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Page 1
SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function.
Boutant M, Joffraud M, Kulkarni SS, García-Casarrubios E, García-Roves PM, Ratajczak J, Fernández-Marcos PJ, Valverde AM, Serrano M, Cantó C. Boutant M, et al. Among authors: garcia casarrubios e. Mol Metab. 2014 Dec 18;4(2):118-31. doi: 10.1016/j.molmet.2014.12.008. eCollection 2015 Feb. Mol Metab. 2014. PMID: 25685699 Free PMC article.
Moderate SIRT1 overexpression protects against brown adipose tissue inflammation.
Escalona-Garrido C, Vázquez P, Mera P, Zagmutt S, García-Casarrubios E, Montero-Pedrazuela A, Rey-Stolle F, Guadaño-Ferraz A, Rupérez FJ, Serra D, Herrero L, Obregon MJ, Valverde ÁM. Escalona-Garrido C, et al. Among authors: garcia casarrubios e. Mol Metab. 2020 Dec;42:101097. doi: 10.1016/j.molmet.2020.101097. Epub 2020 Oct 10. Mol Metab. 2020. PMID: 33049408 Free PMC article.
Carnitine Palmitoyltransferase 1 Increases Lipolysis, UCP1 Protein Expression and Mitochondrial Activity in Brown Adipocytes.
Calderon-Dominguez M, Sebastián D, Fucho R, Weber M, Mir JF, García-Casarrubios E, Obregón MJ, Zorzano A, Valverde ÁM, Serra D, Herrero L. Calderon-Dominguez M, et al. Among authors: garcia casarrubios e. PLoS One. 2016 Jul 20;11(7):e0159399. doi: 10.1371/journal.pone.0159399. eCollection 2016. PLoS One. 2016. PMID: 27438137 Free PMC article.
Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes.
García-Casarrubios E, de Moura C, Arroba AI, Pescador N, Calderon-Dominguez M, Garcia L, Herrero L, Serra D, Cadenas S, Reis F, Carvalho E, Obregon MJ, Valverde ÁM. García-Casarrubios E, et al. Biochim Biophys Acta. 2016 Dec;1861(12 Pt A):1929-1941. doi: 10.1016/j.bbalip.2016.09.016. Epub 2016 Sep 26. Biochim Biophys Acta. 2016. PMID: 27686967
Hepatic cyclooxygenase-2 expression protects against diet-induced steatosis, obesity, and insulin resistance.
Francés DE, Motiño O, Agrá N, González-Rodríguez Á, Fernández-Álvarez A, Cucarella C, Mayoral R, Castro-Sánchez L, García-Casarrubios E, Boscá L, Carnovale CE, Casado M, Valverde ÁM, Martín-Sanz P. Francés DE, et al. Among authors: garcia casarrubios e. Diabetes. 2015 May;64(5):1522-31. doi: 10.2337/db14-0979. Epub 2014 Nov 24. Diabetes. 2015. PMID: 25422106