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Transcription of repA, the gene of the initiation protein of the Pseudomonas plasmid pPS10, is autoregulated by interactions of the RepA protein at a symmetrical operator.
García de Viedma D, Giraldo R, Ruiz-Echevarría MJ, Lurz R, Díaz-Orejas R. García de Viedma D, et al. J Mol Biol. 1995 Mar 24;247(2):211-23. doi: 10.1006/jmbi.1994.0134. J Mol Biol. 1995. PMID: 7707370
A leucine zipper motif determines different functions in a DNA replication protein.
Garcia de Viedma D, Giraldo R, Rivas G, Fernández-Tresguerres E, Diaz-Orejas R. Garcia de Viedma D, et al. EMBO J. 1996 Feb 15;15(4):925-34. EMBO J. 1996. PMID: 8631313 Free PMC article.
Leucines at the d positions of the putative alpha-helix are relevant in the formation of RepA dimers required for transcriptional autoregulation. ...
Leucines at the d positions of the putative alpha-helix are relevant in the formation of RepA dimers required for transcriptional aut …
Specific binding of the replication protein of plasmid pPS10 to direct and inverted repeats is mediated by an HTH motif.
García de Viedma D, Serrano-López A, Díaz-Orejas R. García de Viedma D, et al. Nucleic Acids Res. 1995 Dec 25;23(24):5048-54. doi: 10.1093/nar/23.24.5048. Nucleic Acids Res. 1995. PMID: 8559664 Free PMC article.
[D. García de Viedma, et al. (1996) EMBO J. in press]. RepA monomers bind to four direct repeats at the origin of replication (oriV) to initiate pPS10 replication This report shows that randomly generated mutations in RepA, associated with defficiencies in au …
[D. García de Viedma, et al. (1996) EMBO J. in press]. RepA monomers bind to four direct repeats at the origin of repli …
Host growth temperature and a conservative amino acid substitution in the replication protein of pPS10 influence plasmid host range.
Fernández-Tresguerres ME, Martín M, García de Viedma D, Giraldo R, Díaz-Orejas R. Fernández-Tresguerres ME, et al. Among authors: garcia de viedma d. J Bacteriol. 1995 Aug;177(15):4377-84. doi: 10.1128/jb.177.15.4377-4384.1995. J Bacteriol. 1995. PMID: 7635822 Free PMC article.
Genetic features shared by Mycobacterium tuberculosis strains involved in microevolution events.
Pérez-Lago L, Navarro Y, Herranz M, Bouza E, García-de-Viedma D. Pérez-Lago L, et al. Among authors: garcia de viedma d. Infect Genet Evol. 2013 Jun;16:326-9. doi: 10.1016/j.meegid.2013.02.016. Epub 2013 Mar 14. Infect Genet Evol. 2013. PMID: 23499710
A Mycobacterium tuberculosis Beijing strain persists at high rates and extends its geographic boundaries 20 years after importation.
Pérez-Lago L, Campos-Herrero MI, Cañas F, Copado R, Sante L, Pino B, Lecuona M, Gil ÓD, Martín C, Muñoz P, García-de-Viedma D, Samper S. Pérez-Lago L, et al. Among authors: garcia de viedma d. Sci Rep. 2019 Mar 18;9(1):4687. doi: 10.1038/s41598-019-40525-6. Sci Rep. 2019. PMID: 30886337 Free PMC article.
In-Depth Characterization and Functional Analysis of Clonal Variants in a Mycobacterium tuberculosis Strain Prone to Microevolution.
Navarro Y, Pérez-Lago L, Herranz M, Sierra O, Comas I, Sicilia J, Bouza E, García de Viedma D. Navarro Y, et al. Among authors: garcia de viedma d. Front Microbiol. 2017 Apr 24;8:694. doi: 10.3389/fmicb.2017.00694. eCollection 2017. Front Microbiol. 2017. PMID: 28484440 Free PMC article.
Mycobacterium tuberculosis Acquires Limited Genetic Diversity in Prolonged Infections, Reactivations and Transmissions Involving Multiple Hosts.
Herranz M, Pole I, Ozere I, Chiner-Oms Á, Martínez-Lirola M, Pérez-García F, Gijón P, Serrano MJR, Romero LC, Cuevas O, Comas I, Bouza E, Pérez-Lago L, García-de-Viedma D. Herranz M, et al. Among authors: garcia de viedma d. Front Microbiol. 2018 Jan 19;8:2661. doi: 10.3389/fmicb.2017.02661. eCollection 2017. Front Microbiol. 2018. PMID: 29403447 Free PMC article.
Equatorial Guinea, a multidrug-resistant tuberculosis hotspot in Central Africa.
Izco S, Eyene J, Pérez-Lago L, Herranz M, Biyé L, Noeske J, Pérez-García F, Omoha D, Ruiz-Serrano MJ, Ondó M, Mbang T, Momo JC, Angue M, Ebee TS, García-de-Viedma D, Bouza E. Izco S, et al. Among authors: garcia de viedma d. Eur Respir J. 2017 Jan 11;49(1):1600952. doi: 10.1183/13993003.00952-2016. Print 2017 Jan. Eur Respir J. 2017. PMID: 28077475 No abstract available.
Paying attention to the details in Mycobacterium tuberculosis: Strain-specific single-nucleotide polymorphisms and clonal variants.
García de Viedma D. García de Viedma D. Int J Mycobacteriol. 2016 Dec;5 Suppl 1:S76. doi: 10.1016/j.ijmyco.2016.09.013. Epub 2016 Oct 21. Int J Mycobacteriol. 2016. PMID: 28043627 No abstract available.
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