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A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury.
Kuba K, Imai Y, Rao S, Gao H, Guo F, Guan B, Huan Y, Yang P, Zhang Y, Deng W, Bao L, Zhang B, Liu G, Wang Z, Chappell M, Liu Y, Zheng D, Leibbrandt A, Wada T, Slutsky AS, Liu D, Qin C, Jiang C, Penninger JM. Kuba K, et al. Among authors: gao h. Nat Med. 2005 Aug;11(8):875-9. doi: 10.1038/nm1267. Epub 2005 Jul 10. Nat Med. 2005. PMID: 16007097 Free PMC article.
A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity.
Yang J, Wang W, Chen Z, Lu S, Yang F, Bi Z, Bao L, Mo F, Li X, Huang Y, Hong W, Yang Y, Zhao Y, Ye F, Lin S, Deng W, Chen H, Lei H, Zhang Z, Luo M, Gao H, Zheng Y, Gong Y, Jiang X, Xu Y, Lv Q, Li D, Wang M, Li F, Wang S, Wang G, Yu P, Qu Y, Yang L, Deng H, Tong A, Li J, Wang Z, Yang J, Shen G, Zhao Z, Li Y, Luo J, Liu H, Yu W, Yang M, Xu J, Wang J, Li H, Wang H, Kuang D, Lin P, Hu Z, Guo W, Cheng W, He Y, Song X, Chen C, Xue Z, Yao S, Chen L, Ma X, Chen S, Gou M, Huang W, Wang Y, Fan C, Tian Z, Shi M, Wang FS, Dai L, Wu M, Li G, Wang G, Peng Y, Qian Z, Huang C, Lau JY, Yang Z, Wei Y, Cen X, Peng X, Qin C, Zhang K, Lu G, Wei X. Yang J, et al. Among authors: gao h. Nature. 2020 Oct;586(7830):572-577. doi: 10.1038/s41586-020-2599-8. Epub 2020 Jul 29. Nature. 2020. PMID: 32726802
Ocular conjunctival inoculation of SARS-CoV-2 can cause mild COVID-19 in rhesus macaques.
Deng W, Bao L, Gao H, Xiang Z, Qu Y, Song Z, Gong S, Liu J, Liu J, Yu P, Qi F, Xu Y, Li F, Xiao C, Lv Q, Xue J, Wei Q, Liu M, Wang G, Wang S, Yu H, Chen T, Liu X, Zhao W, Han Y, Qin C. Deng W, et al. Among authors: gao h. Nat Commun. 2020 Sep 2;11(1):4400. doi: 10.1038/s41467-020-18149-6. Nat Commun. 2020. PMID: 32879306 Free PMC article.
An animal model of SARS produced by infection of Macaca mulatta with SARS coronavirus.
Qin C, Wang J, Wei Q, She M, Marasco WA, Jiang H, Tu X, Zhu H, Ren L, Gao H, Guo L, Huang L, Yang R, Cong Z, Guo L, Wang Y, Liu Y, Sun Y, Duan S, Qu J, Chen L, Tong W, Ruan L, Liu P, Zhang H, Zhang J, Zhang H, Liu D, Liu Q, Hong T, He W. Qin C, et al. Among authors: gao h. J Pathol. 2005 Jul;206(3):251-9. doi: 10.1002/path.1769. J Pathol. 2005. PMID: 15892035 Free PMC article.
Sequential infection with H1N1 and SARS-CoV-2 aggravated COVID-19 pathogenesis in a mammalian model, and co-vaccination as an effective method of prevention of COVID-19 and influenza.
Bao L, Deng W, Qi F, Lv Q, Song Z, Liu J, Gao H, Wei Q, Yu P, Xu Y, Qu Y, Li F, Xue J, Gong S, Liu M, Wang G, Wang S, Zhao B, Cong B, Qin C. Bao L, et al. Among authors: gao h. Signal Transduct Target Ther. 2021 May 20;6(1):200. doi: 10.1038/s41392-021-00618-z. Signal Transduct Target Ther. 2021. PMID: 34016949 Free PMC article.
Susceptibility and Attenuated Transmissibility of SARS-CoV-2 in Domestic Cats.
Bao L, Song Z, Xue J, Gao H, Liu J, Wang J, Guo Q, Zhao B, Qu Y, Qi F, Gong S, Liu M, Lv Q, Li D, Han Y, Zhao W, Deng S, Liu Y, Xiang Z, Yang B, Deng W, Yu H, Cong Z, Wei Q, Xu J, Gao GF, Qin C. Bao L, et al. Among authors: gao h, gao gf. J Infect Dis. 2021 Apr 23;223(8):1313-1321. doi: 10.1093/infdis/jiab104. J Infect Dis. 2021. PMID: 33605423 Free PMC article.
The Effects of ATIR Blocker on the Severity of COVID-19 in Hypertensive Inpatients and Virulence of SARS-CoV-2 in Hypertensive hACE2 Transgenic Mice.
Jiang X, Li H, Liu Y, Bao L, Zhan L, Gao H, Deng W, Xue J, Liu J, Liu X, Li J, Wang J, Wu S, Yan M, Luo W, Jose PA, Qin C, Yang X, Zhang D, Yang Z. Jiang X, et al. Among authors: gao h. J Cardiovasc Transl Res. 2022 Feb;15(1):38-48. doi: 10.1007/s12265-021-10147-3. Epub 2022 Jan 1. J Cardiovasc Transl Res. 2022. PMID: 34973134 Free PMC article.
Integrated histopathological, lipidomic, and metabolomic profiles reveal mink is a useful animal model to mimic the pathogenicity of severe COVID-19 patients.
Song Z, Bao L, Deng W, Liu J, Ren E, Lv Q, Liu M, Qi F, Chen T, Deng R, Li F, Liu Y, Wei Q, Gao H, Yu P, Han Y, Zhao W, Zheng J, Liang X, Yang F, Qin C. Song Z, et al. Among authors: gao h. Signal Transduct Target Ther. 2022 Jan 28;7(1):29. doi: 10.1038/s41392-022-00891-6. Signal Transduct Target Ther. 2022. PMID: 35091528 Free PMC article.
SARS-CoV-2 infection aggravates chronic comorbidities of cardiovascular diseases and diabetes in mice.
Ma Y, Lu D, Bao L, Qu Y, Liu J, Qi X, Yu L, Zhang X, Qi F, Lv Q, Liu Y, Shi X, Sun C, Li J, Wang J, Han Y, Gao K, Dong W, Liu N, Gao S, Xue J, Wei Q, Pan S, Gao H, Zhang L, Qin C. Ma Y, et al. Among authors: gao s, gao h, gao k. Animal Model Exp Med. 2021 Mar 6;4(1):2-15. doi: 10.1002/ame2.12155. eCollection 2021 Mar. Animal Model Exp Med. 2021. PMID: 33738432 Free PMC article.
SARS-CoV-2 crosses the blood-brain barrier accompanied with basement membrane disruption without tight junctions alteration.
Zhang L, Zhou L, Bao L, Liu J, Zhu H, Lv Q, Liu R, Chen W, Tong W, Wei Q, Xu Y, Deng W, Gao H, Xue J, Song Z, Yu P, Han Y, Zhang Y, Sun X, Yu X, Qin C. Zhang L, et al. Among authors: gao h. Signal Transduct Target Ther. 2021 Sep 6;6(1):337. doi: 10.1038/s41392-021-00719-9. Signal Transduct Target Ther. 2021. PMID: 34489403 Free PMC article.
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