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The A3 adenosine receptor agonist CF502 inhibits the PI3K, PKB/Akt and NF-kappaB signaling pathway in synoviocytes from rheumatoid arthritis patients and in adjuvant-induced arthritis rats.
Ochaion A, Bar-Yehuda S, Cohen S, Amital H, Jacobson KA, Joshi BV, Gao ZG, Barer F, Patoka R, Del Valle L, Perez-Liz G, Fishman P. Ochaion A, et al. Among authors: gao zg. Biochem Pharmacol. 2008 Aug 15;76(4):482-94. doi: 10.1016/j.bcp.2008.05.032. Epub 2008 Jun 17. Biochem Pharmacol. 2008. PMID: 18602896 Free PMC article.
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