Gao H - Search Results

1

Addressing MIST (Metabolites in Safety Testing): bioanalytical approaches to address metabolite exposures in humans and animals.

Gao H, Obach RS. Gao H, et al. Curr Drug Metab. 2011 Jul;12(6):578-86. doi: 10.2174/138920011795713661. Curr Drug Metab. 2011. PMID: 21434861

2

Metabolism of a 5HT₆ Antagonist, 2-Methyl-1-(Phenylsulfonyl)-4-(Piperazin-1-yl)-1H-Benzo[d]imidazole (SAM-760): Impact of Sulfonamide Metabolism on Diminution of a Ketoconazole-Mediated Clinical Drug-Drug Interaction.

Sawant-Basak A, Obach RS, Doran A, Lockwood P, Schildknegt K, Gao H, Mancuso J, Tse S, Comery TA. Sawant-Basak A, et al. Among authors: gao h. Drug Metab Dispos. 2018 Jul;46(7):934-942. doi: 10.1124/dmd.118.080457. Epub 2018 Apr 25. Drug Metab Dispos. 2018. PMID: 29695615

3

Unbiased Scanning Method and Data Banking Approach Using Ultra-High Performance Liquid Chromatography Coupled with High-Resolution Mass Spectrometry for Quantitative Comparison of Metabolite Exposure in Plasma across Species Analyzed at Different Dates.

Gao H, Deng S, Obach RS. Gao H, et al. Anal Chem. 2015 Dec 1;87(23):11771-6. doi: 10.1021/acs.analchem.5b03469. Epub 2015 Nov 16. Anal Chem. 2015. PMID: 26528960

4

Data-driven approach for cross-species comparative metabolite exposure assessment: how to establish fundamental bioanalytical parameters for the peak area ratio method.

Gao H, Obach RS. Gao H, et al. Bioanalysis. 2014 Mar;6(5):641-50. doi: 10.4155/bio.14.15. Bioanalysis. 2014. PMID: 24620806

5

Meeting report: metabolites in safety testing (MIST) symposium-safety assessment of human metabolites: what's REALLY necessary to ascertain exposure coverage in safety tests?

Gao H, Jacobs A, White RE, Booth BP, Obach RS. Gao H, et al. AAPS J. 2013 Oct;15(4):970-3. doi: 10.1208/s12248-013-9502-6. Epub 2013 Jul 3. AAPS J. 2013. PMID: 23821354 Free PMC article.

6

A simple liquid chromatography-tandem mass spectrometry method to determine relative plasma exposures of drug metabolites across species for metabolite safety assessments.

Gao H, Deng S, Obach RS. Gao H, et al. Drug Metab Dispos. 2010 Dec;38(12):2147-56. doi: 10.1124/dmd.110.034637. Epub 2010 Sep 16. Drug Metab Dispos. 2010. PMID: 20847138

7

Leveraging of Rifampicin-Dosed Cynomolgus Monkeys to Identify Bile Acid 3-O-Sulfate Conjugates as Potential Novel Biomarkers for Organic Anion-Transporting Polypeptides.

Thakare R, Gao H, Kosa RE, Bi YA, Varma MVS, Cerny MA, Sharma R, Kuhn M, Huang B, Liu Y, Yu A, Walker GS, Niosi M, Tremaine L, Alnouti Y, Rodrigues AD. Thakare R, et al. Among authors: gao h. Drug Metab Dispos. 2017 Jul;45(7):721-733. doi: 10.1124/dmd.117.075275. Epub 2017 Apr 10. Drug Metab Dispos. 2017. PMID: 28396527

8

Deuterium isotope effects on drug pharmacokinetics. I. System-dependent effects of specific deuteration with aldehyde oxidase cleared drugs.

Sharma R, Strelevitz TJ, Gao H, Clark AJ, Schildknegt K, Obach RS, Ripp SL, Spracklin DK, Tremaine LM, Vaz AD. Sharma R, et al. Among authors: gao h. Drug Metab Dispos. 2012 Mar;40(3):625-34. doi: 10.1124/dmd.111.042770. Epub 2011 Dec 21. Drug Metab Dispos. 2012. PMID: 22190693

9

A simple liquid chromatography-tandem mass spectrometry method to determine relative plasma exposures of drug metabolites across species for metabolite safety assessments (metabolites in safety testing). II. Application to unstable metabolites.

Gao H, Obach RS. Gao H, et al. Drug Metab Dispos. 2012 Jul;40(7):1290-6. doi: 10.1124/dmd.112.044552. Epub 2012 Mar 28. Drug Metab Dispos. 2012. PMID: 22456937

10

Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections.

Mitton-Fry MJ, Arcari JT, Brown MF, Casavant JM, Finegan SM, Flanagan ME, Gao H, George DM, Gerstenberger BS, Han S, Hardink JR, Harris TM, Hoang T, Huband MD, Irvine R, Lall MS, Megan Lemmon M, Li C, Lin J, McCurdy SP, Mueller JP, Mullins L, Niosi M, Noe MC, Pattavina D, Penzien J, Plummer MS, Risley H, Schuff BP, Shanmugasundaram V, Starr JT, Sun J, Winton J, Young JA. Mitton-Fry MJ, et al. Among authors: gao h. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5989-94. doi: 10.1016/j.bmcl.2012.07.005. Epub 2012 Jul 20. Bioorg Med Chem Lett. 2012. PMID: 22892121

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