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Human adenovirus type 35: nucleotide sequence and vector development.
Gao W, Robbins PD, Gambotto A. Gao W, et al. Gene Ther. 2003 Nov;10(23):1941-9. doi: 10.1038/sj.gt.3302097. Gene Ther. 2003. PMID: 14528318
The viral genome exhibits a compact organization similar to other adenoviral serotypes, with overlapping genes on both strands. ...Moreover, production of the E1-deleted recombinant Ad35 vector was achieved by transient transduction of a plasmid encoding the Ad35 E1 …
The viral genome exhibits a compact organization similar to other adenoviral serotypes, with overlapping genes on both strands. ...Mo …
Adenovirus-transduced dendritic cells injected into skin or lymph node prime potent simian immunodeficiency virus-specific T cell immunity in monkeys.
Brown K, Gao W, Alber S, Trichel A, Murphey-Corb M, Watkins SC, Gambotto A, Barratt-Boyes SM. Brown K, et al. J Immunol. 2003 Dec 15;171(12):6875-82. doi: 10.4049/jimmunol.171.12.6875. J Immunol. 2003. PMID: 14662894
To test this hypothesis in a relevant primate model, we used recombinant adenovirus serotype 5 vectors expressing SIV Gag Ag to transduce monocyte-derived DC from rhesus macaques, and then immunized donor animals either by intradermal or intranodal injections. ...Surprisin …
To test this hypothesis in a relevant primate model, we used recombinant adenovirus serotype 5 vectors expressing SIV Gag Ag to trans …
Dendritic cells transduced to express interleukin-4 prevent diabetes in nonobese diabetic mice with advanced insulitis.
Feili-Hariri M, Falkner DH, Gambotto A, Papworth GD, Watkins SC, Robbins PD, Morel PA. Feili-Hariri M, et al. Hum Gene Ther. 2003 Jan 1;14(1):13-23. doi: 10.1089/10430340360464679. Hum Gene Ther. 2003. PMID: 12573055
In this report, as a means of treating NOD mice with more advanced insulitis, we infected DC with adenoviral vectors expressing interleukin (IL)-4 (Ad.IL-4), eGFP (Ad.eGFP), or empty vector (Ad psi 5). ...
In this report, as a means of treating NOD mice with more advanced insulitis, we infected DC with adenoviral vectors expressing inter …
Epidermal growth factor receptor-transfected bone marrow stromal cells exhibit enhanced migratory response and therapeutic potential against murine brain tumors.
Sato H, Kuwashima N, Sakaida T, Hatano M, Dusak JE, Fellows-Mayle WK, Papworth GD, Watkins SC, Gambotto A, Pollack IF, Okada H. Sato H, et al. Cancer Gene Ther. 2005 Sep;12(9):757-68. doi: 10.1038/sj.cgt.7700827. Cancer Gene Ther. 2005. PMID: 15832173
We have created a novel cellular vehicle for gene therapy of malignant gliomas by transfection of murine bone marrow stroma cells (MSCs) with a cDNA encoding epidermal growth factor receptor (EGFR). ...
We have created a novel cellular vehicle for gene therapy of malignant gliomas by transfection of murine bone marrow stroma cells (MS …
Exosomes derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritis.
Kim SH, Lechman ER, Bianco N, Menon R, Keravala A, Nash J, Mi Z, Watkins SC, Gambotto A, Robbins PD. Kim SH, et al. J Immunol. 2005 May 15;174(10):6440-8. doi: 10.4049/jimmunol.174.10.6440. J Immunol. 2005. PMID: 15879146
We have demonstrated previously that local, adenoviral-mediated gene transfer of viral IL-10 to a single joint of rabbits and mice with experimental arthritis can suppress disease in both the treated and untreated contralateral joints. ...Thus DC-derived exosomes may repre …
We have demonstrated previously that local, adenoviral-mediated gene transfer of viral IL-10 to a single joint of rabbits and mice wi …
Rapid Generation of Multiple Loci-Engineered Marker-free Poxvirus and Characterization of a Clinical-Grade Oncolytic Vaccinia Virus.
Guo ZS, Liu Z, Sathaiah M, Wang J, Ravindranathan R, Kim E, Huang S, Kenniston TW, Bell JC, Zeh HJ 3rd, Butterfield LH, Gambotto A, Bartlett DL. Guo ZS, et al. Among authors: gambotto a. Mol Ther Methods Clin Dev. 2017 Sep 30;7:112-122. doi: 10.1016/j.omtm.2017.09.007. eCollection 2017 Dec 15. Mol Ther Methods Clin Dev. 2017. PMID: 29085848 Free PMC article.
Lentiviral vectors encoding human MUC1-specific, MHC-unrestricted single-chain TCR and a fusion suicide gene: potential for universal and safe cancer immunotherapy.
Chen X, Gao W, Gambotto A, Finn OJ. Chen X, et al. Cancer Immunol Immunother. 2009 Jun;58(6):977-87. doi: 10.1007/s00262-008-0624-0. Epub 2008 Nov 21. Cancer Immunol Immunother. 2009. PMID: 19023569
MUC1 tumor antigen is a target for immunotherapy of most human adenocarcinomas and some hematological malignancies. Expression of a MUC1-specific, MHC-unrestricted single-chain T cell receptor (scTCR) on cells of both innate and adaptive immune system through recons …
MUC1 tumor antigen is a target for immunotherapy of most human adenocarcinomas and some hematological malignancies. Expression of …
Adenovirus 5- and 35-based immunotherapy enhances the strength but not breadth or quality of immunity during chronic SIV infection.
Soloff AC, Liu X, Gao W, Day RD, Gambotto A, Barratt-Boyes SM. Soloff AC, et al. Eur J Immunol. 2009 Sep;39(9):2437-49. doi: 10.1002/eji.200839130. Eur J Immunol. 2009. PMID: 19670380
Boosting with human adenovirus serotype 35-based vectors during a second ART cycle increased Ag-specific T cells to 50-fold above pre-vaccination levels and boosted CD4(+) Tcm numbers but did not expand the breadth or quality of immunity or control virus levels following d …
Boosting with human adenovirus serotype 35-based vectors during a second ART cycle increased Ag-specific T cells to 50-fold above pre …
Development of an adenovirus-based respiratory syncytial virus vaccine: preclinical evaluation of efficacy, immunogenicity, and enhanced disease in a cotton rat model.
Kim E, Okada K, Beeler JA, Crim RL, Piedra PA, Gilbert BE, Gambotto A. Kim E, et al. J Virol. 2014 May;88(9):5100-8. doi: 10.1128/JVI.03194-13. Epub 2014 Feb 26. J Virol. 2014. PMID: 24574396 Free PMC article.
The lack of a vaccine against respiratory syncytial virus (RSV) is a challenging and serious gap in preventive medicine. Herein, we characterize the immunogenicity of an adenovirus serotype 5-based RSV vaccine encoding the fusion (F) protein (Ad5.RSV-F) and the prot …
The lack of a vaccine against respiratory syncytial virus (RSV) is a challenging and serious gap in preventive medicine. Herei …
Assessment of route of administration and dose escalation for an adenovirus-based influenza A Virus (H5N1) vaccine in chickens.
Steitz J, Wagner RA, Bristol T, Gao W, Donis RO, Gambotto A. Steitz J, et al. Clin Vaccine Immunol. 2010 Sep;17(9):1467-72. doi: 10.1128/CVI.00180-10. Epub 2010 Jul 21. Clin Vaccine Immunol. 2010. PMID: 20660133 Free PMC article.
A dose as low as 10(7) viral particles (vp) of adenovirus-based H5N1 vaccine per chicken was sufficient to generate a robust humoral immune response, which correlated with the previously reported level of protection. ...However, only the subcutaneous route of immuni
A dose as low as 10(7) viral particles (vp) of adenovirus-based H5N1 vaccine per chicken was sufficient to generate a robust h
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