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A novel GSK-3β inhibitor YQ138 prevents neuronal injury induced by glutamate and brain ischemia through activation of the Nrf2 signaling pathway.
Pang T, Wang YJ, Gao YX, Xu Y, Li Q, Zhou YB, Xu L, Huang ZJ, Liao H, Zhang LY, Gao JR, Ye Q, Li J. Pang T, et al. Acta Pharmacol Sin. 2016 Jun;37(6):741-52. doi: 10.1038/aps.2016.3. Epub 2016 Apr 25. Acta Pharmacol Sin. 2016. PMID: 27108601 Free PMC article.
Synthesis and biological evaluation of 3-([1,2,4]triazolo[4,3-a]pyridin-3-yl)-4-(indol-3-yl)-maleimides as potent, selective GSK-3β inhibitors and neuroprotective agents.
Ye Q, Mao W, Zhou Y, Xu L, Li Q, Gao Y, Wang J, Li C, Xu Y, Xu Y, Liao H, Zhang L, Gao J, Li J, Pang T. Ye Q, et al. Bioorg Med Chem. 2015 Mar 1;23(5):1179-88. doi: 10.1016/j.bmc.2014.12.026. Epub 2014 Dec 20. Bioorg Med Chem. 2015. PMID: 25662701
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