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Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease.
Marco-Contelles J, León R, de los Ríos C, Samadi A, Bartolini M, Andrisano V, Huertas O, Barril X, Luque FJ, Rodríguez-Franco MI, López B, López MG, García AG, Carreiras Mdo C, Villarroya M. Marco-Contelles J, et al. Among authors: garcia ag. J Med Chem. 2009 May 14;52(9):2724-32. doi: 10.1021/jm801292b. J Med Chem. 2009. PMID: 19374444
Synthesis, biological evaluation and molecular modelling of diversely functionalized heterocyclic derivatives as inhibitors of acetylcholinesterase/butyrylcholinesterase and modulators of Ca2+ channels and nicotinic receptors.
Marco JL, de los Ríos C, García AG, Villarroya M, Carreiras MC, Martins C, Eleutério A, Morreale A, Orozco M, Luque FJ. Marco JL, et al. Among authors: garcia ag. Bioorg Med Chem. 2004 May 1;12(9):2199-218. doi: 10.1016/j.bmc.2004.02.017. Bioorg Med Chem. 2004. PMID: 15080920
New multipotent tetracyclic tacrines with neuroprotective activity.
Marco-Contelles J, León R, de los Ríos C, García AG, López MG, Villarroya M. Marco-Contelles J, et al. Among authors: garcia ag. Bioorg Med Chem. 2006 Dec 15;14(24):8176-85. doi: 10.1016/j.bmc.2006.09.025. Epub 2006 Sep 26. Bioorg Med Chem. 2006. PMID: 17005406
Tacrine-melatonin hybrids as multifunctional agents for Alzheimer's disease, with cholinergic, antioxidant, and neuroprotective properties.
Fernández-Bachiller MI, Pérez C, Campillo NE, Páez JA, González-Muñoz GC, Usán P, García-Palomero E, López MG, Villarroya M, García AG, Martínez A, Rodríguez-Franco MI. Fernández-Bachiller MI, et al. Among authors: garcia ag, garcia palomero e. ChemMedChem. 2009 May;4(5):828-41. doi: 10.1002/cmdc.200800414. ChemMedChem. 2009. PMID: 19308922
547 results