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The PI3K p110delta controls T-cell development, differentiation and regulation.
Patton DT, Garçon F, Okkenhaug K. Patton DT, et al. Among authors: garcon f. Biochem Soc Trans. 2007 Apr;35(Pt 2):167-71. doi: 10.1042/BST0350167. Biochem Soc Trans. 2007. PMID: 17371229 Review.
Travel informations on the Tec kinases during lymphocyte activation.
Garçon F, Nunès JA. Garçon F, et al. Adv Exp Med Biol. 2006;584:15-27. doi: 10.1007/0-387-34132-3_2. Adv Exp Med Biol. 2006. PMID: 16802596 Review. No abstract available.
The p110delta isoform of phosphoinositide 3-kinase controls clonal expansion and differentiation of Th cells.
Okkenhaug K, Patton DT, Bilancio A, Garçon F, Rowan WC, Vanhaesebroeck B. Okkenhaug K, et al. Among authors: garcon f. J Immunol. 2006 Oct 15;177(8):5122-8. doi: 10.4049/jimmunol.177.8.5122. J Immunol. 2006. PMID: 17015696
CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer.
Garçon F, Patton DT, Emery JL, Hirsch E, Rottapel R, Sasaki T, Okkenhaug K. Garçon F, et al. Blood. 2008 Feb 1;111(3):1464-71. doi: 10.1182/blood-2007-08-108050. Epub 2007 Nov 15. Blood. 2008. PMID: 18006698
p110gamma and p110delta isoforms of phosphoinositide 3-kinase differentially regulate natural killer cell migration in health and disease.
Saudemont A, Garçon F, Yadi H, Roche-Molina M, Kim N, Segonds-Pichon A, Martín-Fontecha A, Okkenhaug K, Colucci F. Saudemont A, et al. Among authors: garcon f. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5795-800. doi: 10.1073/pnas.0808594106. Epub 2009 Mar 18. Proc Natl Acad Sci U S A. 2009. PMID: 19297623 Free PMC article.
The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell development.
Ramadani F, Bolland DJ, Garcon F, Emery JL, Vanhaesebroeck B, Corcoran AE, Okkenhaug K. Ramadani F, et al. Among authors: garcon f. Sci Signal. 2010 Aug 10;3(134):ra60. doi: 10.1126/scisignal.2001104. Sci Signal. 2010. PMID: 20699475 Free PMC article.
Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage.
Angulo I, Vadas O, Garçon F, Banham-Hall E, Plagnol V, Leahy TR, Baxendale H, Coulter T, Curtis J, Wu C, Blake-Palmer K, Perisic O, Smyth D, Maes M, Fiddler C, Juss J, Cilliers D, Markelj G, Chandra A, Farmer G, Kielkowska A, Clark J, Kracker S, Debré M, Picard C, Pellier I, Jabado N, Morris JA, Barcenas-Morales G, Fischer A, Stephens L, Hawkins P, Barrett JC, Abinun M, Clatworthy M, Durandy A, Doffinger R, Chilvers ER, Cant AJ, Kumararatne D, Okkenhaug K, Williams RL, Condliffe A, Nejentsev S. Angulo I, et al. Among authors: garcon f. Science. 2013 Nov 15;342(6160):866-71. doi: 10.1126/science.1243292. Epub 2013 Oct 17. Science. 2013. PMID: 24136356 Free PMC article.
PI3Kδ promotes CD4(+) T-cell interactions with antigen-presenting cells by increasing LFA-1 binding to ICAM-1.
Garçon F, Okkenhaug K. Garçon F, et al. Immunol Cell Biol. 2016 May;94(5):486-95. doi: 10.1038/icb.2016.1. Epub 2016 Jan 7. Immunol Cell Biol. 2016. PMID: 26740009 Free PMC article.
Intravital Imaging of Adoptive T-Cell Morphology, Mobility and Trafficking Following Immune Checkpoint Inhibition in a Mouse Melanoma Model.
Lau D, Garçon F, Chandra A, Lechermann LM, Aloj L, Chilvers ER, Corrie PG, Okkenhaug K, Gallagher FA. Lau D, et al. Among authors: garcon f. Front Immunol. 2020 Jul 22;11:1514. doi: 10.3389/fimmu.2020.01514. eCollection 2020. Front Immunol. 2020. PMID: 32793206 Free PMC article.
Tec kinase migrates to the T cell-APC interface independently of its pleckstrin homology domain.
Garçon F, Bismuth G, Isnardon D, Olive D, Nunès JA. Garçon F, et al. J Immunol. 2004 Jul 15;173(2):770-5. doi: 10.4049/jimmunol.173.2.770. J Immunol. 2004. PMID: 15240663
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