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Depletion of WRN protein causes RACK1 to activate several protein kinase C isoforms.
Massip L, Garand C, Labbé A, Perreault E, Turaga RV, Bohr VA, Lebel M. Massip L, et al. Among authors: Garand C. Oncogene. 2010 Mar 11;29(10):1486-97. doi: 10.1038/onc.2009.443. Epub 2009 Dec 7. Oncogene. 2010. PMID: 19966859 Free PMC article.
In this study, we show that a knock down of the WRN protein in normal human fibroblasts induces phosphorylation and activation of several protein kinase C (PKC) enzymes. Using a tandem affinity purification strategy, we found that WRN physically and functionally interacts with receptor for activated C-kinase 1 (RACK1), a highly conserved anchoring protein involved in various biological processes, such as cell growth and proliferation. ...
In this study, we show that a knock down of the WRN protein in normal human fibroblasts induces phosphorylation and activation of several pr …
Different non-synonymous polymorphisms modulate the interaction of the WRN protein to its protein partners and its enzymatic activities.
Gagné JP, Lachapelle S, Garand C, Tsofack SP, Coulombe Y, Caron MC, Poirier GG, Masson JY, Lebel M. Gagné JP, et al. Among authors: Garand C. Oncotarget. 2016 Dec 27;7(52):85680-85696. doi: 10.18632/oncotarget.13341. Oncotarget. 2016. PMID: 27863399 Free PMC article.
Down regulation of miR-124 in both Werner syndrome DNA helicase mutant mice and mutant Caenorhabditis elegans wrn-1 reveals the importance of this microRNA in accelerated aging.
Dallaire A, Garand C, Paquel ER, Mitchell SJ, de Cabo R, Simard MJ, Lebel M. Dallaire A, et al. Among authors: Garand C. Aging (Albany NY). 2012 Sep;4(9):636-47. doi: 10.18632/aging.100489. Aging (Albany NY). 2012. PMID: 23075628 Free PMC article.
Resveratrol improves insulin resistance hyperglycemia and hepatosteatosis but not hypertriglyceridemia, inflammation, and life span in a mouse model for Werner syndrome.
Labbé A, Garand C, Cogger VC, Paquet ER, Desbiens M, Le Couteur DG, Lebel M. Labbé A, et al. Among authors: Garand C. J Gerontol A Biol Sci Med Sci. 2011 Mar;66(3):264-78. doi: 10.1093/gerona/glq184. Epub 2010 Oct 25. J Gerontol A Biol Sci Med Sci. 2011. PMID: 20974729
Ascorbate improves metabolic abnormalities in Wrn mutant mice but not the free radical scavenger catechin.
Lebel M, Massip L, Garand C, Thorin E. Lebel M, et al. Among authors: Garand C. Ann N Y Acad Sci. 2010 Jun;1197:40-4. doi: 10.1111/j.1749-6632.2010.05189.x. Ann N Y Acad Sci. 2010. PMID: 20536831 Free PMC article. Review.
Vitamin C supplementation reduced oxidative stress in liver and heart tissues and reversed hypertriglyceridemia, hyperglycemia, and insulin resistance and reduced fat weight in mutant Wrn(Deltahel/Deltahel) mice. ...Finally, vitamin C and catechin hydrate did not affect the metabolic status of wild-type mice. These results indicate that vitamin C supplementation could be beneficial for WS patients....
Vitamin C supplementation reduced oxidative stress in liver and heart tissues and reversed hypertriglyceridemia, hyperglycemia, and i …
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