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Using deuterium in drug discovery: leaving the label in the drug.
Gant TG. Gant TG. J Med Chem. 2014 May 8;57(9):3595-611. doi: 10.1021/jm4007998. Epub 2013 Dec 2. J Med Chem. 2014. PMID: 24294889
Discovery of novel isothiazole inhibitors of the TrkA kinase: structure-activity relationship, computer modeling, optimization, and identification of highly potent antagonists.
Lippa B, Morris J, Corbett M, Kwan TA, Noe MC, Snow SL, Gant TG, Mangiaracina M, Coffey HA, Foster B, Knauth EA, Wessel MD. Lippa B, et al. Among authors: gant tg. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3444-8. doi: 10.1016/j.bmcl.2006.04.003. Epub 2006 Apr 24. Bioorg Med Chem Lett. 2006. PMID: 16632359
Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer's disease.
Helal CJ, Sanner MA, Cooper CB, Gant T, Adam M, Lucas JC, Kang Z, Kupchinsky S, Ahlijanian MK, Tate B, Menniti FS, Kelly K, Peterson M. Helal CJ, et al. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5521-5. doi: 10.1016/j.bmcl.2004.09.006. Bioorg Med Chem Lett. 2004. PMID: 15482916
Potent and cellularly active 4-aminoimidazole inhibitors of cyclin-dependent kinase 5/p25 for the treatment of Alzheimer's disease.
Helal CJ, Kang Z, Lucas JC, Gant T, Ahlijanian MK, Schachter JB, Richter KE, Cook JM, Menniti FS, Kelly K, Mente S, Pandit J, Hosea N. Helal CJ, et al. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5703-7. doi: 10.1016/j.bmcl.2009.08.019. Epub 2009 Aug 8. Bioorg Med Chem Lett. 2009. PMID: 19700321
Pharmacological characterization of CP-547,632, a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for cancer therapy.
Beebe JS, Jani JP, Knauth E, Goodwin P, Higdon C, Rossi AM, Emerson E, Finkelstein M, Floyd E, Harriman S, Atherton J, Hillerman S, Soderstrom C, Kou K, Gant T, Noe MC, Foster B, Rastinejad F, Marx MA, Schaeffer T, Whalen PM, Roberts WG. Beebe JS, et al. Cancer Res. 2003 Nov 1;63(21):7301-9. Cancer Res. 2003. PMID: 14612527
Expression, purification, and enzymatic characterization of the dual specificity mitogen-activated protein kinase phosphatase, MKP-4.
Hong SB, Lubben TH, Dolliver CM, Petrolonis AJ, Roy RA, Li Z, Parsons TF, Li P, Xu H, Reilly RM, Trevillyan JM, Nichols AJ, Tummino PJ, Gant TG. Hong SB, et al. Among authors: gant tg. Bioorg Chem. 2005 Feb;33(1):34-44. doi: 10.1016/j.bioorg.2004.08.001. Bioorg Chem. 2005. PMID: 15668181
Plasma glucose levels are reduced in rats and mice treated with an inhibitor of glucose-6-phosphate translocase.
Parker JC, VanVolkenburg MA, Levy CB, Martin WH, Burk SH, Kwon Y, Giragossian C, Gant TG, Carpino PA, McPherson RK, Vestergaard P, Treadway JL. Parker JC, et al. Among authors: gant tg. Diabetes. 1998 Oct;47(10):1630-6. doi: 10.2337/diabetes.47.10.1630. Diabetes. 1998. PMID: 9753303
Substituted naphthalenones as a new structural class of HIV-1 reverse transcriptase inhibitors.
Alam M, Bechtold CM, Patick AK, Skoog MT, Gant TG, Colonno RJ, Meyers AI, Li H, Trimble J, Lin PF. Alam M, et al. Among authors: gant tg. Antiviral Res. 1993 Oct;22(2-3):131-41. doi: 10.1016/0166-3542(93)90091-v. Antiviral Res. 1993. PMID: 7506510