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Induction of PA2.26, a cell-surface antigen expressed by active fibroblasts, in mouse epidermal keratinocytes during carcinogenesis.
Gandarillas A, Scholl FG, Benito N, Gamallo C, Quintanilla M. Gandarillas A, et al. Mol Carcinog. 1997 Sep;20(1):10-8. doi: 10.1002/(sici)1098-2744(199709)20:1<10::aid-mc3>3.0.co;2-m. Mol Carcinog. 1997. PMID: 9328432
The monoclonal antibody PA2.26, produced against mouse epidermal keratinocytes transformed with 7,12-dimethylbenz[a]anthracene (DMBA), recognizes a 43- to 47-kDa cell-surface protein that was absent from non-tumorigenic epidermal keratinocytes but present in transfo …
The monoclonal antibody PA2.26, produced against mouse epidermal keratinocytes transformed with 7,12-dimethylbenz[a]anthracene (DMBA) …
Inefficient differentiation response to cell cycle stress leads to genomic instability and malignant progression of squamous carcinoma cells.
Alonso-Lecue P, de Pedro I, Coulon V, Molinuevo R, Lorz C, Segrelles C, Ceballos L, López-Aventín D, García-Valtuille A, Bernal JM, Mazorra F, Pujol RM, Paramio J, Ramón Sanz J, Freije A, Toll A, Gandarillas A. Alonso-Lecue P, et al. Cell Death Dis. 2017 Jun 29;8(6):e2901. doi: 10.1038/cddis.2017.259. Cell Death Dis. 2017. PMID: 28661481 Free PMC article.
Consistently, in a series of human biopsies, non-metastatic SCCs displayed a higher degree of chromosomal alterations and higher expression of the S phase regulator Cyclin E and the DNA damage signal γH2AX than the less aggressive, non-squamous, basal cell carcinoma …
Consistently, in a series of human biopsies, non-metastatic SCCs displayed a higher degree of chromosomal alterations and high …
c-Myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver.
Baena E, Gandarillas A, Vallespinós M, Zanet J, Bachs O, Redondo C, Fabregat I, Martinez-A C, de Alborán IM. Baena E, et al. Proc Natl Acad Sci U S A. 2005 May 17;102(20):7286-91. doi: 10.1073/pnas.0409260102. Epub 2005 Apr 27. Proc Natl Acad Sci U S A. 2005. PMID: 15857952 Free PMC article.
The c-Myc protein is a transcription factor implicated in the regulation of multiple biological processes, including cell proliferation, cell growth, and apoptosis. In vivo overexpression of c-myc is linked to tumor development in a number of mouse models. Here, we …
The c-Myc protein is a transcription factor implicated in the regulation of multiple biological processes, including cell proliferati …
Biochemical characterization of Artemia ras p21.
Gandarillas A, Renart J, Quintanilla M. Gandarillas A, et al. Mol Cell Biochem. 1992 May 13;112(1):29-33. doi: 10.1007/BF00229640. Mol Cell Biochem. 1992. PMID: 1513332
Changes in keratin expression during malignant progression of transformed mouse epidermal keratinocytes.
Caulín C, Bauluz C, Gandarillas A, Cano A, Quintanilla M. Caulín C, et al. Exp Cell Res. 1993 Jan;204(1):11-21. doi: 10.1006/excr.1993.1003. Exp Cell Res. 1993. PMID: 7677983
On the other hand, K8 does not generally colocalize with K13, a keratin also aberrantly expressed by epidermal cell cultures when induced to differentiate by high Ca2+ medium. ...However, this relation is inverted in tumors induced by PDVC57 cells, in a good correla …
On the other hand, K8 does not generally colocalize with K13, a keratin also aberrantly expressed by epidermal cell cultures when ind …
Expression of intermediate filament proteins by normal and transformed mouse epidermal-keratinocytes in culture.
Caulin C, Gandarillas A, Scholl F, Quintanilla M. Caulin C, et al. Int J Oncol. 1993 Mar;2(3):373-9. doi: 10.3892/ijo.2.3.373. Int J Oncol. 1993. PMID: 21573564
These results reinforce our previous suggestion that the expression of these keratins during mouse epidermal carcinogenesis is a marker of malignant transformation. The comparison of the two-dimensional electrophoresis intermediate filament protein profiles of transformed …
These results reinforce our previous suggestion that the expression of these keratins during mouse epidermal carcinogenesis is a mark …
Evidence that apoptosis and terminal differentiation of epidermal keratinocytes are distinct processes.
Gandarillas A, Goldsmith LA, Gschmeissner S, Leigh IM, Watt FM. Gandarillas A, et al. Exp Dermatol. 1999 Feb;8(1):71-9. doi: 10.1111/j.1600-0625.1999.tb00350.x. Exp Dermatol. 1999. PMID: 10206724
Although there are clear parallels between apoptosis and epidermal terminal differentiation it is unclear whether terminal differentiation of keratinocytes is a form of apoptosis. ...However, the majority of viable epidermal layers in diseased skin were positive by TUNEL l …
Although there are clear parallels between apoptosis and epidermal terminal differentiation it is unclear whether terminal differentiation o …
Factors Secreted by Cancer-Associated Fibroblasts that Sustain Cancer Stem Properties in Head and Neck Squamous Carcinoma Cells as Potential Therapeutic Targets.
Álvarez-Teijeiro S, García-Inclán C, Villaronga MÁ, Casado P, Hermida-Prado F, Granda-Díaz R, Rodrigo JP, Calvo F, Del-Río-Ibisate N, Gandarillas A, Morís F, Hermsen M, Cutillas P, García-Pedrero JM. Álvarez-Teijeiro S, et al. Among authors: gandarillas a. Cancers (Basel). 2018 Sep 17;10(9):334. doi: 10.3390/cancers10090334. Cancers (Basel). 2018. PMID: 30227608 Free PMC article.
Response of head and neck epithelial cells to a DNA damage-differentiation checkpoint involving polyploidization.
Sanz-Gómez N, Freije A, Ceballos L, Obeso S, Sanz JR, García-Reija F, Morales-Angulo C, Gandarillas A. Sanz-Gómez N, et al. Among authors: gandarillas a. Head Neck. 2018 Nov;40(11):2487-2497. doi: 10.1002/hed.25376. Epub 2018 Oct 12. Head Neck. 2018. PMID: 30311985
Keratinocyte Differentiation by Flow Cytometry.
Sanz-Gómez N, Freije A, Gandarillas A. Sanz-Gómez N, et al. Among authors: gandarillas a. Methods Mol Biol. 2020;2109:83-92. doi: 10.1007/7651_2019_237. Methods Mol Biol. 2020. PMID: 31123997
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