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An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway.
Garner TP, Reyna DE, Priyadarshi A, Chen HC, Li S, Wu Y, Ganesan YT, Malashkevich VN, Cheng EH, Gavathiotis E. Garner TP, et al. Among authors: ganesan yt. Mol Cell. 2016 Aug 4;63(3):485-97. doi: 10.1016/j.molcel.2016.06.010. Epub 2016 Jul 14. Mol Cell. 2016. PMID: 27425408 Free PMC article.
An interconnected hierarchical model of cell death regulation by the BCL-2 family.
Chen HC, Kanai M, Inoue-Yamauchi A, Tu HC, Huang Y, Ren D, Kim H, Takeda S, Reyna DE, Chan PM, Ganesan YT, Liao CP, Gavathiotis E, Hsieh JJ, Cheng EH. Chen HC, et al. Among authors: ganesan yt. Nat Cell Biol. 2015 Oct;17(10):1270-81. doi: 10.1038/ncb3236. Epub 2015 Sep 7. Nat Cell Biol. 2015. PMID: 26344567 Free PMC article.
An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway.
Garner TP, Reyna DE, Priyadarshi A, Chen HC, Li S, Wu Y, Ganesan YT, Malashkevich VN, Cheng EH, Gavathiotis E. Garner TP, et al. Among authors: ganesan yt. Mol Cell. 2016 Oct 20;64(2):431. doi: 10.1016/j.molcel.2016.10.005. Mol Cell. 2016. PMID: 27768876 Free article. No abstract available.
PUMA and BIM are required for oncogene inactivation-induced apoptosis.
Bean GR, Ganesan YT, Dong Y, Takeda S, Liu H, Chan PM, Huang Y, Chodosh LA, Zambetti GP, Hsieh JJ, Cheng EH. Bean GR, et al. Among authors: ganesan yt. Sci Signal. 2013 Mar 26;6(268):ra20. doi: 10.1126/scisignal.2003483. Sci Signal. 2013. PMID: 23532334 Free PMC article.
Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis.
Tanaka K, Yu HA, Yang S, Han S, Selcuklu SD, Kim K, Ramani S, Ganesan YT, Moyer A, Sinha S, Xie Y, Ishizawa K, Osmanbeyoglu HU, Lyu Y, Roper N, Guha U, Rudin CM, Kris MG, Hsieh JJ, Cheng EH. Tanaka K, et al. Among authors: ganesan yt. Cancer Cell. 2021 Sep 13;39(9):1245-1261.e6. doi: 10.1016/j.ccell.2021.07.006. Epub 2021 Aug 12. Cancer Cell. 2021. PMID: 34388376 Free PMC article.
Bcl-xL stimulates Bax relocation to mitochondria and primes cells to ABT-737.
Renault TT, Teijido O, Missire F, Ganesan YT, Velours G, Arokium H, Beaumatin F, Llanos R, Athané A, Camougrand N, Priault M, Antonsson B, Dejean LM, Manon S. Renault TT, et al. Among authors: ganesan yt. Int J Biochem Cell Biol. 2015 Jul;64:136-46. doi: 10.1016/j.biocel.2015.03.020. Epub 2015 Apr 8. Int J Biochem Cell Biol. 2015. PMID: 25862283