Epub 2016 Jun 7. Biochim Biophys Acta. 2016. PMID: 27287543 Free PMC article.
Mitochondrial Complex II is a key mitochondrial enzyme connecting the tricarboxylic acid (TCA) cycle and the electron transport chain. ...Whether or not OAA inhibition of complex II is a physiologically relevant process is a significant, but still controversi …
Mitochondrial Complex II is a key mitochondrial enzyme connecting the tricarboxylic acid (TCA) cycle and the electron transport chain …
Characterisation of the active/de-active transition of mitochondrial complex I.
Babot M, Birch A, Labarbuta P, Galkin A. Babot M, et al. Biochim Biophys Acta. 2014 Jul;1837(7):1083-92. doi: 10.1016/j.bbabio.2014.02.018. Epub 2014 Feb 22. Biochim Biophys Acta. 2014. PMID: 24569053 Free PMC article. Review.
The A-form in situ can undergo de-activation when the activity of the respiratory chain is limited (i.e. in the absence of oxygen). ...The A/D transition could represent an intrinsic mechanism which provides a fast response of the mitochondrial respiratory ch …
The A-form in situ can undergo de-activation when the activity of the respiratory chain is limited (i.e. in the absence of oxygen). . …
Ischemic A/D transition of mitochondrial complex I and its role in ROS generation.
Dröse S, Stepanova A, Galkin A. Dröse S, et al. Biochim Biophys Acta. 2016 Jul;1857(7):946-57. doi: 10.1016/j.bbabio.2015.12.013. Epub 2016 Jan 9. Biochim Biophys Acta. 2016. PMID: 26777588 Free PMC article. Review.
In addition, this review discusses in detail the impact of the A/D transition on ROS production by complex I and the S-nitrosation of a critical cysteine residue of subunit ND3 as a strategy to prevent oxidative damage and tissue damage during ischemia-reperf …
In addition, this review discusses in detail the impact of the A/D transition on ROS production by complex I and the S-nitrosation of …
ND3, ND1 and 39kDa subunits are more exposed in the de-active form of bovine mitochondrial complex I.
Babot M, Labarbuta P, Birch A, Kee S, Fuszard M, Botting CH, Wittig I, Heide H, Galkin A. Babot M, et al. Biochim Biophys Acta. 2014 Jun;1837(6):929-39. doi: 10.1016/j.bbabio.2014.02.013. Epub 2014 Feb 21. Biochim Biophys Acta. 2014. PMID: 24560811 Free PMC article.
An intriguing feature of mitochondrial complex I from several species is the so-called A/D transition, whereby the idle enzyme spontaneously converts from the active (A) form to the de-active (D) form. ...Using lysine-specific fluorescent labelling and a DIGE …
An intriguing feature of mitochondrial complex I from several species is the so-called A/D transition, whereby the idle enzyme sponta …
Identification of the mitochondrial ND3 subunit as a structural component involved in the active/deactive enzyme transition of respiratory complex I.
Galkin A, Meyer B, Wittig I, Karas M, Schägger H, Vinogradov A, Brandt U. Galkin A, et al. J Biol Chem. 2008 Jul 25;283(30):20907-13. doi: 10.1074/jbc.M803190200. Epub 2008 May 23. J Biol Chem. 2008. PMID: 18502755 Free PMC article.
Apparently, a specific cysteine becomes accessible to chemical modification only in the deactive form of the enzyme. By selective fluorescence labeling and proteomic analysis, we have identified this residue as cysteine-39 of the mitochondrially encoded ND3 subunit of bovi …
Apparently, a specific cysteine becomes accessible to chemical modification only in the deactive form of the enzyme. By selective flu …
The proton pumping stoichiometry of purified mitochondrial complex I reconstituted into proteoliposomes.
Galkin A, Dröse S, Brandt U. Galkin A, et al. Biochim Biophys Acta. 2006 Dec;1757(12):1575-81. doi: 10.1016/j.bbabio.2006.10.001. Epub 2006 Oct 7. Biochim Biophys Acta. 2006. PMID: 17094937
For purified complex I reconstituted into proteoliposomes we measured a very similar pumping stoichiometry of 3.6H(+)/2e . This is the first demonstration that the proton pump of complex I stayed fully functional after purification of the enzyme....
For purified complex I reconstituted into proteoliposomes we measured a very similar pumping stoichiometry of 3.6H(+)/2e . This is th …
The Redox-Bohr group associated with iron-sulfur cluster N2 of complex I.
Zwicker K, Galkin A, Dröse S, Grgic L, Kerscher S, Brandt U. Zwicker K, et al. J Biol Chem. 2006 Aug 11;281(32):23013-7. doi: 10.1074/jbc.M603442200. Epub 2006 Jun 7. J Biol Chem. 2006. PMID: 16760472
A group exhibiting redox-linked protonation that is associated with iron-sulfur cluster N2 of complex I has been proposed to act as a central component of the proton pumping machinery. Here we show that a histidine in the 49-kDa subunit that resides near iron
A group exhibiting redox-linked protonation that is associated with iron-sulfur cluster N2 of complex I has been proposed to act as
HDQ (1-hydroxy-2-dodecyl-4(1H)quinolone), a high affinity inhibitor for mitochondrial alternative NADH dehydrogenase: evidence for a ping-pong mechanism.
Eschemann A, Galkin A, Oettmeier W, Brandt U, Kerscher S. Eschemann A, et al. J Biol Chem. 2005 Feb 4;280(5):3138-42. doi: 10.1074/jbc.M411217200. Epub 2004 Nov 8. J Biol Chem. 2005. PMID: 15533932
We have identified 1-hydroxy-2-dodecyl-4(1H)quinolone as a high affinity inhibitor of alternative NADH dehydrogenase from Yarrowia lipolytica. ...We found that the kinetics of alternative NADH dehydrogenase follow a ping-pong mechanism. This suggests that NADH and t …
We have identified 1-hydroxy-2-dodecyl-4(1H)quinolone as a high affinity inhibitor of alternative NADH dehydrogenase from Yarrowia li …
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