Gan LS - Search Results

1

CYP3A4 induction by xenobiotics: biochemistry, experimental methods and impact on drug discovery and development.

Luo G, Guenthner T, Gan LS, Humphreys WG. Luo G, et al. Among authors: gan ls. Curr Drug Metab. 2004 Dec;5(6):483-505. doi: 10.2174/1389200043335397. Curr Drug Metab. 2004. PMID: 15578943 Review.

2

Concurrent induction and mechanism-based inactivation of CYP3A4 by an L-valinamide derivative.

Luo G, Lin J, Fiske WD, Dai R, Yang TJ, Kim S, Sinz M, LeCluyse E, Solon E, Brennan JM, Benedek IH, Jolley S, Gilbert D, Wang L, Lee FW, Gan LS. Luo G, et al. Among authors: gan ls. Drug Metab Dispos. 2003 Sep;31(9):1170-5. doi: 10.1124/dmd.31.9.1170. Drug Metab Dispos. 2003. PMID: 12920173

3

CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes.

Luo G, Cunningham M, Kim S, Burn T, Lin J, Sinz M, Hamilton G, Rizzo C, Jolley S, Gilbert D, Downey A, Mudra D, Graham R, Carroll K, Xie J, Madan A, Parkinson A, Christ D, Selling B, LeCluyse E, Gan LS. Luo G, et al. Among authors: gan ls. Drug Metab Dispos. 2002 Jul;30(7):795-804. doi: 10.1124/dmd.30.7.795. Drug Metab Dispos. 2002. PMID: 12065438

4

Effect of DPC 333 [(2R)-2-{(3R)-3-amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a human tumor necrosis factor alpha-converting enzyme inhibitor, on the disposition of methotrexate: a transporter-based drug-drug interaction case study.

Luo G, Garner CE, Xiong H, Hu H, Richards LE, Brouwer KL, Duan J, Decicco CP, Maduskuie T, Shen H, Lee FW, Gan LS. Luo G, et al. Among authors: gan ls. Drug Metab Dispos. 2007 Jun;35(6):835-40. doi: 10.1124/dmd.106.013946. Epub 2007 Mar 1. Drug Metab Dispos. 2007. PMID: 17332143

5

Interaction of ritonavir on tissue distribution of a [(14)c]L-valinamide, a potent human immunodeficiency virus-1 protease inhibitor, in rats using quantitative whole-body autoradiography.

Solon EG, Balani SK, Luo G, Yang TJ, Haines PJ, Wang L, Demond T, Diamond S, Christ DD, Gan LS, Lee FW. Solon EG, et al. Among authors: gan ls. Drug Metab Dispos. 2002 Nov;30(11):1164-9. doi: 10.1124/dmd.30.11.1164. Drug Metab Dispos. 2002. PMID: 12386120

6

Evaluation of drug-transporter interactions using in vitro and in vivo models.

Xia CQ, Milton MN, Gan LS. Xia CQ, et al. Among authors: gan ls. Curr Drug Metab. 2007 May;8(4):341-63. doi: 10.2174/138920007780655423. Curr Drug Metab. 2007. PMID: 17504223 Review.

7

Metabolism of (S)-5,6-difluoro-4-cyclopropylethynyl-4-trifluoromethyl-3, 4-dihydro-2(1H)-quinazolinone, a non-nucleoside reverse transcriptase inhibitor, in human liver microsomes. Metabolic activation and enzyme kinetics.

Chen H, Chen W, Gan LS, Mutlib AE. Chen H, et al. Among authors: gan ls. Drug Metab Dispos. 2003 Jan;31(1):122-32. doi: 10.1124/dmd.31.1.122. Drug Metab Dispos. 2003. PMID: 12485961

8

Investigation of drug-drug interaction potential of bortezomib in vivo in female Sprague-Dawley rats and in vitro in human liver microsomes.

Lu C, Gallegos R, Li P, Xia CQ, Pusalkar S, Uttamsingh V, Nix D, Miwa GT, Gan LS. Lu C, et al. Among authors: gan ls. Drug Metab Dispos. 2006 Apr;34(4):702-8. doi: 10.1124/dmd.105.008060. Epub 2006 Jan 27. Drug Metab Dispos. 2006. PMID: 16443666

9

Relative contributions of the five major human cytochromes P450, 1A2, 2C9, 2C19, 2D6, and 3A4, to the hepatic metabolism of the proteasome inhibitor bortezomib.

Uttamsingh V, Lu C, Miwa G, Gan LS. Uttamsingh V, et al. Among authors: gan ls. Drug Metab Dispos. 2005 Nov;33(11):1723-8. doi: 10.1124/dmd.105.005710. Epub 2005 Aug 15. Drug Metab Dispos. 2005. PMID: 16103134

10

An indirect screen for brain uptake of 1,2-diarylethane melanocortin 4 receptor antagonists in rats.

Yin W, Gan LS, Wu JT, Balani SK, Yang H, Lee FW. Yin W, et al. Among authors: gan ls. Drug Metab Lett. 2007 Aug;1(3):195-8. doi: 10.2174/187231207781369753. Drug Metab Lett. 2007. PMID: 19356043

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