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Page 1
A Review of Ganoderma Triterpenoids and Their Bioactivities.
Galappaththi MCA, Patabendige NM, Premarathne BM, Hapuarachchi KK, Tibpromma S, Dai DQ, Suwannarach N, Rapior S, Karunarathna SC. Galappaththi MCA, et al. Biomolecules. 2022 Dec 22;13(1):24. doi: 10.3390/biom13010024. Biomolecules. 2022. PMID: 36671409 Free PMC article. Review.
More than 600 chemical compounds including alkaloids, meroterpenoids, nucleobases, nucleosides, polysaccharides, proteins, steroids and triterpenes were extracted and identified from Ganoderma, with triterpenes serving as the primary components. In recent yea …
More than 600 chemical compounds including alkaloids, meroterpenoids, nucleobases, nucleosides, polysaccharides, proteins, steroids and t
GLSP and GLSP-derived triterpenes attenuate atherosclerosis and aortic calcification by stimulating ABCA1/G1-mediated macrophage cholesterol efflux and inactivating RUNX2-mediated VSMC osteogenesis.
Zheng G, Zhao Y, Li Z, Hua Y, Zhang J, Miao Y, Guo Y, Li L, Shi J, Dong Z, Yang S, Fan G, Ma C. Zheng G, et al. Theranostics. 2023 Feb 21;13(4):1325-1341. doi: 10.7150/thno.80250. eCollection 2023. Theranostics. 2023. PMID: 36923537 Free PMC article.
Presently, the drug to treat aortic calcification remains not to be available. Ganoderma lucidum spore powder (GLSP) is from Ganoderma lucidum which is a Traditional Chinese Medicine with the homology of medicine and food. ...Furthermore, we determined the major com …
Presently, the drug to treat aortic calcification remains not to be available. Ganoderma lucidum spore powder (GLSP) is from Ganod
Triterpenes from antler-shaped fruiting body of Ganoderma lucidum and their hepatoprotective activities.
Shao H, Li Y, Wu C, Chen R, Kang J. Shao H, et al. Phytochemistry. 2024 Aug;224:114148. doi: 10.1016/j.phytochem.2024.114148. Epub 2024 May 18. Phytochemistry. 2024. PMID: 38763311
Seven previously undescribed triterpenes (1-7), as well as one triterpene (8) previously described as a synthetic product, were isolated from the antler-shaped fruiting body of Ganoderma lucidum. ...
Seven previously undescribed triterpenes (1-7), as well as one triterpene (8) previously described as a synthetic product, wer …
Triterpenes from Ganoderma lucidum inhibit hepatocellular carcinoma by regulating enhancer-associated lncRNA in vivo.
Zhao R, Zhang C, Tang C, Wu X, Hu S, Luo Q, Jia N, Fan L, Wang Y, Jiang W, Chen Q. Zhao R, et al. J Ethnopharmacol. 2025 Jan 10;336:118706. doi: 10.1016/j.jep.2024.118706. Epub 2024 Aug 24. J Ethnopharmacol. 2025. PMID: 39186989
ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (G. lucidum) has been widely used as adjuvant of anti-tumor therapy for variety tumors. ...The UPLC-MS method was used to identify the triterpenes of G. lucidum, and the in vitro experiments were used to verify which …
ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (G. lucidum) has been widely used as adjuvant of anti-tumor therapy for variety tum …
Protective effect of triterpenes of Ganoderma lucidum on lipopolysaccharide-induced inflammatory responses and acute liver injury.
Hu Z, Du R, Xiu L, Bian Z, Ma C, Sato N, Hattori M, Zhang H, Liang Y, Yu S, Wang X. Hu Z, et al. Cytokine. 2020 Mar;127:154917. doi: 10.1016/j.cyto.2019.154917. Epub 2019 Nov 24. Cytokine. 2020. PMID: 31775117
Ganoderma lucidum is a popular medicinal mushroom, which has been used as therapeutic for centuries in traditional Chinese medicine. Although G. lucidum showed strong protective effects in prevention or treatment of a variety of inflammatory diseases, the mechanisms underl
Ganoderma lucidum is a popular medicinal mushroom, which has been used as therapeutic for centuries in traditional Chinese medicine.
Lanostane triterpenes from the mushroom Ganoderma resinaceum and their inhibitory activities against alpha-glucosidase.
Chen XQ, Zhao J, Chen LX, Wang SF, Wang Y, Li SP. Chen XQ, et al. Phytochemistry. 2018 May;149:103-115. doi: 10.1016/j.phytochem.2018.01.007. Epub 2018 Feb 25. Phytochemistry. 2018. PMID: 29490285
Eighteen previously undescribed lanostane triterpenes and thirty known analogues were obtained from the fruiting bodies of Ganoderma resinaceum. ...The structure-activity relationships of ganoderma triterpenes on alpha-glucosidase inhibition showed tha …
Eighteen previously undescribed lanostane triterpenes and thirty known analogues were obtained from the fruiting bodies of Ganoder
Ganoderma triterpenes retard renal cyst development by downregulating Ras/MAPK signaling and promoting cell differentiation.
Su L, Liu L, Jia Y, Lei L, Liu J, Zhu S, Zhou H, Chen R, Lu HAJ, Yang B. Su L, et al. Kidney Int. 2017 Dec;92(6):1404-1418. doi: 10.1016/j.kint.2017.04.013. Epub 2017 Jul 12. Kidney Int. 2017. PMID: 28709639 Free article.
Here our aim was to investigate the effect of Ganoderma triterpenes (GT) on the development of kidney cysts. Importantly, GT attenuated cyst development in two mouse models of ADPKD with phenotypes of severe cystic kidney disease. ...
Here our aim was to investigate the effect of Ganoderma triterpenes (GT) on the development of kidney cysts. Importantly, GT a …
Ganoderma lucidum triterpenes ameliorate age-related cognitive impairment via regulating Eubacterium lentum-mediated serine metabolism.
Zhou Z, Yu T, Wang Z, Xu F, Liu W, Ai H, Zhang T, Ding K, Chen Q, Yan Y, Hao H, Su L, Jia N, Qian X, Fan X, Liu Y, Wang G, Hu K, Liang Y. Zhou Z, et al. Phytomedicine. 2025 Dec;149:157557. doi: 10.1016/j.phymed.2025.157557. Epub 2025 Nov 13. Phytomedicine. 2025. PMID: 41270387
OBJECTIVE: This study aims to investigate the therapeutic potential and underlying mechanisms of Ganoderma lucidum triterpenes (GLTs) in ameliorating cognitive impairment associated with aging. ...
OBJECTIVE: This study aims to investigate the therapeutic potential and underlying mechanisms of Ganoderma lucidum triterpenes
The Phytochemistry of Ganoderma Species and their Medicinal Potentials.
Blundell R, Camilleri E, Baral B, Karpiński TM, Neza E, Atrooz OM. Blundell R, et al. Am J Chin Med. 2023;51(4):859-882. doi: 10.1142/S0192415X23500404. Epub 2023 Mar 31. Am J Chin Med. 2023. PMID: 36999543 Review.
The Ganoderma genus is known for its diverse use as a functional food and therapeutic agent. This fungus has over 428 species, with Ganoderma lucidum being the most studied. The Ganoderma species produce several secondary metabolites and bioactive compounds l …
The Ganoderma genus is known for its diverse use as a functional food and therapeutic agent. This fungus has over 428 species, with …
745 results