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NADPH oxidase and hydrogen peroxide mediate insulin-induced calcium increase in skeletal muscle cells.
Espinosa A, García A, Härtel S, Hidalgo C, Jaimovich E. Espinosa A, et al. J Biol Chem. 2009 Jan 23;284(4):2568-75. doi: 10.1074/jbc.M804249200. Epub 2008 Nov 20. J Biol Chem. 2009. PMID: 19028699
Skeletal muscle is one of the main physiological targets of insulin, a hormone that triggers a complex signaling cascade and that enhances the production of reactive oxygen species (ROS) in different cell types. ...We used the translocation of p47phox from the cytop …
Skeletal muscle is one of the main physiological targets of insulin, a hormone that triggers a complex signaling cascade and t …
Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis.
Parra V, Eisner V, Chiong M, Criollo A, Moraga F, Garcia A, Härtel S, Jaimovich E, Zorzano A, Hidalgo C, Lavandero S. Parra V, et al. Cardiovasc Res. 2008 Jan 15;77(2):387-97. doi: 10.1093/cvr/cvm029. Epub 2007 Oct 4. Cardiovasc Res. 2008. PMID: 18006463
AIMS: In cells, mitochondria are organized as a network of interconnected organelles that fluctuate between fission and fusion events (mitochondrial dynamics). ...C(2)-ceramide, but not dihydro-C(2)-ceramide, promoted rapid fragmentation of the mitochondrial network in …
AIMS: In cells, mitochondria are organized as a network of interconnected organelles that fluctuate between fission and fusion events …
Ryanodine receptor-mediated Ca(2+) release underlies iron-induced mitochondrial fission and stimulates mitochondrial Ca(2+) uptake in primary hippocampal neurons.
Sanmartín CD, Paula-Lima AC, García A, Barattini P, Hartel S, Núñez MT, Hidalgo C. Sanmartín CD, et al. Front Mol Neurosci. 2014 Mar 11;7:13. doi: 10.3389/fnmol.2014.00013. eCollection 2014. Front Mol Neurosci. 2014. PMID: 24653672 Free PMC article.
Here, we describe that 24 h incubation of primary hippocampal neurons with iron enhanced agonist-induced RyR-mediated Ca(2) (+) release and promoted mitochondrial network fragmentation in 43% of neurons, a response significantly prevented by RyR inhibition and by the antio …
Here, we describe that 24 h incubation of primary hippocampal neurons with iron enhanced agonist-induced RyR-mediated Ca(2) (+) release and …
[Association of age with sperm DNA fragmentation].
Horta F, Madariaga M, García A, Hartel S, Smith R. Horta F, et al. Rev Med Chil. 2011 Mar;139(3):306-12. Epub 2011 Aug 25. Rev Med Chil. 2011. PMID: 21879161 Spanish.
These were separated in a group aged less than forty years and a second group aged more than forty years. Sperm DNA fragmentation was studied by TUNEL (terminal deoxynucleotidyl transferase-mediated 2'-deoxyuridine 5'-triphosphate nick end-labeling) and SCD (sperm c …
These were separated in a group aged less than forty years and a second group aged more than forty years. Sperm DNA fragmentat …
RyR2-Mediated Ca2+ Release and Mitochondrial ROS Generation Partake in the Synaptic Dysfunction Caused by Amyloid β Peptide Oligomers.
SanMartín CD, Veloso P, Adasme T, Lobos P, Bruna B, Galaz J, García A, Hartel S, Hidalgo C, Paula-Lima AC. SanMartín CD, et al. Front Mol Neurosci. 2017 Apr 25;10:115. doi: 10.3389/fnmol.2017.00115. eCollection 2017. Front Mol Neurosci. 2017. PMID: 28487634 Free PMC article.
Based on our results, we propose that AβOs-induced Ca(2+) entry and ROS generation jointly stimulate RyR2 activity, causing mitochondrial Ca(2+) overload and fragmentation in a feed forward injurious cycle. ...
Based on our results, we propose that AβOs-induced Ca(2+) entry and ROS generation jointly stimulate RyR2 activity, causing mitochondrial Ca …
Gold-standard for computer-assisted morphological sperm analysis.
Chang V, Garcia A, Hitschfeld N, Härtel S. Chang V, et al. Comput Biol Med. 2017 Apr 1;83:143-150. doi: 10.1016/j.compbiomed.2017.03.004. Epub 2017 Mar 2. Comput Biol Med. 2017. PMID: 28279863
Although this paper does not provide a computational tool for morphological sperm analysis, we present a set of experiments for comparing sperm head description and classification common techniques. ...Indeed, there is a clear need for a specific shape …
Although this paper does not provide a computational tool for morphological sperm analysis, we present a set of experiments fo …
Chile's National Center for Health Information Systems: A Public-Private Partnership to Foster Health Care Information Interoperability.
Capurro D, Echeverry A, Figueroa R, Guiñez S, Taramasco C, Galindo C, Avendaño A, García A, Härtel S. Capurro D, et al. Stud Health Technol Inform. 2017;245:693-695. Stud Health Technol Inform. 2017. PMID: 29295186
Despite the continuous technical advancements around health information standards, a critical component to their widespread adoption involves political agreement between a diverse set of stakeholders. ...In this vision paper we present the path that Chile is taking …
Despite the continuous technical advancements around health information standards, a critical component to their widespread adoption …
Influence of Acromial Morphologic Characteristics and Acromioclavicular Arthrosis on the Effect of Platelet-Rich Plasma on Partial Tears of the Supraspinatus Tendon.
Berná-Mestre JD, Fernández C, Carbonell G, García A, García-Vidal JA, Mirapeix FMI, Berná-Serna JD. Berná-Mestre JD, et al. Among authors: garcia a. AJR Am J Roentgenol. 2020 Jul 8:1-9. doi: 10.2214/AJR.19.22331. Online ahead of print. AJR Am J Roentgenol. 2020. PMID: 32755169
The combination of a poly-caprolactone/nano-hydroxyapatite honeycomb scaffold and mesenchymal stem cells promotes bone regeneration in rat calvarial defects.
Naudot M, Garcia AG, Jankovsky N, Barre A, Zabijak L, Azdad SZ, Collet L, Bedoui F, Hébraud A, Schlatter G, Devauchelle B, Marolleau JP, Legallais C, Le Ricousse S. Naudot M, et al. Among authors: garcia ag. J Tissue Eng Regen Med. 2020 Aug 4. doi: 10.1002/term.3114. Online ahead of print. J Tissue Eng Regen Med. 2020. PMID: 32755059
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