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The human polycystin-2 protein represents an integral membrane protein with six membrane-spanning domains and intracellular N- and C-termini.
Hoffmeister H, Gallagher AR, Rascle A, Witzgall R. Hoffmeister H, et al. Among authors: gallagher ar. Biochem J. 2011 Jan 15;433(2):285-94. doi: 10.1042/BJ20101141. Biochem J. 2011. PMID: 21044049
Molecular basis of autosomal-dominant polycystic kidney disease.
Gallagher AR, Hidaka S, Gretz N, Witzgall R. Gallagher AR, et al. Cell Mol Life Sci. 2002 Apr;59(4):682-93. doi: 10.1007/s00018-002-8457-z. Cell Mol Life Sci. 2002. PMID: 12022474 Review.
An ever-expanding story of cyst formation.
Gallagher AR, Obermüller N, Cedzich A, Gretz N, Witzgall R. Gallagher AR, et al. Cell Tissue Res. 2000 Jun;300(3):361-71. doi: 10.1007/s004410000215. Cell Tissue Res. 2000. PMID: 10928266 Review.
The rat pkd2 protein assumes distinct subcellular distributions in different organs.
Obermüller N, Gallagher AR, Cai Y, Gassler N, Gretz N, Somlo S, Witzgall R. Obermüller N, et al. Among authors: gallagher ar. Am J Physiol. 1999 Dec;277(6):F914-25. doi: 10.1152/ajprenal.1999.277.6.F914. Am J Physiol. 1999. PMID: 10600939
The polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeleton.
Gallagher AR, Cedzich A, Gretz N, Somlo S, Witzgall R. Gallagher AR, et al. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4017-22. doi: 10.1073/pnas.97.8.4017. Proc Natl Acad Sci U S A. 2000. PMID: 10760273 Free PMC article.
Steviol retards renal cyst growth through reduction of CFTR expression and inhibition of epithelial cell proliferation in a mouse model of polycystic kidney disease.
Yuajit C, Muanprasat C, Gallagher AR, Fedeles SV, Kittayaruksakul S, Homvisasevongsa S, Somlo S, Chatsudthipong V. Yuajit C, et al. Among authors: gallagher ar. Biochem Pharmacol. 2014 Apr 1;88(3):412-21. doi: 10.1016/j.bcp.2014.01.038. Epub 2014 Feb 8. Biochem Pharmacol. 2014. PMID: 24518257
Polycystin-1: a master regulator of intersecting cystic pathways.
Fedeles SV, Gallagher AR, Somlo S. Fedeles SV, et al. Among authors: gallagher ar. Trends Mol Med. 2014 May;20(5):251-60. doi: 10.1016/j.molmed.2014.01.004. Epub 2014 Jan 31. Trends Mol Med. 2014. PMID: 24491980 Free PMC article. Review.
A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation.
Fedeles SV, Tian X, Gallagher AR, Mitobe M, Nishio S, Lee SH, Cai Y, Geng L, Crews CM, Somlo S. Fedeles SV, et al. Among authors: gallagher ar. Nat Genet. 2011 Jun 19;43(7):639-47. doi: 10.1038/ng.860. Nat Genet. 2011. PMID: 21685914 Free PMC article.
Isolated polycystic liver disease genes define effectors of polycystin-1 function.
Besse W, Dong K, Choi J, Punia S, Fedeles SV, Choi M, Gallagher AR, Huang EB, Gulati A, Knight J, Mane S, Tahvanainen E, Tahvanainen P, Sanna-Cherchi S, Lifton RP, Watnick T, Pei YP, Torres VE, Somlo S. Besse W, et al. Among authors: gallagher ar. J Clin Invest. 2017 May 1;127(5):1772-1785. doi: 10.1172/JCI90129. Epub 2017 Apr 4. J Clin Invest. 2017. PMID: 28375157 Free PMC article.
A truncated polycystin-2 protein causes polycystic kidney disease and retinal degeneration in transgenic rats.
Gallagher AR, Hoffmann S, Brown N, Cedzich A, Meruvu S, Podlich D, Feng Y, Könecke V, de Vries U, Hammes HP, Gretz N, Witzgall R. Gallagher AR, et al. J Am Soc Nephrol. 2006 Oct;17(10):2719-30. doi: 10.1681/ASN.2005090979. Epub 2006 Aug 30. J Am Soc Nephrol. 2006. PMID: 16943309
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