Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2010 1
2011 1
2012 1
2015 2
2017 2
2018 4
2019 3
2020 5
2021 3
2022 4
2023 2
2024 4
2025 6
2026 2

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

36 results

Results by year

Filters applied: . Clear all
Page 2
Effects of Reishimmune-S, a Fungal Immunomodulatory Peptide Supplement, on the Quality of Life and Circulating Natural Killer Cell Profiles of Patients With Early Breast Cancer Receiving Adjuvant Endocrine Therapy.
Su YW, Huang WY, Lin SH, Yang PS. Su YW, et al. Integr Cancer Ther. 2024 Jan-Dec;23:15347354241242120. doi: 10.1177/15347354241242120. Integr Cancer Ther. 2024. PMID: 38590244 Free PMC article.
OBJECTIVES: To evaluate the effects of Reishimmune-S, a fungal immunomodulatory peptide, on the quality of life (QoL) and natural killer (NK) cell subpopulations in patients receiving adjuvant endocrine therapy (ET) for breast cancer (BC). ...
OBJECTIVES: To evaluate the effects of Reishimmune-S, a fungal immunomodulatory peptide, on the quality of life (QoL) and natural kil …
Ganoderma microsporum immunomodulatory protein as an extracellular epidermal growth factor receptor (EGFR) degrader for suppressing EGFR-positive lung cancer cells.
Hua WJ, Yeh H, Lin ZH, Tseng AJ, Huang LC, Qiu WL, Tu TH, Wang DH, Hsu WH, Hwang WL, Lin TY. Hua WJ, et al. Cancer Lett. 2023 Dec 1;578:216458. doi: 10.1016/j.canlet.2023.216458. Epub 2023 Oct 20. Cancer Lett. 2023. PMID: 37865161
A newly developed strategy for cancer therapy is induction of EGFR degradation. GMI, an immunomodulatory protein from the medicinal mushroom Ganoderma microsporum, exhibits anticancer activity. ...
A newly developed strategy for cancer therapy is induction of EGFR degradation. GMI, an immunomodulatory protein from the medi …
GMI, a fungal immunomodulatory protein, ameliorates SARS-CoV-2 envelope protein-induced inflammation in macrophages via inhibition of MAPK pathway.
Lin ZH, Yeh H, Lo HC, Hua WJ, Ni MY, Wang LK, Chang TT, Yang MH, Lin TY. Lin ZH, et al. Int J Biol Macromol. 2023 Jun 30;241:124648. doi: 10.1016/j.ijbiomac.2023.124648. Epub 2023 Apr 28. Int J Biol Macromol. 2023. PMID: 37119883 Free PMC article.
Clinically, COVID-19 is often accompanied by a severe immune response (cytokine storm) which produces a large number of cytokines, such as TNF-alpha, IL-6 and IL-12, and consequently causes acute respiratory distress syndrome (ARDS). GMI is a type of fungal immunomodulatory …
Clinically, COVID-19 is often accompanied by a severe immune response (cytokine storm) which produces a large number of cytokines, such as T …
Ganoderma microsporum immunomodulatory protein acts as a multifunctional broad-spectrum antiviral against SARS-CoV-2 by interfering virus binding to the host cells and spike-mediated cell fusion.
Ho HPT, Vo DNK, Lin TY, Hung JN, Chiu YH, Tsai MH. Ho HPT, et al. Biomed Pharmacother. 2022 Nov;155:113766. doi: 10.1016/j.biopha.2022.113766. Epub 2022 Sep 28. Biomed Pharmacother. 2022. PMID: 36271550 Free PMC article.
Due to this characteristic, a broad-spectrum inhibitor against SARS-CoV-2 infection is urgently demanded. Ganoderma microsporum immunomodulatory protein (GMI) was previously reported to alleviate infection of SARS-CoV-2 through ACE2 downregulation wher …
Due to this characteristic, a broad-spectrum inhibitor against SARS-CoV-2 infection is urgently demanded. Ganoderma microsporum …
GMI, a protein from Ganoderma microsporum, induces ACE2 degradation to alleviate infection of SARS-CoV-2 Spike-pseudotyped virus.
Yeh H, Vo DNK, Lin ZH, Ho HPT, Hua WJ, Qiu WL, Tsai MH, Lin TY. Yeh H, et al. Phytomedicine. 2022 Aug;103:154215. doi: 10.1016/j.phymed.2022.154215. Epub 2022 May 28. Phytomedicine. 2022. PMID: 35691077 Free PMC article.
Therefore, the blocking of SARS-CoV-2 infection may be potential therapeutic strategies. Ganoderma microsporum immunomodulatory protein (GMI), a small fungal protein, is cloned from Ganoderma microsporum. ...GMI slightly interfered …
Therefore, the blocking of SARS-CoV-2 infection may be potential therapeutic strategies. Ganoderma microsporum immunomodula …
Safety assessment of the fungal immunomodulatory protein from Ganoderma microsporum (GMI) derived from engineered Pichia pastoris: Genetic toxicology, a 13-week oral gavage toxicity study, and an embryo-fetal developmental toxicity study in Sprague-Dawley rats.
Fu HY, Hseu RS. Fu HY, et al. Toxicol Rep. 2022 May 26;9:1240-1254. doi: 10.1016/j.toxrep.2022.05.013. eCollection 2022. Toxicol Rep. 2022. PMID: 36518484 Free PMC article.
The 12.4 kDa fungal immunomodulatory protein from Ganoderma microsporum (GMI) has bioactivity in vitro and in vivo. ...
The 12.4 kDa fungal immunomodulatory protein from Ganoderma microsporum (GMI) has bioactivity in vitro and in vi …
Immunomodulatory protein from ganoderma microsporum protects against oxidative damages and cognitive impairments after traumatic brain injury.
Chao MW, Liao CW, Lin CH, Tseng CY. Chao MW, et al. Mol Cell Neurosci. 2022 May;120:103735. doi: 10.1016/j.mcn.2022.103735. Epub 2022 May 11. Mol Cell Neurosci. 2022. PMID: 35562037
Recent interests have focused on the benefits of supplements or natural products like Ganoderma. Studies have indicated that immunomodulatory protein from Ganoderma microsporum (GMI) inhibits oxidative stress in lung cancer cells A549 and induces cance …
Recent interests have focused on the benefits of supplements or natural products like Ganoderma. Studies have indicated that immunomodula …
GMI, an Immunomodulatory Peptide from Ganoderma microsporum, Restrains Periprosthetic Joint Infections via Modulating the Functions of Myeloid-Derived Suppressor Cells and Effector T Cells.
Peng KT, Chen JL, Kuo LT, Yu PA, Hsu WH, Lee CW, Chang PJ, Huang TY. Peng KT, et al. Int J Mol Sci. 2021 Jun 25;22(13):6854. doi: 10.3390/ijms22136854. Int J Mol Sci. 2021. PMID: 34202218 Free PMC article.
This study finds that GMI, a fungal immunomodulatory peptide isolated from Ganoderma microsporum, suppresses MDSC expansion to promote the proliferation of cytotoxic T cells. ...
This study finds that GMI, a fungal immunomodulatory peptide isolated from Ganoderma microsporum, suppresses MDSC expan …
Combination treatment of Src inhibitor Saracatinib with GMI, a Ganoderma microsporum immunomodulatory protein, induce synthetic lethality via autophagy and apoptosis in lung cancer cells.
Chiu LY, Hsin IL, Tsai JN, Chen CJ, Ou CC, Wu WJ, Sheu GT, Ko JL. Chiu LY, et al. J Cell Physiol. 2021 Feb;236(2):1148-1157. doi: 10.1002/jcp.29924. Epub 2020 Jul 19. J Cell Physiol. 2021. PMID: 32686156
Saracatinib is an oral Src-kinase inhibitor and has been studied in preclinical models and clinical trials of cancer therapy. GMI, a fungal immunomodulatory protein from Ganoderma microsporum, possesses antitumor capacity. The aim of this study is to e …
Saracatinib is an oral Src-kinase inhibitor and has been studied in preclinical models and clinical trials of cancer therapy. GMI, a fungal …
Functional proteomic analysis reveals that fungal immunomodulatory protein reduced expressions of heat shock proteins correlates to apoptosis in lung cancer cells.
Lin TY, Hua WJ, Yeh H, Tseng AJ. Lin TY, et al. Phytomedicine. 2021 Jan;80:153384. doi: 10.1016/j.phymed.2020.153384. Epub 2020 Oct 16. Phytomedicine. 2021. PMID: 33113507
BACKGROUND: Ling Zhi-8 (LZ-8) and GMI are two fungal immunomodulatory proteins (FIPs) with a similar structure and amino acid sequence and are respectively obtained from the medicinal mushroom Ganoderma lucidum and Ganoderma microsporum. ...LZ-8-induce …
BACKGROUND: Ling Zhi-8 (LZ-8) and GMI are two fungal immunomodulatory proteins (FIPs) with a similar structure and amino acid …
36 results